Abstract：
:With countless biological details emerging from cancer experiments, there is a growing need for minimal mathematical models which simultaneously advance our understanding of single tumors and metastasis, provide patient-personalized predictions, whilst avoiding excessive hard-to-measure input parameters which complicate simulation, analysis and interpretation. Here we present a model built around a co-evolving resource network and cell population, yielding good agreement with primary tumors in a murine mammary cell line EMT6-HER2 model in BALB/c mice and with clinical metastasis data. Seeding data about the tumor and its vasculature from in vivo images, our model predicts corridors of future tumor growth behavior and intervention response. A scaling relation enables the estimation of a tumor's most likely evolution and pinpoints specific target sites to control growth. Our findings suggest that the clinically separate phenomena of individual tumor growth and metastasis can be viewed as mathematical copies of each other differentiated only by network structure.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Choe SC,Zhao G,Zhao Z,Rosenblatt JD,Cho HM,Shin SU,Johnson NFdoi
10.1038/srep00031subject
Has Abstractpub_date
2011-01-01 00:00:00pages
31issn
2045-2322journal_volume
1pub_type
杂志文章abstract：:Dengue virus (DENV) causes a wide range of illnesses in humans, including dengue fever and dengue haemorrhagic fever. Current animal models of DENV infection are limited for understanding infectious diseases in humans. Bonnet monkeys (Macaca radiata), a type of Old World monkey, have been used to study experimental an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21582-9
更新日期：2018-02-21 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-65654-1
更新日期：2020-05-26 00:00:00
abstract：:Adult hippocampal neurogenesis is associated with learning and affective behavioural regulation. Its diverse functionality is segregated along the septotemporal axis from the dorsal to ventral hippocampus. However, features distinguishing immature neurons in these regions have yet to be characterized. Additionally, al...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30467
更新日期：2016-07-29 00:00:00
abstract：:Cholestasis impairs liver regeneration following partial liver resection (PHx). Bile acid receptor farnesoid X-receptor (FXR) is a key mediator of liver regeneration. The effects of FXR agonist obeticholic acid (OCA) on liver (re)growth were therefore studied in cholestatic rats. Animals underwent sham surgery or reve...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33070-1
更新日期：2018-11-08 00:00:00
abstract：:Magnetic vortex is one of the simplest topologically non-trivial textures in condensed matter physics. It is the ground state of submicron magnetic elements (dots) of different shapes: cylindrical, square etc. So far, the vast majority of the vortex dynamics studies were focused on thin dots with thickness 5-50 nm and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13881
更新日期：2015-09-10 00:00:00
abstract：:A large volcanic sulfate increase observed in ice core records around 1450 C.E. has been attributed in previous studies to a volcanic eruption from the submarine Kuwae caldera in Vanuatu. Both EPMA-WDS (electron microprobe analysis using a wavelength dispersive spectrometer) and SEM-EDS (scanning electron microscopy a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50939-x
更新日期：2019-10-08 00:00:00
abstract：:It is well known that haem serves as the prosthetic group of various haemoproteins that function in oxygen transport, respiratory chain, and drug metabolism. However, much less is known about the functions of the catabolites of haem in mammalian cells. Haem is enzymatically degraded to iron, carbon monoxide (CO), and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10488
更新日期：2015-05-20 00:00:00
abstract：:Psychological distress induces oxidative stress and alters mitochondrial metabolism in the nervous and immune systems. Psychological distress promotes alterations in brain metabolism and neurochemistry in wild-type (WT) rats in a similar manner as in Parkinsonian rats lacking endogenous PTEN-induced kinase 1 (PINK1), ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66745-9
更新日期：2020-06-17 00:00:00
abstract：:Of the 7-8 silk fibers making up an orb-web only the hierarchical structural organization of semicrystalline radial fibers -composed of major ampullate silk- has been studied in detail, given its fascinating mechanical features. While major ampullate silk's nanofibrillar morphology is well established, knowhow on meso...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74638-0
更新日期：2020-10-23 00:00:00
abstract：:Dogs (Canis familiaris) are the first animals to be domesticated by humans and the only ones domesticated by mobile hunter-gatherers. Wolves and humans were both persistent, pack hunters of large prey. They were species competing over resources in partially overlapping ecological niches and capable of killing each oth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78214-4
更新日期：2021-01-07 00:00:00
abstract：:Coral reefs face a crisis due to local and global anthropogenic stressors. A large proportion of the ~50% coral loss on the Great Barrier Reef has been attributed to outbreaks of the crown-of-thorns-seastar (COTS). A widely assumed cause of primary COTS outbreaks is increased larval survivorship due to higher food ava...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08402
更新日期：2015-02-12 00:00:00
abstract：:Marine pollution is a significant issue in recent decades, with the increase in industries and their waste harming the environment and ecosystems. Notably, the rise in shellfish industries contributes to tons of shellfish waste composed of up to 58% chitin. Chitin, the second most ample polymer next to cellulose, is i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68772-y
更新日期：2020-07-17 00:00:00
abstract：:An evaluation of energy thresholding and acquisition mode for metal artifact reduction in Photon-counting detector CT (PCD-CT) compared to conventional energy-integrating detector CT (EID-CT) was performed. Images of a hip prosthesis phantom placed in a water bath were acquired on a scanner with PCD-CT and EID-CT (tub...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77904-3
更新日期：2020-12-03 00:00:00
abstract：:Active video games (exergames) may provide short-term increase in energy expenditure. We explored the effects of gender and prior experience on aerobic and anaerobic energy systems contributions, and the activity profiles of 40 participants playing with a swimming exergame. We recorded oxygen consumption and assessed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05583-8
