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The association of chronic anxiousness with cardiovascular disease and mortality in the community: results from the Gutenberg Health Study.

Abstract：

:In a large German community sample of adults, we investigated the association of chronic anxiousness with cardiovascular disease and mortality. Self-reported anxiousness from 11,643 German adults between 40 and 80 years of age from the Gutenberg Health Study (GHS) was analyzed over 5 years. Multivariable regression modeling assessed the relation between the variables, cardiovascular disease and mortality. Twelve percent of the participants reported consistently raised (chronic) anxiousness over at least 2.5 years. Anxiousness was more often reported by female, younger participants with a lower socioeconomic status, smokers and those with a family history of stroke and myocardial infarction. New onset of cardiovascular disease was linked to chronic anxiousness in men and new onset of anxiousness in women. However, chronic anxiousness did not predict all-cause mortality. Our results revealed that anxiousness is highly prevalent in German adults from middle to old age, affecting women in particular. In our study, we found sex-specific associations between new onset of cardiovascular disease and different forms of anxiousness in men and women. We suggest that even subclinical levels of anxiety need to be considered as cardiovascular risk factors. To elucidate potential harm of anxiousness for mental and physical health, we propose sex-specific analyses in further research studies, taking age and the course of anxiousness into account.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Reiner IC,Tibubos AN,Werner AM,Ernst M,Brähler E,Wiltink J,Michal M,Schulz A,Wild PS,Münzel T,Arnold N,Mahmoudpour SH,Lackner KJ,Pfeiffer N,Beutel ME

doi

10.1038/s41598-020-69427-8

subject

Has Abstract

pub_date

2020-07-24 00:00:00

pages

12436

issue

1

issn

2045-2322

pii

10.1038/s41598-020-69427-8

journal_volume

10

pub_type

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