Effects of neuregulin-1 administration on neurogenesis in the adult mouse hippocampus, and characterization of immature neurons along the septotemporal axis.

abstract：:Bacterial cell wall is targeted by many antibiotics. Among them are lantibiotics, which realize their function via interaction with plasma membrane lipid-II molecule - a chemically conserved part of the cell wall synthesis pathway. To investigate structural and dynamic properties of this molecule, we have performed a ...

journal_title：Scientific reports

authors： Chugunov A,Pyrkova D,Nolde D,Polyansky A,Pentkovsky V,Efremov R

更新日期：2013-01-01 00:00:00

abstract：:A novel protein, designated as DOI, isolated from the Chinese yam (Dioscorea opposita Thunb.) could be the first protein drug for the treatment of menopausal syndrome and an alternative to hormone replacement therapy (HRT), which is known to have undesirable side effects. DOI is an acid- and thermo-stable protein with...

journal_title：Scientific reports

authors： Wong KL,Lai YM,Li KW,Lee KF,Ng TB,Cheung HP,Zhang YB,Lao L,Wong RN,Shaw PC,Wong JH,Zhang ZJ,Lam JK,Ye WC,Sze SC

更新日期：2015-07-10 00:00:00

abstract：:APOBEC3G (A3G) belongs to the family of cytosine deaminases that play an important role in the innate immune response. Similar to other, two-domain members of the APOBEC family, A3G is prone to concentration-dependent oligomerization, which is an integral for its function in the cell. It is shown that oligomerization ...

journal_title：Scientific reports

authors： Pan Y,Zagorski K,Shlyakhtenko LS,Lyubchenko YL

更新日期：2018-12-18 00:00:00

abstract：:Enterovirus A89 (EV-A89) is a novel member of the EV-A species. To date, only one full-length genome sequence (the prototype strain) has been published. Here, we report the molecular identification and genomic characterization of a Chinese EV-A89 strain, KSYPH-TRMH22F/XJ/CHN/2011, isolated in 2011 from a contact of an...

journal_title：Scientific reports

authors： Fan Q,Zhang Y,Hu L,Sun Q,Cui H,Yan D,Sikandaner H,Tang H,Wang D,Zhu Z,Zhu S,Xu W

更新日期：2015-12-21 00:00:00

abstract：:Elevated prostaglandin E2 (PGE2) levels are observed in colorectal cancer (CRC) patients, and this increase is associated with poor prognosis. Increased synthesis of PGE2 in CRC has been shown to occur through COX-2-dependent mechanisms; however, loss of the PGE2-catabolizing enzyme, 15-hydroxyprostaglandin dehydrogen...

journal_title：Scientific reports

authors： Monteleone NJ,Moore AE,Iacona JR,Lutz CS,Dixon DA

更新日期：2019-04-01 00:00:00

abstract：:Obesity affects male fertility and maternal diabetes affects the offspring sperm epigenome. However, the effects of in utero exposure to maternal glucose intolerance in combination with postnatal high fat, high sucrose (HFHS) diet consumption on offspring spermatogenesis is not clear. The present study was designed to...

journal_title：Scientific reports

authors： Mao J,Pennington KA,Talton OO,Schulz LC,Sutovsky M,Lin Y,Sutovsky P

更新日期：2018-05-16 00:00:00

abstract：:In order to ensure successful development, cells of the early mammalian embryo must differentiate to either trophectoderm (TE) or inner cell mass (ICM), followed by epiblast (EPI) or primitive endoderm (PE) specification within the ICM. Here, we deciphered the mechanism that assures the correct order of these sequenti...

journal_title：Scientific reports

authors： Wigger M,Kisielewska K,Filimonow K,Plusa B,Maleszewski M,Suwińska A

更新日期：2017-11-09 00:00:00

abstract：:Human motor skill learning is driven by the necessity to adapt to new situations. While supportive contacts are essential for many tasks, little is known about their impact on motor learning. To study the effect of contacts an innovative full-body experimental paradigm was established. The task of the subjects was to ...

journal_title：Scientific reports

authors： Rueckert E,Čamernik J,Peters J,Babič J

更新日期：2016-06-22 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is a chronic disease, and dietary modification is a crucial part of disease management. Okara is a sustainable source of fibre-rich food. Most of the valorization research on okara focused more on the physical attributes instead of the possible health attributes. The fermentation of oka...

journal_title：Scientific reports

authors： Chan LY,Takahashi M,Lim PJ,Aoyama S,Makino S,Ferdinandus F,Ng SYC,Arai S,Fujita H,Tan HC,Shibata S,Lee CK

