Abstract：
:The physiologic response to tobacco smoke can be measured by gene-expression profiling of the airway epithelium. Temporal resolution of kinetics of gene-expression alterations upon smoking-cessation might delineate distinct biological processes that are activated during recovery from tobacco smoke exposure. Using whole genome gene-expression profiling of individuals initiating a smoking-cessation attempt, we sought to characterize the kinetics of gene-expression alterations in response to short-term smoking-cessation in the nasal epithelium. RNA was extracted from the nasal epithelial of active smokers at baseline and at 4, 8, 16, and 24-weeks after smoking-cessation and put onto Gene ST arrays. Gene-expression levels of 119 genes were associated with smoking-cessation (FDR < 0.05, FC ≥1.7) with a majority of the changes occurring by 8-weeks and a subset changing by 4-weeks. Genes down-regulated by 4- and 8-weeks post-smoking-cessation were involved in xenobiotic metabolism and anti-apoptotic functions respectively. These genes were enriched among genes previously found to be induced in smokers and following short-term in vitro exposure of airway epithelial cells to cigarette smoke (FDR < 0.05). Our findings suggest that the nasal epithelium can serve as a minimally-invasive tool to measure the reversible impact of smoking and broadly, may serve to assess the physiological impact of changes in smoking behavior.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hijazi K,Malyszko B,Steiling K,Xiao X,Liu G,Alekseyev YO,Dumas YM,Hertsgaard L,Jensen J,Hatsukami D,Brooks DR,O'Connor G,Beane J,Lenburg ME,Spira Adoi
10.1038/s41598-019-43295-3subject
Has Abstractpub_date
2019-05-06 00:00:00pages
6978issue
1issn
2045-2322pii
10.1038/s41598-019-43295-3journal_volume
9pub_type
杂志文章abstract：:With countless biological details emerging from cancer experiments, there is a growing need for minimal mathematical models which simultaneously advance our understanding of single tumors and metastasis, provide patient-personalized predictions, whilst avoiding excessive hard-to-measure input parameters which complica...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00031
更新日期：2011-01-01 00:00:00
abstract：:Modulation of initial burst and long term release from electrospun fibrous mats can be achieved by sandwiching the drug loaded mats between hydrophobic layers of fibrous polycaprolactone (PCL). Ibuprofen (IBU) loaded PCL fibrous mats (12% PCL-IBU) were sandwiched between fibrous polycaprolactone layers during the proc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74885-1
更新日期：2020-10-23 00:00:00
abstract：:Working memory (WM) impairments in ADHD have been consistently reported along with deficits in attentional control. Yet, it is not clear which specific WM processes are affected in this condition. A deficient coupling between attention and WM has been reported. Nevertheless, most studies focus on the capacity to retai...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64678-x
更新日期：2020-05-08 00:00:00
abstract：:IgE, forming an immune complex with small proteins, can enhance the specific antibody and CD4(+) T cell responses in vivo. The effects require the presence of CD23 (Fcε-receptor II)(+) B cells, which capture IgE-complexed antigens (Ag) in the circulation and transport them to splenic B cell follicles. In addition, als...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28290
更新日期：2016-06-16 00:00:00
abstract：:The current study aimed to evaluate the efficacy of linked color imaging (LCI) in improving the visibility of superficial non-ampullary duodenal epithelial tumors (SNADETs). We prospectively evaluated 44 consecutive patients diagnosed with SNADETs. Three trainees and three experts assessed the visibility scores of whi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77726-3
更新日期：2020-11-26 00:00:00
abstract：:Pregnancy and puerperium are typified by marked biobehavioral changes. These changes, which are traceable in both mothers and fathers, play an important role in parenthood and may modulate social cognition abilities. However, the latter effects remain notably unexplored in parents of newborns (PNs). To bridge this gap...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62622-7
更新日期：2020-04-01 00:00:00
abstract：:In the recent years, new molecular methods have been proposed to discriminate multicentric hepatocellular carcinomas (HCC) from intrahepatic metastases. Some of these methods utilize sequencing data to assess similarities between cancer genomes, whilst other achieved the same results with transcriptome and methylome d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40843-9
更新日期：2019-03-14 00:00:00
