Single genetic locus improvement of iron, zinc and β-carotene content in rice grains.

abstract：:Caterpillars of the silk moth genus Hyalophora (Lepidoptera; Saturniidae) construct multilayered cocoons that function as overwintering housing during the pupal to adult developmental period. While all cocoons share the primary function of protecting the developing moth, cocoons spun by different Hyalophora silk moth ...

journal_title：Scientific reports

authors： Guerra PA,Lawson LP,Gatto LJ,Albright ME,Smith SJ

更新日期：2020-03-27 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) and cytokeratin 18 (CK18) were previously reported to be elevated in nonalcoholic fatty liver disease (NAFLD). We aim to analyze the differential roles of FGF21, cell apoptosis marker CK18 fragment M30 and total cell death marker CK18 M65ED in monitoring the different stages of NAFL...

journal_title：Scientific reports

authors： Wu G,Li H,Fang Q,Zhang J,Zhang M,Zhang L,Wu L,Hou X,Lu J,Bao Y,Jia W

更新日期：2017-07-11 00:00:00

abstract：:Among atrial fibrillation (AF) patients, Danish nationwide registries (2011-2015) were used to examine temporal trends of initiation patterns of oral anticoagulation (OAC) treatment according to age. Overall, 43,299 AF patients initiating vitamin K antagonists (VKA) (42%), dabigatran (29%), rivaroxaban (13%), or apixa...

journal_title：Scientific reports

authors： Staerk L,Fosbøl EL,Gadsbøll K,Sindet-Pedersen C,Pallisgaard JL,Lamberts M,Lip GY,Torp-Pedersen C,Gislason GH,Olesen JB

更新日期：2016-08-11 00:00:00

abstract：:In the study of non-equilibrium polariton condensates it is usually assumed that the dispersion relation of polaritons is parabolic in nature. We show that considering the true non-parabolic kinetic energy of polaritons leads to significant changes in the behaviour of the condensate due to the curvature of the dispers...

journal_title：Scientific reports

authors： Pinsker F,Ruan X,Alexander TJ

更新日期：2017-05-15 00:00:00

abstract：:Hypothalamic growth hormone-releasing hormone (GHRH) neurons orchestrate body growth/maturation and have been implicated in feeding responses and ageing. However, the electrical patterns that dictate GHRH neuron functions have remained elusive. Since the inhibitory neuropeptide somatostatin (SST) is considered to be a...

journal_title：Scientific reports

authors： Osterstock G,Mitutsova V,Barre A,Granier M,Fontanaud P,Chazalon M,Carmignac D,Robinson IC,Low MJ,Plesnila N,Hodson DJ,Mollard P,Méry PF

更新日期：2016-04-13 00:00:00

abstract：:ABO blood group is associated with cardiovascular disease, with significantly lower risk in blood group O individuals. ABO(H) blood group determinants are expressed on different glycoproteins on platelet surfaces. In addition, ABO(H) structures are also present on VWF glycans. These ABO(H) carbohydrates influence both...

journal_title：Scientific reports

authors： O'Donghaile D,Jenkins PV,McGrath RT,Preston L,Field SP,Ward SE,O'Sullivan JM,O'Donnell JS

更新日期：2020-10-27 00:00:00

abstract：:The melanin-concentrating hormone (MCH) is a peptidergic neuromodulator synthesized by neurons in the lateral hypothalamus and zona incerta. MCHergic neurons project throughout the central nervous system, indicating the involvements of many physiological functions, but the role in pain has yet to be determined. In thi...

journal_title：Scientific reports

authors： Jang JH,Park JY,Oh JY,Bae SJ,Jang H,Jeon S,Kim J,Park HJ

更新日期：2018-01-15 00:00:00

abstract：:Astrocyte reactivation has been discovered to be an important contributor to several neurological diseases. In vitro models involving human astrocytes have the potential to reveal disease-specific mechanisms of these cells and to advance research on neuropathological conditions. Here, we induced a reactive phenotype i...

journal_title：Scientific reports

authors： Hyvärinen T,Hagman S,Ristola M,Sukki L,Veijula K,Kreutzer J,Kallio P,Narkilahti S

更新日期：2019-11-15 00:00:00

abstract：:By moving the alkoxy group on the spacer from position 5 to position 4 to add another protocol for the algorithm for intermolecular and intramolecular hydrogen bonding interactions, highly regioselectivity of noncovalent synthesis of the hydrazide-based cyclic hexamers was achieved: one out of thirteen possible isomer...

journal_title：Scientific reports

authors： Yang Y,Huang F,Chen CF,Xia M,Cai Q,Qian FJ,Xiang J

更新日期：2013-01-01 00:00:00

abstract：:MiR-204 and miR-211 (miR-204/211) share the same seed site sequence, targeting many of the same genes. Their role in cancer development remains controversial, as both cell proliferative and suppressive effects have been identified. This study aimed to address the relationship between the two structurally similar micro...

