Abstract：
:Our previous studies have shown that sulbactam can play a neuroprotection role in hippocampal neurons by upregulating the expression and function of glial glutamate transporter-1 (GLT-1) during ischemic insult. Here, using rat global cerebral ischemia model, we studied in vivo the role of p38 mitogen-activated protein kinases (MAPK) in the sulbactam-induced GLT-1 upregulation and neuroprotection against ischemia. The hippocampal CA1 field was selected as observing target. The expressions of phosphorylated-p38 MAPK and GLT-1 were assayed with western blot analysis and immunohistochemistry. The condition of delayed neuronal death (DND) was assayed with neuropathological evaluation under thionin staining. It was shown that administration of sulbactam protected CA1 hippocampal neurons against ischemic insult accompanied with significantly upregulation in the expressions of phosphorylated-p38 MAPK and GLT-1. The time course analysis showed that sulbactam activated p38 MAPK before the GLT-1 upregulation in either normal or global cerebral ischemic rats. Furthermore, inhibiting p38 MAPK activation by SB203580 blocked the GLT-1 upregulation and neuroprotection induced by sulbactam. The above results suggested that p38 MAPK, at least partly, participated in the sulbactam-induced brain tolerance to ischemia mediated by GLT-1 upregulation in rats.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Xian XH,Gao JX,Qi J,Fan SJ,Zhang M,Li WBdoi
10.1038/s41598-020-77583-0subject
Has Abstractpub_date
2020-11-26 00:00:00pages
20601issue
1issn
2045-2322pii
10.1038/s41598-020-77583-0journal_volume
10pub_type
杂志文章abstract：:In this paper, the composition, structure, morphology and kinetics of evolution during isothermal oxidation of Fe48Cr15Mo14Y2C15B6 metallic glass powder in the supercooled region are investigated by an integrated ex-situ and in-situ characterization and modelling approach. Raman and X-ray diffraction spectra establish...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43317-0
更新日期：2019-05-02 00:00:00
abstract：:Transforming growth factor-β (TGF-β) signaling plays a key role in progression and metastasis of HCC. This study was undertaken to gain the proof of concept of a small-molecule inhibitor of TGF-β type I receptor kinase, EW-7197 as a potent anti-cancer therapy for HCC. We identified tissue inhibitors of metalloproteina...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16492
更新日期：2015-11-09 00:00:00
abstract：:Ultraviolet (UV) B radiation is a dangerous environmental stressor, which can lead to photoaging, inflammation, immune suppression and tumour formation. A recent report has shown the transcriptional activation of several skin-specific genes including matrix metalloproteases (MMPs) in response to UV irradiation. Here, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20999-6
更新日期：2018-02-08 00:00:00
abstract：:We examined the associations of age and serum magnesium, iron, lead, copper, and zinc levels with bone mineral density (BMD) in 2412 children under 3 years of age in order to find a tool to monitor BMD in children without the use of expensive imaging techniques. One-way ANOVA and chi-square tests were used to determin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81501-3
更新日期：2021-01-21 00:00:00
abstract：:The concept of brain circuit disorders has been proposed for a variety of neuropsychiatric diseases, characterized by pathological disturbances of neuronal networks including changes in oscillatory signaling of re-entrant cortico-subcortical loops in the basal ganglia system. Parts of this circuitry play a pivotal rol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15872-x
更新日期：2017-11-14 00:00:00
abstract：:Neonates are more susceptible to infections than adults. This susceptibility is thought to reflect neonates' qualitative and quantitative defects in the adaptive and innate immune responses. Differential expression of cell surface receptors may result in altered thresholds of neonatal immune cell activation. We determ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32693
更新日期：2016-09-06 00:00:00
abstract：:We study a minimal model of the stress-driven p53 regulatory network that includes competition between active and mutant forms of the tumor-suppressor gene p53. Depending on the nature and level of the external stress signal, four distinct dynamical states of p53 are observed. These states can be distinguished by diff...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82054-1
更新日期：2021-01-27 00:00:00