abstract：:Intuition and insight can be deployed on the same continuum. Intuition is the unconscious ability to create links between information; insight is a process by which a sudden comprehension and resolution of a situation arises (i.e. euréka). In the present study, real and virtual environments were used to trigger intuit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81532-w
更新日期：2021-01-21 00:00:00
abstract：:Whether the retinal process alone or retinal and cortical processes jointly determine afterimage (AI) formation has long been debated. Based on the retinal rebound responses, recent work proposes that afterimage signals are exclusively generated in the retina, although later modified by cortical mechanisms. We tested ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41101
更新日期：2017-01-23 00:00:00
abstract：:The specification and growth of organs is controlled simultaneously by networks of transcription factors. While the connection between these transcription factors with fate determinants is increasingly clear, how they establish the link with the cell cycle is far less understood. Here we investigate this link in the d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04936-7
更新日期：2017-07-07 00:00:00
abstract：:Maoto, a traditional Japanese Kampo medicine, has been used to treat various respiratory diseases, including respiratory infections and influenza. Ephedrine (EPD), the main ingredient in maoto, is also clinically used to treat respiratory diseases. However, the pharmacokinetics and distribution of EPD in the lungs aft...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44098
更新日期：2017-03-08 00:00:00
abstract：:Long non-coding RNAs (lncRNAs) form the largest transcript class in the human transcriptome. These lncRNA are expressed not only in the cells, but they are also present in the cell-derived extracellular vesicles such as exosomes. The function of these lncRNAs in cancer biology is not entirely clear, but they appear to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24922
更新日期：2016-04-22 00:00:00
abstract：:The relationship among the single nucleotide polymorphisms (SNPs) of the C-X-C motif chemokine ligand 12 gene (CXCL12) and the serum lipid profiles in the Chinese population has rarely been described, especially in somewhat old-fashioned and isolated Maonan minority. The goal of the current study was to elucidate the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55725-3
更新日期：2019-12-20 00:00:00
abstract：:Two related models for T cell signalling initiation suggest either that T cell receptor (TCR) engagement leads to its recruitment to ordered membrane domains, often referred to as lipid rafts, where signalling molecules are enriched or that ordered TCR-containing membrane nanodomains coalesce upon TCR engagement. That...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10082
更新日期：2015-05-08 00:00:00
abstract：:The discovery of the insertion of IbT-DNA1 and IbT-DNA2 into the cultivated (hexaploid) sweetpotato [Ipomoea batatas (L.) Lam.] genome constitutes a clear example of an ancient event of Horizontal Gene Transfer (HGT). However, it remains unknown whether the acquisition of both IbT-DNAs by the cultivated sweetpotato oc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48691-3
更新日期：2019-08-29 00:00:00
abstract：:The spread of multidrug-resistant Staphylococcus aureus strains, including methicillin-resistant S. aureus (MRSA), has shortened the useful life of anti-staphylococcal drugs enormously. Two approaches can be followed to address this problem: screening various sources for new leads for antibiotics or finding ways to di...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03716-7
更新日期：2017-06-19 00:00:00
abstract：:The aesthetic value of landscapes contributes to human well-being. However, studies which have investigated the link between biodiversity and ecosystem services have not taken aesthetic value into account. In this study we evaluated how the aesthetics of coralligenous reefs, a key marine ecosystem in the Mediterranean...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34229
更新日期：2016-09-28 00:00:00
abstract：:In a large German community sample of adults, we investigated the association of chronic anxiousness with cardiovascular disease and mortality. Self-reported anxiousness from 11,643 German adults between 40 and 80 years of age from the Gutenberg Health Study (GHS) was analyzed over 5 years. Multivariable regression mo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69427-8
更新日期：2020-07-24 00:00:00
abstract：:In eye movement perimetry (EMP), the saccadic reaction time (SRT) to 'seen' visual stimuli are delayed in glaucoma. Evaluating SRT behaviour in hemi-field sectors could refine its clinical implication. The development phase included 60 controls retrospectively and for the test cohort in evaluation phase, another 30 he...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81762-y
