Abstract：
:Crohn's disease (CD) has been associated with an increased consumption of n-6 polyunsaturated fatty acid (PUFA), while greater intake of n-3 PUFA has been associated with a reduced risk. We sought to investigate serum fatty acid composition in CD, and associations of fatty acids with disease activity, cytokines, and adipokines. Serum was prospectively collected from 116 CD subjects and 27 non-IBD controls. Clinical disease activity was assessed by the Harvey Bradshaw Index (HBI). Serum fatty acids were measured by gas chromatography. Serum cytokines and adipokines were measured by Luminex assay. Dietary histories were obtained from a subset of patients. Nine serum cytokines and adipokines were increased in CD versus controls. CD subjects had increased percentage serum monounsaturated fatty acids (MUFA), dihomo-gamma linolenic acid (DGLA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and oleic acid, but decreased arachidonic acid (AA) versus controls. The % total n-3 fatty acids and % EPA directly correlated with pro-inflammatory cytokine levels and HBI, whereas the % total n-6 fatty acids were inversely correlated with pro-inflammatory cytokine levels and HBI. CD subjects had increased caloric intake versus controls, but no alterations in total fat or PUFA intake. We found differences in serum fatty acids, most notably PUFA, in CD that correlated both with clinical disease activity and inflammatory cytokines. Our findings indicate that altered fatty acid metabolism or utilization is present in CD and is related to disease activity.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Scoville EA,Allaman MM,Adams DW,Motley AK,Peyton SC,Ferguson SL,Horst SN,Williams CS,Beaulieu DB,Schwartz DA,Wilson KT,Coburn LAdoi
10.1038/s41598-019-39232-zsubject
Has Abstractpub_date
2019-02-27 00:00:00pages
2882issue
1issn
2045-2322pii
10.1038/s41598-019-39232-zjournal_volume
9pub_type
杂志文章abstract：:Volcanic activity is often preceded or accompanied by different types of seismo-volcanic signals. Among these signals, the so-called tornillo (Spanish for "screw") events are considered to belong to a unique class of volcano-seismicity characterised by a long-duration coda, amplitude modulation and high-quality factor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43842-y
更新日期：2019-05-14 00:00:00
abstract：:Electrohydrodynamic (EHD) jet printing has a variety of benefits compared to conventional inkjet techniques, such as high resolution and the ability to work with high-viscosity pastes. In this work, Ag nanoparticles with 4000 cPs were chosen because they are printable on various substrates for electronic devices. The ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45504-5
更新日期：2019-06-24 00:00:00
abstract：:This work highlights the possibility of using microstructured fibres with predefined doped regions to produce functional microstructures at a fibre facet with differential chemical etching. A specially designed silica microstructured fibre (MSF) that possesses specific boron-doped silica regions was fabricated for the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21279
更新日期：2016-02-19 00:00:00
abstract：:The temporal correspondence between two arbitrarily chosen pairs of alternating features can generally be reported for rates up to 3-4 Hz. This limit is however surpassed for specialised visual mechanisms that encode conjunctions of features. Here we show that this 3-4 Hz limit is exceeded for eye gaze and eyebrow pai...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27242-2
更新日期：2018-06-13 00:00:00
abstract：:The role of miRNAs in mediating insecticide resistance remains largely unknown, even for the model species Drosophila melanogaster. Building on prior research, this study used microinjection of synthetic miR-310s mimics into DDT-resistant 91-R flies and observed both a significant transcriptional repression of computa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71250-0
更新日期：2020-09-01 00:00:00
abstract：:Mesenchymal stem cells (MSCs) are multi-potent cells that are self-renewable and possess the potential to differentiate into multiple lineages. Several studies demonstrated that MSCs could regulate a Th17/Treg balance and could be a potential therapeutic target for Rheumatoid Arthritis (RA). A20 is highly expressed in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18693-0
更新日期：2018-01-11 00:00:00
abstract：:Orbital angular momentum (OAM) multiplexing technique has recently emerged and generated widespread interests since the OAM was discovered as a property of electromagnetic wave and acoustic wave. It was widely acknowledged that OAM multiplexing can achieve very high effective degrees of freedom (EDOF) and improve the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61329-z
