Abstract：
:Uropathogenic strains of Escherichia coli establish urinary tract infections by attaching to host epithelial cells using adhesive organelles called fimbriae. Fimbriae are helix-like structures with a remarkable adaptability, offering safeguarding for bacteria exposed to changing fluid forces in the urinary tract. We challenged this property of P-fimbriae by cross-linking their subunits with shaft-specific antibodies and measuring the corresponding force response at a single organelle level. Our data show compromised extension and rewinding of P-fimbriae in the presence of antibodies and reduced fimbrial elasticity, which are important properties of fimbriae contributing to the ability of bacteria to cause urinary tract infections. The reduced elasticity found by cross-linking fimbrial subunits could thus be another assignment for antibodies; in addition to marking bacteria as foreign, antibodies physically compromise fimbrial function. We suggest that our assay and results will be a starting point for further investigations aimed at inhibiting sustained bacterial adhesion by antibodies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Mortezaei N,Singh B,Bullitt E,Uhlin BE,Andersson Mdoi
10.1038/srep03393subject
Has Abstractpub_date
2013-12-02 00:00:00pages
3393issn
2045-2322pii
srep03393journal_volume
3pub_type
杂志文章abstract：:A plasmonic Ag/TiO2 photocatalytic composite was designed by selecting Ag quantum dots (Ag QDs) to act as a surface plasmon resonance (SPR) photosensitizer for driving the visible-light driven photoelectrocatalytic hydrogen evolution. Vertically oriented hierarchical TiO2 nanotube arrays (H-TiO2-NTAs) with macroporous...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10461
更新日期：2015-06-12 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-40288-0
更新日期：2019-04-17 00:00:00
abstract：:High efficiency polymer:fullerene photovoltaic device layers self-assemble with hierarchical features from ångströms to 100's of nanometers. The feature size, shape, composition, orientation, and order all contribute to device efficiency and are simultaneously difficult to study due to poor contrast between carbon bas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30915
更新日期：2016-08-08 00:00:00
abstract：:Practical applications of bacteriophages in medicine and biotechnology induce a great need for technologies of phage purification. None of the popular methods offer solutions for separation of a phage from another similar phage. We used affinity chromatography combined with competitive phage display (i) to purify T4 b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03220
更新日期：2013-11-14 00:00:00
abstract：:The Ah receptor (AhR) is a ligand-dependent transcription factor belonging to the basic helix-loop-helix Per-Arnt-Sim (bHLH-PAS) superfamily. Binding to and activation of the AhR by a variety of chemicals results in the induction of expression of diverse genes and production of a broad spectrum of biological and toxic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47138-z
更新日期：2019-07-23 00:00:00
abstract：:Rapid changes observed today in mountain glaciers need to be put into a longer-term context to understand global sea-level contributions, regional climate-glacier systems and local landscape evolution. In this study we determined volume changes for 400 mountain glaciers across the Southern Alps, New Zealand for three ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70276-8
更新日期：2020-08-07 00:00:00
abstract：:The increasing availability of electronic health care records has provided remarkable progress in the field of population health. In particular the identification of disease risk factors has flourished under the surge of available data. Researchers can now access patient data across a broad range of demographics and g...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30465
更新日期：2016-07-27 00:00:00
abstract：:Antidepressants have been the object of an international controversy for about thirty years. Some patients are inclined to develop suicidal ideation (SI) at antidepressant onset; this phenomenon is known as Treatment Emergent Suicidal Ideation (TESI), and it has conducted regulatory bodies to prompt warnings on antide...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/s41598-019-39622-3
更新日期：2019-02-22 00:00:00
abstract：:Recent studies have revealed the systematic altering of gene expression in human peripheral blood during the early stages of ischemic stroke, which suggests a new potential approach for the rapid diagnosis or prediction of stroke onset. Nevertheless, due to the difficulties of collecting human samples during proper di...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29693
更新日期：2016-07-13 00:00:00
abstract：:Improving spatial accessibility to hospitals is a major task for health care systems which can be facilitated using recent methodological improvements of spatial accessibility measures. We used the integrated floating catchment area (iFCA) method to analyze spatial accessibility of general inpatient care (internal med...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76212-0
更新日期：2020-11-05 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-62381-5
更新日期：2020-04-06 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41598-020-70939-6
更新日期：2020-08-12 00:00:00
abstract：:Ultrasound has significantly increased safety and effectiveness in regional anesthesia. However, little is known about its clinical use. We studied clinical approaches currently used by anesthesiologists, conducted a nationwide survey, and analyzed data collected in ordered logistic regression models. All active membe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45700-3
更新日期：2019-06-24 00:00:00
abstract：:The Paraná delta, growing at a rate of c. 2 km(2) yr(-1) since 6,000 yrs, is one of the most complete records of the Late Holocene in southern South America. The evolution of this 17,400 km(2) delta enclosed in Plata estuary, can be tracked by a series of 343 successive coastal-ridges showing a c.11 years period, in c...
