当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Convergent Evolution of Copy Number Alterations in Multi-Centric Hepatocellular Carcinoma.

Convergent Evolution of Copy Number Alterations in Multi-Centric Hepatocellular Carcinoma.

Abstract：

:In the recent years, new molecular methods have been proposed to discriminate multicentric hepatocellular carcinomas (HCC) from intrahepatic metastases. Some of these methods utilize sequencing data to assess similarities between cancer genomes, whilst other achieved the same results with transcriptome and methylome data. Here, we attempt to classify two HCC patients with multi-centric disease using the recall-rates of somatic mutations but find that difficult because their tumors share some chromosome-scale copy-number alterations (CNAs) but little-to-no single-nucleotide variants. To resolve the apparent conundrum, we apply a phasing strategy to test if those shared CNAs are identical by descent. Our findings suggest that the conflicting alterations occur on different homologous chromosomes, which argues for multi-centric origin of respective HCCs.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Lackner C,Quagliata L,Cross W,Ribi S,Heinimann K,Paradiso V,Quintavalle C,Kovacova M,Baumhoer D,Piscuoglio S,Terracciano L,Kovac M

doi

10.1038/s41598-019-40843-9

subject

Has Abstract

pub_date

2019-03-14 00:00:00

pages

4611

issue

1

issn

2045-2322

pii

10.1038/s41598-019-40843-9

journal_volume

9

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Hyperspectral Imaging for Determining Pigment Contents in Cucumber Leaves in Response to Angular Leaf Spot Disease.

    abstract：:Hyperspectral imaging technique was employed to determine spatial distributions of chlorophyll (Chl), and carotenoid (Car) contents in cucumber leaves in response to angular leaf spot (ALS). Altogether, 196 hyperspectral images of cucumber leaves with five infection severities of ALS were captured by a hyperspectral i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27790

    authors： Zhao YR,Li X,Yu KQ,Cheng F,He Y

    更新日期：2016-06-10 00:00:00

  • Properties of orb weaving spider glycoprotein glue change during Argiope trifasciata web construction.

    abstract：:An orb web's prey capture thread relies on its glue droplets to retain insects until a spider can subdue them. Each droplet's viscoelastic glycoprotein adhesive core extends to dissipate the forces of prey struggle as it transfers force to stiffer, support line flagelliform fibers. In large orb webs, switchback captur...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56707-1

    authors： Opell BD,Stellwagen SD

    更新日期：2019-12-30 00:00:00

  • Agouti Related Peptide Secreted Via Human Mesenchymal Stem Cells Upregulates Proteasome Activity in an Alzheimer's Disease Model.

    abstract：:The activity of the ubiquitin proteasome system (UPS) is downregulated in aggregation diseases such as Alzheimer's disease (AD). In this study, we investigated the therapeutic potential of the Agouti-related peptide (AgRP), which is secreted by human mesenchymal stem cells (MSCs), in terms of its effect on the regulat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep39340

    authors： Lee NK,Park SE,Kwon SJ,Shim S,Byeon Y,Kim JH,Na DL,Chang JW

    更新日期：2017-01-04 00:00:00

  • Genetic analysis of the molecular regulation of electric fields-guided glia migration.

    abstract：:In a developing nervous system, endogenous electric field (EF) influence embryonic growth. We reported the EF-directed migration of both rat Schwann cells (SCs) and oligodendrocyte precursor cells (OPCs) and explored the molecular mechanism using RNA-sequencing assay. However, previous studies revealed the differentia...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-74085-x

    authors： Yao L,Shippy T,Li Y

    更新日期：2020-10-08 00:00:00

  • Genome-wide analysis of tomato long non-coding RNAs and identification as endogenous target mimic for microRNA in response to TYLCV infection.

    abstract：:Recently, a large number of long noncoding RNAs (lncRNAs) have emerged as important regulators of many biological processes in animals and plants. However, how lncRNAs function during plant DNA virus infection is largely unknown. We performed strand-specific paired-end RNA sequencing of tomato samples infected with To...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16946

    authors： Wang J,Yu W,Yang Y,Li X,Chen T,Liu T,Ma N,Yang X,Liu R,Zhang B

    更新日期：2015-12-18 00:00:00

  • The Potential Risk Assessment of Phenoxyethanol with a Versatile Model System.

