Abstract:
:Contact investigation is an important and effective active case-finding strategy, but there is a lack of research on congregate settings in countries with an intermediate incidence. This study determined the incidence of and risk factors for tuberculosis (TB) development after exposure in congregate settings. This retrospective cohort study included 116,742 contacts identified during the investigation of 2,609 TB cases diagnosed from January to December 2015. We searched the Korean National Tuberculosis Surveillance System TB registry to identify contacts that developed active TB during follow-up until May 2018. During the mean observation period of 2.9 years, 499 of 116,742 contacts (0.4%) developed new active TB. From these contacts, 404 (81.0%) developed TB within 2 years after exposure. The 2-year Kaplan-Meier cumulative risk for TB was the highest in contacts aged ≥65 years [1%; 95% confidence interval (CI), 0.8-1.3]. Contacts with LTBI who completed chemoprophylaxis exhibited a lower risk of active TB development than those without chemoprophylaxis (adjusted hazard ratio, 0.16; 95% CI, 0.08-0.29). Aggressive contact investigation is effective for the early detection and prevention of TB in congregate settings. The risk of progression to active TB among contacts with LTBI can be minimised by the completion of chemoprophylaxis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Park SY,Han S,Kim YM,Kim J,Lee S,Yang J,Kim UN,Park MSdoi
10.1038/s41598-020-57697-1subject
Has Abstractpub_date
2020-01-28 00:00:00pages
1306issue
1issn
2045-2322pii
10.1038/s41598-020-57697-1journal_volume
10pub_type
杂志文章abstract::This corrects the article DOI: 10.1038/srep42627. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/srep46966
更新日期:2018-04-06 00:00:00
abstract::Rab27 is an essential molecule of vesicle fusion and trafficking in exosome secretion process, which plays important roles in cancer progression and metastasis. Recent studies reported that Rab27 expression is also associated with cancer prognosis. Therefore, we performed a meta-analysis to reveal the prognostic signi...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-020-71104-9
更新日期:2020-08-24 00:00:00
abstract::In this paper, we present a strategy to improve delivery of femtosecond laser pulses from a regenerative amplifier through a hollow core photonic crystal fiber for temporally focused wide-field two-photon endomicroscopy. For endomicroscope application, wide-field two-photon excitation has the advantage of requiring no...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06626
更新日期:2014-10-15 00:00:00
abstract::A dual mode rare-earth based vanadate material (YVO4: Ho3+/Yb3+), prepared through ethylene glycol assisted hydrothermal method, demonstrating both downconversion and upconversion, along with systematic investigation of the luminescence spectroscopy within 12-300 K is presented herein. The energy transfer processes ha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36342
更新日期:2016-11-02 00:00:00
abstract::Despite the fact that 2015 was the international year of light, no mention was made of the fact that radiation contains entropy as well as energy, with different spectral distributions. Whereas the energy function has been vastly studied, the radiation entropy distribution has not been analysed at the same speed. The ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01622-6
更新日期:2017-05-10 00:00:00
abstract::We perform a detailed theoretical and experimental investigation of supercontinuum generation in large-mode-area photonic crystal fibers pumped by a high-energy, high-repetition rate picosecond Nd:YVO4 laser, with the goal of using it as the Stokes beam in coherent anti-Stokes Raman scattering setup. We analyze the in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27811-5
更新日期:2018-06-22 00:00:00
abstract::Diagnostic criteria for pathological gambling and alcohol dependence (AD) include repeated addictive behavior despite severe negative consequences. However, the concept of loss aversion (LA) as a facet of value-based decision making has not yet been used to directly compare these disorders. We hypothesized reduced LA ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16433-y
更新日期:2017-11-24 00:00:00
abstract::We report on the synthesis and electrical properties of nine new alkylated silane self-assembled monolayers (SAMs) - (EtO)3Si(CH2)nN = CHPhX where n = 3 or 11 and X = 4-CF3, 3,5-CF3, 3-F-4-CF3, 4-F, or 2,3,4,5,6-F, and explore their rectification behavior in relation to their molecular structure. The electrical proper...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38092
更新日期:2016-11-29 00:00:00
abstract::House dust mites (HDMs) are one of the major causes of allergies in the world. The group 23 allergen, Der p 23, from Dermatophagoides pteronyssinus, is a major allergen amongst HDM-sensitized individuals. This study aims to determine the specific immunoglobulin E (sIgE) binding frequency and IgE-binding residues of re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79820-y
更新日期:2021-01-13 00:00:00
abstract::Intrasynovial tendon injuries are among the most challenging in orthopedics. Despite significant improvements in operative and rehabilitation methods, functional outcomes continue to be limited by adhesions, gap formation, and rupture. Adhesions result from excessive inflammation, whereas tendon gapping and rupture re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29474-8
更新日期:2018-07-23 00:00:00
abstract::In this study, we made a comparative efficacy and safety assessment of two different fixed combinations of drugs, viz., tafluprost/timolol (TAF/TIM) and latanoprost/carteolol (LAT/CAR), by determining their effects on intraocular pressure (IOP) in ocular normotensive monkeys and examining their toxic effects on ocular...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44028-2
更新日期:2019-05-16 00:00:00
abstract::Multipotential stromal cells (MSCs) demonstrate strong immunomodulation capabilities following culture expansion. We have previously demonstrated that human cancellous bone fragments (CBFs) clinically used as viable allografts for spinal fusion have resident MSCs that exhibit T cell immunomodulation after monolayer ex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31979-1
更新日期:2018-09-10 00:00:00
abstract::The order Chlamydiales are biphasic intracellular bacterial pathogens infecting humans and domesticated animals. Wildlife infections have also been reported, with the most studied example being Chlamydia pecorum infections in the koala, an iconic Australian marsupial. In koalas, molecular evidence suggests that spill-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13164-y