更新日期：2021-01-29 00:00:00
abstract：:The COVID-19 pandemic caused by the SARS-CoV-2 requires a fast development of antiviral drugs. SARS-CoV-2 viral main protease (Mpro, also called 3C-like protease, 3CLpro) is a potential target for drug design. Crystal and co-crystal structures of the SARS-CoV-2 Mpro have been solved, enabling the rational design of in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77794-5
更新日期：2020-11-30 00:00:00
abstract：:Many stroke survivors with aphasia in the acute period experience spontaneous recovery within the first six months after the stroke. However, approximately 30-40% sustain permanent aphasia and the factors determining incomplete recovery are unclear. Suboptimal recovery may be influenced by disruption of areas seemingl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07607-9
更新日期：2017-08-15 00:00:00
abstract：:Melanoma patients' plasma contains exosomes produced by malignant and normal cells. Plasma exosomes were isolated and separated by immunocapture into two fractions: melanoma cell-derived exosomes (MTEX) and normal cell-derived exosomes (non-MTEX). Immunosuppressive effects of MTEX on primary human immune cells were ev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56542-4
更新日期：2020-01-09 00:00:00
abstract：:Stryphnodendron adstringens is a medicinal plant belonging to the Leguminosae family, and it is commonly found in the southeastern savannas, endemic to the Cerrado biome. The goal of this study was to assemble and annotate the chloroplast genome of S. adstringens and to compare it with previously known genomes of the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50620-3
更新日期：2019-10-02 00:00:00
abstract：:An accurate knowledge of tissue optical properties (absorption coefficients, μa, and reduced scattering coefficients, μs') is critical for precise modeling of light propagation in biological tissue, essential for developing diagnostic and therapeutic optical techniques that utilize diffusive photons. A great number of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45736-5
更新日期：2019-06-24 00:00:00
abstract：:Huanglongbing (HLB) (citrus greening disease) is one of the most serious bacterial diseases of citrus. It is caused by (1) Candidatus Liberibacter africanus, transmitted by Trioza erytreae and (2) C.L. asiaticus and C.L. americanus, transmitted by Diaphorina citri. As part of a multidisciplinary project on D. citri (w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64132-y
更新日期：2020-04-28 00:00:00
abstract：:Harvesting light for optical torque is of significant importance, owing to its ability to rotate nano- or micro-objects. Nevertheless, applying a strong optical torque remains a challenging task: angular momentum must conserve but light is limited. A simple argument shows the tendency for two objects with strong mutua...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27927
更新日期：2016-06-13 00:00:00
abstract：:ideR, an essential gene of Mycobacterium tuberculosis, is an attractive drug target as its conditional knockout displayed attenuated growth phenotype in vitro and in vivo. To the best of our knowledge, no inhibitors of IdeR are identified. We carried out virtual screening of NCI database against the IdeR DNA binding d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04748-9
更新日期：2017-07-05 00:00:00
abstract：:Accurate intraocular lens (IOL) power calculation is always a challenge in ophthalmology, and unoptimized process may lead to inaccurate refractive outcomes. Quality control circle (QCC) has shown its success in many fields as a process management tool. However, its efficacy in ophthalmology remains unclear. Here we u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14171-9
更新日期：2017-11-01 00:00:00
abstract：:Unlike their wolf ancestors, dogs have unique social skills for communicating and cooperating with humans. Previously, significant heritabilities for human-directed social behaviors have been found in laboratory beagles. Here, a Genome-Wide Association Study identified two genomic regions associated with dog's human-d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33439
更新日期：2016-09-29 00:00:00
abstract：:Stable isotope mixing models are regularly used to provide probabilistic estimates of source contributions to dietary mixtures. Whilst Bayesian implementations of isotope mixing models have become prominent, the use of appropriate diet-tissue discrimination factors (DTDFs) remains as the least resolved aspect. The DTD...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73019-x
更新日期：2020-09-25 00:00:00
