Abstract:
:Hyperphosphorylation of tau and imbalanced expression of 3R-tau and 4R-tau as a result of dysregulation of tau exon 10 splicing are believed to be pivotal to the pathogenesis of tau pathology, but the molecular mechanism leading to the pathologic tau formation in Alzheimer's disease (AD) brain is not fully understood. In the present study, we found that casein kinase 1ε (CK1ε) was increased significantly in AD brains. Overexpression of CK1ε in cultured cells led to increased tau phosphorylation at many sites. Moreover, we found that CK1ε suppressed tau exon 10 inclusion. Levels of CK1ε were positively correlated to tau phosphorylation, 3R-tau expression and tau pathology, and negatively correlated to 4R-tau in AD brains. Overexpression of CK1ε in the mouse hippocampus increased tau phosphorylation and impaired spontaneous alternation behavior. These data suggest that CK1ε is involved in the regulation of tau phosphorylation, the alternative splicing of tau exon 10, and cognitive performance. Up-regulation of CK1ε might contribute to tau pathology by hyperphosphorylating tau and by dysregulating the alternative splicing of tau exon 10 in AD.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chen C,Gu J,Basurto-Islas G,Jin N,Wu F,Gong CX,Iqbal K,Liu Fdoi
10.1038/s41598-017-13791-5subject
Has Abstractpub_date
2017-10-18 00:00:00pages
13478issue
1issn
2045-2322pii
10.1038/s41598-017-13791-5journal_volume
7pub_type
杂志文章abstract::Horizontal gene transfer (HGT) is a main mechanism of bacterial evolution endowing bacteria with new genetic traits. The transfer of mobile genetic elements such as plasmids (conjugation) requires the close proximity of cells. HGT between genetically distinct bacteria largely depends on cell movement in water films, w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36390
更新日期:2016-11-04 00:00:00
abstract::Overexpression of hST3Gal1 leads to hypersialylation of cell-surface glycoconjugates, a cancer-associated condition that promotes cell growth, migration and invasion. Upregulation of this enzyme in ovarian cancer is linked to cancer progression and metastasis, contributing also to chemotherapy resistance. Strategies f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54384-8
更新日期:2019-11-29 00:00:00
abstract::Somatic copy number alterations (SCNAs) affecting oncogenic drivers have a firmly established role in promoting cancer. However, no agreed-upon standard exists for calling locus-specific amplifications and deletions in each patient sample. Here, we report the correlative analysis of copy number amplitude and length wi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19649
更新日期:2016-01-20 00:00:00
abstract::The state of preservation of wood in two samples from the Hanson Logboat, currently on display in Derby Museum and Art Gallery, was analysed using elemental analysis (EA), pyrolysis-gas chromatography/flame ionisation detection (Py-GC/FID), pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) and scanning electro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14057-w
更新日期:2017-10-20 00:00:00
abstract::Changes in climate extremes pose far-reaching consequences to ecological processes and hydrologic cycles in alpine ecosystems of the arid mountain regions. Therefore, regional assessments in various climates and mountain regions are needed for understanding the uncertainties of the change trends for extreme climate ev...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02345-4
更新日期:2017-05-22 00:00:00
abstract::Hesperiidae is one of the largest families of butterflies. Our knowledge of the higher systematics on hesperiids from China is still very limited. We infer the phylogenetic relationships of the subfamilies of Chinese skippers based on three mitochondrial genes (cytochrome b (Cytb), the NADH dehydrogenase subunit 1 (ND...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11140
更新日期:2015-06-10 00:00:00
abstract::Canalization is a result of intrinsic developmental buffering that ensures phenotypic robustness under genetic variation and environmental perturbation. As a consequence, animal phenotypes are remarkably consistent within a species under a wide range of conditions, a property that seems contradictory to evolutionary c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16717
更新日期:2015-11-18 00:00:00
abstract::Prognosis of patients with advanced sarcoma after progression from FDA approved therapies remains grim. In this study, clinical outcomes of 100 patients with advanced sarcoma who received treatment on novel targeted therapy trials were evaluated. Outcomes of interest included best response, clinical benefit rate, prog...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35448
更新日期:2016-10-17 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-63873-0
更新日期:2020-04-17 00:00:00
abstract::Toxins are believed to play a crucial role in Burkholderia pseudomallei pathogenicity, however to date, only a few have been identified. The discovery of additional toxic molecules is limited by the lack of a sensitive indicator of B. pseudomallei toxicity. Previously, from a whole genome transcriptome analysis of B. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27475
更新日期:2016-06-07 00:00:00
abstract::Difficulties in the production of lignin from rice straw because of high silica content in the recovered lignin reduce its recovery yield and applications as bio-fuel and aromatic chemicals. Therefore, the objective of this study is to develop a novel method to reduce the silica content in lignin from rice straw more ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77867-5
更新日期:2020-12-04 00:00:00
abstract::This study was conducted to identify risk factors associated with AIV infections in live bird retail stalls (LBRS) in Lahore District, Pakistan. A cross-sectional survey of LBRS was conducted from December 2009-February 2010 using two-stage cluster sampling based on probability proportional to size. A total of 280 oro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23895-1
更新日期:2018-04-04 00:00:00
abstract::The applications of machine learning/deep learning (ML/DL) methods in meteorology have developed considerably in recent years. Massive amounts of meteorological data are conducive to improving the training effect and model performance of ML/DL, but the establishment of training datasets is often time consuming, especi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71831-z
更新日期:2020-09-14 00:00:00
