Co-delivery of VEGF and bFGF via a PLGA nanoparticle-modified BAM for effective contracture inhibition of regenerated bladder tissue in rabbits.

abstract：:Enterovirus 71 (EV71) is the predominant causative pathogen of hand-foot-and-mouth disease (HFMD). Contrary to other HFMD-causing enterovirus, EV71 can lead to severe neurological complications, even death. MicroRNAs (miRNAs) are small non-coding RNAs that constitute the largest family of gene regulators participating...

journal_title：Scientific reports

authors： Zheng C,Zheng Z,Sun J,Zhang Y,Wei C,Ke X,Liu Y,Deng L,Wang H

更新日期：2017-11-27 00:00:00

abstract：:An atmospheric component of the Philippine-Taiwan Oscillations (PTOa) is used to examine its potential connection with tropical cyclone (TC) frequency in the western North Pacific in the period of 1979-2014. During positive PTOa years, more TCs are observed in the tropical western Pacific south of 18 °N where cyclonic...

journal_title：Scientific reports

authors： Chang YK,Miyazawa Y,Kodaira T,Behera S

更新日期：2018-11-29 00:00:00

abstract：:Photosensitizer protoporphyrin IX (PpIX) fluorescence, intracellular localization and cell response to photodynamic therapy (PDT) were analyzed in MCF10A normal breast epithelial cells and a panel of human breast cancer cells including estrogen receptor (ER) positive, human epidermal growth factor receptor 2 (HER2) po...

journal_title：Scientific reports

authors： Palasuberniam P,Yang X,Kraus D,Jones P,Myers KA,Chen B

更新日期：2015-08-18 00:00:00

abstract：:Lower respiratory infections, such as community-acquired pneumonia (CAP), and chronic obstructive pulmonary disease (COPD) rank among the most frequent causes of death worldwide. Improved diagnostics and profound pathophysiological insights are urgent clinical needs. In our cohort, we analysed transcriptional networks...

journal_title：Scientific reports

authors： Bertrams W,Griss K,Han M,Seidel K,Klemmer A,Sittka-Stark A,Hippenstiel S,Suttorp N,Finkernagel F,Wilhelm J,Greulich T,Vogelmeier CF,Vera J,Schmeck B

更新日期：2020-01-14 00:00:00

abstract：:The marine bacterial strain Desulfovibrio ferrophilus IS5, known for its lithotrophic growth ability to use metallic iron as a sole electron donor and for causing corrosion of steel, was used in the current study. Four commonly used biocides in the oil and gas industry, namely tetrakis(hydroxymethyl) phosphonium sulfa...

journal_title：Scientific reports

authors： Sharma M,Liu H,Chen S,Cheng F,Voordouw G,Gieg L

更新日期：2018-11-09 00:00:00

abstract：:Affinity measure is a key factor that determines the quality of the analysis of a complex network. Here, we introduce a type of statistics, activation forces, to weight the links of a complex network and thereby develop a desired affinity measure. We show that the approach is superior in facilitating the analysis thro...

journal_title：Scientific reports

authors： Guo J,Guo H,Wang Z

更新日期：2011-01-01 00:00:00

abstract：:Angiogenin (hANG), a member of the Ribonuclease A superfamily has angiogenic, neurotrophic and neuroprotective activities. Mutations in hANG have been found in patients with Amyotrophic lateral sclerosis (ALS). The zebrafish (Danio rerio) rnasel-1, 2 and 3 are orthologues of hANG and of these only Rnasel-1 and Rnasel-...

journal_title：Scientific reports

authors： Ferguson R,Holloway DE,Chandrasekhar A,Acharya KR,Subramanian V

更新日期：2019-02-01 00:00:00

abstract：:Factor induced reprogramming of fibroblasts is an orchestrated but inefficient process. At the epigenetic level, it results in drastic chromatin changes to erase the existing somatic "memory" and to establish the pluripotent state. Accordingly, alterations of chromatin regulators including Ezh2 influence iPSC generati...

journal_title：Scientific reports

authors： Rao RA,Dhele N,Cheemadan S,Ketkar A,Jayandharan GR,Palakodeti D,Rampalli S

更新日期：2015-02-04 00:00:00

abstract：:C-phycocyanin (C-PC) pigment, as a natural blue dye, has particular applications in various fields. It is a water-soluble protein which has anticancer, antioxidant and anti-inflammatory properties. Here, we introduce an efficient procedure for the purification of C-PC pigment, followed by conducting a comprehensive in...

journal_title：Scientific reports

authors： Safaei M,Maleki H,Soleimanpour H,Norouzy A,Zahiri HS,Vali H,Noghabi KA

更新日期：2019-07-01 00:00:00

abstract：:The primary motor cortex (M1) is highly influenced by premotor/motor areas both within and across hemispheres. Dual site transcranial magnetic stimulation (dsTMS) has revealed interhemispheric interactions mainly at early latencies. Here, we used dsTMS to systematically investigate long-latency causal interactions bet...

