Abstract:
:The use of cardiac troponins (cTn) is the gold standard for diagnosing myocardial infarction. Independent of myocardial infarction (MI), however, sex, age and kidney function affect cTn levels. Here we developed a method to adjust cTnI levels for age, sex, and renal function, maintaining a unified cut-off value such as the 99th percentile. A total of 4587 individuals enrolled in a prospective longitudinal study were used to develop a model for adjustment of cTn. cTnI levels correlated with age and estimated glomerular filtration rate (eGFR) in males/females with rage = 0.436/0.518 and with reGFR = -0.142/-0.207. For adjustment, these variables served as covariates in a linear regression model with cTnI as dependent variable. This adjustment model was then applied to a real-world cohort of 1789 patients with suspected acute MI (AMI) (N = 407). Adjusting cTnI showed no relevant loss of diagnostic information, as evidenced by comparable areas under the receiver operator characteristic curves, to identify AMI in males and females for adjusted and unadjusted cTnI. In specific patients groups such as in elderly females, adjusting cTnI improved specificity for AMI compared with unadjusted cTnI. Specificity was also improved in patients with renal dysfunction by using the adjusted cTnI values. Thus, the adjustments improved the diagnostic ability of cTnI to identify AMI in elderly patients and in patients with renal dysfunction. Interpretation of cTnI values in complex emergency cases is facilitated by our method, which maintains a single diagnostic cut-off value in all patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Boeckel JN,Palapies L,Klotsche J,Zeller T,von Jeinsen B,Perret MF,Kleinhaus SL,Pieper L,Tzikas S,Leistner D,Bickel C,Stalla GK,Lehnert H,Lindahl B,Wittchen HU,Silber S,Baldus S,Maerz W,Dimmeler S,Blankenberg S,Mündoi
10.1038/s41598-018-26120-1subject
Has Abstractpub_date
2018-05-24 00:00:00pages
8087issue
1issn
2045-2322pii
10.1038/s41598-018-26120-1journal_volume
8pub_type
杂志文章abstract::DNA methylation is an important epigenetic mark that regulates gene expression. Dnmt1 plays an important role in maintaining DNA methylation patterns on daughter DNA strands. Studies have shed light into the functional role of Dnmt1 regulation in the hematopoietic and epidermal systems. Here we show that Dnmt1 is requ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35355
更新日期:2016-10-18 00:00:00
abstract::Metagenomics brings in new discoveries and insights into the uncultured microbial world. One fundamental task in metagenomics analysis is to determine the taxonomy of raw sequence fragments. Modern sequencing technologies produce relatively short fragments and greatly increase the number of fragments, and thus make th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09947-y
更新日期:2017-08-25 00:00:00
abstract::Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive immune-mediated joint deterioration. Current treatments are not antigen specific and are associated with various adverse. We have previously demonstrated that tolerogenic dendritic cells (Tol-DC) are potent antigen-specific immune regulato...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43188
更新日期:2017-02-23 00:00:00
abstract::In situ reduction of selenite to elemental selenium (Se(0)), by microorganisms in sediments and soils is an important process and greatly affects the environmental distribution and the biological effects of selenium. However, the mechanism behind such a biological process remains unrevealed yet. Here we use Shewanella...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03735
更新日期:2014-01-17 00:00:00
abstract::In clinical diagnostics and pathogen detection, profiling of complex samples for low-level genotypes represents a significant challenge. Advances in speed, sensitivity, and extent of multiplexing of molecular pathogen detection assays are needed to improve patient care. We report the development of an integrated platf...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42326
更新日期:2017-02-08 00:00:00
abstract::Patients with dengue virus (DENV) infection may also present acute viral encephalitis through an unknown mechanism. Here, we report that encephalitic DENV-infected mice exhibited progressive hunchback posture, limbic seizures, limbic weakness, paralysis, and lethality 7 days post-infection. These symptoms were accompa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27670
更新日期:2016-06-09 00:00:00
abstract::Increased evidence suggests that dysregulation of cholesterol metabolism may be a key event contributing to progression of multiple sclerosis (MS). Using an experimental autoimmune encephalomyelitis (EAE) model of MS we revealed specific changes in the mRNA and protein expression of key molecules involved in the maint...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02638-8
更新日期:2017-06-02 00:00:00
abstract::Protein kinases are frequently mutated in human cancers, which leads to altered signaling pathways and contributes to tumor growth and progression. ERK3 is an atypical mitogen-activated protein kinase (MAPK) containing an S-E-G activation motif rather than the conserved T-X-Y motif in conventional MAPKs such as ERK1/2...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15135-9
更新日期:2017-11-03 00:00:00
abstract::Liquids exhibit a sudden increase in viscosity when cooled fast enough, avoiding thermodynamically predicted route of crystallization. This phenomenon, known as glass transition, leads to the formation of non-periodic structures known as glasses. Extensive studies have been conducted on model materials to understand g...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41231-z
更新日期:2019-03-14 00:00:00
abstract::The paper presents the procedure for planning an experiment to create standard sets of reagents for a technetium-99m generator based on glucose derivatives. All stages are presented from researching the required quantities of a substance, a reducing agent, a stabilizer and auxiliary components to developing lyophilize...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61707-7
更新日期:2020-03-20 00:00:00
abstract::In the field of correlative microscopy, light and electron microscopy form a powerful combination for morphological analyses in zoology. Due to sample thickness limitations, these imaging techniques often require sectioning to investigate small animals and thereby suffer from various artefacts. A recently introduced n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60977-5
更新日期:2020-03-03 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-30644-x
更新日期:2018-08-09 00:00:00
abstract::The recombination is one of the most frequently identified drivers of double-stranded DNA viruses evolution. However, the recombination events in African swine fever virus (ASFV) genomes have been poorly annotated. We hypothesize that the genetic determinants of ASFV variability are potential hot-spots for recombinati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75377-y
