dendPoint: a web resource for dendrimer pharmacokinetics investigation and prediction.

abstract：:We studied whether in patients with stable COPD blood gases (BG), especially oxygenated hemoglobin (OxyHem) as a novel biomarker confer information on disease burden and prognosis and how this adds to the information provided by the comorbidity pattern and systemic inflammation. Data from 2137 patients (GOLD grades 1-...

journal_title：Scientific reports

authors： Trudzinski FC,Jörres RA,Alter P,Kahnert K,Waschki B,Herr C,Kellerer C,Omlor A,Vogelmeier CF,Fähndrich S,Watz H,Welte T,Jany B,Söhler S,Biertz F,Herth F,Kauczor HU,Bals R,COSYCONET consortium.

更新日期：2020-06-29 00:00:00

abstract：:The heterogeneity of metabolic reactions leads to a non-uniform distribution of temperature in different parts of the living cell. The demand to study normal functioning and pathological abnormalities of cellular processes requires the development of new visualization methods. Previously, we have shown that the 35-kDa...

journal_title：Scientific reports

authors： Maksimov EG,Yaroshevich IA,Tsoraev GV,Sluchanko NN,Slutskaya EA,Shamborant OG,Bobik TV,Friedrich T,Stepanov AV

更新日期：2019-06-20 00:00:00

abstract：:Unexpected reactor accidents and radioisotope production and consumption have led to a continuous increase in the global-scale contamination of radionuclides. In particular, anthropogenic radioiodine has become critical due to its highly volatile mobilization and recycling in global environments, resulting in widespre...

journal_title：Scientific reports

authors： Lee SY,Lee JY,Min JH,Kim SS,Baik MH,Chung SY,Lee M,Lee Y

更新日期：2016-06-17 00:00:00

abstract：:We aimed to investigate the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) in evaluating blunt abdominal trauma for patients presenting to the emergency department. Electronic search of Scopus and Pubmed was performed from inception to September 2016. Human studies investigating the diagnostic accuracy of ...

journal_title：Scientific reports

authors： Zhang Z,Hong Y,Liu N,Chen Y

更新日期：2017-06-30 00:00:00

abstract：:Tick-borne diseases are the most common vector-borne diseases in the United States, with serology being the primary method of diagnosis. We developed the first multiplex, array-based assay for serodiagnosis of tick-borne diseases called the TBD-Serochip. The TBD-Serochip was designed to discriminate antibody responses...

journal_title：Scientific reports

authors： Tokarz R,Mishra N,Tagliafierro T,Sameroff S,Caciula A,Chauhan L,Patel J,Sullivan E,Gucwa A,Fallon B,Golightly M,Molins C,Schriefer M,Marques A,Briese T,Lipkin WI

更新日期：2018-02-16 00:00:00

abstract：:Crystalline atomic layers on solid surfaces are composed of a single building block, unit cell, that is copied and stacked together to form the entire two-dimensional crystal structure. However, it appears that this is not an unique possibility. We report here on synthesis and characterization of the one-atomic-layer-...

journal_title：Scientific reports

authors： Gruznev DV,Bondarenko LV,Matetskiy AV,Mihalyuk AN,Tupchaya AY,Utas OA,Eremeev SV,Hsing CR,Chou JP,Wei CM,Zotov AV,Saranin AA

更新日期：2016-01-19 00:00:00

abstract：:This research utilized an external longitudinal dataset of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) to compare and validate various predictive models that support the current recommendations to select the most effective predictive risk models to estimate short- and long-term mortality and fa...

journal_title：Scientific reports

authors： Shen Y,Wang X,Zhang S,Qin G,Liu Y,Lu Y,Liang F,Zhuang X

更新日期：2016-09-16 00:00:00

abstract：:Topological quantum computation is a promising technique to achieve large-scale, error-corrected computation. Quantum hardware is used to create a large, 3-dimensional lattice of entangled qubits while performing computation requires strategic measurement in accordance with a topological circuit specification. The spe...