journal_title：Scientific reports

authors： Lee H,Lee S,Bae H,Kang HS,Kim SJ

更新日期：2016-04-28 00:00:00

abstract：:Ovarian cancer is a highly aggressive disease and novel treatments are required. Thyroid hormones binding to αvβ3 integrin produced growth-promoting activities in ovarian cancer and we hypothesized that natural thyroid hormone derivatives may antagonize these actions. The effect of three antagonists, tetraiodoacetic a...

journal_title：Scientific reports

authors： Shinderman-Maman E,Cohen K,Moskovich D,Hercbergs A,Werner H,Davis PJ,Ellis M,Ashur-Fabian O

更新日期：2017-11-28 00:00:00

abstract：:Theoretical model required for the evolution of regular dislocation pattern should simultaneously take into account both static distribution and dynamic evolution of dislocation pattern. In principle, there exists a stable uniformly moving dislocation with both core and far field advancing at the same constant velocit...

journal_title：Scientific reports

authors： Li P,Zhang ZF

更新日期：2017-06-22 00:00:00

abstract：:Human pancreatic islet amyloid polypeptide (hIAPP) and beta amyloid (Aβ) can accumulate in Type 2 diabetes (T2D) and Alzheimer's disease (AD) brains and evidence suggests that interaction between the two amyloidogenic proteins can lead to the formation of heterocomplex aggregates. However, the structure and consequenc...

journal_title：Scientific reports

authors： Bharadwaj P,Solomon T,Sahoo BR,Ignasiak K,Gaskin S,Rowles J,Verdile G,Howard MJ,Bond CS,Ramamoorthy A,Martins RN,Newsholme P

更新日期：2020-06-25 00:00:00

abstract：:The ability to avoid predators is crucial to wild prey animals' survival. Potential danger is signalled, among others, by the presence of predator scents. These odors are used in research both to trigger and to study fear reactions in laboratory animals; they are also employed as repellents against pest rodent species...

journal_title：Scientific reports

authors： Stryjek R,Mioduszewska B,Spaltabaka-Gędek E,Juszczak GR

更新日期：2018-06-21 00:00:00

abstract：:Infection of humans with Chlamydia trachomatis, a bacterial pathogen with a unique intracellular replication cycle, may cause a variety of clinical manifestations. These are linked to various serovars of the pathogen; trachoma to serovars A-C, oculogenital infections to serovars D-K, and lymphogranuloma venereum to se...

journal_title：Scientific reports

authors： Lesiak-Markowicz I,Schötta AM,Stockinger H,Stanek G,Markowicz M

更新日期：2019-12-04 00:00:00

abstract：:Advancements in microfabrication has enabled manufacturing of microscopic neurostimulation electrodes with smaller footprint than ever possible. The smaller electrodes can potentially reduce tissue damage and allow better spatial resolution for neural stimulation. Although electrodes of any shape can easily be fabrica...

journal_title：Scientific reports

authors： Park H,Takmakov P,Lee H

更新日期：2018-03-12 00:00:00

abstract：:We propose that a parallel coordinates plot can be used to study multidimensional data particularly to explore discovery of patterns across the variables. This can assist researchers from the health sciences to visualize their cohort data with interactive data analysis. The study used data from Mother and Child in the...

journal_title：Scientific reports

authors： Mitku AA,Zewotir T,North D,Naidoo RN

更新日期：2020-04-30 00:00:00

abstract：:There are no clinical guidelines for the timing of cholecystectomy (CCY) after performing therapeutic endoscopic retrograde cholangiopancreatography (ERCP) for choledocholithiasis. We tried to analyze the clinical practice patterns, medical expenses, and subsequent outcomes between the early CCY, delayed CCY, and no C...

journal_title：Scientific reports

authors： Wang CC,Tsai MC,Wang YT,Yang TW,Chen HY,Sung WW,Huang SM,Tseng MH,Lin CC

更新日期：2019-02-18 00:00:00

abstract：:Perhaps, oxidative stress progresses pupation in some Lepidopteran insects; however, the reasons for this remain obscure. In our previous study, we clarified Bombyx mori SOD1 (BmSOD1) and B. mori SOD2 (BmSOD2) proteins respond in common to ultraviolet irradiation (UV) oxidative stress and metamorphosis. This result st...

journal_title：Scientific reports

authors： Nojima Y,Bono H,Yokoyama T,Iwabuchi K,Sato R,Arai K,Tabunoki H

更新日期：2019-10-11 00:00:00

abstract：:The promising ability of a plasma wiggler based on laser wakefield acceleration to produce betatron X-rays with photon energies of a few keV to hundreds of keV and a peak brilliance of 10(22)-10(23) photons/s/mm(2)/mrad(2)/0.1%BW has been demonstrated, providing an alternative to large-scale synchrotron light sources....

journal_title：Scientific reports

authors： Ma Y,Chen L,Li D,Yan W,Huang K,Chen M,Sheng Z,Nakajima K,Tajima T,Zhang J

更新日期：2016-07-26 00:00:00

abstract：:Cassava is an important staple crop in tropical and sub-tropical areas. As a common farming practice, cassava is usually cultivated intercropping with other crops and subjected to various degrees of shading, which causes reduced productivity. Herein, a comparative transcriptomic analysis was performed on a series of d...