    abstract：:In this study, the toxic effects of phenoxyethanol (Phy-Et), which is widely used in cosmetic industry, has been investigated with Allium test by means of physiological, cytogenetic, anatomical and biochemical parameters. To determine the changes in physiological reactions weight gain, relative injury rate, germinatio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-58170-9

    authors： Akgündüz MÇ,Çavuşoğlu K,Yalçın E

    更新日期：2020-01-27 00:00:00

  • Natural history footage provides new reef fish biodiversity information for a pristine but rarely visited archipelago.

    abstract：:There remain parts of our planet that are seldom visited by humans, let alone scientists. In such locations, crowd-sourced or citizen scientist data can be critical in describing biodiversity and detecting change. Rangitāhua, the Kermadec Islands, are 750 km from the nearest human-habitation. Although our knowledge of...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-60136-w

    authors： Liggins L,Sweatman JA,Trnski T,Duffy CAJ,Eddy TD,Aguirre JD

    更新日期：2020-02-21 00:00:00

  • Clinical Impact of Single Nucleotide Polymorphism in PD-L1 on Response to Nivolumab for Advanced Non-Small-Cell Lung Cancer Patients.

    abstract：:This study was intended to determine the efficacy of nivolumab, we evaluated treatment response with respect to PD-1/PD-L1 SNPs among patients with NSCLC. A total of 50 patients with NSCLC were treated with nivolumab and were also evaluated for PD-1/PD-L1 single nucleotide polymorphisms (SNPs) from plasma DNA. We inve...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45124

    authors： Nomizo T,Ozasa H,Tsuji T,Funazo T,Yasuda Y,Yoshida H,Yagi Y,Sakamori Y,Nagai H,Hirai T,Kim YH

    更新日期：2017-03-23 00:00:00

  • miR-744-5p contributes to ocular inflammation in patients with primary Sjogrens Syndrome.

    abstract：:In primary Sjögren's syndrome (pSS) the exocrine glands become infiltrated with lymphocytes instigating severe damage to the salivary and lacrimal glands causing dry eyes and dry mouth. Previous investigations have suggested that dysregulated localized and systemic inflammation contributes to the development and patho...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-020-64422-5

    authors： Pilson Q,Smith S,Jefferies CA,Ní Gabhann-Dromgoole J,Murphy CC

    更新日期：2020-05-04 00:00:00

  • Hybridizing salamanders experience accelerated diversification.

    abstract：:Whether hybridization generates or erodes species diversity has long been debated, but to date most studies have been conducted at small taxonomic scales. Salamanders (order Caudata) represent a taxonomic order in which hybridization plays a prevalent ecological and evolutionary role. We employed a recently developed ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-63378-w

    authors： Patton AH,Margres MJ,Epstein B,Eastman J,Harmon LJ,Storfer A

    更新日期：2020-04-16 00:00:00

  • Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion.

    abstract：:The hippocampus has a significant association with memory, cognition and emotions. The dopaminergic projections from both the ventral tegmental area and substantia nigra are thought to be involved in hippocampal activity. To date, however, few studies have investigated dopaminergic innervation in the hippocampus or th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44426

    authors： Castro-Hernández J,Adlard PA,Finkelstein DI

    更新日期：2017-03-14 00:00:00

  • Early urban impact on Mediterranean coastal environments.

    abstract：:A common belief is that, unlike today, ancient urban areas developed in a sustainable way within the environmental limits of local natural resources and the ecosystem's capacity to respond. This long-held paradigm is based on a weak knowledge of the processes underpinning the emergence of urban life and the rise of an...

    journal_title：Scientific reports

    pub_type： 历史文章,杂志文章

    doi：10.1038/srep03540

    authors： Kaniewski D,Van Campo E,Morhange C,Guiot J,Zviely D,Shaked I,Otto T,Artzy M

    更新日期：2013-12-18 00:00:00

  • Association between the ambient temperature and the occurrence of human Salmonella and Campylobacter infections.

    abstract：:Salmonella spp. and thermotolerant Campylobacter spp. are the most important causes of human bacterial diarrheal infections worldwide. These bacterial species are influenced by several factors like behaviour of the host, shedding, environment incl. directly or indirectly through ambient temperature, and the infections...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep28442

    authors： Yun J,Greiner M,Höller C,Messelhäusser U,Rampp A,Klein G

    更新日期：2016-06-21 00:00:00

  • Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47phox.

    abstract：:Interleukin (IL)-27, a member of the IL-12 cytokine family, plays an important and diverse role in the function of the immune system. We have previously demonstrated that IL-27 is an anti-viral cytokine which inhibits HIV-1, HIV-2, Influenza virus and herpes simplex virus infection, and enhances the potential of react...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43441

    authors： Sowrirajan B,Saito Y,Poudyal D,Chen Q,Sui H,DeRavin SS,Imamichi H,Sato T,Kuhns DB,Noguchi N,Malech HL,Lane HC,Imamichi T