journal_title：Scientific reports

authors： Paler A,Devitt SJ,Nemoto K,Polian I

更新日期：2014-04-11 00:00:00

abstract：:The correlations between early responses and the variations in physical density and primary tumor volume (TV) according to cone-beam computed tomography (CBCT) during chemoradiotherapy for non-small cell lung cancer (NSCLC) patients were investigated. 54 patients with inoperable and locally advanced NSCLC were include...

journal_title：Scientific reports

authors： Wen Q,Zhu J,Meng X,Ma C,Bai T,Sun X,Yu J

更新日期：2017-11-07 00:00:00

abstract：:Metastasis of head and neck tumors is responsible for a high mortality rate. Understanding its biochemistry may allow insights into tumorigenesis. To that end we carried out RNA-Seq analyses of 5 SCC9 derived oral cancer cell lines displaying increased invasive potential. Differentially expressed genes (DEGs) were ann...

journal_title：Scientific reports

authors： Pérez-Valencia JA,Prosdocimi F,Cesari IM,da Costa IR,Furtado C,Agostini M,Rumjanek FD

更新日期：2018-01-31 00:00:00

abstract：:SLC7A10 (Asc-1) is a sodium-independent amino acid transporter known to facilitate transport of a number of amino acids including glycine, L-serine, L-alanine, and L-cysteine, as well as their D-enantiomers. It has been described as a neuronal transporter with a primary role related to modulation of excitatory glutama...

journal_title：Scientific reports

authors： Ehmsen JT,Liu Y,Wang Y,Paladugu N,Johnson AE,Rothstein JD,du Lac S,Mattson MP,Höke A

更新日期：2016-10-19 00:00:00

abstract：:Under the usual approximation of treating a biological particle as a spheroidal droplet, we consider the analysis of its size and shape with the high frequency photoacoustics and develop a numerical method which can simulate its characteristic photoacoustic waves. This numerical method is based on the calculation of s...

journal_title：Scientific reports

authors： Li Y,Fang H,Min C,Yuan X

更新日期：2015-10-07 00:00:00

abstract：:Cardiorenal syndrome is defined by primary heart failure conditions influencing or leading to renal injury or dysfunction. Dilated cardiomyopathy (DCM) is a major co-existing form of heart failure (HF) with renal diseases. Myocardin (MYOCD), a cardiac-specific co-activator of serum response factor (SRF), is increased ...

journal_title：Scientific reports

authors： Mittal A,Rana S,Sharma R,Kumar A,Prasad R,Raut SK,Sarkar S,Saikia UN,Bahl A,Dhandapany PS,Khullar M

更新日期：2019-04-10 00:00:00

abstract：:Working memory (WM) impairments in ADHD have been consistently reported along with deficits in attentional control. Yet, it is not clear which specific WM processes are affected in this condition. A deficient coupling between attention and WM has been reported. Nevertheless, most studies focus on the capacity to retai...

journal_title：Scientific reports

authors： Ortega R,López V,Carrasco X,Escobar MJ,García AM,Parra MA,Aboitiz F

更新日期：2020-05-08 00:00:00

abstract：:MicroRNAs (miRNAs) are short noncoding RNAs derived from the 3' and 5' ends of the same precursor. However, the biological function and mechanism of miRNA arm expression preference remain unclear in breast cancer. We found significant decreases in the expression levels of miR-193a-5p but no significant differences in ...

journal_title：Scientific reports

authors： Tsai KW,Leung CM,Lo YH,Chen TW,Chan WC,Yu SY,Tu YT,Lam HC,Li SC,Ger LP,Liu WS,Chang HT

更新日期：2016-06-16 00:00:00

abstract：:Ruminants obtain nutrients from microbial fermentation of plant material, primarily in their rumen, a multilayered forestomach. How the different layers of the rumen wall respond to diet and influence microbial fermentation, and how these process are regulated, is not well understood. Gene expression correlation netwo...

journal_title：Scientific reports

authors： Xiang R,McNally J,Rowe S,Jonker A,Pinares-Patino CS,Oddy VH,Vercoe PE,McEwan JC,Dalrymple BP

