Abstract：
:Small-molecule inhibitors of non-canonical IκB kinases TANK-binding kinase 1 (TBK1) and IκB kinase ε (IKKε) have shown to stimulate β-cell regeneration in multiple species. Here we demonstrate that TBK1 is predominantly expressed in β-cells in mammalian islets. Proteomic and transcriptome analyses revealed that genetic silencing of TBK1 increased expression of proteins and genes essential for cell proliferation in INS-1 832/13 rat β-cells. Conversely, TBK1 overexpression decreased sensitivity of β-cells to the elevation of cyclic AMP (cAMP) levels and reduced proliferation of β-cells in a manner dependent on the activity of cAMP-hydrolyzing phosphodiesterase 3 (PDE3). While the mitogenic effect of (E)3-(3-phenylbenzo[c]isoxazol-5-yl)acrylic acid (PIAA) is derived from inhibition of TBK1, PIAA augmented glucose-stimulated insulin secretion (GSIS) and expression of β-cell differentiation and proliferation markers in human embryonic stem cell (hESC)-derived β-cells and human islets. TBK1 expression was increased in β-cells upon diabetogenic insults, including in human type 2 diabetic islets. PIAA enhanced expression of cell cycle control molecules and β-cell differentiation markers upon diabetogenic challenges, and accelerated restoration of functional β-cells in streptozotocin (STZ)-induced diabetic mice. Altogether, these data suggest the critical function of TBK1 as a β-cell autonomous replication barrier and present PIAA as a valid therapeutic strategy augmenting functional β-cells.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jia YF,Jeeva S,Xu J,Heppelmann CJ,Jang JS,Slama MQ,Tapadar S,Oyelere AK,Kang SM,Matveyenko AV,Peterson QP,Shin CHdoi
10.1038/s41598-020-76600-6subject
Has Abstractpub_date
2020-11-09 00:00:00pages
19374issue
1issn
2045-2322pii
10.1038/s41598-020-76600-6journal_volume
10pub_type
杂志文章abstract：:It remains a grand challenge to achieve both high activity and durability in Pt electrocatalysts for oxygen reduction reaction (ORR) in fuel cells. Here we develop a class of Pt highly concave cubic (HCC) nanocrystals, which are enriched with high-index facets, to enable high ORR activity. The durability of HCC nanocr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02580
更新日期：2013-01-01 00:00:00
abstract：:African black-footed cats (Felis nigripes) are endangered wild felids. One male and full-sibling female African black-footed cat developed vision deficits and mydriasis as early as 3 months of age. The diagnosis of early-onset progressive retinal atrophy (PRA) was supported by reduced direct and consensual pupillary l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43918
更新日期：2017-03-21 00:00:00
abstract：:The aim of this study was to identify novel plasma metabolic signatures with possible relevance during multiple myeloma (MM) development and progression. A biochemical quantitative phenotyping platform based on targeted electrospray ionization tandem mass spectrometry technology was used to aid in the identification o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75862-4
更新日期：2020-12-14 00:00:00
abstract：:We report a meta-analysis of virtual reality (VR) interventions for anxiety and depression outcomes, as well as treatment attrition. We included randomized controlled trials comparing VR interventions, alone or in combination, to control conditions or other active psychological interventions. Effects sizes (Hedges' g)...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-018-28113-6
更新日期：2018-07-09 00:00:00
abstract：:In this study, we aimed to elucidate the origin of domestic chickens and their evolutionary history over the course of their domestication. We conducted a large-scale genetic study using mitochondrial DNA D-loop sequences and 28 microsatellite DNA markers to investigate the diversity of 298 wild progenitor red junglef...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81589-7
更新日期：2021-01-21 00:00:00
abstract：:Deficits in GABAergic inhibitory neurotransmission are a reliable finding in schizophrenia (SCZ) patients. Previous studies have reported that unaffected first-degree relatives of patients with SCZ demonstrate neurophysiological abnormalities that are intermediate between probands and healthy controls. In this study, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43629
更新日期：2017-02-27 00:00:00
abstract：:Users of social media often share their feelings or emotional states through their posts. In this study, we developed a deep learning model to identify a user's mental state based on his/her posting information. To this end, we collected posts from mental health communities in Reddit. By analyzing and learning posting...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68764-y
更新日期：2020-07-16 00:00:00
