Physiologically based pharmacokinetic modelling of atomoxetine with regard to CYP2D6 genotypes.

abstract：:Randomizing the layer thickness of superlattices (SL) can lead to localization of coherent phonons and thereby reduces the lattice thermal conductivity κ l . In this work, we propose strategies that can suppress incoherent phonon transport in the above random multilayer (RML) structure to further reduce κ l . Molecula...

journal_title：Scientific reports

authors： Chakraborty P,Cao L,Wang Y

更新日期：2017-08-15 00:00:00

abstract：:Sustainable canola production is essential to meet growing human demands for vegetable oil, biodiesel, and meal for stock feed markets. Blackleg, caused by the fungal pathogen, Leptosphaeria maculans is a devastating disease that can lead to significant yield loss in many canola production regions worldwide. Breakdown...

journal_title：Scientific reports

authors： Raman R,Diffey S,Barbulescu DM,Coombes N,Luckett D,Salisbury P,Cowley R,Marcroft S,Raman H

更新日期：2020-03-10 00:00:00

abstract：:Bone is a dynamic organ continuously undergoing shaping, repairing and remodeling. The homeostasis of bone is maintained by the balance between osteoblastic bone formation and osteoclastic bone resorption. Osteoclasts (OCs) are specialized multinucleated cells derived from hematopoietic stem cells (HSCs) or monocytes/...

journal_title：Scientific reports

authors： Dou C,Cao Z,Yang B,Ding N,Hou T,Luo F,Kang F,Li J,Yang X,Jiang H,Xiang J,Quan H,Xu J,Dong S

更新日期：2016-02-09 00:00:00

abstract：:Externally manipulating memories by presenting conditioned stimuli (CS) during sleep is a new approach to investigating memory processing during sleep. However, whether presenting a CS during REM or NREM sleep enhances or extinguishes fear memory has not been clearly delineated. In this study, mice underwent trace fea...

journal_title：Scientific reports

authors： Purple RJ,Sakurai T,Sakaguchi M

更新日期：2017-04-12 00:00:00

abstract：:Within year individual variation in the timing of seasonal reproduction within wild bird populations in highly seasonal environments can be pronounced, but the molecular and physiological mechanisms responsible for this variation are unclear. We investigated the relationship between Clock gene poly-Q length, activatio...

journal_title：Scientific reports

authors： Zhang S,Xu X,Wang W,Yang W,Liang W

更新日期：2017-11-03 00:00:00

abstract：:One-carbon metabolism is essential for multiple cellular processes and can be assessed by the concentration of folate metabolites in the blood. One-carbon metabolites serve as methyl donors that are required for epigenetic regulation. Deficiencies in these metabolites are associated with a variety of poor health outco...

journal_title：Scientific reports

authors： Knight AK,Park HJ,Hausman DB,Fleming JM,Bland VL,Rosa G,Kennedy EM,Caudill MA,Malysheva O,Kauwell GPA,Sokolow A,Fisher S,Smith AK,Bailey LB

更新日期：2018-11-15 00:00:00

abstract：:Clinical and experimental studies indicate that muscarinic acetylcholine receptors are potential pharmacological targets for the treatment of neurological diseases. Although these receptors have been described in human, bovine and rat cerebral microvascular tissue, a subtype functional characterization in mouse brain ...

journal_title：Scientific reports

authors： Radu BM,Osculati AMM,Suku E,Banciu A,Tsenov G,Merigo F,Di Chio M,Banciu DD,Tognoli C,Kacer P,Giorgetti A,Radu M,Bertini G,Fabene PF

更新日期：2017-07-11 00:00:00

abstract：:Plutonium and radiocaesium are hazardous contaminants released by the Fukushima Daiichi nuclear power plant (FDNPP) disaster and their distribution in the environment requires careful characterisation using isotopic information. Comprehensive spatial survey of 134Cs and 137Cs has been conducted on a regular basis sinc...

journal_title：Scientific reports

authors： Dunne JA,Martin PG,Yamashiki Y,Ang IXY,Scott TB,Richards DA

更新日期：2018-11-14 00:00:00

abstract：:Mathematical modelling has been widely used to predict the effects of perturbations to brain networks. An important example is epilepsy surgery, where the perturbation in question is the removal of brain tissue in order to render the patient free of seizures. Different dynamical models have been proposed to represent ...

journal_title：Scientific reports

authors： Junges L,Lopes MA,Terry JR,Goodfellow M

更新日期：2019-05-14 00:00:00

abstract：:Classical swine fever virus (CSFV) non-structural protein 3 (NS3) is a multifunctional non-structural protein that plays a major role in viral replication. However, how exactly NS3 exerts these functions remains unknown. Here, we identified tumour necrosis factor receptor-associated factor 6 (TRAF6) as a novel NS3-int...

journal_title：Scientific reports

authors： Lv H,Dong W,Cao Z,Li X,Wang J,Qian G,Lv Q,Wang C,Guo K,Zhang Y

更新日期：2017-07-27 00:00:00

abstract：:Due to the obesity epidemic, non-alcoholic steatohepatitis (NASH) is a prevalent liver disease, characterized by fat accumulation and inflammation of the liver. However, due to a lack of mechanistic insight, diagnostic and therapeutic options for NASH are poor. Recent evidence has indicated cathepsin D (CTSD), a lysos...

