Abstract:
:Boolean networks are widely used to model gene regulatory networks and to design therapeutic intervention strategies to affect the long-term behavior of systems. In this paper, we investigate the less-studied one-bit perturbation, which falls under the category of structural intervention. Previous works focused on finding the optimal one-bit perturbation to maximally alter the steady-state distribution (SSD) of undesirable states through matrix perturbation theory. However, the application of the SSD is limited to Boolean networks with about ten genes. In 2007, Xiao et al. proposed to search the optimal one-bit perturbation by altering the sizes of the basin of attractions (BOAs). However, their algorithm requires close observation of the state-transition diagram. In this paper, we propose an algorithm that efficiently determines the BOA size after a perturbation. Our idea is that, if we construct the basin of states for all states, then the size of the BOA of perturbed networks can be obtained just by updating the paths of the states whose transitions have been affected. Results from both synthetic and real biological networks show that the proposed algorithm performs better than the exhaustive SSD-based algorithm and can be applied to networks with about 25 genes.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hu M,Shen L,Zan X,Shang X,Liu Wdoi
10.1038/srep26247subject
Has Abstractpub_date
2016-05-19 00:00:00pages
26247issn
2045-2322pii
srep26247journal_volume
6pub_type
杂志文章abstract::Metamaterial absorbers can provide good solutions for radar-cross-section (RCS) reduction. In spite of their attractive features of thinness, lightness, and low cost, resonant metamaterial absorbers have a drawback of narrow bandwidth. For practical radar applications, wideband absorbers are necessary. In this paper, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31823
更新日期:2016-08-22 00:00:00
abstract::Magnetic skyrmions are promising candidates for the next generation of spintronic devices due to their small size and topologically protected structure. One challenge for using these magnetic states in applications lies on controlling the nucleation process and stabilization that usually requires an external force. He...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40705-4
更新日期:2019-03-11 00:00:00
abstract::Nitrogen-doped carbon sponge-type nanostructures (N-CSTNs) containing coaxial multiwalled carbon nanotubes are synthesized at 1020 °C by using a modified chemical vapor deposition (CVD) arrangement. Here, the CVD reactor is supplied by two flows coming from two independent sprayers (called sprayer A and sprayer B). Th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20079-9
更新日期:2018-02-14 00:00:00
abstract::Scleroderma is a refractory autoimmune skin fibrotic disorder. Alterations of microRNAs in lesional skin could be a new approach to treating the disease. Here, we found that expression of miR-155 was up regulated in lesional skin tissue from patients with either systemic or localized scleroderma, and correlated with f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20314
更新日期:2016-02-01 00:00:00
abstract::A new species of fossil conifer wood, Podocarpoxylon donghuaiense sp. nov., is described from the late Eocene of Nadu Formation in Baise Basin of the Guangxi Province, South China. This fossil wood is characterized by distinct growth rings, circular to oval tracheids in cross section, 1-2-seriate opposite pits on radi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32294
更新日期:2016-08-30 00:00:00
abstract::For people with synaesthesia ordinary stimuli such as digits or letters induce concurrent experiences such as colours. Synaesthesia is associated with a memory advantage and the aim of this study was to investigate whether this advantage persists across time. We tested recognition memory of four different types of syn...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60388-6
更新日期:2020-02-26 00:00:00
abstract::Aedes aegypti mosquitoes are the primary vectors of numerous viruses that impact human health. As manipulation of reproduction has been proposed to suppress mosquito populations, elucidation of biological processes that enable males and females to successfully reproduce is necessary. One essential process is female sp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71904-z
更新日期:2020-09-10 00:00:00
abstract::Secondary ion mass spectrometry is an excellent technique of analytical chemistry, where primary ions sputter a solid sample generating the secondary ions which are determined. Although the ion yield is inherently low, it can be enhanced by using a post-ionization of sputtered neutral species. Our novel approach integ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06562-9
更新日期:2017-07-20 00:00:00
abstract::An increase of nucleolar number and size has made nucleoli essential markers for cytology and tumour development. However, the underlying basis for their structural integrity and abundance remains unclear. Protein phosphatase PPM1D was found to be up-regulated in different carcinomas including breast cancers. Here, we...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33272
更新日期:2016-09-13 00:00:00
abstract::Birds have a remarkable ability to obtain navigational information from the Earth's magnetic field. The primary detection mechanism of this compass sense is uncertain but appears to involve the quantum spin dynamics of radical pairs formed transiently in cryptochrome proteins. We propose here a new version of the curr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09914-7
更新日期:2017-09-14 00:00:00
abstract::Alexithymia is a psychological construct characterized by deficits in processing emotional stimuli. However, little is known about the processing of odours in alexithymia, even though there is extensive proof that emotion and olfaction are closely linked. The present study is aimed at investigating how alexithymic ind...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14404-x
更新日期:2017-10-26 00:00:00
abstract::Metamagnetism occuring inside a ferromagnetic phase is peculiar. Therefore, Sr4Ru3O10, a T C = 105 K ferromagnet, has attracted much attention in recent years, because it develops a pronounced metamagnetic anomaly below T C for magnetic fields applied in the crystallographic ab-plane. The metamagnetic transition move...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03648-2
更新日期:2017-06-20 00:00:00
abstract::Previous studies have consistently reported an association between circulating levels of branched-chain amino acids (BCAAs) or adipokines and insulin resistance; however, the association between BCAA and adipokine levels remains to be clarified. In this cross-sectional study involving 678 participants (435 men) withou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19388-w
