Abstract：
:The role of miRNAs in mediating insecticide resistance remains largely unknown, even for the model species Drosophila melanogaster. Building on prior research, this study used microinjection of synthetic miR-310s mimics into DDT-resistant 91-R flies and observed both a significant transcriptional repression of computationally-predicted endogenous target P450 detoxification genes, Cyp6g1 and Cyp6g2, and also a concomitant increase in DDT susceptibility. Additionally, co-transfection of D. melanogaster S2 cells with dual luciferase reporter constructs validated predictions that miR-310s bind to target binding sites in the 3' untranslated regions (3'-UTR) of both Cyp6g1 and Cyp6g2 in vitro. Findings in the current study provide empirical evidence for a link between reduced miRNA expression and an insecticidal resistance phenotype through reduced targeted post-transcriptional suppression of transcripts encoding proteins involved in xenobiotic detoxification. These insights are important for understanding the breadth of adaptive molecular changes that have contributed to the evolution of DDT resistance in D. melanogaster.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Seong KM,Coates BS,Pittendrigh BRdoi
10.1038/s41598-020-71250-0subject
Has Abstractpub_date
2020-09-01 00:00:00pages
14394issue
1issn
2045-2322pii
10.1038/s41598-020-71250-0journal_volume
10pub_type
杂志文章abstract：:Interleukin-6 (IL-6) overproduction has been involved in the pathogenesis of several chronic inflammatory diseases and the administration of an anti-IL-6 receptor monoclonal antibody has been proven clinically efficient to treat them. However, the drawbacks of monoclonal antibodies have led our group to develop an inn...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-01-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2020-01-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-04-07 00:00:00
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pub_type： 杂志文章,meta分析
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pub_type： 临床试验,杂志文章
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