journal_title：Scientific reports

authors： Houben T,Oligschlaeger Y,Hendrikx T,Bitorina AV,Walenbergh SMA,van Gorp PJ,Gijbels MJJ,Friedrichs S,Plat J,Schaap FG,Lütjohann D,Hofker MH,Shiri-Sverdlov R

更新日期：2017-06-14 00:00:00

abstract：:Skin burns due to accidental exposure to hot steam have often been reported to be more severe than the ones occurring from dry heat. While skin burns due to flames or radiant heat have been thoroughly characterized, the mechanisms leading to steam burns are not well understood and a conundrum still exists: can second ...

journal_title：Scientific reports

authors： Zhai L,Adlhart C,Spano F,Innocenti Malini R,Piątek AK,Li J,Rossi RM

更新日期：2018-05-02 00:00:00

abstract：:Identification of mutants with impairments in auxin biosynthesis and dynamics by forward genetic screening is hindered by the complexity, redundancy and necessity of the pathways involved. Furthermore, although a few auxin-deficient mutants have been recently identified by screening for altered responses to shade, eth...

journal_title：Scientific reports

authors： Wu L,Luo P,Di DW,Wang L,Wang M,Lu CK,Wei SD,Zhang L,Zhang TZ,Amakorová P,Strnad M,Novák O,Guo GQ

更新日期：2015-07-06 00:00:00

abstract：:The Anfinsen hypothesis, the demonstration of which led to the Nobel prize in Chemistry, posits that all information required to determine a proteins' three dimensional structure is contained within its amino acid sequence. This suggests that it should be possible, in theory, to fold any protein in vitro. In practice,...

journal_title：Scientific reports

authors： Biter AB,de la Peña AH,Thapar R,Lin JZ,Phillips KJ

更新日期：2016-01-19 00:00:00

abstract：:The majority of colorectal cancer (CRC) arises from precursor lesions known as polyps. The molecular determinants that distinguish benign from malignant polyps remain unclear. To molecularly characterize polyps, we utilized Cancer Adjacent Polyp (CAP) and Cancer Free Polyp (CFP) patients. CAPs had tissues from the res...

journal_title：Scientific reports

authors： Druliner BR,Wang P,Bae T,Baheti S,Slettedahl S,Mahoney D,Vasmatzis N,Xu H,Kim M,Bockol M,O'Brien D,Grill D,Warner N,Munoz-Gomez M,Kossick K,Johnson R,Mouchli M,Felmlee-Devine D,Washechek-Aletto J,Smyrk T,Oberg A,

更新日期：2018-02-16 00:00:00

abstract：:While p-n homojunctions in two-dimensional transition metal dichalcogenide materials have been widely reported, few show an ideality factor that is constant over more than a decade in current. In this paper, electric double layer p-i-n junctions in WSe2 are shown with substantially constant ideality factors (2-3) over...

journal_title：Scientific reports

authors： Fathipour S,Paletti P,Fullerton-Shirey SK,Seabaugh AC

更新日期：2020-07-30 00:00:00

abstract：:This study was carried out to use hyperspectral imaging technique for determining color (L*, a* and b*) and eggshell strength and identifying cracked chicken eggs. Partial least squares (PLS) models based on full and selected wavelengths suggested by regression coefficient (RC) method were established to predict the f...

journal_title：Scientific reports

authors： Xie C,He Y

更新日期：2016-02-17 00:00:00

abstract：:The aim of the study was to investigate the role of endogenous sulfur dioxide (SO2)/ aspartate aminotransferase 1 (AAT1) pathway in stretch-induced excessive collagen expression and its mechanism. The mechanical stretch downregulated SO2/AAT1 pathway and increased collagen I and III protein expression. Importantly, AA...

journal_title：Scientific reports

authors： Liu J,Yu W,Liu Y,Chen S,Huang Y,Li X,Liu C,Zhang Y,Li Z,Du J,Tang C,Du J,Jin H

更新日期：2016-02-16 00:00:00

abstract：:The charge transport properties of hybrid halide perovskites are investigated with a combination of density functional theory including van der Waals interaction and the Boltzmann theory for diffusive transport in the relaxation time approximation. We find the mobility of electrons to be in the range 5-10 cm(2)V(-1)s(...

journal_title：Scientific reports

authors： Motta C,El-Mellouhi F,Sanvito S

更新日期：2015-08-03 00:00:00

abstract：:This study evaluated the prognostic value of a panel of 29 oncogenes derived from the analysis of The Cancer Genome Atlas (TCGA data) or from the recent literature on bladder tumors on a well-characterized series of muscle-invasive bladder cancer (MIBC) and non-MIBC (NMIBC) samples and tried to identify molecular prog...