更新日期:2020-10-28 00:00:00
abstract::Aldosterone antagonists slow the progression of chronic kidney disease (CKD), but their use is limited by hyperkalemia, especially when associated with RAS inhibitors. We examined the renoprotective effects of Ly, a novel non-steroidal mineralocorticoid receptor (MR) blocker, through two experimental protocols: In Pro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08383-2
更新日期:2017-08-11 00:00:00
abstract::While the glass transition at non-zero temperature seems to be hard to access for experimental, theoretical, or simulation studies, jamming at zero temperature has been studied in great detail. Motivated by the exploration of the energy landscape that has been successfully used to investigate athermal jamming, we intr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20152-3
更新日期:2018-01-30 00:00:00
abstract::Colorectal cancer (CRC) is one of the most prevalent cancers worldwide and Alpha B-crystallin (CRYAB) protein has been identified as a prognostic biomarker for CRC. We evaluated CRYAB C-802G (rs14133)polymorphism in association with CRC risk and survival in Chinese population. We genotyped for CRYAB C-802G (rs14133), ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29589-y
更新日期:2018-08-06 00:00:00
abstract::The ability to harvest thermal energy and manipulate heat fluxes has recently attracted a great deal of research interest because this is critical to achieve efficient solar-to-thermal energy conversion in the technology of concentrated solar thermal collectors. Thermal metamaterials with engineered thermal conduction...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11552
更新日期:2015-06-25 00:00:00
abstract::Antimicrobial peptides (AMPs) exhibit broad-spectrum antimicrobial activity, and have promise as new therapeutic agents. While the adult North American bullfrog (Rana [Lithobates] catesbeiana) is a prolific source of high-potency AMPs, the aquatic tadpole represents a relatively untapped source for new AMP discovery. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38442-1
更新日期:2019-02-06 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-46785-6
更新日期:2019-07-17 00:00:00
abstract::Obesity causes a wide range of systemic diseases and is associated with mood and anxiety disorders. It is also associated with dopaminergic reward system function. However, the relationships between microstructural properties of the dopaminergic system and body mass index (BMI) have not been investigated. In this stud...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69438-5
更新日期:2020-07-28 00:00:00
abstract::Accidental transmission of prions during neurosurgery has been reported as a consequence of re-using contaminated surgical instruments. Several decontamination methods have been studied using the 263K-hamster prion; however, no studies have directly evaluated human prions. A newly developed in vitro amplification syst...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24993
更新日期:2016-04-26 00:00:00
abstract::Nanomedicine development currently suffers from a lack of efficient tools to predict pharmacokinetic behavior without relying upon testing in large numbers of animals, impacting success rates and development costs. This work presents dendPoint, the first in silico model to predict the intravenous pharmacokinetics of d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51789-3
更新日期:2019-10-29 00:00:00
abstract::Hydraulic extended-reach limit (HERL) model of horizontal extended-reach well (ERW) can predict the maximum measured depth (MMD) of the horizontal ERW. The HERL refers to the well's MMD when drilling fluid cannot be normally circulated by drilling pump. Previous model analyzed the following two constraint conditions, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03261-3
更新日期:2017-06-08 00:00:00
abstract::Malaria has steadily increased in the Peruvian Amazon over the last five years. This study aimed to determine the parasite prevalence and micro-geographical heterogeneity of Plasmodium vivax parasitaemia in communities of the Peruvian Amazon. Four cross-sectional active case detection surveys were conducted between Ma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07818-0
更新日期:2017-08-14 00:00:00
abstract::The aim was to assess the cognitive dysfunction and physical disability after autologous hematopoietic stem cell transplantation (AHSCT), to explore the potential factors influencing disability regression after AHSCT and to estimate the safety of low-dose immunosuppressive therapy in highly active Multiple Sclerosis (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78160-1
更新日期:2020-12-04 00:00:00
abstract::We investigated the association between impulsivity related traits and BMI at the observational and genetic epidemiology level in a cross-sectional population of healthy young American-European adults. We studied 998 students and university staff of European ancestry recruited from Chicago (Illinois) and Athens (Georg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53922-8
更新日期:2019-11-26 00:00:00
abstract::The simplest and most commonly used acoustic levitator is comprised of a transmitter and an opposing reflecting surface. This type of device, however, is only able to levitate objects along one direction, at distances multiple of half of a wavelength. In this work, we show how a customised reflective acoustic metamate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60978-4
更新日期:2020-03-06 00:00:00
abstract::PAP80-2a, purified from Pholiota adiposa mycelia, is a polysaccharide exhibiting prominent antitumor effects. However, the yield of PAP80-2a was low and its structure has not been characterized, impeding the exploration of its structure-function relationship, thus influencing the development of oral drugs for antitumo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38251-6
更新日期:2019-02-11 00:00:00
abstract::In the study, we analyzed role of p53 in predicting outcome in visceral metastasis breast cancer (VMBC) patients. 97 consecutive VMBC patients were studied. P53 positivity rate was 29.9%. In the p53-negative group, median disease free survival (DFS), and time from primary breast cancer diagnosis to death (OS1), time f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02246
更新日期:2013-01-01 00:00:00
abstract::Ultrasonic mating signals in moths are argued to have evolved via exploitation of the receivers' sensory bias towards bat echolocation calls. We have demonstrated that female moths of the Asian corn borer are unable to distinguish between the male courtship song and bat calls. Females react to both the male song and b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02003
更新日期:2013-01-01 00:00:00