abstract::Hydrogen is known to be present as an impurity in amorphous oxide semiconductors at the 0.1% level. Using amorphous ZnO as a simplified model system, we show that the hydrogens pair up at oxygen vacancies in the amorphous network, where they form metal-H-metal bridge bonds. These bonds are shown to create filled defec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17290-5
更新日期:2017-12-04 00:00:00
abstract::Chimpanzees (Pan troglodytes), one of humankinds' closest living relatives, are known to hunt and consume the meat of various animal taxa. Although some researchers have presented indirect evidence that chimpanzees may also prey on tortoises, until now, direct observations of this behaviour did not exist. Here, we pro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43301-8
更新日期:2019-05-23 00:00:00
abstract::Recently, CuZr-based bulk metallic glass (BMG) composites reinforced by the TRIP (transformation-induced plasticity) effect have been explored in attempt to accomplish an optimal of trade-off between strength and ductility. However, the design of such BMG composites with advanced mechanical properties still remains a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42518
更新日期:2017-02-13 00:00:00
abstract::Autophagy is the major intracellular degradation system by which cytoplasmic materials are delivered to and degraded in the vacuole/lysosome in eukaryotic cells. MoAtg14 in M. oryzae, a hitherto uncharacterized protein, is the highly divergent homolog of the yeast Atg14 and the mammal BARKOR. The MoATG14 deletion muta...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40018
更新日期:2017-01-09 00:00:00
abstract::Prediction of infection trends, estimating the efficacy of contact tracing, testing or impact of influx of infected are of vital importance for administration during an ongoing epidemic. Most effective methods currently are empirical in nature and their relation to parameters of interest to administrators are not evid...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73308-5
更新日期:2020-10-06 00:00:00
abstract::The C1q complement/TNF-related protein superfamily (CTRPs) displays differential effects on the regulation of metabolic homeostasis, governing cardiovascular function. However, whether and how they may serve as predictor/pro-diagnosis factors for assessing the risks of coronary artery disease (CAD) remains controversi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57877-z
更新日期:2020-01-21 00:00:00
abstract::Manipulating the polarization states of electromagnetic (EM) waves, a fundamental issue in optics, attracted intensive attention recently. However, most of the devices realized so far are either too bulky in size, and/or are passive with only specific functionalities. Here we combine theory and experiment to demonstra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27503
更新日期:2016-06-08 00:00:00
abstract::Ornamental plants represent a major pathway of invasion for alien pests worldwide. Commodity risk analyses are carried out to assess the risk posed by a new trade in a commodity, but they are restricted by our limited knowledge of the pests carried by traded plants. We used the sentinel nursery technique to identify i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29551-y
更新日期:2018-07-25 00:00:00
abstract::In order to clearly understand the intrinsic microwave absorption properties of carbon nanomaterials, we proposed an efficient strategy to synthesize high purity metal-free carbon nanotubes (CNTs) over water-soluble K2CO3 particles through chemical vapor decomposition and water-washing process. The comparison results ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28310
更新日期:2016-06-21 00:00:00
abstract::This corrects the article DOI: 10.1038/srep16188. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/srep46909
更新日期:2017-12-22 00:00:00
abstract::We demonstrate a tool for quantitative measurements in the extreme ultraviolet (EUV) spectral region measuring spatially resolved atomic ionization products at the focus of an EUV beam. The ionizing radiation is a comb of the 11(th)-15(th) harmonics of a Ti:Sapphire femtosecond laser beam produced in a Xenon gas jet. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21556
更新日期:2016-02-12 00:00:00
abstract::Platelet microvesicles (pMVs) are submicron-sized heterogeneous vesicles released upon activation and contain several membrane receptors and proteins (CD41, CD61, CD62, CXCR4, PAR-1, etc.). We have revealed their ability to adhere to the triblock copolymer pluronic-F127 (PF127) and form a platelet microvesicular nanoc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57057-8
更新日期:2020-01-13 00:00:00
abstract::Four plant tumorigenic strains 932, 1019, 1078T and 1081 isolated from cane gall tumors on thornless blackberry (Rubus sp.) were characterized. They shared low sequence identity with related Rhizobium spp. based on comparisons of 16S rRNA gene (≤98%) and housekeeping genes atpD, recA and rpoB (<90%). Phylogenetic anal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27485-z
更新日期:2018-06-13 00:00:00
abstract::Pressure therapy has been proved to be an effective treatment for hypertrophic scars in a clinical setting. However, evidence-based data are controversial and the precise mechanism of action of this technique remains unknown. The aim of this study was to investigate the potential molecular mechanisms of pressure thera...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29840-6
更新日期:2018-08-07 00:00:00
abstract::The increase in volume and variety of pharmaceuticals found in natural water bodies has become an increasingly serious environmental problem. The implementation of cold plasma technology, specifically gas-phase pulsed corona discharge (PCD), for sulfamethizole abatement was studied in the present work. It was observed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27061-5
更新日期:2018-06-07 00:00:00
abstract::Part of the symptomatology of post-traumatic stress disorder (PTSD) are alterations in arousal and reactivity which could be related to a maladaptive increase in the automated sensory change detection system of the brain. In the current EEG study we investigated whether the brain's response to a simple auditory sensor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16669-8
更新日期:2017-11-29 00:00:00
abstract::Retrotransposons can represent half of eukaryotic genomes. Retrotransposon dysregulation destabilizes genomes and has been linked to various human diseases. Emerging regulators of retromobility include RNA-DNA hybrid-containing structures known as R-loops. Accumulation of these structures at the transposons of yeast 1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73018-y
更新日期:2020-09-29 00:00:00