journal_title：Scientific reports

authors： Le Goux C,Vacher S,Schnitzler A,Barry Delongchamps N,Zerbib M,Peyromaure M,Sibony M,Allory Y,Bieche I,Damotte D,Pignot G

更新日期：2020-10-06 00:00:00

abstract：:The mechanism of droplet drying is a widely concerned fundamental issue since controlling the deposition morphology of droplet has significant influence on printing, biology pattern, self-assembling and other solution-based devices fabrication. Here we reveal a striking different kinetics-controlled deposition regime ...

journal_title：Scientific reports

authors： Li Y,Yang Q,Li M,Song Y

更新日期：2016-04-19 00:00:00

abstract：:Extracellular vesicles (EVs) have important roles in physiology, pathology, and more recently have been identified as efficient carriers of therapeutic cargoes. For efficient study of EVs, a single-step, rapid and scalable isolation strategy is necessary. Chromatography techniques are widely used for isolation of biol...

journal_title：Scientific reports

authors： Heath N,Grant L,De Oliveira TM,Rowlinson R,Osteikoetxea X,Dekker N,Overman R

更新日期：2018-04-10 00:00:00

abstract：:Porous materials display enhanced scattering mechanisms that greatly influence their transport properties. Metal-assisted chemical etching (MACE) enables fabrication of porous silicon nanowires starting from a doped Si wafer by using a metal template that catalyzes the etching process. Here, we report on the low therm...

journal_title：Scientific reports

authors： Ferrando-Villalba P,D'Ortenzi L,Dalkiranis GG,Cara E,Lopeandia AF,Abad L,Rurali R,Cartoixà X,De Leo N,Saghi Z,Jacob M,Gambacorti N,Boarino L,Rodríguez-Viejo J

更新日期：2018-08-24 00:00:00

abstract：:Hot-iron disbudding, a routine procedure that prevents horn bud growth through cauterization, is painful for calves. The resulting burns remain sensitive to touch for weeks, but it is unknown whether calves experience ongoing, non-evoked pain. We evaluated conditioned place preference for analgesia in 44 calves disbud...

journal_title：Scientific reports

authors： Adcock SJJ,Tucker CB

更新日期：2020-03-02 00:00:00

abstract：:We developed PANDA (Propagation of Affinity and Domain Architecture) to predict protein functions in the format of Gene Ontology (GO) terms. PANDA at first executes profile-profile alignment algorithm to search against PfamA, KOG, COG, and SwissProt databases, and then launches PSI-BLAST against UniProt for homologue ...

journal_title：Scientific reports

authors： Wang Z,Zhao C,Wang Y,Sun Z,Wang N

更新日期：2018-02-22 00:00:00

abstract：:Type 2 diabetes mellitus is a major health concern worldwide; however, the molecular mechanism underlying its development is poorly understood. The hormone amylin is postulated to be involved, as human amylin forms amyloid in the pancreases of diabetic patients, and oligomers have been shown to be cytotoxic to β-cells...

journal_title：Scientific reports

authors： Nie T,Zhang S,Vazhoor Amarsingh G,Liu H,McCann MJ,Cooper GJS

更新日期：2019-10-10 00:00:00

abstract：:Microbeam radiation therapy is a novel preclinical technique, which uses synchrotron-generated X-rays for the treatment of brain tumours and drug-resistant epilepsies. In order to safely translate this approach to humans, a more in-depth knowledge of the long-term radiobiology of microbeams in healthy tissues is requi...

journal_title：Scientific reports

authors： Fardone E,Bravin A,Conti A,Bräuer-Krisch E,Requardt H,Bucci D,Le Duc G,Battaglia G,Romanelli P

更新日期：2017-10-30 00:00:00

abstract：:Molecular tests hold great potential for tuberculosis (TB) diagnosis, but are costly, time consuming, and HIV-infected patients are often sputum scarce. Therefore, alternative approaches are needed. We evaluated automated digital chest radiography (ACR) as a rapid and cheap pre-screen test prior to Xpert MTB/RIF (Xper...

journal_title：Scientific reports

authors： Philipsen RH,Sánchez CI,Maduskar P,Melendez J,Peters-Bax L,Peter JG,Dawson R,Theron G,Dheda K,van Ginneken B

更新日期：2015-07-27 00:00:00

abstract：:As a source of genetic variation, almond germplasm resources are of great significance in breeding. To better reveal the mutation characteristics and evolution patterns of the almond chloroplast (cp) genome, the complete cp genomes from six almond species were analyzed. The lengths of the chloroplast genome of the six...

journal_title：Scientific reports

authors： Wang W,Yang T,Wang HL,Li ZJ,Ni JW,Su S,Xu XQ

更新日期：2020-06-23 00:00:00

abstract：:By growing monolayer FeSe on SrTiO3(001) surface, researchers obtain the highest superconducting transition-temperature for iron-based superconductor. Here, we study the antiferromagnetic (AFM) checkerboard monolayer FeSe adsorbed on SrTiO3(001) surface. We show that the system has a considerable charge transfer from ...

journal_title：Scientific reports

authors： Zheng F,Wang Z,Kang W,Zhang P

更新日期：2013-01-01 00:00:00