Abstract：
:Accounting for about 1.5 million deaths annually, lung cancer is the prevailing cause of cancer deaths worldwide, mostly associated with long-term smoking effects. Numerous small-animal studies are performed currently in order to better understand the pathogenesis of the disease and to develop treatment strategies. Within this letter, we propose to exploit X-ray dark-field imaging as a novel diagnostic tool for the detection of lung cancer on projection radiographs. Here, we demonstrate in living mice bearing lung tumors, that X-ray dark-field radiography provides significantly improved lung tumor detection rates without increasing the number of false-positives, especially in the case of small and superimposed nodules, when compared to conventional absorption-based imaging. While this method still needs to be adapted to larger mammals and finally humans, the technique presented here can already serve as a valuable tool in evaluating novel lung cancer therapies, tested in mice and other small animal models.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Scherer K,Yaroshenko A,Bölükbas DA,Gromann LB,Hellbach K,Meinel FG,Braunagel M,Berg JV,Eickelberg O,Reiser MF,Pfeiffer F,Meiners S,Herzen Jdoi
10.1038/s41598-017-00489-xsubject
Has Abstractpub_date
2017-03-24 00:00:00pages
402issue
1issn
2045-2322pii
10.1038/s41598-017-00489-xjournal_volume
7pub_type
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