abstract：:Lytic bacteriophages are valuable therapeutic agents against bacterial infections. There is continual effort to obtain new phages to increase the effectivity of phage preparations against emerging phage-resistant strains. Here we described the genomic diversity of spontaneous host-range mutants of kayvirus 812. Five m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41868-w
更新日期：2019-04-02 00:00:00
abstract：:We utilized several computational approaches to evaluate the binding energies of tyrosine (Tyr) and several unnatural Tyr analogs, to several orthogonal aaRSes derived from Methanocaldococcus jannaschii and Escherichia coli tyrosyl-tRNA synthetases. The present study reveals the following: (1) AutoDock Vina and ROSETT...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12632
更新日期：2015-07-29 00:00:00
abstract：:Peatland ecosystem services include drinking water provision, flood mitigation, habitat provision and carbon sequestration. Dissolved organic carbon (DOC) removal is a key treatment process for the supply of potable water downstream from peat-dominated catchments. A transition from peat-forming Sphagnum moss to vascul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36751
更新日期：2016-11-18 00:00:00
abstract：:Coupled networks are extremely fragile because a node failure of a network would trigger a cascade of failures on the entire system. Existing studies mainly focused on the cascading failures and the robustness of coupled networks when the networks suffer from attacks. In reality, it is necessary to recover the damaged...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08439
更新日期：2015-02-13 00:00:00
abstract：:X-ray free-electron lasers (XFELs) provide extremely bright and highly spatially coherent x-ray radiation with femtosecond pulse duration. Currently, they are widely used in biology and material science. Knowledge of the XFEL statistical properties during an experiment may be vitally important for the accurate interpr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19793-1
更新日期：2018-02-02 00:00:00
abstract：:The extracellular matrix (ECM) is a highly dynamic network constantly remodeled by a fine-tuned protein formation and degradation balance. Matrix metalloproteinases (MMPs) constitute key orchestrators of ECM degradation. Their activity is controlled by tissue inhibitors of metalloproteinases (TIMPs) and glycosaminogly...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41355-2
更新日期：2019-03-20 00:00:00
abstract：:Herbicides are the most commonly used means of controlling weeds. Recently, there has been growing concern over the potential impacts of global climate change, specifically, increasing temperatures and elevated carbon dioxide (CO2) concentrations, on the sensitivity of weeds to herbicides. Here, glyphosate response of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38729-x
更新日期：2019-02-18 00:00:00
abstract：:Sufficient tissue oxygenation is required for regular brain function; thus oxygen supply must be tightly regulated to avoid hypoxia and irreversible cell damage. If hypoxia occurs the transcription factor complex hypoxia-inducible factor (HIF) will accumulate and coordinate adaptation of cells to hypoxia. However, eve...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75838-4
更新日期：2020-11-05 00:00:00
abstract：:We have observed that one in three patients admitted to the Neurological Rehabilitation Ward for Children and Adolescents due to a syndrome or disease associated with neurodysfunction is short of stature for their age. In order to identify the relationship between growth defects (short stature) and syndromes or diseas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52918-8
更新日期：2019-11-11 00:00:00
abstract：:The generation of novelty is central to any creative endeavor. Novelty generation and the relationship between novelty and individual hedonic value have long been subjects of study in social psychology. However, few studies have utilized large-scale datasets to quantitatively investigate these issues. Here we consider...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02758
更新日期：2013-09-26 00:00:00
abstract：:ERF transcription factors play critical roles in plant immune responses. Here, we report the function of AtERF014, a nucleus-localized transcriptional activator, in Arabidopsis immunity. Expression of AtERF014 was induced by Pseudomonas syringae pv. tomato (Pst) and Botrytis cinerea (Bc). AtERF014-overexpressing (OE) ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30251
更新日期：2016-07-22 00:00:00
abstract：:Gait is an important health indicator and poor gait is strongly associated with disability and risk of falls. Thyroid dysfunction is suggested as a potential determinant of gait deterioration, but this has not been explored in a population-based study. We therefore investigated the association of thyroid function with...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep38912
