Abstract：
:Bacterial cells have characteristic spatial and temporal scales. For instance, Escherichia coli, the typical rod-shaped bacteria, always maintains a relatively constant cell width and cell division time. However, whether the external physical perturbation of cell width has an impact on cell division time remains largely unexplored. In this work, we developed two microchannel chips, namely straight channels and 'necked' channels, to precisely regulate the width of E. coli cells and to investigate the correlation between cell width and division time of the cells. Our results show that, in the straight channels, the wide cells divide much slower than narrow cells. In the 'necked' channels, the cell division is remarkably promoted compared to that in straight channels with the same width. Besides, fluorescence time-lapse microscopy imaging of FtsZ dynamics shows that the cell pre-constriction time is more sensitive to cell width perturbation than cell constriction time. Finally, we revealed a significant anticorrelation between the death rate and the division rate of cell populations with different widths. Our work provides new insights into the correlation between the geometrical property and division time of E. coli cells and sheds new light on the future study of spatial-temporal correlation in cell physiology.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liang B,Quan B,Li J,Loton C,Bredeche MF,Lindner AB,Xu Ldoi
10.1038/s41598-020-74778-3subject
Has Abstractpub_date
2020-10-20 00:00:00pages
17847issue
1issn
2045-2322pii
10.1038/s41598-020-74778-3journal_volume
10pub_type
杂志文章abstract：:Technical advances including liquid chromatography-tandem mass spectrometry and its data analysis enable detailed proteomic analysis of the nasal mucus. Alterations of the nasal mucus proteome may provoke substantial changes of the nasal physiology and have already been associated with rhinologic diseases such as alle...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-35776-8
更新日期：2018-12-03 00:00:00
abstract：:In this study, we had exploited the advancement in computer technology to determine the stability of four apomyoglobin variants namely wild type, E109A, E109G and G65A/G73A by conducting conventional molecular dynamics simulations in explicit urea solution. Variations in RMSD, native contacts and solvent accessible su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44651
更新日期：2017-03-16 00:00:00
abstract：:Conifer wood is an exceptionally stiff and strong material when its cellulose microfibrils are well aligned. However, it is not well understood how the polymer components cellulose, hemicelluloses and lignin co-operate to resist tensile stress in wood. From X-ray scattering, neutron scattering and spectroscopic data, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79676-2
更新日期：2021-01-11 00:00:00
abstract：:Almost 150 years after the first identification of Neandertal skeletal material, the cognitive and symbolic abilities of these populations remain a subject of intense debate. We present 99 new Neandertal remains from the Troisième caverne of Goyet (Belgium) dated to 40,500-45,500 calBP. The remains were identified thr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29005
更新日期：2016-07-06 00:00:00
abstract：:Congenital ptosis may be associated with abnormalities of visual development and function, including amblyopia, strabismus and refractive errors. However, the prevalence estimates of these abnormalities vary widely. We performed a systematic review and meta-analysis to estimate the prevalence of amblyopia, strabismus ...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-018-26671-3
更新日期：2018-05-29 00:00:00
abstract：:Organic nanofibers have found various applications in optoelectronic devices. In such devices, exciton diffusion is a major aspect concerning their efficiency. In the case of singlet excitons, Förster transfer is the mechanism responsible for this process. Temperature and morphology are factors known to influence exci...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32232-5
更新日期：2018-09-19 00:00:00
abstract：:To discover epigenetic changes that may underly neuroblastoma pathogenesis, we identified differentially methylated genes in neuroblastoma cells compared to neural crest cells, the presumptive precursors cells for neuroblastoma, by using genome-wide DNA methylation analysis. We previously described genes that were hyp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55382-6
更新日期：2019-12-12 00:00:00
abstract：:We developed a virus-like particle (VLP)-based therapeutic vaccine against angiotensin II receptor type 1, ATR-AP205-001, which could significantly reduce the blood pressure and protect target organs of hypertensive animals. In this study, we focused on the immunological effect and safety of the VLP-based vaccine. By ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12996-y
更新日期：2017-10-03 00:00:00
abstract：:Patients who undergo total hip arthroplasty (THA) may experience a large amount of blood loss. The objective of our study is to include randomized controlled trials (RCTs) and compare the clinical outcomes of fibrin sealant (FS) versus placebo after a THA. In October 2015, we searched the following databases: Medline,...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
doi：10.1038/s41598-017-16779-3
更新日期：2018-01-08 00:00:00
abstract：:Biomass burning aerosols mainly consist of black carbon (BC) and organic aerosols (OAs), and some of OAs are brown carbon (BrC). This study simulates the colors of BrC, BC and their mixture with scattering OAs in the ambient atmosphere by using a combination of light scattering simulations, a two-stream radiative tran...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28267
更新日期：2016-06-16 00:00:00
abstract：:3-D modeling of coupled thermo-hydro-mechanical (THM) processes in enhanced geothermal systems using the control volume finite element code was done. In a first, a comparative analysis on the effects of coupled processes, operational parameters and reservoir parameters on heat extraction was conducted. We found that s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14273-4
更新日期：2017-12-06 00:00:00
abstract：:SerpinB3 has been recently described as an early marker of liver carcinogenesis, but the potential mechanistic role of this serpin in tumor development is still poorly understood. Overexpression of Myc often correlates with more aggressive tumour forms, supporting its involvement in carcinogenesis. Yes-associated prot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17701
更新日期：2015-12-04 00:00:00
abstract：:Plant defensins (PDFs) are cysteine-rich peptides that have a range of biological functions, including defence against fungal pathogens. However, little is known about their role in defence against bacteria. In this study, we showed that the protein encoded by ARABIDOPSIS THALIANA PLANT DEFENSIN TYPE 1.1 (AtPDF1.1) is...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08497-7
