A Novel PET Imaging Probe for the Detection and Monitoring of Translocator Protein 18 kDa Expression in Pathological Disorders.

abstract：:Urinary incontinence of idiopathic nature is a common complication of bladder cancer, yet, the mechanisms underlying changes in bladder contractility associated with cancer are not known. Here by using tensiometry on detrusor smooth muscle (DSM) strips from normal rats and rats with bladder cancer induced by known uro...

journal_title：Scientific reports

authors： Philyppov IB,Sotkis GV,Rock A,Roudbaraki M,Bonnal JL,Mauroy B,Prevarskaya N,Shuba YM

更新日期：2020-11-12 00:00:00

abstract：:Ovarian cancer is one of the leading causes of death in gynecological malignancies, and the resistance to chemotherapeutic agents remains a major challenge to successful ovarian cancer chemotherapy. Dihydromyricetin (DHM), a natural flavonoid derived from Ampeopsis Grossdentata, has been widely applied in food industr...

journal_title：Scientific reports

authors： Xu Y,Wang S,Chan HF,Lu H,Lin Z,He C,Chen M

更新日期：2017-04-24 00:00:00

abstract：:The distinguishing of the multiphoton quantum interference effect from the classical one forms one of the most important issues in modern quantum mechanics and experimental quantum optics. For a long time, the two-photon interference (TPI) of correlated photons has been recognized as a pure quantum effect that cannot ...

journal_title：Scientific reports

authors： Kim H,Kwon O,Moon HS

更新日期：2019-12-05 00:00:00

abstract：:Adverse events during the prenatal and early postnatal period of life are associated with development of cardiovascular disease in adulthood. Prenatal exposure to excess testosterone (T) in sheep induces adverse reproductive and metabolic programming leading to polycystic ovarian syndrome, insulin resistance and hyper...

journal_title：Scientific reports

authors： Vyas AK,Hoang V,Padmanabhan V,Gilbreath E,Mietelka KA

更新日期：2016-06-22 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is usually preceded by the oral premalignant lesions, mainly oral leukoplakia (OLK) after repeated insults of carcinogens, tobacco. B(a)P and DMBA are key carcinogens in tobacco smoke. In the present study, for the first time we established the cancerous cell line OSCC-BD induced by...

journal_title：Scientific reports

authors： Dong Y,Zhao Q,Ma X,Ma G,Liu C,Chen Z,Yu L,Liu X,Zhang Y,Shao S,Xiao J,Li J,Zhang W,Fu M,Dong L,Yang X,Guo X,Xue L,Fang F,Zhan Q,Zhang L

更新日期：2015-08-03 00:00:00

abstract：:To investigate how consensus is reached on a large self-organized peer-to-peer network, we extended the naming game model commonly used in language and communication to Naming Game in Groups (NGG). Differing from other existing naming game models, in NGG everyone in the population (network) can be both speaker and hea...

journal_title：Scientific reports

authors： Gao Y,Chen G,Chan RH

更新日期：2014-08-21 00:00:00

abstract：:The interactions of L-type calcium channels (LTCCs) and NMDA receptors (NMDARs) in memories are poorly understood. Here we investigated the specific roles of anterior piriform cortex (aPC) LTCCs and NMDARs in early odor preference memory in mice. Using calcium imaging in aPC slices, LTCC activation was shown to be dep...

journal_title：Scientific reports

authors： Mukherjee B,Yuan Q

更新日期：2016-10-14 00:00:00

abstract：:Whether the clinical trial treatment effect of urate-lowering therapy (ULT) in patient with chronic kidney disease (CKD) is generalizable to real-word settings is unclear. This study aimed to compare febuxostat with allopurinol for uric acid reduction and renal protection in patients with CKD. Adult CKD patients newly...

journal_title：Scientific reports

authors： Peng YL,Tain YL,Lee CT,Yang YH,Huang YB,Wen YH,Hsu CN

更新日期：2020-07-01 00:00:00

abstract：:Atomoxetine is a norepinephrine reuptake inhibitor indicated in the treatment of attention-deficit/hyperactivity disorder. It is primarily metabolized by CYP2D6 to its equipotent metabolite, 4-hydroxyatomoxetine, which promptly undergoes further glucuronidation to an inactive 4-HAT-O-glucuronide. Clinical trials have ...

journal_title：Scientific reports

authors： Kim SH,Byeon JY,Kim YH,Lee CM,Lee YJ,Jang CG,Lee SY

更新日期：2018-08-17 00:00:00

abstract：:Tau is a microtubule-associated protein whose C-terminal domain consisting of four repeat regions R1, R2, R3 and R4 binds to microtubules to stabilize them. In several neurodegenerative diseases, tau detaches from microtubules to form insoluble aggregates leading to tauopathy. Microtubules are made up of αβ tubulin su...