更新日期：2017-07-12 00:00:00
abstract：:At the species level, plants can respond to climate changes by changing their leaf traits; however, there is scant information regarding the responses of morphological, physiological and anatomical traits of plant functional types (PFTs) to aridity. Herein, the leaf traits of five PFTs representing 17 plant species in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40900
更新日期：2017-01-20 00:00:00
abstract：:Copper ions play a vital role in a variety of fundamental physiological processes not only in human beings and plants, but also for extensive insects and microorganisms. In this paper, a novel water-soluble ruthenium(II) complex as a turn-on copper(II) ions luminescent sensor based on o-(phenylazo)aniline was designed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08172
更新日期：2015-02-02 00:00:00
abstract：:In this prospective pilot study, we aimed to evaluate the ability of cardiac magnetic resonance imaging (CMR) parameters of right ventricular function and pulmonary artery stiffness to identify pulmonary hypertension (PH), predict major adverse cardiovascular events (MACEs) in patients with secondary PH due to chronic...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-32784-6
更新日期：2018-09-27 00:00:00
abstract：:Fano resonance presents an asymmetric line shape formed by an interference of a continuum coupled with a discrete autoionized state. In this paper, we show several simple circuits for Fano resonances from the stable-input impedance mechanism, where the elements consisting of inductors and capacitors are formulated for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31884
更新日期：2016-08-22 00:00:00
abstract：:The pathogenesis of severe dengue remains unclear, particularly the mechanisms underlying the plasma leakage that results in hypovolaemic shock in a small proportion of individuals. Maximal leakage occurs several days after peak viraemia implicating immunological pathways. Skin is a highly vascular organ and also an i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14640-1
更新日期：2017-10-27 00:00:00
abstract：:Understanding the traits that might be linked with biological invasions represents a great challenge for preventing non-target effects on local biodiversity. In predatory insects, the ability to exploit habitats for oviposition and the physiological response to prey availability differs between species. Those species ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03471-9
更新日期：2017-06-16 00:00:00
abstract：:Often ignored and regarded as mere transcriptional noise, long noncoding RNAs (lncRNAs) are starting to be considered key regulators of gene expression across the Eukarya domain of life. In the model diatom Phaeodactylum tricornutum, we have previously reported the occurrence of 1,510 intergenic lncRNAs (lincRNAs), ma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71002-0
更新日期：2020-08-24 00:00:00
abstract：:We previously identified novel bioactive polysaccharides from Bactrocera cucurbitae and Antheraea yamamai that activate innate immunity in RAW264 murine macrophages. However, in terms of potential applications in the cultivation of prawns, there were problems with the availability of these insects. However, we have no...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27241-3
更新日期：2018-06-11 00:00:00
abstract：:In the era of precision medicine the treatment options for cancer patients and subsequent outcomes are expected to improve. We present a review of patients enrolled in first-in-human Phase1 trials at University of Alabama at Birmingham. Between 1/2015-6/2017, 162 cancer patients (whole cohort, WC) were enrolled on pha...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
doi：10.1038/s41598-020-64906-4
更新日期：2020-05-13 00:00:00
abstract：:Bleaching, the loss of algal symbionts, occurs in marine photosymbiotic organisms at water temperatures minimally exceeding average summer SST (sea surface temperatures). Pre-adaptation allows organisms to persist under warmer conditions, providing the tolerance can be carried to new habitats. Here we provide evidence...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30930
更新日期：2016-08-09 00:00:00
abstract：:The ability of human metaphase-II arrested eggs to activate following fertilisation declines with advancing maternal age. Egg activation is triggered by repetitive increases in intracellular Ca(2+) concentration ([Ca(2+)]i) in the ooplasm as a result of sperm-egg fusion. We therefore hypothesised that eggs from older ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19357
更新日期：2016-01-20 00:00:00
abstract：:Controlling thickness and tightness of surface passivation shells is crucial for many applications of core-shell nanoparticles (NP). Usually, to determine shell thickness, core and core/shell particle are measured individually requiring the availability of both nanoobjects. This is often not fulfilled for functional n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77530-z
更新日期：2020-11-26 00:00:00
abstract：:The benzodiazepine midazolam is widely used in critical care medicine. Midazolam has a clinically active metabolite, 1-hydroxymidazolam. The contribution of 1-hydroxymidazolam to the effects of midazolam is controversial. The aim of the current study was to compare the actions of midazolam and 1-hydroxymidazolam on ne...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03154-5
更新日期：2017-06-14 00:00:00
abstract：:Clostridium difficile is a gastrointestinal pathogen but how the bacterium colonises this niche is still little understood. Sortase enzymes covalently attach specific bacterial proteins to the peptidoglycan cell wall and are often involved in colonisation by pathogens. Here we show C. difficile proteins CD2537 and CD3...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08322-1
更新日期：2017-08-23 00:00:00
abstract：:Because of the scanty pipeline of antibiotics newly obtained from nature, chemical modification of established drugs is one of the major streams of current antibacterial research. Intuitive and easy-to-use assays are critical for identifying drug candidates with novel modes of action. In this study, we demonstrated th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01267-5
更新日期：2017-04-25 00:00:00
abstract：:Research on argillite as a possible host rock for nuclear waste disposal is still an open subject since many issues need to be clarified. In the Underground Research Laboratories constructed for this purpose, a damaged zone around the excavation has been systematically observed and characterized by the appearance of m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08815
更新日期：2015-03-06 00:00:00
