Cerebral blood flow predicts differential neurotransmitter activity.

abstract：:Accounting for about 1.5 million deaths annually, lung cancer is the prevailing cause of cancer deaths worldwide, mostly associated with long-term smoking effects. Numerous small-animal studies are performed currently in order to better understand the pathogenesis of the disease and to develop treatment strategies. Wi...

journal_title：Scientific reports

authors： Scherer K,Yaroshenko A,Bölükbas DA,Gromann LB,Hellbach K,Meinel FG,Braunagel M,Berg JV,Eickelberg O,Reiser MF,Pfeiffer F,Meiners S,Herzen J

更新日期：2017-03-24 00:00:00

abstract：:The Raman spectral features from spinal cord tissue sections of transgenic, ALS model mice and non-transgenic mice were compared using 457 nm excitation line, profiting from the favourable signal intensity obtained in the molecular fingerprint region at this wavelength. Transverse sections from four SOD1G93A mice at 7...

journal_title：Scientific reports

authors： Picardi G,Spalloni A,Generosi A,Paci B,Mercuri NB,Luce M,Longone P,Cricenti A

更新日期：2018-08-30 00:00:00

abstract：:Quantum Zeno effect shows that frequent observations can slow down or even stop the unitary time evolution of an unstable quantum system. This effect can also be regarded as a physical consequence of the statistical indistinguishability of neighboring quantum states. The accessibility of quantum Zeno dynamics under un...

journal_title：Scientific reports

authors： Zhang YR,Fan H

更新日期：2015-06-23 00:00:00

abstract：:In preclinical stages of drug development, anticipating potential adverse drug effects such as toxicity is an important issue for both saving resources and preventing public health risks. Current in vitro cytotoxicity tests are restricted by their predictive potential and their ability to provide mechanistic informati...

journal_title：Scientific reports

authors： García-Cañaveras JC,Castell JV,Donato MT,Lahoz A

更新日期：2016-06-06 00:00:00

abstract：:Organic matter production and decomposition primarily modulate the atmospheric O2 and CO2 levels. The long term marine primary productivity is controlled by the terrestrial input of phosphorus (P), while the marine P cycle would also affect organic matter production. In the past 540 million years, the evolution of ter...

journal_title：Scientific reports

authors： Wang R,Lang X,Ding W,Liu Y,Huang T,Tang W,Shen B

更新日期：2020-04-02 00:00:00

abstract：:Tuneable pressure effects associated with changing interlayer distances in two-dimensional graphene oxide (GO)/reduced GO (rGO) layers are demonstrated through monitoring the changes in the spin-crossover (SCO) temperature (T 1/2) of [Fe(Htrz)2(trz)](BF4) nanoparticles (NPs) incorporated in the interlayer spaces of th...

journal_title：Scientific reports

authors： Sekimoto Y,Ohtani R,Nakamura M,Koinuma M,Lindoy LF,Hayami S

更新日期：2017-09-22 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Sameni S,Malacrida L,Tan Z,Digman MA

更新日期：2018-04-11 00:00:00

abstract：:In 2013, U.S. swine producers were confronted with the disruptive emergence of porcine epidemic diarrhoea (PED). Movement of animals among farms is hypothesised to have played a role in the spread of PED among farms. Via this or other mechanisms, the rate of spread may also depend on the geographic density of farms an...

journal_title：Scientific reports

authors： O'Dea EB,Snelson H,Bansal S

更新日期：2016-03-07 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Baiocchini A,Del Nonno F,Taibi C,Visco-Comandini U,D'Offizi G,Piacentini M,Falasca L

更新日期：2020-01-24 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Lopeman RC,Harrison J,Rathbone DL,Desai M,Lambert PA,Cox JAG

更新日期：2020-03-06 00:00:00

abstract：:The challenge in the treatment of glioblastoma is the failure to identify the cancer invasive area outside the contrast-enhancing tumour which leads to the high local progression rate. Our study aims to identify its progression from the preoperative MR radiomics. 57 newly diagnosed cerebral glioblastoma patients were ...

