Abstract：
:Dengue virus (DENV) causes a wide range of illnesses in humans, including dengue fever and dengue haemorrhagic fever. Current animal models of DENV infection are limited for understanding infectious diseases in humans. Bonnet monkeys (Macaca radiata), a type of Old World monkey, have been used to study experimental and natural infections by flaviviruses, but Old World monkeys have not yet been used as DENV infection models. In this study, the replication levels of several DENV strains were evaluated using peripheral blood mononuclear cells. Our findings indicated that DENV-4 09-48 strain, isolated from a traveller returning from India in 2009, was a highly replicative virus. Three bonnet monkeys were infected with 09-48 strain and antibody responses were assessed. DENV nonstructural protein 1 antigen was detected and high viraemia was observed. These results indicated that bonnet monkeys and 09-48 strain could be used as a reliable primate model for the study of DENV.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kato F,Ishida Y,Kawakami A,Takasaki T,Saijo M,Miura T,Hishiki Tdoi
10.1038/s41598-018-21582-9subject
Has Abstractpub_date
2018-02-21 00:00:00pages
3421issue
1issn
2045-2322pii
10.1038/s41598-018-21582-9journal_volume
8pub_type
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