journal_title：Scientific reports

authors： Fiori F,Chiappini E,Candidi M,Romei V,Borgomaneri S,Avenanti A

更新日期：2017-11-02 00:00:00

abstract：:Invasive Salmonella diseases, both typhoid and invasive non-typhoidal Salmonella (iNTS), are seasonal bloodstream infections causing important morbidity and mortality globally in Africa. The reservoirs and transmission of both are not fully understood. We hypothesised that differences in the time-lagged relationships ...

journal_title：Scientific reports

authors： Thindwa D,Chipeta MG,Henrion MYR,Gordon MA

更新日期：2019-12-30 00:00:00

abstract：:The loss of retinal pericytes (RPCs) is a hallmark of early stage diabetic retinopathy (DR), but the mechanism underlying RPC death is unclear. Although it was postulated in previous studies using bovine RPCs that autoantibodies against RPCs might develop and induce RPC death, it is unknown whether autoantibodies agai...

journal_title：Scientific reports

authors： Zhang L,Li Y,Payne J,Srivastava S,Fan X,Fung J,Li X,Kern TS,Lin F

更新日期：2016-02-03 00:00:00

abstract：:Odors elicit complex patterns of activated olfactory sensory neurons. Knowing the complete olfactome, i.e. the responses in all sensory neurons for all relevant odorants, is desirable to understand olfactory coding. The DoOR project combines all available Drosophila odorant response data into a single consensus respon...

journal_title：Scientific reports

authors： Münch D,Galizia CG

更新日期：2016-02-25 00:00:00

abstract：:Bacterial pneumonia is a major cause of acute lung injury and acute respiratory distress syndrome, characterized by alveolar barrier disruption. NLRP3 is best known for its ability to form inflammasomes and to regulate IL-1β and IL-18 production in myeloid cells. Here we show that NLRP3 protects the integrity of the a...

journal_title：Scientific reports

authors： Kostadinova E,Chaput C,Gutbier B,Lippmann J,Sander LE,Mitchell TJ,Suttorp N,Witzenrath M,Opitz B

更新日期：2016-08-01 00:00:00

abstract：:The family of materials defined as ZrSiX (X = S, Se, Te) has been established as Dirac node-line semimetals, and subsequent study is urgent to exploit the promising applications of unusual magnetoresistance (MR) properties. Herein, we systematically investigated the anisotropic MR in the newly-discovered Dirac node-li...

journal_title：Scientific reports

authors： Pan H,Tong B,Yu J,Wang J,Fu D,Zhang S,Wu B,Wan X,Zhang C,Wang X,Song F

更新日期：2018-06-19 00:00:00

abstract：:A number of studies have shown that visible and near infrared spectroscopy (VIS-NIRS) offers a rapid on-site measurement tool for the determination of total contaminant concentration of petroleum hydrocarbons compounds (PHC), heavy metals and metalloids (HM) in soil. However none of them have yet assessed the feasibil...

journal_title：Scientific reports

authors： Cipullo S,Nawar S,Mouazen AM,Campo-Moreno P,Coulon F

更新日期：2019-03-14 00:00:00

abstract：:CD4+latency-associated peptide (LAP)+ T cells are a newly discovered T cell subset with suppressive function on immune responses. In this study, we investigate the role of CD4+LAP+ T cells on mice corneal allograft survival by down-regulating their expression using anti-LAP mAb. We show that a blockage of LAP leads to...

journal_title：Scientific reports

authors： Li S,Lu H,Sella R,Zhang W,Dong H,Guo C,Afshari NA,Pan Z,Jie Y

更新日期：2018-05-22 00:00:00

abstract：:Mutations in the Norrin (NDP) gene cause severe developmental blood vessel defects in the retina leading to congenital blindness. In the retina of Ndph-knockout mice only the superficial capillary network develops. Here, a detailed characterization of this mouse model at late stages of the disease using in vivo retina...

journal_title：Scientific reports

authors： Beck SC,Karlstetter M,Garcia Garrido M,Feng Y,Dannhausen K,Mühlfriedel R,Sothilingam V,Seebauer B,Berger W,Hammes HP,Seeliger MW,Langmann T

更新日期：2018-04-13 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Blanco Alvarez S,Brisbois J,Melinte S,Kramer RBG,Silhanek AV

更新日期：2020-02-27 00:00:00

abstract：:The fishery for Antarctic krill is currently managed using a precautionary, ecosystem-based approach to limiting catch, with performance indices from a long-term monitoring program focused on several krill-dependent predators that are used to track ecosystem health. Concerns over increased fishing in concentrated area...