更新日期：2019-11-26 00:00:00

abstract：:Pyramidal neurons in the rodent hippocampus exhibit spatial tuning during spatial navigation, and they are reactivated in specific temporal order during sharp-wave ripples observed in quiet wakefulness or slow wave sleep. However, analyzing representations of sleep-associated hippocampal ensemble spike activity remain...

journal_title：Scientific reports

authors： Chen Z,Grosmark AD,Penagos H,Wilson MA

更新日期：2016-08-30 00:00:00

abstract：:Switching magnetizations with femtosecond circularly polarized lasers may have revolutionary impacts on magnetic data storage and relevant applications. Achievements in ferrimagnetic and ferromagnetic materials of various structures strongly imply a general phenomenon of fundamental atom-laser interaction. Rotating an...

journal_title：Scientific reports

authors： Chen XJ

更新日期：2017-01-24 00:00:00

abstract：:Survivors of childhood acute lymphoblastic leukemia (cALL) are at higher risk of developing cardiometabolic complications. We aimed at exploring the associations between biomarkers of inflammation, oxidative stress, endothelial function, endotoxemia and cardiometabolic risk factors. We conducted a cross-sectional anal...

journal_title：Scientific reports

authors： Morel S,Léveillé P,Samoilenko M,Franco A,England J,Malaquin N,Tu V,Cardin GB,Drouin S,Rodier F,Lippé S,Krajinovic M,Laverdière C,Sinnett D,Lefebvre G,Levy E,Marcil V

更新日期：2020-12-09 00:00:00

abstract：:This study aims to evaluate the diagnostic accuracy of digital breast tomosynthesis-guided vacuum assisted breast biopsy (DBT-VABB) of screening detected suspicious mammographic abnormalities comprising of calcifications, asymmetric densities, architectural distortions and spiculated masses. In this institutionally ap...

journal_title：Scientific reports

authors： Bohan S,Ramli Hamid MT,Chan WY,Vijayananthan A,Ramli N,Kaur S,Rahmat K

更新日期：2021-01-08 00:00:00

abstract：:Exposure to light at night (LAN) is associated with insomnia in humans. Light provides the main input to the master clock in the hypothalamic suprachiasmatic nucleus (SCN) that coordinates the sleep-wake cycle. We aimed to develop a rodent model for the effects of LAN on sleep. Therefore, we exposed male Wistar rats t...

journal_title：Scientific reports

authors： Stenvers DJ,van Dorp R,Foppen E,Mendoza J,Opperhuizen AL,Fliers E,Bisschop PH,Meijer JH,Kalsbeek A,Deboer T

更新日期：2016-10-20 00:00:00

abstract：:Boolean networks are widely used to model gene regulatory networks and to design therapeutic intervention strategies to affect the long-term behavior of systems. In this paper, we investigate the less-studied one-bit perturbation, which falls under the category of structural intervention. Previous works focused on fin...

journal_title：Scientific reports

authors： Hu M,Shen L,Zan X,Shang X,Liu W

更新日期：2016-05-19 00:00:00

abstract：:Green microalgae contain many active pigments such as carotenoids having antioxidant and protective activity on human cells. Here we investigate the biological activity of an ethanol/water extract of the marine green microalga Tetraselmis suecica containing high levels of carotenoids such as the xanthophylls lutein, v...

journal_title：Scientific reports

authors： Sansone C,Galasso C,Orefice I,Nuzzo G,Luongo E,Cutignano A,Romano G,Brunet C,Fontana A,Esposito F,Ianora A

更新日期：2017-01-24 00:00:00

abstract：:Following retinal degeneration, retinal remodeling can cause neuronal microcircuits to undergo structural alterations, which particularly affect the dendrites of bipolar cells. However, the mechanisms and functional consequences of such changes remain unclear. Here, we used Royal College of Surgeon (RCS) rats as a mod...

journal_title：Scientific reports

authors： Fu Y,Hou B,Weng C,Liu W,Dai J,Zhao C,Yin ZQ

更新日期：2017-04-21 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： de Genaro IS,de Almeida FM,Hizume-Kunzler DC,Moriya HT,Silva RA,Cruz JCG,Lopes RB,Righetti RF,de Paula Vieira R,Saiki M,Martins MA,Tibério IFLC,Arantes-Costa FM,Saraiva-Romanholo BM

更新日期：2018-12-12 00:00:00

abstract：:An empirical approach was taken to screen a novel synthetic compound library designed to be active against Gram-positive bacteria. We obtained five compounds that were active against spores from the model organism Bacillus subtilis and the food-borne pathogen Bacillus cereus during our population based experiments. Us...

journal_title：Scientific reports

authors： Omardien S,Ter Beek A,Vischer N,Montijn R,Schuren F,Brul S

更新日期：2018-06-14 00:00:00

abstract：:Enrichment of colloidal particles in continuous flow has not only numerous applications but also poses a great challenge in controlling physical forces that are required for achieving particle enrichment. Here, we for the first time experimentally demonstrate the electrokinetically-driven continuous-flow enrichment of...