更新日期：2020-03-23 00:00:00
abstract：:Invasive alien species represent one of the major factors of global loss of biodiversity and disruption of natural ecosystems. The small Indian mongoose, Urva auropunctata, is considered one of the wild carnivore species with the greatest negative impact on global biodiversity. Understanding of the factors underpinnin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64502-6
更新日期：2020-05-04 00:00:00
abstract：:Vitellogenin is the main yolk precursor protein in insect oocytes. It is synthesized in the fat body and released into the hemolymph. To reach the oocyte surface, vitellogenin must cross a single layer of follicular epithelium cells. The transport of vitellogenin across the follicular epithelium has been suggested to ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52789-z
更新日期：2019-11-11 00:00:00
abstract：:Interactions of water with cellulose are of both fundamental and technological importance. Here, we characterize the properties of water associated with cellulose using deuterium labeling, neutron scattering and molecular dynamics simulation. Quasi-elastic neutron scattering provided quantitative details about the dyn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12035-w
更新日期：2017-09-19 00:00:00
abstract：:Photoacoustic tomography (PAT) offers three-dimensional (3D) structural and functional imaging of living biological tissue with label-free, optical absorption contrast. These attributes lend PAT imaging to a wide variety of applications in clinical medicine and preclinical research. Despite advances in live animal ima...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01113
更新日期：2013-01-01 00:00:00
abstract：:Enzymes that cleave polysaccharides in lignocellulose, i. e., cellulases, xylanases, and accessory enzymes, play crucial roles in the natural decomposition of plant-derived biomass and its efficient and sustainable processing into biofuels or other bulk chemicals. The analysis of open reading frame cthe_2195 from the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11598-y
更新日期：2017-09-11 00:00:00
abstract：:Older patients, especially those with malignancy, may have an increased risk of pulmonary embolism (PE). However, few studies have evaluated the clinical characteristics and prognosis of older patients. We evaluated the clinical characteristics, prognosis, and risk factors in older patients with lung cancer complicate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58345-4
更新日期：2020-01-27 00:00:00
abstract：:Autografts tend to be unreliable in older patients. Some of these age-related skeletal changes appear to be attributable to a decline in endogenous WNT signaling. We used a functional in vivo transplantation assay to demonstrate that the bone-forming capacity of an autograft can be traced back to a Wnt-responsive cell...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18375-x
更新日期：2018-01-08 00:00:00
abstract：:The transition to agriculture was a key event in human history. The extent to which this transition is associated with biological changes in different world regions remains debated. Cultural and osteological records in Lower Nubia throughout the Holocene have been interpreted as a result of in situ differentiation or ...
journal_title：Scientific reports
pub_type： 历史文章,杂志文章
doi：10.1038/srep31040
更新日期：2016-08-09 00:00:00
abstract：:The fusion of villous cytotrophoblasts into the multinucleated syncytiotrophoblast is critical for the essential functions of the mammalian placenta. Using RNA-Seq gene expression and quantitative protein expression, we identified genes and their cognate proteins which are coordinately up- or down-regulated in two cel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23379-2
更新日期：2018-03-23 00:00:00
abstract：:The Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) has been counted on for conserving threatened marine fish since it regulates the commercial international trade of these species. Implementation of the international treaty for Mantas included on CITES Appendix II is challengin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37567
更新日期：2016-11-23 00:00:00
abstract：:Regulation of the chromatin state is crucial for biological processes such as the regulation of transcription, DNA replication, and DNA damage repair. Here we show that knockdown of the BRD8 bromodomain protein - a subunit of the p400/Tip60 complex - leads to p21 induction, and concomitant cell cycle arrest in G1/S. W...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32323-3
更新日期：2018-09-20 00:00:00
abstract：:Pathologic diagnoses mainly depend on visual scoring by pathologists, a process that can be time-consuming, laborious, and susceptible to inter- and/or intra-observer variations. This study proposes a novel method to enhance pathologic scoring of renal allograft rejection. A fully automated system using a convolutiona...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41479-5
