Genetic and physical mapping of loci for resistance to blackleg disease in canola (Brassica napus L.).

abstract：:Arrestins desensitize G protein-coupled receptors (GPCRs) and act as mediators of signalling. Here we investigated the interactions of arrestin-1 with two functionally distinct forms of the dim-light photoreceptor rhodopsin. Using unbiased scanning mutagenesis we probed the individual contribution of each arrestin res...

journal_title：Scientific reports

authors： Peterhans C,Lally CC,Ostermaier MK,Sommer ME,Standfuss J

更新日期：2016-06-28 00:00:00

abstract：:While there is a rich literature on transcription dynamics during the development of many organisms, protein data is limited. We used iTRAQ isotopic labeling and mass spectrometry to generate the largest developmental proteomic dataset for any animal. Expression dynamics of nearly 4,000 proteins of Xenopus laevis was ...

journal_title：Scientific reports

authors： Sun L,Bertke MM,Champion MM,Zhu G,Huber PW,Dovichi NJ

更新日期：2014-03-14 00:00:00

abstract：:The physiologic response to tobacco smoke can be measured by gene-expression profiling of the airway epithelium. Temporal resolution of kinetics of gene-expression alterations upon smoking-cessation might delineate distinct biological processes that are activated during recovery from tobacco smoke exposure. Using whol...

journal_title：Scientific reports

authors： Hijazi K,Malyszko B,Steiling K,Xiao X,Liu G,Alekseyev YO,Dumas YM,Hertsgaard L,Jensen J,Hatsukami D,Brooks DR,O'Connor G,Beane J,Lenburg ME,Spira A

更新日期：2019-05-06 00:00:00

abstract：:It is well known that supercritical water is a favourable medium for biomass conversion followed by its hydrodeoxygenation (HDO). Moreover, the actual kinetics and mechanism of reaction occurring in the supercritical water are not yet completely understood, either by experimental or computational approaches. Within th...

journal_title：Scientific reports

authors： Agrawal K,Kishore N

更新日期：2020-06-08 00:00:00

abstract：:Malignant peripheral nerve sheath tumors (MPNST) are aggressive cancers that occur spontaneously (sporadic MPNST) or from benign plexiform neurofibromas in neurofibromatosis type 1 (NF1) patients. MPNSTs metastasize easily, are therapy resistant and are frequently fatal. The molecular changes underlying the malignant ...

journal_title：Scientific reports

authors： Amirnasr A,Verdijk RM,van Kuijk PF,Kartal P,Vriends ALM,French PJ,van Royen ME,Taal W,Sleijfer S,Wiemer EAC

更新日期：2020-02-19 00:00:00

abstract：:The TCP transcription factors usually act as integrators of multiple growth regulatory and environmental stimuli. However, little is known about this gene family in the important tropical crop cassava (Manihot esculenta). In this study, 36 TCP genes were identified and renamed based on cassava whole-genome sequence an...

journal_title：Scientific reports

authors： Lei N,Yu X,Li S,Zeng C,Zou L,Liao W,Peng M

更新日期：2017-08-30 00:00:00

abstract：:This study aims to examine the long-term effect of adjuvant treatment in Korean Medicine (KM) clinics in ischemic stroke patients, using a national sample cohort from the National Health Insurance Service in Korea between 2010 and 2013. The National Health Insurance Service - National Sample Cohort database from 2002 ...

journal_title：Scientific reports

authors： Lee YS,Kwon S,Chae Y,Jang BH,Ko SG

更新日期：2018-01-26 00:00:00

abstract：:Entanglement is at the heart of many unusual and counterintuitive features of quantum mechanics. Once two quantum subsystems have become entangled, it is no longer possible to ascribe an independent state to either; instead, the subsystems are completely described only as part of a greater, composite system. As a cons...

journal_title：Scientific reports

authors： Bouchard F,Harris J,Mand H,Bent N,Santamato E,Boyd RW,Karimi E

更新日期：2015-10-15 00:00:00

abstract：:Cisplatin, a highly effective and widely used chemotherapeutic agent, has a major limitation for its nephrotoxicity. We recently identified a novel strategy for attenuating its nephrotoxicity in chemotherapy by an effective adjuvant via epigenetic modification through targeting HDAC2. Molecular docking and SPR assay f...

journal_title：Scientific reports

authors： Ma T,Huang C,Meng X,Li X,Zhang Y,Ji S,Li J,Ye M,Liang H

更新日期：2016-05-05 00:00:00

abstract：:A peptide vaccine designed to induce T-cell immunity to telomerase, GV1001, has been shown to modulate cellular signaling pathways and confer a direct anti-cancer effect through the interaction with heat shock protein (HSP) 90 and 70. Here, we have found that GV1001 can modulate transactivation protein-mediated human ...

