Thyroid hormones derivatives reduce proliferation and induce cell death and DNA damage in ovarian cancer.

abstract：:CVB3 is a common human pathogen to be highly lethal to newborns and causes viral myocarditis and pancreatitis in adults. However, there is no vaccine available for clinical use. CVB3 capsid protein VP1 is an immunodominant structural protein, containing several B- and T-cell epitopes. However, immunization of mice wit...

journal_title：Scientific reports

authors： Qi X,Xiong S

更新日期：2017-02-02 00:00:00

abstract：:Application of metabolic magnetic resonance imaging measures such as cerebral blood flow in translational medicine is limited by the unknown link of observed alterations to specific neurophysiological processes. In particular, the sensitivity of cerebral blood flow to activity changes in specific neurotransmitter syst...

journal_title：Scientific reports

authors： Dukart J,Holiga Š,Chatham C,Hawkins P,Forsyth A,McMillan R,Myers J,Lingford-Hughes AR,Nutt DJ,Merlo-Pich E,Risterucci C,Boak L,Umbricht D,Schobel S,Liu T,Mehta MA,Zelaya FO,Williams SC,Brown G,Paulus M,Honey GD,

更新日期：2018-03-06 00:00:00

abstract：:An understanding of load sharing among constituent phases aids in designing mechanical properties of multiphase materials. Here we investigate load partitioning between the body-centered-cubic iron matrix and NiAl-type precipitates in a ferritic alloy during uniaxial tensile tests at 364 and 506 °C on multiple length ...

journal_title：Scientific reports

authors： Sun Z,Song G,Sisneros TA,Clausen B,Pu C,Li L,Gao Y,Liaw PK

更新日期：2016-03-16 00:00:00

abstract：:Photomechanical nanocomposites embedded with light-absorbing nanoparticles show promising applications in photoresponsive actuations. Near infrared (nIR)-responsive nanocomposites based photomechanical soft actuators can offer lightweight functional and underexploited entry into soft robotics, active optics, drug deli...

journal_title：Scientific reports

authors： Niu D,Jiang W,Liu H,Zhao T,Lei B,Li Y,Yin L,Shi Y,Chen B,Lu B

更新日期：2016-06-06 00:00:00

abstract：:MicroRNAs (miRNAs) are short noncoding RNAs derived from the 3' and 5' ends of the same precursor. However, the biological function and mechanism of miRNA arm expression preference remain unclear in breast cancer. We found significant decreases in the expression levels of miR-193a-5p but no significant differences in ...

journal_title：Scientific reports

authors： Tsai KW,Leung CM,Lo YH,Chen TW,Chan WC,Yu SY,Tu YT,Lam HC,Li SC,Ger LP,Liu WS,Chang HT

更新日期：2016-06-16 00:00:00

abstract：:A significant advantage of a graphene biosensor is that it inherently represents a continuum of independent and aligned sensor-units. We demonstrate a nanoscale version of a micro-physiometer - a device that measures cellular metabolic activity from the local acidification rate. Graphene functions as a matrix of indep...

journal_title：Scientific reports

authors： Paulus GL,Nelson JT,Lee KY,Wang QH,Reuel NF,Grassbaugh BR,Kruss S,Landry MP,Kang JW,Vander Ende E,Zhang J,Mu B,Dasari RR,Opel CF,Wittrup KD,Strano MS

更新日期：2014-10-31 00:00:00

abstract：:Agrostemma githago L. (corn cockle) is an herbaceous plant mainly growing in Europe. The seeds of the corn cockle are toxic and poisonings were widespread in the past by consuming contaminated flour. The toxic principle of Agrostemma seeds was attributed to triterpenoid secondary metabolites. Indeed, this is in part t...

journal_title：Scientific reports

authors： Weise C,Schrot A,Wuerger LTD,Adolf J,Gilabert-Oriol R,Sama S,Melzig MF,Weng A

更新日期：2020-09-21 00:00:00

abstract：:Healthy sleep, positive general affect, and the ability to regulate emotional experiences are fundamental for well-being. In contrast, various mental disorders are associated with altered rapid eye movement (REM) sleep, negative affect, and diminished emotion regulation abilities. However, the neural processes mediati...

journal_title：Scientific reports

authors： Glosemeyer RW,Diekelmann S,Cassel W,Kesper K,Koehler U,Westermann S,Steffen A,Borgwardt S,Wilhelm I,Müller-Pinzler L,Paulus FM,Krach S,Stolz DS

更新日期：2020-10-14 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is a chronic disease, and dietary modification is a crucial part of disease management. Okara is a sustainable source of fibre-rich food. Most of the valorization research on okara focused more on the physical attributes instead of the possible health attributes. The fermentation of oka...

journal_title：Scientific reports

authors： Chan LY,Takahashi M,Lim PJ,Aoyama S,Makino S,Ferdinandus F,Ng SYC,Arai S,Fujita H,Tan HC,Shibata S,Lee CK