更新日期：2017-08-23 00:00:00
abstract：:Ocean uptake of anthropogenic CO2 reduces pH and saturation state of calcium carbonate materials of seawater, which could reduce the calcification rate of some marine organisms, triggering a negative feedback on the growth of atmospheric CO2. We quantify the effect of this CO2-calcification feedback by conducting a se...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20284
更新日期：2016-02-03 00:00:00
abstract：:Dirac-like surface states on surfaces of topological insulators have a chiral spin structure with spin locked to momentum, which is interesting in physics and may also have important applications in spintronics. In this work, by measuring the tunable helicity-dependent photocurrent (HDP), we present an identification ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04889
更新日期：2014-05-08 00:00:00
abstract：:Acoustic manipulation by an ultrasonic phased array provides an entirely new approach to processes such as coalescence, mixing, separation, and evaporation occurring in the generation of new materials, physical property measurement, the biomedical industry, etc. However, to date, ultrasonic phased arrays have not been...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28451-5
更新日期：2018-07-05 00:00:00
abstract：:Iridescent color appearances are widespread in nature. They arise from the interaction of light with micron- and submicron-sized physical structures spatially arranged with periodic geometry and are usually associated with bright angle-dependent hues. Iridescence has been reported for many animals and marine organisms...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19906
更新日期：2016-01-28 00:00:00
abstract：:Electroceutical wound dressings, especially those involving current flow with silver based electrodes, show promise for treating biofilm infections. However, their mechanism of action is poorly understood. We have developed an in vitro agar based model using a bioluminescent strain of Pseudomonas aeruginosa to measure...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37891-y
更新日期：2019-02-14 00:00:00
abstract：:Knowledge of the ecology of N2-fixing (diazotrophic) plankton is mainly limited to oligotrophic (sub)tropical oceans. However, diazotrophs are widely distributed and active throughout the global ocean. Likewise, relatively little is known about the temporal dynamics of diazotrophs in productive areas. Between February...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39586-4
更新日期：2019-03-06 00:00:00
abstract：:The analysis of cell type-specific activity patterns during behaviors is important for better understanding of how neural circuits generate cognition, but has not been well explored from in vivo neurophysiological datasets. Here, we describe a computational approach to uncover distinct cell subpopulations from in vivo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12474
更新日期：2015-07-27 00:00:00
abstract：:Lytic bacteriophages are valuable therapeutic agents against bacterial infections. There is continual effort to obtain new phages to increase the effectivity of phage preparations against emerging phage-resistant strains. Here we described the genomic diversity of spontaneous host-range mutants of kayvirus 812. Five m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41868-w
更新日期：2019-04-02 00:00:00
abstract：:Colistin remains one of the few antibiotics effective against multi-drug resistant (MDR) hospital pathogens, such as Klebsiella pneumoniae. Yet resistance to this last-line drug is rapidly increasing. Characterized mechanisms of colR in K. pneumoniae are largely due to chromosomal mutations in two-component regulators...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28199-y
更新日期：2018-06-29 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-48627-x
更新日期：2019-08-28 00:00:00
abstract：:Efforts for tissue engineering vascular grafts focuses on the tunica media and intima, although the tunica adventitia serves as the primary structural support for blood vessels. In surgery, during endarterectomies, surgeons can strip the vessel, leaving the adventitia as the main strength layer to close the vessel. He...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21681-7
更新日期：2018-02-19 00:00:00
abstract：:Elastic waves are guided along finite structures such as cylinders, plates, or rods through reflection, refraction, and mode conversion at the interfaces. Such wave propagation is ubiquitous in the world around us, and studies of elastic waveguides first emerged in the later part of the 19(th) century. Early work on e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11112
更新日期：2015-06-08 00:00:00
abstract：:Huntington's disease (HD) is a neurodegenerative disorder whose major symptoms include progressive motor and cognitive dysfunction. Cognitive decline is a critical quality of life concern for HD patients and families. The enzyme histone deacetylase 3 (HDAC3) appears to be important in HD pathology by negatively regula...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05125-2
更新日期：2017-07-20 00:00:00
abstract：:Interleukin-10 (IL-10) plays a central role in regulation of intestinal mucosal homeostasis and prevention of inflammatory bowel disease (IBD). We previously reported that CD11b(hi) regulatory dendritic cells (DCs) can produce more IL-10, and CD11b can negatively regulate Toll-like receptors (TLRs)-induced inflammator...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26252
更新日期：2016-05-18 00:00:00
abstract：:We report the results of an experiment on radio-tracking of individual grey field slugs in an arable field and associated data modelling designed to investigate the effect of slug population density in their movement. Slugs were collected in a commercial winter wheat field in which a 5x6 trapping grid had been establi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74643-3
更新日期：2020-10-21 00:00:00
abstract：:Infertility is currently a major public health problem. Anti-sperm antibodies (ASAs) markedly reduce sperm quality, which can subsequently lead to male and/or female infertility. The accurate detection of ASAs derived from specific spermatozoa is, therefore, clinically useful. We have focused on the spermatozoa-specif...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22844
更新日期：2016-03-09 00:00:00
abstract：:Stevia is a natural source of commercially important steviol glycosides (SGs), which share biosynthesis route with gibberellic acids (GAs) through plastidal MEP and cytosolic MVA pathways. Ontogeny-dependent deviation in SGs biosynthesis is one of the key factor for global cultivation of Stevia, has not been studied a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12025-y
更新日期：2017-09-19 00:00:00