journal_title：Scientific reports

authors： Kim H,Choi MS,Inn KS,Kim BJ

更新日期：2016-07-01 00:00:00

abstract：:Unnatural chiral α-amino acids are widely used in fields of organic chemistry, biochemistry and medicinal chemistry, and their synthesis has attracted extensive attention. Although the asymmetric synthesis provides some efficient protocols, noble and elaborate catalysts, ligands and additives are usually required whic...

journal_title：Scientific reports

authors： Jiang M,Jin Y,Yang H,Fu H

更新日期：2016-05-17 00:00:00

abstract：:Bacterial communities in wastewater treatment plants (WWTPs) affect plant functionality through their role in the removal of pollutants from wastewater. Bacterial communities vary extensively based on plant operating conditions and influent characteristics. The capacity of WWTPs can also affect the bacterial community...

journal_title：Scientific reports

authors： Kim YK,Yoo K,Kim MS,Han I,Lee M,Kang BR,Lee TK,Park J

更新日期：2019-10-15 00:00:00

abstract：:Fetal cardiomyocytes actively proliferate to form the primitive heart in utero in mammals, but they stop dividing shortly after birth. The identification of essential molecules maintaining this active cardiomyocyte proliferation is indispensable for potential adult heart regeneration. A recent study has shown that thi...

journal_title：Scientific reports

authors： Hashimoto K,Kodama A,Honda T,Hanashima A,Ujihara Y,Murayama T,Nishimatsu SI,Mohri S

更新日期：2017-06-30 00:00:00

abstract：:The development of the peripheral nervous system relies on long-distance signaling from target organs back to the soma. In sympathetic neurons, this long-distance signaling is mediated by target derived Nerve Growth Factor (NGF) interacting with its axonal receptor, TrkA. This ligand receptor complex internalizes into...

journal_title：Scientific reports

authors： Barford K,Keeler A,McMahon L,McDaniel K,Yap CC,Deppmann CD,Winckler B

更新日期：2018-03-16 00:00:00

abstract：:Ring-opening graft polymerization (ROGP) of L-Lactide (L-LA) is a practical method of altering the physical and chemical properties of lignocellulose. Previous studies have mainly investigated cellulose and tin-based catalysts, particularly of tin(II) 2-ethylhexanoate (Sn(oct)2), at high temperatures and reported low ...

journal_title：Scientific reports

authors： Zhang X,Wang H,Liu C,Zhang A,Ren J

更新日期：2017-04-03 00:00:00

abstract：:Hyperphosphorylation of tau and imbalanced expression of 3R-tau and 4R-tau as a result of dysregulation of tau exon 10 splicing are believed to be pivotal to the pathogenesis of tau pathology, but the molecular mechanism leading to the pathologic tau formation in Alzheimer's disease (AD) brain is not fully understood....

journal_title：Scientific reports

authors： Chen C,Gu J,Basurto-Islas G,Jin N,Wu F,Gong CX,Iqbal K,Liu F

更新日期：2017-10-18 00:00:00

abstract：:Bisphosphonates have benefits in breast cancer and multiple myeloma patients and have been used with adoptive immunotherapy with γδ T cells expressing Vγ2 Vδ2 TCRs. Although treatment with γδ T cells is safe, it has shown limited efficacy. Present bisphosphonates stimulate γδ T cells but were designed to inhibit bone ...

journal_title：Scientific reports

authors： Tanaka Y,Iwasaki M,Murata-Hirai K,Matsumoto K,Hayashi K,Okamura H,Sugie T,Minato N,Morita CT,Toi M

更新日期：2017-07-20 00:00:00

abstract：:We aim to evaluate the association of systolic and diastolic blood pressure (SBP and DBP) with estimated urinary sodium (Na) and potassium(K) excretions, and their gram-to-gram Na/K ratio across various salt-diet regions during 2005-2009 in China. A prospective cohort study was conducted to recruit 46,285 participants...

journal_title：Scientific reports

authors： Yin L,Deng G,Mente A,Sun Y,Liu X,Zhang X,Wang X,Wang Y,Bo J,Chen H,Liu X,Gao N,Bai X,Rangarajan S,Li W

更新日期：2018-04-30 00:00:00

abstract：:We used swept-source (SS) optical coherence tomography (OCT) and OCT angiography (OCTA) to investigate the effects of moderate physical exercise on retinal and choroidal vessel densities (VDs) and thicknesses in children. One eye in each of 40 myopic children (mean age, 11.70 years) and 18 emmetropic children (mean ag...

journal_title：Scientific reports

authors： Li S,Pan Y,Xu J,Li X,Spiegel DP,Bao J,Chen H

更新日期：2021-01-21 00:00:00

abstract：:We report the control of imazalil (IMZ) antifungal activity utilizing its non-covalent assembly with β-cyclodextrins (β-CD) and cucurbit[8]uril (CB8) macrocycles, as well as its stimuli-responsive disassembly with cadaverine. The NMR results are consistent with inclusion of a single IMZ molecule inside the cavities of...