journal_title：Scientific reports

authors： Yan JL,Li C,van der Hoorn A,Boonzaier NR,Matys T,Price SJ

更新日期：2020-06-16 00:00:00

abstract：:Ten to twenty percent of the hepatocellular carcinoma (HCC) patients fulfilling the Milan criteria (MC) recurred within three years after orthotopic liver transplantation (OLT). We therefore utilize a training cohort to develop an improved prognostic model for predicting the recurrence in these patients. By univariate...

journal_title：Scientific reports

authors： Feng J,Wu J,Zhu R,Feng D,Yu L,Zhang Y,Bu D,Li C,Zhou Y,Si L,Liu Y,Liang Z,Xu J,Wu T

更新日期：2017-03-09 00:00:00

abstract：:The importance of microbial natural products has been widely demonstrated in the search for new antibiotics. However, the functional role of microbial metabolites in nature remains to be deciphered. Several natural products are known to mediate microbial interactions through metabolic exchange. One approach to investi...

journal_title：Scientific reports

authors： Caraballo-Rodríguez AM,Dorrestein PC,Pupo MT

更新日期：2017-07-14 00:00:00

abstract：:Confocal Raman spectroscopy (CRS) can provide information about oocyte competency through measurement of changes in the macromolecular architecture during oocyte development and maturation. Hitherto most spectroscopic studies have been limited to fixed oocytes due to the inherent difficulties working with live cells. ...

journal_title：Scientific reports

authors： Heraud P,Marzec KM,Zhang QH,Yuen WS,Carroll J,Wood BR

更新日期：2017-08-21 00:00:00

abstract：:Unimolecular dual agonists for the glucagon-like peptide 1 receptor (GLP1R) and glucagon receptor (GCGR) are emerging as a potential new class of important therapeutics in type 2 diabetes (T2D). Reliable and quantitative assessments of in vivo occupancy on each receptor would improve the understanding of the efficacy ...

journal_title：Scientific reports

authors： Eriksson O,Haack T,Hijazi Y,Teichert L,Tavernier V,Laitinen I,Berglund JE,Antoni G,Velikyan I,Johansson L,Pierrou S,Wagner M,Tillner J

更新日期：2020-10-07 00:00:00

abstract：:A difficult problem in quantum network communications is how to efficiently transmit quantum information over large-scale networks with common channels. We propose a solution by developing a quantum encoding approach. Different quantum states are encoded into a coherent superposition state using quantum linear optics....

journal_title：Scientific reports

authors： Luo MX,Xu G,Chen XB,Yang YX,Wang X

更新日期：2014-04-02 00:00:00

abstract：:The Acoustic Complexity Index (ACI) is increasingly applied to the study of biodiversity in aquatic habitats. However, it remains unknown which types of acoustic information are highlighted by this index in underwater environments. This study explored the robustness of the ACI to fine variations in fish sound abundanc...

journal_title：Scientific reports

authors： Bolgan M,Amorim MCP,Fonseca PJ,Di Iorio L,Parmentier E

更新日期：2018-07-12 00:00:00

abstract：:The authors present the preparation procedure and a computational model of a three-layered fibrous scaffold for prolonged drug release. The scaffold, produced by emulsion/sequential electrospinning, consists of a poly(D,L-lactic-co-glycolic acid) (PLGA) fiber layer sandwiched between two poly(ε-caprolactone) (PCL) lay...

journal_title：Scientific reports

authors： Milosevic M,Stojanovic DB,Simic V,Grkovic M,Bjelovic M,Uskokovic PS,Kojic M

更新日期：2020-07-07 00:00:00

abstract：:Here, we report results on systematic analysis of DNA substrate preferences of three N6-adenine β-class DNA methyltransferases that are part of the type II restriction-modification systems. The studied enzymes were: M.EcoVIII, M.HindIII and M.LlaCI, which although found in phylogenetically distant bacteria (γ-proteoba...

journal_title：Scientific reports

authors： Wons E,Mruk I,Kaczorowski T

更新日期：2018-05-29 00:00:00

abstract：:The definition of a precise illumination region is essential in many applications where the electromagnetic field should be confined in some specific volume. By using conventional structures, it is difficult to achieve an adequate confinement distance (or volume) with negligible levels of radiation leakage beyond it. ...

journal_title：Scientific reports

authors： Bonache J,Zamora G,Paredes F,Zuffanelli S,Aguilà P,Martín F

更新日期：2016-11-25 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Righi S,Takács K