journal_title：Scientific reports

authors： Zhao C,Ge Z,Song Y,Yang C

更新日期：2017-09-07 00:00:00

abstract：:Cancer cachexia is a complex multi-organ syndrome characterized by body weight loss, weakness, muscle atrophy and fat depletion. With a prevalence of 1 million people in Europe and only limited therapeutic options, there is a high medical need for new approaches to treat cachexia. Our latest results highlighted microb...

journal_title：Scientific reports

authors： Pötgens SA,Brossel H,Sboarina M,Catry E,Cani PD,Neyrinck AM,Delzenne NM,Bindels LB

更新日期：2018-08-17 00:00:00

abstract：:Cryo-electron tomography (cryo-ET) is one of the most advanced technologies for the in situ visualization of molecular machines by producing three-dimensional (3D) biological structures. However, cryo-ET imaging has two serious disadvantages-low dose and low image contrast-which result in high-resolution information b...

journal_title：Scientific reports

authors： Huang X,Li S,Gao S

更新日期：2018-02-07 00:00:00

abstract：:This study investigated the feasibility of using polycaprolactone (PCL) nanofiber-based air filters to capture PM2.5 particles emitted from fused deposition modeling (FDM) 3D printing. Generation and aggregation of emitted particles were investigated under different testing environments. The results show that: (1) the...

journal_title：Scientific reports

authors： Rao C,Gu F,Zhao P,Sharmin N,Gu H,Fu J

更新日期：2017-09-04 00:00:00

abstract：:NGS (Next Generation Sequencing) technologies allows us to determine key gene expression signatures that correlate with resistance (and responsiveness) to anti-cancer therapeutics. We have undertaken a transcriptomic and chromatin immunoprecipitation followed by sequencing (ChIP-seq) approach to describe differences i...

journal_title：Scientific reports

authors： Nava M,Dutta P,Farias-Eisner R,Vadgama JV,Wu Y

更新日期：2019-03-26 00:00:00

abstract：:Spin injection, manipulation and detection are the integral parts of spintronics devices and have attracted tremendous attention in the last decade. It is necessary to judiciously choose the right combination of materials to have compatibility with the existing semiconductor technology. Conventional metallic magnets w...

journal_title：Scientific reports

authors： Bhat SG,Kumar PS

更新日期：2014-07-07 00:00:00

abstract：:Glycans are biologically important structures synthesised by glycosyltransferase (GT) enzymes. Disruptive genetic null variants in GT genes can lead to serious illness but benign phenotypes are also seen, including antigenic differences on the red blood cell (RBC) surface, giving rise to blood groups. To characterise ...

journal_title：Scientific reports

authors： Jöud M,Möller M,Olsson ML

更新日期：2018-04-16 00:00:00

abstract：:Ligninolytic peroxidases are microbial enzymes involved in depolymerisation of lignin, a plant cell wall polymer found in land plants. Among fungi, only Dikarya were found to degrade lignin. The increase of available fungal genomes allows performing an expert annotation of lignin-degrading peroxidase encoding sequence...

journal_title：Scientific reports

authors： Mathé C,Fawal N,Roux C,Dunand C

更新日期：2019-12-30 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with aggregation of TAR DNA-binding protein-43 (TDP-43) in neuronal cells and manifests as motor neuron dysfunction &muscle atrophy. The carboxyl-terminal prion-like domain of TDP-43 can aggregate in vitro into toxic β-sheet rich amylo...

journal_title：Scientific reports

authors： Prasad A,Raju G,Sivalingam V,Girdhar A,Verma M,Vats A,Taneja V,Prabusankar G,Patel BK

更新日期：2016-12-21 00:00:00

abstract：:The role of soil organic carbon in global carbon cycles is receiving increasing attention both as a potentially large and uncertain source of CO2 emissions in response to predicted global temperature rises, and as a natural sink for carbon able to reduce atmospheric CO2. There is general agreement that the technical p...

journal_title：Scientific reports

authors： Zomer RJ,Bossio DA,Sommer R,Verchot LV

更新日期：2017-11-14 00:00:00

abstract：:Lon is an essential, multitasking AAA(+) protease regulating many cellular processes in species across all kingdoms of life. Altered expression levels of the human mitochondrial Lon protease (hLon) are linked to serious diseases including myopathies, paraplegia, and cancer. Here, we present the first 3D structure of f...

journal_title：Scientific reports

authors： Kereïche S,Kováčik L,Bednár J,Pevala V,Kunová N,Ondrovičová G,Bauer J,Ambro Ľ,Bellová J,Kutejová E,Raška I

更新日期：2016-09-16 00:00:00