Abstract：
:Currently, a comprehensive assessment between mitochondrial DNA (mtDNA) content and cancer risk is lacking. We designed this meta-analysis to test the hypothesis that altered mtDNA copy number might influence genetic susceptibility to some specific types of cancer. The processes of literature search, eligibility appraisal and data retrieval were independently completed in duplicate. The mtDNA copy number which was dichotomized or classified into tertiles was compared between cancer cases and controls. Twenty-six articles with 38 study groups were analyzed among 6682 cases and 9923 controls. When dichotomizing mtDNA copy number at the median value, there was an 11% increased cancer risk for carriers of high mtDNA content (P = 0.320). By cancer type, high mtDNA content was associated with an increased risk for lymphoma (OR = 1.76; P = 0.023) but a reduced risk for skeleton cancer (OR = 0.39; P = 0.001). Carriers of the 2(nd) and 3(rd) tertiles of mtDNA copy number had an 1.74-fold (P = 0.010) and 2.07-fold (P = 0.021) increased risk of lymphoma, respectively. By contrast, there was correspondingly a 56% (P < 0.001) and 80% (P < 0.001) reduced risk of skeleton cancer. Our findings suggested that elevated mtDNA content was associated with a higher risk for lymphoma, but a lower risk for skeleton cancer.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Mi J,Tian G,Liu S,Li X,Ni T,Zhang L,Wang Bdoi
10.1038/srep10039subject
Has Abstractpub_date
2015-05-08 00:00:00pages
10039issn
2045-2322pii
srep10039journal_volume
5pub_type
杂志文章,meta分析abstract：:Protein degradation is an essential mechanism for maintaining proteostasis in response to internal and external perturbations. Disruption of this process is implicated in many human diseases. We present a new technique, QUAD (Quantification of Azidohomoalanine Degradation), to analyze the global degradation rates in t...
journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-01-19 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2020-08-11 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-09-28 00:00:00
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pub_type： 杂志文章
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更新日期：2017-03-22 00:00:00
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pub_type： 杂志文章
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更新日期：2021-01-12 00:00:00
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pub_type： 杂志文章
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更新日期：2019-09-20 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep14442
更新日期：2015-10-13 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-09-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-10-29 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
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更新日期：2017-09-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-02-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-05-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-10-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-04-30 00:00:00