journal_title：Scientific reports

authors： Bhandare VV,Kumbhar BV,Kunwar A

更新日期：2019-07-25 00:00:00

abstract：:Securin overexpression correlates with poor prognosis in various tumours. We have previously shown that securin depletion promotes radiation-induced senescence and enhances radiosensitivity in human cancer cells. However, the underlying molecular mechanisms and the paracrine effects remain unknown. In this study, we s...

journal_title：Scientific reports

authors： Yu YC,Yang PM,Chuah QY,Huang YH,Peng CW,Lee YJ,Chiu SJ

更新日期：2013-01-01 00:00:00

abstract：:There are three sex ratio strategies (SRS) in nature-male-biased sex ratio, female-biased sex ratio and, equal sex ratio. It was R. A. Fisher who first explained why most species in nature display a sex ratio of ½. Consequent SRS theories such as Hamilton's local mate competition (LMC) and Clark's local resource compe...

journal_title：Scientific reports

authors： Wang Y,Wang R,Li Y,Sam Ma Z

更新日期：2016-12-23 00:00:00

abstract：:The exovesicles (EVs) are involved in pathologic host-parasite immune associations and have been recently used as biomarkers for diagnosis of infectious diseases. The release of EVs by Trypanosoma cruzi, the causative agent of Chagas disease, has recently been described, with different protein cargoes including the MA...

journal_title：Scientific reports

authors： Díaz Lozano IM,De Pablos LM,Longhi SA,Zago MP,Schijman AG,Osuna A

更新日期：2017-03-15 00:00:00

abstract：:The common variants in lysyl oxidase-like 1 gene (LOXL1) are associated with exfoliation glaucoma (XFG) patients developed through exfoliation syndrome (XFS). However, the risk allele of a variant in LOXL1 has been found to be inverted between Asian and Caucasian populations. Therefore, we newly performed a genome-wid...

journal_title：Scientific reports

authors： Nakano M,Ikeda Y,Tokuda Y,Fuwa M,Ueno M,Imai K,Sato R,Omi N,Adachi H,Kageyama M,Mori K,Kinoshita S,Tashiro K

更新日期：2014-06-18 00:00:00

abstract：:Chromosome changes are one of the hallmarks of human malignancies. Chromosomal rearrangement is frequent in human cancers. One of the consequences of chromosomal rearrangement is gene fusions in the cancer genome. We have previously identified a panel of fusion genes in aggressive prostate cancers. In this study, we s...

journal_title：Scientific reports

authors： Yu YP,Liu P,Nelson J,Hamilton RL,Bhargava R,Michalopoulos G,Chen Q,Zhang J,Ma D,Pennathur A,Luketich J,Nalesnik M,Tseng G,Luo JH

更新日期：2019-01-31 00:00:00

abstract：:The hitherto difficult task of reliably estimating populations of wide-ranging megafauna has been enabled by advances in capture-recapture methodology. Here we combine photographic sampling with a Bayesian spatially-explicit capture-recapture (SCR) model to estimate population parameters for the endangered Asian eleph...

journal_title：Scientific reports

authors： Goswami VR,Yadava MK,Vasudev D,Prasad PK,Sharma P,Jathanna D

更新日期：2019-06-12 00:00:00

abstract：:Although diatoms have been extensively studied as bioreactors, only a limited number of efficient gene promoters are available. Therefore, the development of new endogenous promoters is important for the heterologous production of a variety of recombinant proteins. Herein, we identified the most abundant secreted prot...

journal_title：Scientific reports

authors： Erdene-Ochir E,Shin BK,Kwon B,Jung C,Pan CH

更新日期：2019-07-09 00:00:00

abstract：:Norfloxacin (NOF) is an environmentally harmful and ubiquitous aquatic pollutant with extensive production and application. In this study, a novel composition named carbon-based composite photocatalytic material of zinc oxide and zinc sulphide (ZnO/ZnS@BC) was successfully obtained by the impregnation-roasting method ...

journal_title：Scientific reports

authors： Liu W,He T,Wang Y,Ning G,Xu Z,Chen X,Hu X,Wu Y,Zhao Y

更新日期：2020-07-17 00:00:00

abstract：:Higher plants have been shown to experience a juvenile vegetative phase, an adult vegetative phase, and a reproductive phase during its postembryonic development and distinct lateral organ morphologies have been observed at the different development stages. Populus euphratica, commonly known as a desert poplar, has de...

journal_title：Scientific reports

authors： Ma X,Ma J,Fan D,Li C,Jiang Y,Luo K

更新日期：2016-09-08 00:00:00

abstract：:Soil physical properties and soil organic carbon (SOC) are considered as important factors of soil quality. Arable land, grassland, and forest land coexist in the saline-alkali reclamation area of the Yellow River Delta (YRD), China. Such different land uses strongly influence the services of ecosystem to induce soil ...