    更新日期：2017-02-27 00:00:00

  • A quantitative description of the transition between intuitive altruism and rational deliberation in iterated Prisoner's Dilemma experiments.

    abstract：:What is intuitive: pro-social or anti-social behaviour? To answer this fundamental question, recent studies analyse decision times in game theory experiments under the assumption that intuitive decisions are fast and that deliberation is slow. These analyses keep track of the average time taken to make decisions under...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52359-3

    authors： Gallotti R,Grujić J

    更新日期：2019-11-19 00:00:00

  • Silver nanowires decorated with silver nanoparticles for low-haze flexible transparent conductive films.

    abstract：:Silver nanowires have attracted much attention for use in flexible transparent conductive films (TCFs) due to their low sheet resistance and flexibility. However, the haze was too high for replacing indium-tin-oxide in high-quality display devices. Herein, we report flexible TCFs, which were prepared using a scalable ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16371

    authors： Menamparambath MM,Ajmal CM,Kim KH,Yang D,Roh J,Park HC,Kwak C,Choi JY,Baik S

    更新日期：2015-11-17 00:00:00

  • Autapse-induced multiple coherence resonance in single neurons and neuronal networks.

    abstract：:We study the effects of electrical and chemical autapse on the temporal coherence or firing regularity of single stochastic Hodgkin-Huxley neurons and scale-free neuronal networks. Also, we study the effects of chemical autapse on the occurrence of spatial synchronization in scale-free neuronal networks. Irrespective ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep30914

    authors： Yilmaz E,Ozer M,Baysal V,Perc M

    更新日期：2016-08-02 00:00:00

  • Ginseng oligopeptides protect against irradiation-induced immune dysfunction and intestinal injury.

    abstract：:Intestinal injury and immune dysfunction are commonly encountered after irradiation therapy. While the curative abilities of ginseng root have been reported in prior studies, there is little known regarding its role in immunoregulation of intestinal repairability in cancer patients treated with irradiation. Our curren...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-32188-6

    authors： He LX,Zhang ZF,Zhao J,Li L,Xu T,Bin Sun,Ren JW,Liu R,Chen QH,Wang JB,Salem MM,Pettinato G,Zhou JR,Li Y

    更新日期：2018-09-17 00:00:00

  • Chemical activation of RARβ induces post-embryonically bilateral limb duplication during Xenopus limb regeneration.

    abstract：:The anuran amphibian Xenopus laevis can regenerate its limbs for a limited time during the larval stage, while limbs are still developing. Using this regeneration model, we evaluated the proximo-distal blastema cell identity when endogenous retinoids were increased by CYP26 inhibition or when RAR-specific agonists alt...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01886

    authors： Cuervo R,Chimal-Monroy J

    更新日期：2013-01-01 00:00:00

  • Measurement of bunch length and temporal distribution using accelerating radio frequency cavity in low-emittance injector.

    abstract：:We demonstrate an experimental methodology for measuring the temporal distribution of pico-second level electron bunch with low energy using radial electric and azimuthal magnetic fields of an accelerating ([Formula: see text] mode) radio frequency (RF) cavity that is used for accelerating electron beams in a linear a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76054-w

    authors： Hwang JG,Miyajima T,Honda Y,Kim ES

    更新日期：2020-11-03 00:00:00

  • The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin.

    abstract：:Defective hepatic autophagy is observed in obesity and diabetes, whereas autophagy is inhibited by insulin in hepatocytes. Insulin-induced anti-autophagy is mediated by non-canonical Gαi3 signaling via an unknown mechanism. Previously, we identified the anti-autophagic activity of Tnfaip8 via activation of mammalian t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-06576-3

    authors： Kim JS,Park J,Kim MS,Ha JY,Jang YW,Shin DH,Son JH

    更新日期：2017-07-24 00:00:00

  • Exploring corrections to the Optomechanical Hamiltonian.

    abstract：:We compare two approaches for deriving corrections to the "linear model" of cavity optomechanics, in order to describe effects that are beyond first order in the radiation pressure coupling. In the regime where the mechanical frequency is much lower than the cavity one, we compare: (I) a widely used phenomenological H...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26739-0

    authors： Sala K,Tufarelli T

    更新日期：2018-06-14 00:00:00

  • Author Correction: Isolation and identification of two pairs of cytotoxic diterpene tautomers and their tautomerization mechanisms.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-61343-1

    authors： Dai LP,Li XF,Feng QM,Zhang LX,Liu QY,Xu EP,Wu H,Wang ZM

    更新日期：2020-03-04 00:00:00

  • Degree of conversion of experimental resin composites containing bioactive glass 45S5: the effect of post-cure heating.