更新日期:2018-01-18 00:00:00
abstract::Using census data we identify geographic patterns in residency changes in Lesotho over a decade. Using kriging to spatially interpolate data from 8,510 households we identify regions where households have members temporarily living away from home (divided households). Further, using a multivariate analysis and data fr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17598
更新日期:2015-12-02 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-57570-1
更新日期:2020-01-14 00:00:00
abstract::Tyrosinase efficiently catalyzes the ortho-hydroxylation of monophenols and the oxidation of diphenols without any additional cofactors. Although it is of significant interest for the biosynthesis of catechol derivatives, the rapid catechol oxidase activity and inactivation of tyrosinase have hampered its practical ut...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17635-0
更新日期:2017-12-08 00:00:00
abstract::Channelopathy mutations prove informative on disease causing mechanisms and channel gating dynamics. We have identified a novel heterozygous mutation in the KCNA1 gene of a young proband displaying typical signs and symptoms of Episodic Ataxia type 1 (EA1). This mutation is in the S4 helix of the voltage-sensing domai...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03041-z
更新日期:2017-07-04 00:00:00
abstract::Cardiopulmonary resuscitation (CPR) training and its quality are critical in improving the survival rate of cardiac arrest. This randomized controlled study investigated the efficacy of a newly developed CPR training program for the public in a Taiwanese setting. A total of 832 adults were randomized to either a tradi...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-67193-1
更新日期:2020-06-22 00:00:00
abstract::Whole-slide imaging of histologic sections captures tissue microenvironments and cytologic details in expansive high-resolution images. These images can be mined to extract quantitative features that describe tissues, yielding measurements for hundreds of millions of histologic objects. A central challenge in utilizin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15092-3
更新日期:2017-11-06 00:00:00
abstract::Temperature-modulated space-charge-limited-current spectroscopy (TMSCLC) is applied to quantitatively evaluate the density of trap states in the band-gap with high energy resolution of semiconducting hybrid lead halide perovskite single crystals. Interestingly multicomponent deep trap states were observed in the pure ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40139-y
更新日期:2019-03-04 00:00:00
abstract::Crohn's disease (CD) has been associated with an increased consumption of n-6 polyunsaturated fatty acid (PUFA), while greater intake of n-3 PUFA has been associated with a reduced risk. We sought to investigate serum fatty acid composition in CD, and associations of fatty acids with disease activity, cytokines, and a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39232-z
更新日期:2019-02-27 00:00:00
abstract::The overuse of antibiotics results in the development of antibiotic resistance and limits the useful life of these drugs in fighting bacteria, including Aeromonas hydrophila, a well-known opportunistic pathogen that causes serious infections in fish and other animals. In this study, we investigated the adaptive resist...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39413
更新日期:2016-12-19 00:00:00
abstract::Perivascular spaces (PVSs) in brain have a close relationship with typical neurological diseases. The quantitative studies of PVSs are meaningful but usually difficult, due to their thin and weak signals and also background noise in the 7 T brain magnetic resonance images (MRI). To clearly distinguish the PVSs in the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09336-5
更新日期:2017-08-17 00:00:00
abstract::Anopheles gambiae and Aedes aegypti are perhaps the best studied mosquito species and important carriers of human malaria and arbovirus, respectively. Mosquitoes have daily rhythms in behaviors and show a wide range of activity patterns. Although Anopheles is known to be principally nocturnal and Aedes principally diu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61733-5
更新日期:2020-03-19 00:00:00
abstract::Perinatal depression involves interplay between individual chronic and acute disease burdens, biological and psychosocial environmental and behavioural factors. Here we explored the predictive potential of specific psycho-socio-demographic characteristics for antenatal and postpartum depression symptoms and contributi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30874-z
更新日期:2018-08-24 00:00:00
abstract::The aim of this study was to use functional neuroimaging to investigate whether oxytocin modulates the neural response to visual food cues in brain regions involved in the control of food intake. Twenty-four normal weight volunteers received intranasal oxytocin (24 IU) or placebo in a double-blind, randomized crossove...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04600-0
更新日期:2017-06-27 00:00:00
abstract::Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associated with AIS. Among them is a locus on chromosome 6q24.1 that we identified by a GWAS in a Japanese cohort. T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29011-7
更新日期:2018-08-01 00:00:00
abstract::It is known that a developing avian embryo resorbs micronutrients (calcium and other chemical elements) from the inner layer of the eggshell, inducing thinning and overall changes in the shell's chemical composition. However, an aspect yet to be explored relates to the local changes in the multi-elemental composition ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79040-4
更新日期:2020-12-17 00:00:00
abstract::In social interactions, including cooperation and conflict, individuals can adjust their behaviour over the shorter term through learning within a generation, and natural selection can change behaviour over the longer term of many generations. Here we investigate the evolution of cognitive bias by individuals investin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52781-7
更新日期:2019-11-08 00:00:00
abstract::There is an increasing appreciation for the role of the human Y chromosome in phenotypic differences between the sexes in health and disease. Previous studies have shown that genetic variation within the Y chromosome is associated with cholesterol levels, which is an established risk factor for atherosclerosis, the un...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17165-9
更新日期:2017-12-01 00:00:00