更新日期：2019-03-26 00:00:00
abstract：:A major limitation for better understanding the role of the human gut virome in health and disease is the lack of validated methods that allow high throughput virome analysis. To overcome this, we evaluated the quantitative effect of homogenisation, centrifugation, filtration, chloroform treatment and random amplifica...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16532
更新日期：2015-11-12 00:00:00
abstract：:Eurasian Jay (Garrulus glandarius) feathers display periodic variations in the reflected colour from white through light blue, dark blue and black. We find the structures responsible for the colour are continuous in their size and spatially controlled by the degree of spinodal phase separation in the corresponding reg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18317
更新日期：2015-12-21 00:00:00
abstract：:The concept of parity-time (PT) symmetry in SPPs is proposed and confirmed for the first time in this work. By introducing periodic modulation of the effective refractive index in SPP system, the asymmetric propagation is theoretically predicted and numerically demonstrated. After validation of this concept, we apply ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14981
更新日期：2015-10-08 00:00:00
abstract：:Alkaline sulfide-rich hot springs provide a unique environment for microbial community and arsenic (As) biogeochemistry. In this study, a representative alkaline sulfide-rich hot spring, Zimeiquan in the Tengchong geothermal area, was chosen to study arsenic geochemistry and microbial community using Illumina MiSeq se...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25262
更新日期：2016-04-29 00:00:00
abstract：:Exogenous androgenic steroids applied to pregnant sheep programmes a PCOS-like phenotype in female offspring. Via ultrasound guidance we applied steroids directly to ovine fetuses at d62 and d82 of gestation, and examined fetal (day 90 gestation) and postnatal (11 months old) pancreatic structure and function. Of thre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27408
更新日期：2016-06-06 00:00:00
abstract：:Dysregulation of dopaminergic system induced by HIV-1 Tat protein-mediated direct inhibition of the dopamine transporter (DAT) has been implicated as a mediating factor of HIV-1 associated neurocognitive disorders. We have reported that single point mutations on human DAT (hDAT) at tyrosine88 (Y88F), lysine92 (K92M), ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39872-1
更新日期：2019-03-07 00:00:00
abstract：:Small-molecule inhibitors of non-canonical IκB kinases TANK-binding kinase 1 (TBK1) and IκB kinase ε (IKKε) have shown to stimulate β-cell regeneration in multiple species. Here we demonstrate that TBK1 is predominantly expressed in β-cells in mammalian islets. Proteomic and transcriptome analyses revealed that geneti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76600-6
更新日期：2020-11-09 00:00:00
abstract：:On-surface reactions based on Ullmann coupling are known to proceed on coinage-metal substrates (e.g. Au, Ag, Cu), with the chemistry of the surface strongly influencing the reaction progression. In addition, the topography of the surface may be expected to affect the local adsorption geometry of the reactants as well...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13315-1
更新日期：2017-11-06 00:00:00
abstract：:Platelet Derived Growth Factor Receptor (PDGFR) signaling is a central mitogenic pathway in development, as well as tissue repair and homeostasis. The rules governing the binding of PDGF ligand to the receptor to produce activation and downstream signaling have been well defined over the last several decades. In cultu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75774-3
更新日期：2020-11-09 00:00:00
abstract：:Nonunions of the tibia, particularly those located in the distal third of the bone, are relatively common in clinical practice. There is no gold standard for the treatment of nonunions of the tibia. The purpose of our study was to assess the results of treatment with the Ilizarov method in patients with aseptic nonuni...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77569-y
更新日期：2020-11-25 00:00:00
abstract：:The proteolytic system of Lactobacillus plays an essential role in bacterial growth, contributes to the flavor development of fermented products, and can release bioactive health-beneficial peptides during milk fermentation. In this work, a genomic analysis of all genes involved in the proteolytic system of L. delbrue...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09124-1
更新日期：2017-08-17 00:00:00
