Abstract:
:The paper presents the procedure for planning an experiment to create standard sets of reagents for a technetium-99m generator based on glucose derivatives. All stages are presented from researching the required quantities of a substance, a reducing agent, a stabilizer and auxiliary components to developing lyophilized kits and conducting quality control. The radiochemical purity of radiopharmaceuticals prepared on the basis of the developed kits ranged from 90.0 to 99.0%. We also showed the functional suitability of the developed preparations on C57B1/6j mice with an implanted malignant tumor - Lewis lung carcinoma.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Stasyuk E,Sкuridin V,Rogov A,Zelchan R,Sadkin V,Varlamova N,Nestеrov Edoi
10.1038/s41598-020-61707-7subject
Has Abstractpub_date
2020-03-20 00:00:00pages
5121issue
1issn
2045-2322pii
10.1038/s41598-020-61707-7journal_volume
10pub_type
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