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RNA-Seq identifies genes whose proteins are transformative in the differentiation of cytotrophoblast to syncytiotrophoblast, in human primary villous and BeWo trophoblasts.

Abstract：

:The fusion of villous cytotrophoblasts into the multinucleated syncytiotrophoblast is critical for the essential functions of the mammalian placenta. Using RNA-Seq gene expression and quantitative protein expression, we identified genes and their cognate proteins which are coordinately up- or down-regulated in two cellular models of cytotrophoblast to syncytiotrophoblast development, human primary villous and human BeWo cytotrophoblasts. These include hCGβ, TREML2, PAM, CRIP2, INHA, FLRG, SERPINF1, C17orf96, KRT17 and SAA1. These findings provide avenues for further understanding the mechanisms underlying mammalian placental synctiotrophoblast development.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Azar C,Valentine M,Trausch-Azar J,Druley T,Nelson DM,Schwartz AL

doi

10.1038/s41598-018-23379-2

subject

Has Abstract

pub_date

2018-03-23 00:00:00

pages

5142

issue

1

issn

2045-2322

pii

10.1038/s41598-018-23379-2

journal_volume

8

pub_type

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