99mTc-labeled monosaccharide kits: development methods and quality control.

Abstract:

:The paper presents the procedure for planning an experiment to create standard sets of reagents for a technetium-99m generator based on glucose derivatives. All stages are presented from researching the required quantities of a substance, a reducing agent, a stabilizer and auxiliary components to developing lyophilized kits and conducting quality control. The radiochemical purity of radiopharmaceuticals prepared on the basis of the developed kits ranged from 90.0 to 99.0%. We also showed the functional suitability of the developed preparations on C57B1/6j mice with an implanted malignant tumor - Lewis lung carcinoma.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Stasyuk E,Sкuridin V,Rogov A,Zelchan R,Sadkin V,Varlamova N,Nestеrov E

doi

10.1038/s41598-020-61707-7

subject

Has Abstract

pub_date

2020-03-20 00:00:00

pages

5121

issue

1

issn

2045-2322

pii

10.1038/s41598-020-61707-7

journal_volume

10

pub_type

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