journal_title：Scientific reports

authors： Al-Dubaili N,El-Tarabily K,Saleh N

更新日期：2018-02-12 00:00:00

abstract：:Fusarium Head Blight (FHB) caused by Fusarium graminearum pathogens constitutes a major threat to agricultural production because it frequently reduces the yield and quality of the crop. The disease severity is predicted to increase in various regions owing to climate change. Integrated management where biocontrol pla...

journal_title：Scientific reports

authors： Timmusk S,Copolovici D,Copolovici L,Teder T,Nevo E,Behers L

更新日期：2019-01-24 00:00:00

abstract：:This study was conducted to identify risk factors associated with AIV infections in live bird retail stalls (LBRS) in Lahore District, Pakistan. A cross-sectional survey of LBRS was conducted from December 2009-February 2010 using two-stage cluster sampling based on probability proportional to size. A total of 280 oro...

journal_title：Scientific reports

authors： Chaudhry M,Rashid HB,Angot A,Thrusfield M,Bronsvoort BMD,Capua I,Cattoli G,Welburn SC,Eisler MC

更新日期：2018-04-04 00:00:00

abstract：:The considerable range of genetic variation in human populations may partly reflect distinctive processes of adaptation to variable environmental conditions. However, the adaptive genomic signatures remain to be completely elucidated. This research explores candidate loci under selection at the population level by cha...

journal_title：Scientific reports

authors： Fujikura K

更新日期：2016-03-02 00:00:00

abstract：:Recognition of the potential for vegetated coastal ecosystems to store and sequester carbon has led to their increasing inclusion into global carbon budgets and carbon offset schemes. However, kelp forests have been overlooked in evaluations of this 'blue carbon', which have been limited to tidal marshes, mangrove for...

journal_title：Scientific reports

authors： Filbee-Dexter K,Wernberg T

更新日期：2020-07-23 00:00:00

abstract：:Contact investigation is an important and effective active case-finding strategy, but there is a lack of research on congregate settings in countries with an intermediate incidence. This study determined the incidence of and risk factors for tuberculosis (TB) development after exposure in congregate settings. This ret...

journal_title：Scientific reports

authors： Park SY,Han S,Kim YM,Kim J,Lee S,Yang J,Kim UN,Park MS

更新日期：2020-01-28 00:00:00

abstract：:The root system displays a remarkable plasticity that enables plants to adapt to changing environmental conditions. This plasticity is tightly linked to the activity of root apical meristems (RAMs) and to the formation of lateral roots, both controlled by related hormonal crosstalks. In Arabidopsis thaliana, gibberell...

journal_title：Scientific reports

authors： Fonouni-Farde C,Miassod A,Laffont C,Morin H,Bendahmane A,Diet A,Frugier F

更新日期：2019-02-20 00:00:00

abstract：:To explore a simple and easy-to-learn procedure for the isolation of human quiescent hepatic stellate cells (HSCs) that requires no advanced training. Thus reducing costs and increasing efficiency. This protocol will provide sufficient primary cells with minimal contaminants for future basic research on diseases assoc...

journal_title：Scientific reports

authors： Zhai X,Wang W,Dou D,Ma Y,Gang D,Jiang Z,Shi B,Jin B

更新日期：2019-09-04 00:00:00

abstract：:Human pancreatic islet amyloid polypeptide (hIAPP) and beta amyloid (Aβ) can accumulate in Type 2 diabetes (T2D) and Alzheimer's disease (AD) brains and evidence suggests that interaction between the two amyloidogenic proteins can lead to the formation of heterocomplex aggregates. However, the structure and consequenc...

journal_title：Scientific reports

authors： Bharadwaj P,Solomon T,Sahoo BR,Ignasiak K,Gaskin S,Rowles J,Verdile G,Howard MJ,Bond CS,Ramamoorthy A,Martins RN,Newsholme P

更新日期：2020-06-25 00:00:00

abstract：:Healthy neonates exhibit a well-functioning haemostatic system despite peculiarities regarding composition of clotting factors and inhibitors as well as impaired platelet aggregation. Thrombocytopenia and severe bleeding events are feared in sick infants. Recombinant factor VIIa (rFVIIa) is a haemostatic agent used as...

journal_title：Scientific reports

authors： Haidl H,Pohl S,Leschnik B,Gallistl S,Muntean W,Schlagenhauf A

更新日期：2019-05-29 00:00:00

abstract：:Cartilage loss is a leading cause of disability among adults and effective therapy remains elusive. Neonatal chondrocytes (NChons) are an attractive allogeneic cell source for cartilage repair, but their clinical translation has been hindered by scarce donor availability. Here we examine the potential for catalyzing c...

journal_title：Scientific reports

authors： Lai JH,Kajiyama G,Smith RL,Maloney W,Yang F

更新日期：2013-12-19 00:00:00