更新日期：2016-12-14 00:00:00
abstract：:Flexible energy storage devices are highly demanded for various applications. Carbon cloth (CC) woven by carbon fibers (CFs) is typically used as electrode or current collector for flexible devices. The low surface area of CC and the presence of big gaps (ca. micro-size) between individual CFs lead to poor performance...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11792
更新日期：2015-07-07 00:00:00
abstract：:The architecture of the genome influences the functions of DNA from bacteria to eukaryotes. Intrinsically disordered regions (IDR) of eukaryotic histones have pivotal roles in various processes of gene expression. IDR is rare in bacteria, but interestingly, mycobacteria produce a unique histone-like protein, MDP1 that...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26463-9
更新日期：2018-05-29 00:00:00
abstract：:The interplay between structure and function is critical in the understanding of complex systems, their dynamics and their behavior. We investigated the interplay between structural and functional networks by means of the differential identifiability framework, which here quantifies the ability of identifying a partic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71373-4
更新日期：2020-09-04 00:00:00
abstract：:Several zebrafish strains such as AB, Tübingen (TU), Wild India Kolkata (WIK) and Tupfel long fin (TL) have been established for genetic study. Each strain has its morphological and behavioral traits. Motor traits, however, have not been explored in zebrafish strains. We here applied a treadmill for fish (swimmill) an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52592-w
更新日期：2019-11-08 00:00:00
abstract：:Huntington's disease (HD) is a progressive and fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Although HD is monogenic, its molecular manifestation appears highly complex and involves multiple cellular processes. The recent application of high throughput platforms such as mic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05224-0
更新日期：2017-07-12 00:00:00
abstract：:Kaposis's sarcoma associated herpesvirus (KSHV) has been reported to infect, among others, monocytes and dendritic cells DCs impairing their function. However, the underlying mechanisms remain not completely elucidated yet. Here we show that DC exposure to active or UV-inactivated KSHV resulted in STAT3 phosphorylatio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04241
更新日期：2014-02-28 00:00:00
abstract：:Better risk prediction and new molecular targets are key priorities in type 2 diabetes (T2D) research. Little is known about the role of the urine metabolome in predicting the risk of T2D. We aimed to use non-targeted urine metabolomics to discover biomarkers and improve risk prediction for T2D. Urine samples from two...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72456-y
更新日期：2020-10-05 00:00:00
abstract：:Perturbations in lipid metabolic pathways to meet the bioenergetic and biosynthetic requirements is a principal characteristic of cancer cells. Sphingolipids (SPLs) are the largest class of bioactive lipids associated to various aspects of tumorigenesis and have been extensively studied in cancer cell lines and experi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61283-w
更新日期：2020-03-13 00:00:00
abstract：:Several studies have investigated the association between polymorphisms in protamine 1 and 2 genes and male infertility risk, with inconsistent results to date. This meta-analysis based on the 13 published case-control studies, including 7350 cases and 6167 controls, was performed to further establish the potential as...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep15300
更新日期：2015-10-16 00:00:00
abstract：:Identifying vital nodes in complex networks is a critical problem in the field of network theory. To this end, the Collective. Influence (CI) algorithm has been introduced and shows high efficiency and scalability in searching for the influential nodes in. the optimal percolation model. However, the crucial part of th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32874-5
更新日期：2018-09-28 00:00:00
abstract：:Cohesins are vital for chromosome organisation during meiosis and mitosis. In addition to the important function in sister chromatid cohesion, these complexes play key roles in meiotic recombination, DSB repair, homologous chromosome pairing and segregation. Egg-laying mammals (monotremes) feature an unusually complex...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04560-5
更新日期：2017-06-26 00:00:00