更新日期：2019-11-26 00:00:00

abstract：:Insects are a promising alternative protein source. One of the bottlenecks in applying insects in food is the fast darkening initiated during grinding. Besides enzymatic browning, non-enzymatic factors can cause off-colour formation, which differs between species. This study investigates the impact of iron, phenoloxid...

journal_title：Scientific reports

authors： Janssen RH,Canelli G,Sanders MG,Bakx EJ,Lakemond CMM,Fogliano V,Vincken JP

更新日期：2019-02-27 00:00:00

abstract：:Low-noise millimetre-wave signals are valuable for digital sampling systems, arbitrary waveform generation for ultra-wideband communications, and coherent radar systems. However, the phase noise of widely used conventional signal generators (SGs) will increase as the millimetre-wave frequency increases. Our goal has b...

journal_title：Scientific reports

authors： Ishizawa A,Nishikawa T,Goto T,Hitachi K,Sogawa T,Gotoh H

更新日期：2016-05-17 00:00:00

abstract：:In the course of sample preparation for Next Generation Sequencing (NGS), DNA is fragmented by various methods. Fragmentation shows a persistent bias with regard to the cleavage rates of various dinucleotides. With the exception of CpG dinucleotides the previously described biases were consistent with results of the D...

journal_title：Scientific reports

authors： Uroshlev LA,Abdullaev ET,Umarova IR,Il'icheva IA,Panchenko LA,Polozov RV,Kondrashov FA,Nechipurenko YD,Grokhovsky SL

更新日期：2020-05-25 00:00:00

abstract：:Gelatin-methacryloyl (GelMA) is one of the most commonly used photopolymerizable biomaterials in bio-applications. However, GelMA synthesis remains suboptimal, as its reaction parameters have not been fully investigated. The goal of this study is to establish an optimal route for effective and controllable GelMA synth...

journal_title：Scientific reports

authors： Shirahama H,Lee BH,Tan LP,Cho NJ

更新日期：2016-08-09 00:00:00

abstract：:The global problem of unowned domestic cats, driven by their phenomenal reproductive success, carries significant economic, animal welfare and biodiversity costs. Desexing owned cats prior to puberty prevents unwanted litters that contribute to unowned cat populations. The prevalence and predictors of desexing, and th...

journal_title：Scientific reports

authors： Mazeau L,Wylie C,Boland L,Beatty JA

更新日期：2021-01-18 00:00:00

abstract：:Asymmetric cell divisions are required for cellular diversity and defects can lead to altered daughter cell fates and numbers. In a genetic screen for C. elegans mutants with defects in dopaminergic head neuron specification or differentiation, we isolated a new allele of the transcription factor HAM-1 [HSN (Hermaphro...

journal_title：Scientific reports

authors： Offenburger SL,Bensaddek D,Murillo AB,Lamond AI,Gartner A

更新日期：2017-06-28 00:00:00

abstract：:Accidental introduction through ballast water and biofouling are currently the main factors responsible for spreading non-indigenous species in the marine realm. In the Southwestern Atlantic, two scleractinian corals, Tubastraea coccinea and T. tagusensis, have been introduced by opportunistic colonization in 1980 and...

journal_title：Scientific reports

authors： Capel KCC,Creed J,Kitahara MV,Chen CA,Zilberberg C

更新日期：2019-09-27 00:00:00

abstract：:In spite of intensive investigations, the role of spontaneous breathing (SB) activity in ARDS has not been well defined yet and little has been known about the different contribution of inspiratory or expiratory muscles activities during mechanical ventilation in patients with ARDS. In present study, oleic acid-induce...

journal_title：Scientific reports

authors： Zhang X,Du J,Wu W,Zhu Y,Jiang Y,Chen R

更新日期：2017-02-23 00:00:00

abstract：:Several studies have investigated the association between polymorphisms in protamine 1 and 2 genes and male infertility risk, with inconsistent results to date. This meta-analysis based on the 13 published case-control studies, including 7350 cases and 6167 controls, was performed to further establish the potential as...

journal_title：Scientific reports

authors： Jiang W,Sun H,Zhang J,Zhou Q,Wu Q,Li T,Zhang C,Li W,Zhang M,Xia X

更新日期：2015-10-16 00:00:00

abstract：:Fusion transcripts can contribute to diversity of molecular networks in the human cortex. In this study, we explored the occurrence of fusion transcripts in normal human cortex along with single neurons and astrocytes. We identified 1305 non-redundant fusion events from 388 transcriptomes representing 59 human cortice...

journal_title：Scientific reports

authors： Mehani B,Narta K,Paul D,Raj A,Kumar D,Sharma A,Kaurani L,Nayak S,Dash D,Suri A,Sarkar C,Mukhopadhyay A