更新日期:2017-10-09 00:00:00
abstract::Synthetic fertilizer production is associated with a high environmental footprint, as compounds typically dissolve rapidly leaching emissions to the atmosphere or surface waters. We tested two recovered nutrients with slower release patterns, as promising alternatives for synthetic fertilizers: struvite and a commerci...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45290-0
更新日期:2019-07-02 00:00:00
abstract::Meromictic lakes are useful biogeochemical models because of their stratified chemical gradients and separation of redox reactions down the water column. Perennially ice-covered meromictic lakes are particularly stable, with long term constancy in their density profiles. Here we sampled Lake A, a deep meromictic lake ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00604
更新日期:2012-01-01 00:00:00
abstract::Spontaneous preterm birth (sPTB, delivery <37 weeks gestation), accounts for approximately 10% of births worldwide; the aetiology is multifactorial with intra-amniotic infection being one contributing factor. This study aimed to determine whether asymptomatic women with a history of sPTB or cervical surgery have alter...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47756-7
更新日期:2019-08-02 00:00:00
abstract::We present a proposal to realize the quantum Zeno effect (QZE) and quantum Zeno-like effect (QZLE) in a proximal (13)C nuclear spin by controlling a proximal electron spin of a nitrogen vacancy (NV) center. The measurement is performed by applying a microwave pulse to induce the transition between different electronic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17615
更新日期:2015-12-01 00:00:00
abstract::During folliculogenesis, primary oocytes of teleosts grow by several orders of magnitude by-self synthesizing proteins and mRNA, or sequestering from blood specific macromolecular components, such as fatty acids and vitellogenin. All these materials are stored into cortical alveoli, yolk globules or oil droplets durin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45065-7
更新日期:2019-06-20 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-55967-1
更新日期:2019-12-24 00:00:00
abstract::Helicobacter pylori is presumed to infect gastric tissue via the oral cavity in childhood, whereas risk factors for H. pylori infection in the oral cavity are unknown. In this study, we analysed the effects of Streptococcus mutans, a major cariogenic bacterial species, on H. pylori colonisation in the oral cavity, as ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69368-2
更新日期:2020-07-27 00:00:00
abstract::MCM7, a subunit of mini-chromosome maintenance proteins (MCM) complex, plays an important role in initiating DNA replication during the G1 phase and extending DNA strands during the S phase. Here, we demonstrated that MCM7 is not only sustained but maintains association with chromatin during M phase. Remarkably, MCM7 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03148-3
更新日期:2017-06-06 00:00:00
abstract::Asian Longhorned Beetle (ALB) Anoplophora glabripennis is a serious invasive forest pest in several countries including the United States, Canada, and Europe. RNA interference (RNAi) technology is being developed as a novel method for pest management. Here, we identified the ALB core RNAi genes including those coding ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08813-1
更新日期:2017-08-21 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-67554-w
更新日期:2020-06-25 00:00:00
abstract::Noisy galvanic vestibular stimulation (nGVS) delivered at imperceptible intensities can improve vestibular function in health and disease. Here we evaluated whether nGVS effects on vestibular function are only present during active stimulation or may exhibit relevant post-stimulation after-effects. Initially, nGVS amp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59374-9
更新日期:2020-02-13 00:00:00
abstract::Measurements of skeletal muscle cross-sectional area, index, and radiation attenuation utilizing clinical computed tomography (CT) scans are used in assessments of sarcopenia, the loss of skeletal muscle mass and function associated with aging. To classify individuals as sarcopenic, sex-specific cutoffs for 'low' valu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29825-5
更新日期:2018-07-27 00:00:00
abstract::The high theoretical capacity and low discharge potential of silicon have attracted much attention on Si-based anodes. Herein, hollow porous SiO2 nanocubes have been prepared via a two-step hard-template process and evaluated as electrode materials for lithium-ion batteries. The hollow porous SiO2 nanocubes exhibited ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01568
更新日期:2013-01-01 00:00:00
abstract::A two-dimensional electron gas (2DEG) with equal-strength Rashba and Dresselhaus spin-orbit coupling sustains persistent helical spin-wave states, which have remarkably long lifetimes. In the presence of an in-plane magnetic field, there exist single-particle excitations that have the character of propagating helical ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21818-8
更新日期:2018-02-22 00:00:00
abstract::The rapid urbanization in China has been associated with a growing hunger for energy consumption and steadily-increasing CO2 emissions. In this paper, an integrated system dynamics model composed of four sub-models is developed to simulate the urbanization and energy consumption in China from 1998 to 2050. Three scena...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66125-3
更新日期:2020-06-19 00:00:00
abstract::Protein corona significantly affects in vivo fate of nanoparticles including biodistribution and half-life. Without manipulating the physicochemical properties of nanoparticles with considering their biointerference, attaining effective treatment protocols is impossible. For this reason, protein corona evolution and b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66572-y
更新日期:2020-06-15 00:00:00
abstract::Levels of neutral poly-/perfluoroalkyl substances (nPFASs) in air and snow collected from Ny-Ålesund were measured and their air-snow exchange was determined to investigate whether they could re-volatilize into the atmosphere driven by means of air-snow exchange. The total concentration of 12 neutral PFASs ranged from...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08912
更新日期:2015-03-09 00:00:00