journal_title：Scientific reports

authors： Ding Z,Zhang Y,Xiao Y,Liu F,Wang M,Zhu X,Liu P,Sun Q,Wang W,Peng M,Brutnell T,Li P

更新日期：2016-08-19 00:00:00

abstract：:Extracellular vesicles are selectively enriched in RNA that has potential as disease biomarkers. To systemically characterize circulating extracellular RNA (exRNA) profiles, we performed RNA sequencing analysis on plasma extracellular vesicles derived from 50 healthy individuals and 142 cancer patients. Of ~12.6 milli...

journal_title：Scientific reports

authors： Yuan T,Huang X,Woodcock M,Du M,Dittmar R,Wang Y,Tsai S,Kohli M,Boardman L,Patel T,Wang L

更新日期：2016-01-20 00:00:00

abstract：:The objective of this study was to evaluate the clinical ability of Near-Infrared Light-Transillumination (NILT) for approximal dentinal caries detection and to compare with direct digital-radiography (DDR), as well as to determine whether the combination of both techniques improves the diagnostic capacity of the lesi...

journal_title：Scientific reports

authors： Melo M,Pascual A,Camps I,Ata-Ali F,Ata-Ali J

更新日期：2019-10-02 00:00:00

abstract：:OVGP1 is the major non-serum glycoprotein in the oviduct fluid at the time of fertilization and early embryo development. Its activity differs among species. Here, we show that the C-terminal region of recombinant OVGP1 regulates its binding to the extracellular zona pellucida and affects its activity during fertiliza...

journal_title：Scientific reports

authors： Algarra B,Han L,Soriano-Úbeda C,Avilés M,Coy P,Jovine L,Jiménez-Movilla M

更新日期：2016-09-07 00:00:00

abstract：:The objective of this meta-analysis is to compare hybrid surgery (HS) and cervical discectomy and fusion (ACDF) for multilevel cervical degenerative disc diseases (DDD). Systematic searches of all published studies through March 2015 were identified from Cochrane Library, Medline, PubMed, Embase, ScienceDirect, CNKI, ...

journal_title：Scientific reports

authors： Tian P,Fu X,Li ZJ,Sun XL,Ma XL

更新日期：2015-08-26 00:00:00

abstract：:Cardiac resynchronization therapy (CRT) threw lights on heart failure treatment, however, parts of patients showed nonresponse to CRT. Unfortunately, it lacks effective parameters to predict CRT non-response. In present study, we try to seek effective electro-echocardiographic predictors on CRT non-response. This is a...

journal_title：Scientific reports

authors： Yu Z,Chen X,Han F,Qin S,Li M,Wu Y,Su Y,Ge J

更新日期：2017-03-10 00:00:00

abstract：:Coleoid cephalopods have an elaborate camera eye whereas nautiloids have primitive pinhole eye without lens and cornea. The Nautilus pinhole eye provides a unique example to explore the module of lens formation and its evolutionary mechanism. Here, we conducted an RNA-seq study of developing eyes of Nautilus and pygmy...

journal_title：Scientific reports

authors： Ogura A,Yoshida MA,Moritaki T,Okuda Y,Sese J,Shimizu KK,Sousounis K,Tsonis PA

更新日期：2013-01-01 00:00:00

abstract：:Cartilage tissue is avascular and hypoxic which regulates chondrocyte phenotype via stabilization of HIFs. Here, we investigated the role of hypoxia and HIFs in regulation of Rho and canonical Wnt signaling in chondrocytes. Our data demonstrates that hypoxia controls the expression of RhoA in chondrocytes in a context...

journal_title：Scientific reports

authors： Öztürk E,Hobiger S,Despot-Slade E,Pichler M,Zenobi-Wong M

更新日期：2017-08-22 00:00:00

abstract：:CRISPR/Cas9-based gene knockout in animal cells, particularly in teleosts, has proven to be very efficient with regards to mutation rates, but the precise insertion of exogenous DNA or gene knock-in via the homology-directed repair (HDR) pathway has seldom been achieved outside of the model organisms. Here, we succeed...

journal_title：Scientific reports

authors： Simora RMC,Xing,Bangs MR,Wang W,Ma X,Su B,Khan MGQ,Qin Z,Lu C,Alston V,Hettiarachchi D,Johnson A,Li S,Coogan M,Gurbatow J,Terhune JS,Wang X,Dunham RA

更新日期：2020-12-17 00:00:00

abstract：:A novel protein, designated as DOI, isolated from the Chinese yam (Dioscorea opposita Thunb.) could be the first protein drug for the treatment of menopausal syndrome and an alternative to hormone replacement therapy (HRT), which is known to have undesirable side effects. DOI is an acid- and thermo-stable protein with...

journal_title：Scientific reports

authors： Wong KL,Lai YM,Li KW,Lee KF,Ng TB,Cheung HP,Zhang YB,Lao L,Wong RN,Shaw PC,Wong JH,Zhang ZJ,Lam JK,Ye WC,Sze SC

更新日期：2015-07-10 00:00:00