abstract：:The systematics of Oriental freshwater mussels (Bivalvia: Unionidae) is poorly known. Here, we present an integrative revision of the genus Trapezoideus Simpson, 1900 to further understanding of freshwater mussel diversity in the region. We demonstrate that Trapezoideus as currently circumscribed is non-monophyletic, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39365-1
更新日期：2019-03-11 00:00:00
abstract：:Horseradish peroxidase (HRP) mediates efficient conversion of many phenolic contaminants and thus has potential applications for pollution control. Such potentially important applications suffer however from the fact that the enzyme becomes quickly inactivated during phenol oxidation and polymerization. The work here ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03126
更新日期：2013-11-04 00:00:00
abstract：:Long-term potentiation (LTP) is the persistent increase in the strength of the synapses. However, the neural networks would become saturated if there is only synaptic strenghthening. Synaptic weakening could be facilitated by active processes like long-term depression (LTD). Molecular mechanisms that facilitate the we...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15917-1
更新日期：2017-11-14 00:00:00
abstract：:Psoriatic arthritis (PsA) patients have increased risk of both atherosclerosis and osteoporosis. Previous studies revealed that IL-33/ST2 axis may be related to both conditions; however, these associations were never evaluated in a single patients' group. Here we explored the association among plasma levels of IL-33 a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32116
更新日期：2016-08-24 00:00:00
abstract：:N-methyl-D-aspartate (NMDA) receptors are glutamate- and glycine-gated channels composed of two GluN1 and two GluN2 or/and GluN3 subunits. GluN3A expression is developmentally regulated, and changes in this normal pattern of expression, which occur in several brain disorders, alter synaptic maturation and function by ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23344
更新日期：2016-03-22 00:00:00
abstract：:Here we describe a unique microbial biotechnology for simultaneous bioremediation and biomining of twelve ionic metals overcoming the obstacles of multimetal toxicity to microbes. After a thorough search of key microorganisms in microbiomes of many sulfidic springs in Bavaria (Germany) over an area of 200 km2, we foun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46560-7
更新日期：2019-07-16 00:00:00
abstract：:The transition energies and formation energies of N, C, F, Cl, and S as substitutional dopants in Ag3PO4 are studied using first-principles calculations based on the hybrid Hartree-Fock density functional, which correctly reproduces the band gap and thus provides the accurate defect states. Our results show that NO an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12750
更新日期：2015-08-03 00:00:00
abstract：:Research on argillite as a possible host rock for nuclear waste disposal is still an open subject since many issues need to be clarified. In the Underground Research Laboratories constructed for this purpose, a damaged zone around the excavation has been systematically observed and characterized by the appearance of m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08815
更新日期：2015-03-06 00:00:00
abstract：:The regulatory transcriptional factor PATZ1 is constantly downregulated in human thyroid cancer where it acts as a tumour suppressor by targeting p53-dependent genes involved in Epithelial-Mesenchymal Transition and cell migration. The aim of the present work was to elucidate the upstream signalling mechanisms regulat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25268
更新日期：2016-04-29 00:00:00
abstract：:Archaeological evidence suggests that dogs were introduced to the islands of Oceania via Island Southeast Asia around 3,300 years ago, and reached the eastern islands of Polynesia by the fourteenth century AD. This dispersal is intimately tied to human expansion, but the involvement of dogs in Pacific migrations is no...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27363-8
更新日期：2018-06-14 00:00:00
abstract：:Outbreaks of arbovirus infections vectored by invasive Aedes albopictus have already occurred and are predicted to become increasingly frequent in Southern Europe. We present a probabilistic model to assess risk of arbovirus outbreaks based on incident cases worldwide, on the probability of arrival of infected travele...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34664-5
更新日期：2018-11-06 00:00:00