    abstract：:Resin composites containing reinforcing inert glass fillers combined with bioactive glass (BG) can aid in the prevention of secondary caries, which is a major cause of failure of contemporary composite restorations. A series of previous studies on experimental resin composites filled with BG 45S5 has demonstrated that...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54035-y

    authors： Par M,Spanovic N,Tauböck TT,Attin T,Tarle Z

    更新日期：2019-11-21 00:00:00

  • Computational modelling of patient specific spring assisted lambdoid craniosynostosis correction.

    abstract：:Lambdoid craniosynostosis (LC) is a rare non-syndromic craniosynostosis characterised by fusion of the lambdoid sutures at the back of the head. Surgical correction including the spring assisted cranioplasty is the only option to correct the asymmetry at the skull in LC. However, the aesthetic outcome from spring assi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75747-6

    authors： Bozkurt S,Borghi A,van de Lande LS,Jeelani NUO,Dunaway DJ,Schievano S

    更新日期：2020-10-29 00:00:00

  • Discovery, screening and evaluation of a plasma biomarker panel for subjects with psychological suboptimal health state using (1)H-NMR-based metabolomics profiles.

    abstract：:Individuals in the state of psychological suboptimal health keep increasing, only scales and questionnaires were used to diagnose in clinic under current conditions, and symptoms of high reliability and accuracy are destitute. Therefore, the noninvasive and precise laboratory diagnostic methods are needed. This study ...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/srep33820

    authors： Tian JS,Xia XT,Wu YF,Zhao L,Xiang H,Du GH,Zhang X,Qin XM

    更新日期：2016-09-21 00:00:00

  • Sleep, napping and alertness during an overwintering mission at Belgrano II Argentine Antarctic station.

    abstract：:During Antarctic isolation personnel are exposed to extreme photoperiods. A frequent observation is a sleep onset phase delay during winter. It is not known if, as a result, daytime sleeping in the form of naps increases. We sought to assess sleep patterns - with focus on daytime sleeping - and alertness in a Latin Am...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46900-7

    authors： Folgueira A,Simonelli G,Plano S,Tortello C,Cuiuli JM,Blanchard A,Patagua A,Brager AJ,Capaldi VF,Aubert AE,Barbarito M,Golombek DA,Vigo DE

    更新日期：2019-07-26 00:00:00

  • Multi-functional nano silver: A novel disruptive and theranostic agent for pathogenic organisms in real-time.

    abstract：:The present study was aimed at evaluating the fluorescence property, sporicidal potency against Bacillus and Clostridium endospores, and surface disinfecting ability of biogenic nano silver. The nano silver was synthesized using an actinobacterial cell-filtrate. The fluorescence property as well as imaging facilitator...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34058

    authors： Gopinath PM,Ranjani A,Dhanasekaran D,Thajuddin N,Archunan G,Akbarsha MA,Gulyás B,Padmanabhan P

    更新日期：2016-09-26 00:00:00

  • Copper(II) complexes as potential anticancer and Nonsteroidal anti-inflammatory agents: In vitro and in vivo studies.

    abstract：:Copper-based compounds are promising entities for target-specific next-generation anticancer and NSAIDS therapeutics. In lieu of this, benzimidazole scaffold plays an important role, because of their wide variety of potential functionalizations and coordination modes. Herein, we report three copper complexes 1-3 with ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41063-x

    authors： Hussain A,AlAjmi MF,Rehman MT,Amir S,Husain FM,Alsalme A,Siddiqui MA,AlKhedhairy AA,Khan RA

    更新日期：2019-03-27 00:00:00

  • Environmental surveillance identifies multiple introductions of MRSA CC398 in an Equine Veterinary Hospital in the UK, 2011-2016.

    abstract：:Bacterial environmental and surgical site infection (SSI) surveillance was implemented from 2011-2016 in a UK Equine Referral Veterinary Hospital and identified 81 methicillin-resistant Staphylococcus aureus (MRSA) isolates. A cluster of MRSA SSIs occurred in early 2016 with the isolates confirmed as ST398 by multiloc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05559-8

    authors： Bortolami A,Williams NJ,McGowan CM,Kelly PG,Archer DC,Corrò M,Pinchbeck G,Saunders CJ,Timofte D

    更新日期：2017-07-14 00:00:00