更新日期：2020-01-28 00:00:00

abstract：:Administration of lipopolysaccharide (LPS) by various routes produces profound inflammatory pain hypersensitivity. However, the molecular events that induce this response remain largely uncharacterized. In the present study, we sought to elucidate the role of the Rho/Rho kinase (ROCK) pathway in the release of tumor n...

journal_title：Scientific reports

authors： Wang C,Song S,Zhang Y,Ge Y,Fang X,Huang T,Du J,Gao J

更新日期：2015-09-29 00:00:00

abstract：:Membrane type 1 metalloproteinase (MT1-MMP) is an important regulator of cancer invasion, growth and angiogenesis, thus making it an attractive target for cancer imaging and therapy. A non-substrate peptide (MT1-AF7p) that bonded to the "MT-Loop" region of MT1-MMP was identified by using a phage-displayed peptide libr...

journal_title：Scientific reports

authors： Ren L,Wang Y,Zhu L,Shen L,Zhang J,Wang J,Li H,Zheng Q,Yu D,Fang X

更新日期：2018-07-09 00:00:00

abstract：:The evolution of cooperation requires some mechanism that reduces the risk of exploitation for cooperative individuals. Recent studies have shown that men with wide faces are anti-social, and they are perceived that way by others. This suggests that people could use facial width to identify anti-social men and thus li...

journal_title：Scientific reports

authors： Efferson C,Vogt S

更新日期：2013-01-01 00:00:00

abstract：:The analysis of questionnaires often involves representing the high-dimensional responses in a low-dimensional space (e.g., PCA, MCA, or t-SNE). However questionnaire data often contains categorical variables and common statistical model assumptions rarely hold. Here we present a non-parametric approach based on Fishe...

journal_title：Scientific reports

authors： Har-Shemesh O,Quax R,Lansing JS,Sloot PMA

更新日期：2020-05-25 00:00:00

abstract：:This study investigated the glucono-δ-lactone (GDL)-induced aggregation of isoflavones and soy proteins in soymilk. High-performance liquid chromatography (HPLC) analysis indicated that isoflavones mixed with β-conglycinin (7S) and glycinin (11S) proteins formed 7S-isoflavone and 11S-isoflavone complexes in soymilk su...

journal_title：Scientific reports

authors： Hsia SY,Hsiao YH,Li WT,Hsieh JF

更新日期：2016-10-20 00:00:00

abstract：:Multifactorial lifestyle intervention is known to be more effective for ameliorating cognitive decline than single factor intervention; however, the effects of combining exercise with long-chain polyunsaturated fatty acids (LCPUFA) on the elderlies' cognitive function remain unclear. We conducted a randomised, single-...

journal_title：Scientific reports

authors： Tokuda H,Ito M,Sueyasu T,Sasaki H,Morita S,Kaneda Y,Rogi T,Kondo S,Kouzaki M,Tsukiura T,Shibata H

更新日期：2020-07-31 00:00:00

abstract：:Harmaline (HAR), a natural occurrence β-carboline alkaloid, was isolated from the seeds of Peganum harmala and exhibited potent antitumor effect. In this study, the anti-gastric tumor effects of HAR were firstly investigated in vitro and in vivo. The results strongly showed that HAR could inhibit tumor cell proliferat...

journal_title：Scientific reports

authors： Wang Y,Wang C,Jiang C,Zeng H,He X

更新日期：2015-12-18 00:00:00

abstract：:Because of the small particle number of intracellular species participating in genetic circuits, stochastic fluctuations are inevitable. This intracellular noise is detrimental to precise regulation. To maintain the proper function of a cell, some natural motifs attenuate the noise at the protein level. In many biolog...

journal_title：Scientific reports

authors： Liu FY,Lo SC,Shu CC

更新日期：2019-03-04 00:00:00

abstract：:To determine whether p16 INK4a deletion ameliorated renal tubulointerstitial injury by inhibiting a senescence-associated secretory phenotype (SASP) in Bmi-1-deficient (Bmi-1 -/-) mice, renal phenotypes were compared among 5-week-old Bmi-1 and p16 INK4a double-knockout, and Bmi-1 -/- and wild-type mice. Fifth-passage ...

journal_title：Scientific reports

authors： Jin J,Tao J,Gu X,Yu Z,Wang R,Zuo G,Li Q,Lv X,Miao D

更新日期：2017-08-08 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Cencetti G,Clusella P,Fanelli D

更新日期：2020-02-18 00:00:00

abstract：:Hypoxia is a recognized characteristic of tumors that influences efficacy of radiotherapy (RT). Photoacoustic imaging (PAI) is a relatively new imaging technique that exploits the optical characteristics of hemoglobin to provide information on tissue oxygenation. In the present study, PAI based measures of tumor oxyge...

journal_title：Scientific reports

authors： Rich LJ,Seshadri M

更新日期：2016-02-17 00:00:00