更新日期：2019-10-30 00:00:00

abstract：:The ubiquitously expressed aryl hydrocarbon receptor (AhR) induces drug metabolizing enzymes as well as regulators of cell growth, differentiation and apoptosis. Certain AhR ligands promote atherosclerosis, an age-associated vascular disease. Therefore, we investigated the role of AhR in vascular functionality and agi...

journal_title：Scientific reports

authors： Eckers A,Jakob S,Heiss C,Haarmann-Stemmann T,Goy C,Brinkmann V,Cortese-Krott MM,Sansone R,Esser C,Ale-Agha N,Altschmied J,Ventura N,Haendeler J

更新日期：2016-01-21 00:00:00

abstract：:ING2 (inhibitor of growth family member 2) is a component of a chromatin-regulatory complex that represses gene expression and is implicated in cellular processes that promote tumor suppression. However, few direct genomic targets of ING2 have been identified and the mechanism(s) by which ING2 selectively regulates ge...

journal_title：Scientific reports

authors： Bua DJ,Martin GM,Binda O,Gozani O

更新日期：2013-01-01 00:00:00

abstract：:The brain-derived neurotrophic factor BDNF plays a critical role in neuronal development and the induction of L-LTP at glutamatergic synapses in several brain regions. However, the cellular and molecular mechanisms underlying these BDNF effects have not been firmly established. Using in vitro cultures of cortical neur...

journal_title：Scientific reports

authors： Ammar MR,Thahouly T,Hanauer A,Stegner D,Nieswandt B,Vitale N

更新日期：2015-10-06 00:00:00

abstract：:Although diatoms have been extensively studied as bioreactors, only a limited number of efficient gene promoters are available. Therefore, the development of new endogenous promoters is important for the heterologous production of a variety of recombinant proteins. Herein, we identified the most abundant secreted prot...

journal_title：Scientific reports

authors： Erdene-Ochir E,Shin BK,Kwon B,Jung C,Pan CH

更新日期：2019-07-09 00:00:00

abstract：:Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure. Using a screen of small molecule epigenetic probes we identified three compounds which inhibited myogenic differentiation in C2C12 myoblasts; (+)-JQ1, PFI-1, and Bromos...

journal_title：Scientific reports

authors： Roberts TC,Etxaniz U,Dall'Agnese A,Wu SY,Chiang CM,Brennan PE,Wood MJA,Puri PL

更新日期：2017-07-21 00:00:00

abstract：:The aim of the present study was to evaluate the healthy lifestyle behaviors in hypertensive patients (aware, n = 1364 and not aware, n = 1213) based on 2011 national survey of risk factors of non-communicable disease (SuRFNCD) of Iran. Lifestyle score was calculated based on lifestyle behaviors, including smoking sta...

journal_title：Scientific reports

authors： Akbarpour S,Khalili D,Zeraati H,Mansournia MA,Ramezankhani A,Fotouhi A

更新日期：2018-05-31 00:00:00

abstract：:Philanthotoxin-433 (PhTX-433) is an active component of the venom from the Egyptian digger wasp, Philanthus triangulum. PhTX-433 inhibits several excitatory ligand-gated ion channels, and to improve selectivity two synthetic analogues, PhTX-343 and PhTX-12, were developed. Previous work showed a 22-fold selectivity of...

journal_title：Scientific reports

authors： Kachel HS,Patel RN,Franzyk H,Mellor IR

更新日期：2016-11-30 00:00:00

abstract：:We employ nematic liquid crystals as the nonlinear medium to recover noisy images via stochastic resonance, in which nonlinear coupling allows signals to grow at the expense of noise. The process is theoretically analyzed and the cross-correlation is numerically calculated. It is found that the quality of output image...

journal_title：Scientific reports

authors： Feng X,Liu H,Huang N,Wang Z,Zhang Y

更新日期：2019-03-08 00:00:00

abstract：:The goal of this work was to develop a mathematical model to predict Kaplan-Meier survival curves for chemotherapy combined with radiation in Non-Small Cell Lung Cancer patients for use in clinical trial design. The Gompertz model was used to describe tumor growth, radiation effect was simulated by the linear-quadrati...

journal_title：Scientific reports

authors： Geng C,Paganetti H,Grassberger C

更新日期：2017-10-19 00:00:00