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Effect of chain flexibility on cell adhesion: Semi-flexible model-based analysis of cell adhesion to hydrogels.

Abstract：

:Hydrogels have been developed and applied to various biomedical applications due to their biocompatibility. However, understanding of modulation between cells to hydrogel interface is still unclear, and parameters to explain the interaction are not sophisticated enough. In this report, we studied the effect of polymer chain flexibility on cell adhesion to various hydrogel constructs of collagen and fibrin gels. Specifically, novel method of semi-flexible model-based analysis confirmed that chain flexibility mediated microstructure of the hydrogels is a critical factor for cell adhesion on their surfaces. The proposed analysis showed possibility of more accurate prediction of biocompatibility of hydrogels, and it should be considered as one of the important criteria for polymer design and selections for enhancing both biocompatibility and biofunctionality.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Lee J,Song B,Subbiah R,Chung JJ,Choi UH,Park K,Kim SH,Oh SJ

doi

10.1038/s41598-019-38951-7

subject

Has Abstract

pub_date

2019-02-21 00:00:00

pages

2463

issue

1

issn

2045-2322

pii

10.1038/s41598-019-38951-7

journal_volume

9

pub_type

杂志文章

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