abstract：:Arterial stiffness index (ASI) is a non-invasive measure of arterial stiffness using infra-red finger sensors (photoplethysmography). It is a well-suited measure for large populations as it is relatively inexpensive to perform, and data can be acquired within seconds. These features raise interest in using ASI as a to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45703-0
更新日期：2019-06-24 00:00:00
abstract：:We have previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proliferation of Foxp3+ Tregs, but not Foxp3- effector T-cells (Teff), when CD4+ T-cells are co-cultured with GM-CSF derived bone marrow dendritic cells (G-BMDCs). Events downstream of OX40L/OX40 interaction in Tregs respons...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05254-8
更新日期：2017-07-26 00:00:00
abstract：:Feynman once asked physicists to build better electron microscopes to be able to watch biology at work. While electron microscopes can now provide atomic resolution, electron beam induced specimen damage precludes high resolution imaging of sensitive materials, such as single proteins or polymers. Here, we use simulat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01841-x
更新日期：2017-05-10 00:00:00
abstract：:In this study, we sought to enhance the cutting properties of the various blades by coating them with Zr- and Fe-based thin film metallic glasses (TFMGs) to a thickness of 234-255 nm via sputter deposition. In oil-repellency/sliding tests on kitchen blades, the sliding angle and friction forces were as follows: bare b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52054-3
更新日期：2019-10-29 00:00:00
abstract：:Lassa virus (LASV) is the causative agent of Lassa fever (LF), an often-fatal hemorrhagic disease. LF is endemic in Nigeria, Sierra Leone and other West African countries. Diagnosis of LASV infection is challenged by the genetic diversity of the virus, which is greatest in Nigeria. The ReLASV Pan-Lassa Antigen Rapid T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65736-0
更新日期：2020-05-26 00:00:00
abstract：:The recent surge in research on metal-halide-perovskite solar cells has led to a seven-fold increase of efficiency, from ~3% in early devices to over 22% in research prototypes. Oft-cited reasons for this increase are: (i) a carrier diffusion length reaching hundreds of microns; (ii) a low exciton binding energy; and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36108
更新日期：2016-11-08 00:00:00
abstract：:Zooplankton provide the key link between primary production and higher levels of the marine food web and they play an important role in mediating carbon sequestration in the ocean. All commercially harvested fish species depend on zooplankton populations. However, spatio-temporal distributions of zooplankton are notor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37129-x
更新日期：2019-01-24 00:00:00
abstract：:Alpha synuclein (α-syn) is a central player in neurodegeneration, but the mechanisms triggering its pathology are not fully understood. Here we found that α-syn is a highly efficient substrate for arginyltransferase ATE1 and is arginylated in vivo by a novel mid-chain mechanism that targets the acidic side chains of E...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11713-z
更新日期：2017-09-12 00:00:00
abstract：:Recently, a genome-wide analysis identified DNA methylation of the HIF3A (hypoxia-inducible factor 3A) as strongest correlate of BMI. Here we tested the hypothesis that HIF3A mRNA expression and CpG-sites methylation in adipose tissue (AT) and genetic variants in HIF3A are related to parameters of AT distribution and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27969
更新日期：2016-06-27 00:00:00
abstract：:The knowledge of the metallization of warm dense helium has important implications for understanding the thermal histories, stellar structure and magnetic field environment of giant planets. However, it is also a pendent scientific topic. For a revisiting into the properties of warm dense helium, we performed extensiv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41885
更新日期：2017-02-03 00:00:00
abstract：:Mutations in the SNX14 gene cause spinocerebellar ataxia, autosomal recessive 20 (SCAR20) in both humans and dogs. Studies implicating the phenotypic consequences of SNX14 mutations to be consequences of subcellular disruption to autophagy and lipid metabolism have been limited to in vitro investigation of patient-der...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70797-2
更新日期：2020-08-13 00:00:00
abstract：:Triassic archosaurs and stem-archosaurs show a remarkable disparity in their ankle and pelvis morphologies. However, the implications of these different morphologies for specific functions are still poorly understood. Here, we present the first quantitative analysis into the locomotor abilities of a stem-archosaur app...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70175-y
更新日期：2020-09-21 00:00:00