journal_title：Scientific reports

authors： Jiao S,Li J,Li Y,Xu Z,Kong B,Li Y,Shen Y

更新日期：2020-11-23 00:00:00

abstract：:Conventional crystalline β-MnO2 usually exhibits poor electrochemical activities due to the narrow tunnels in its rutile-type structure. In this study, we synthesized a novel 2D β-MnO2 network with long-range order assembled by β-MnO2 nanowires and demonstrated that the novel 2D β-MnO2 network exhibits enhanced electr...

journal_title：Scientific reports

authors： Wei C,Pang H,Zhang B,Lu Q,Liang S,Gao F

更新日期：2013-01-01 00:00:00

abstract：:Microtubule affinity regulating kinase 4 (MARK4) becomes a unique anti-cancer drug target as its overexpression is responsible for different types of cancers. In quest of novel, effective MARK4 inhibitors, some acridone derivatives were synthesized, characterized and evaluated for inhibitory activity against human MAR...

journal_title：Scientific reports

authors： Voura M,Khan P,Thysiadis S,Katsamakas S,Queen A,Hasan GM,Ali S,Sarli V,Hassan MI

更新日期：2019-02-08 00:00:00

abstract：:Relativistic electron rings hold the possibility of very high accelerating rates, and hopefully a relatively cheap and compact accelerator/collimator for ultrahigh energy proton source. In this work, we investigate the generation of helical shaped quasi-monoenergetic relativistic electron beam and high-energy proton b...

journal_title：Scientific reports

authors： Sharma A

更新日期：2018-02-01 00:00:00

abstract：:The brain is a paradigmatic example of a complex system: its functionality emerges as a global property of local mesoscopic and microscopic interactions. Complex network theory allows to elicit the functional architecture of the brain in terms of links (correlations) between nodes (grey matter regions) and to extract ...

journal_title：Scientific reports

authors： Mastrandrea R,Gabrielli A,Piras F,Spalletta G,Caldarelli G,Gili T

更新日期：2017-07-07 00:00:00

abstract：:Electrophysiological field potential dynamics have been widely used to investigate brain functions and related psychiatric disorders. Considering recent demand for its applicability to freely moving subjects, especially for animals in a group and socially interacting with each other, here we propose a new method based...

journal_title：Scientific reports

authors： Inagaki S,Agetsuma M,Ohara S,Iijima T,Yokota H,Wazawa T,Arai Y,Nagai T

更新日期：2019-05-16 00:00:00

abstract：:Arrestin domain-containing 3 (ARRDC3) is a tumor suppressor whose expression is either lost or suppressed in basal-like breast cancer (BLBC). However, the mechanism by which BLBC suppresses ARRDC3 expression is not established. Here, we show that expression of ARRDC3 in BLBC cells is suppressed at the transcriptional ...

journal_title：Scientific reports

authors： Soung YH,Pruitt K,Chung J

更新日期：2014-01-24 00:00:00

abstract：:Cervical carcinoma is the fourth most common cause of death in woman, caused by human papillomavirus (HPV) infections and arising from the cervix. Cytoskeleton-associated protein 2 (CKAP2), also known as tumor-associated microtubule-associated protein, has been linked to tumorigenic effects. In the present study, we s...

journal_title：Scientific reports

authors： Guo QS,Song Y,Hua KQ,Gao SJ

更新日期：2017-05-18 00:00:00

abstract：:Deconvolution is widely used to improve the contrast and clarity of a 3D focal stack collected using a fluorescence microscope. But despite being extensively studied, deconvolution algorithms can introduce reconstruction artifacts when their underlying noise models or priors are violated, such as when imaging biologic...

journal_title：Scientific reports

authors： Ikoma H,Broxton M,Kudo T,Wetzstein G

更新日期：2018-07-31 00:00:00

abstract：:Developing optically transparent magnets at room temperature is an important challenge. They would bring many innovations to various industries, not only for electronic and magnetic devices but also for optical applications. Here we introduce FeCo-(Al-fluoride) nanogranular films exhibiting ferromagnetic properties wi...

journal_title：Scientific reports

authors： Kobayashi N,Masumoto H,Takahashi S,Maekawa S

更新日期：2016-09-28 00:00:00

abstract：:Rice yield have been affected by the increased extreme precipitation events in recent decades. Yet, the spatio-temporal patterns of extreme precipitation by rice type and phenology remain elusive. Here, we investigate the characteristics of four extreme precipitation indices across China's rice paddy and their potenti...

journal_title：Scientific reports

authors： Jian Y,Fu J,Li B,Zhou F

更新日期：2020-06-30 00:00:00