journal_title：Scientific reports
pub_type： 历史文章,杂志文章
doi：10.1038/srep12851
更新日期：2015-08-06 00:00:00
abstract：:Tyrosine hydroxylase (TH) catalyzes the hydroxylation of L-tyrosine to L-DOPA. This is the rate-limiting step in the biosynthesis of the catecholamines - dopamine (DA), norepinephrine (NE), and epinephrine (EP). Catecholamines (CA) play a key role as neurotransmitters and hormones. Aberrant levels of CA are associated...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54461-y
更新日期：2019-12-09 00:00:00
abstract：:At the Ediacaran/Cambrian boundary, ecosystems witnessed an unparalleled biological innovation: the appearance of shelled animals. Here, we report new paleoecological and paleobiological data on Cloudina, which was one of the most abundant shelled animals at the end of the Ediacaran. We report the close association of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05753-8
更新日期：2017-07-14 00:00:00
abstract：:This study proposes a new method of visualizing the ambient dose rate distribution using artificial neural networks (ANNs) from airborne radiation monitoring results. The method was applied to the results of the airborne radiation monitoring which was conducted around the Fukushima Daiichi Nuclear Power Plant by an un...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81546-4
更新日期：2021-01-20 00:00:00
abstract：:Early treatment, soon after infection, reduces HIV transmissions and benefits patients. The Transmission Reduction Intervention Project (TRIP) evaluated a network intervention to detect individuals recently infected (in the past 6 months). TRIP was conducted in Greece (2013-2015) and focused on drug injector networks....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38100
更新日期：2016-12-05 00:00:00
abstract：:A tool to predict peritonitis-associated treatment failure among peritoneal dialysis (PD) patients has not yet been established. We conducted a multicentre, retrospective cohort study among 1,025 PD patients between 2006 and 2016 in Thailand to develop and internally validate such a tool. Treatment failure was defined...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
doi：10.1038/s41598-018-33196-2
更新日期：2018-10-04 00:00:00
abstract：:SerpinB3 has been recently described as an early marker of liver carcinogenesis, but the potential mechanistic role of this serpin in tumor development is still poorly understood. Overexpression of Myc often correlates with more aggressive tumour forms, supporting its involvement in carcinogenesis. Yes-associated prot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17701
更新日期：2015-12-04 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-30644-x
更新日期：2018-08-09 00:00:00
abstract：:Several studies have investigated the association between polymorphisms in protamine 1 and 2 genes and male infertility risk, with inconsistent results to date. This meta-analysis based on the 13 published case-control studies, including 7350 cases and 6167 controls, was performed to further establish the potential as...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep15300
更新日期：2015-10-16 00:00:00
abstract：:Peatlands perform important ecosystem functions, such as carbon storage and nutrient retention, which are affected, among other factors, by vegetation and peat decomposition. The availability of silicon (Si) in peatlands differs strongly, ranging from <1 to >25 mg L-1. Since decomposition of organic material was recen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09130-3
更新日期：2017-08-18 00:00:00
abstract：:Functional neuroimaging, using genetically-encoded Ca2+ sensors in larval zebrafish, offers a powerful combination of high spatiotemporal resolution and higher vertebrate relevance for quantitative neuropharmacological profiling. Here we use zebrafish larvae with pan-neuronal expression of GCaMP6s, combined with light...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06646-6
更新日期：2017-07-26 00:00:00
abstract：:We study the driven translocation of a semi-flexible polymer through a nanopore by means of a modified version of the iso-flux tension propagation theory, and extensive molecular dynamics (MD) simulations. We show that in contrast to fully flexible chains, for semi-flexible polymers with a finite persistence length [F...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07227-3
更新日期：2017-08-07 00:00:00
abstract：:Whipple's disease is a systemic infectious disease associated with the bacterium Tropheryma whipplei. Numerous reports have presented puzzling discrepancies between diagnosis methods. We addressed this confusion using fluorescent in situ hybridization and immunofluorescence assays to evaluate 34 duodenal biopsies and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23883
更新日期：2016-03-30 00:00:00
abstract：:Rapid, sensitive, point-of-care diagnostics are critical for managing infectious diseases. Here we adapt the CRISPR-based SHERLOCK method to develop a rapid, accurate, single copy detection assay for White Spot Syndrome Virus, the most devastating virus impacting global shrimp aquaculture. Further, we combine paper ma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56170-y
更新日期：2019-12-23 00:00:00
abstract：:Ecosystem carbon carrying capacity (CCC) is determined by prevailing climate and natural disturbance regimes, conditions that are projected to change significantly. The interaction of changing climate and its effects on disturbance regimes is expected to affect forest regeneration and growth, which may diminish forest...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02686-0
更新日期：2017-05-25 00:00:00
abstract：:Two-dimensional (2D) transition metal dichalcogenides MX2 (M = Mo, W, X = S, Se, Te) attracts enormous research interests in recent years. Its 2H phase possesses an indirect to direct bandgap transition in 2D limit, and thus shows great application potentials in optoelectronic devices. The 1T' crystalline phase transi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39238-7
更新日期：2019-02-25 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-24103-w
更新日期：2018-04-13 00:00:00