journal_title：Scientific reports

authors： Lowther AD,Staniland I,Lydersen C,Kovacs KM

更新日期：2020-10-28 00:00:00

abstract：:The yield of pepper plants (Capsicum spp.) is their most important trait and is affected by the flower number and flowering time. Capsicum annuum produces a single flower per node and has an early flowering habit. By contrast, Capsicum chinense yields multiple flowers per node and has a late flowering character. Howev...

journal_title：Scientific reports

authors： Zhu Z,Sun B,Wei J,Cai W,Huang Z,Chen C,Cao B,Chen G,Lei J

更新日期：2019-01-31 00:00:00

abstract：:Functional brain connectivity is altered during the pathological processes of Alzheimer's disease (AD), but the specific evolutional rules are insufficiently understood. Resting-state functional magnetic resonance imaging indicates that the functional brain networks of individuals with AD tend to be disrupted in hub-l...

journal_title：Scientific reports

authors： Li W,Wang M,Zhu W,Qin Y,Huang Y,Chen X

更新日期：2016-09-28 00:00:00

abstract：:β-lactam antibiotics act as suicide substrates of transpeptidases responsible for the last cross-linking step of peptidoglycan synthesis in the bacterial cell wall. Nucleophilic attack of the β-lactam carbonyl by the catalytic residue (Ser or Cys) of transpeptidases results in the opening of the β-lactam ring and in t...

journal_title：Scientific reports

authors： Edoo Z,Arthur M,Hugonnet JE

更新日期：2017-08-22 00:00:00

abstract：:Stimulation with lipopolysaccharide (LPS; endotoxin) not only causes rapid production of proinflammatory cytokines, but also induces a state of LPS hypo-responsiveness to a second LPS stimulation (endotoxin tolerance (ET)). Murine bone marrow-derived MCs (BMMCs) and peritoneal MCs (PMCs) developed ET as shown by an ab...

journal_title：Scientific reports

authors： Poplutz M,Levikova M,Lüscher-Firzlaff J,Lesina M,Algül H,Lüscher B,Huber M

更新日期：2017-07-03 00:00:00

abstract：:Skin burns are a significant source of injury in both military and civilian sectors. They are especially problematic in low resource environments where non-fatal injuries can lead to high morbidity rates, prolonged hospitalization, and disability. These multifaceted wounds can be highly complex and must be quickly dia...

journal_title：Scientific reports

authors： Nguyen JQ,Marks HL,Everett T,Haire T,Carlsson A,Chan R,Evans CL

更新日期：2020-06-09 00:00:00

abstract：:The simplest and most commonly used acoustic levitator is comprised of a transmitter and an opposing reflecting surface. This type of device, however, is only able to levitate objects along one direction, at distances multiple of half of a wavelength. In this work, we show how a customised reflective acoustic metamate...

journal_title：Scientific reports

authors： Polychronopoulos S,Memoli G

更新日期：2020-03-06 00:00:00

abstract：:Endothelin-B receptor agonist, IRL-1620, provides significant neuroprotection following cerebral ischemia in rats. Whether this neuroprotection is due to inhibition of apoptosis is unknown. IRL-1620-treated rats following permanent middle cerebral artery occlusion (MCAO) showed significant improvement in neurological ...

journal_title：Scientific reports

authors： Briyal S,Ranjan AK,Hornick MG,Puppala AK,Luu T,Gulati A

更新日期：2019-07-18 00:00:00

abstract：:Materials with a layered structure have attracted tremendous attention because of their unique properties. The ultrathin nanosheet structure can result in extremely rapid intercalation/de-intercalation of Na ions in the charge-discharge progress. Herein, we report a manganese oxide with pre-intercalated K and Na ions ...

journal_title：Scientific reports

authors： Feng M,Du Q,Su L,Zhang G,Wang G,Ma Z,Gao W,Qin X,Shao G

更新日期：2017-05-22 00:00:00

abstract：:Understanding the complex dynamics of cardio-respiratory coupling sheds light on the underlying mechanisms governing the communication between these two physiological systems. Previous research has predominantly considered the coupling at respiratory rates slower than the heart rate and shown that respiratory oscillat...

journal_title：Scientific reports

authors： Perry S,Khovanova NA,Khovanov IA

更新日期：2019-02-07 00:00:00

abstract：:Bacteria are able to de-epoxidize or epimerize deoxynivalenol (DON), a mycotoxin, to deepoxy-deoxynivalenol (deepoxy-DON or DOM-1) or 3-epi-deoxynivalenol (3-epi-DON), respectively. Using different approaches, the intestinal toxicity of 3 molecules was compared and the molecular basis for the reduced toxicity investig...

journal_title：Scientific reports

authors： Pierron A,Mimoun S,Murate LS,Loiseau N,Lippi Y,Bracarense AP,Schatzmayr G,He JW,Zhou T,Moll WD,Oswald IP

更新日期：2016-07-06 00:00:00