更新日期：2016-12-14 00:00:00

abstract：:rag1 -/- zebrafish have been employed in immunological research as a useful immunodeficient vertebrate model, but with only fragmentary evidence for the lack of functional adaptive immunity. rag1-null zebrafish exhibit differences from their human and murine counterparts in that they can be maintained without any spec...

journal_title：Scientific reports

authors： Tokunaga Y,Shirouzu M,Sugahara R,Yoshiura Y,Kiryu I,Ototake M,Nagasawa T,Somamoto T,Nakao M

更新日期：2017-08-08 00:00:00

abstract：:Blockage of pores by particles is found in many processes, including filtration and oil extraction. We present filtration experiments through a linear array of ten channels with one dimension which is sub-micron, through which a dilute dispersion of Brownian polystyrene spheres flows under the action of a fixed pressu...

journal_title：Scientific reports

authors： Liot O,Singh A,Bacchin P,Duru P,Morris JF,Joseph P

更新日期：2018-08-20 00:00:00

abstract：:We have employed a model system, inspired by SNARE proteins, to facilitate membrane fusion between Giant Unilamellar Vesicles (GUVs) and Large Unilamellar Vesicles (LUVs) under physiological conditions. In this system, two synthetic lipopeptide constructs comprising the coiled-coil heterodimer-forming peptides K4, (KI...

journal_title：Scientific reports

authors： Mora NL,Boyle AL,Kolck BJV,Rossen A,Pokorná Š,Koukalová A,Šachl R,Hof M,Kros A

更新日期：2020-02-20 00:00:00

abstract：:Mitochondria-generated reactive oxygen species (mROS) are frequently associated with DNA damage and cell cycle arrest, but physiological increases in mROS serve to regulate specific cell functions. T3 is a major regulator of mROS, including hydrogen peroxide (H2O2). Here we show that exogenous thyroid hormone (T3) adm...

journal_title：Scientific reports

authors： Tan L,Bogush N,Naib H,Perry J,Calvert JW,Martin DIK,Graham RM,Naqvi N,Husain A

更新日期：2019-11-27 00:00:00

abstract：:Interaction between the epithelium and mesenchyme coordinates patterning and differentiation of oral cavity structures including teeth, palatal rugae and tongue papillae. SHH is one of the key signaling molecules for this interaction. Epithelial expression of Shh in the tooth buds and tongue papillae is regulated by a...

journal_title：Scientific reports

authors： Sagai T,Amano T,Maeno A,Kiyonari H,Seo H,Cho SW,Shiroishi T

更新日期：2017-10-11 00:00:00

abstract：:Using species distribution models and information on genetic structure and within-population variance observed in a series of common garden trials, we reconstructed a historical biogeography of trembling aspen in North America. We used an ensemble classifier modelling approach (RandomForest) to reconstruct palaeoclima...

journal_title：Scientific reports

authors： Ding C,Schreiber SG,Roberts DR,Hamann A,Brouard JS

更新日期：2017-07-05 00:00:00

abstract：:Organisms possess multiple DNA polymerases (Pols) and use each for a different purpose. One of the five Pols in Escherichia coli, DNA polymerase IV (Pol IV), encoded by the dinB gene, is known to participate in lesion bypass at certain DNA adducts. To understand how cells choose Pols when the replication fork encounte...

journal_title：Scientific reports

authors： Le TT,Furukohri A,Tatsumi-Akiyama M,Maki H

更新日期：2017-10-16 00:00:00

abstract：:The proton exchange membrane fuel cells are the promising sustainable energy sources. The present study focuses on the enhancement the fuel cell performance and the protection of the stainless steel bipolar plate from the corrosion using polyaniline/Zn-Porphyrin composites coatings. The electrochemical properties (pol...

journal_title：Scientific reports

authors： Deyab MA,Mele G

更新日期：2020-02-24 00:00:00

abstract：:The objective of this study was to determine if Ihh is required for fracture healing. Fibular fracture was created in adult Col2a1-CreERT2; Ihhfl/fl mice. Ihhfl/fl mice received Tamoxifen (TM) to delete Ihh. WT mice received Cyclopamine to inhibit Hh pathway. Callus tissue properties and Ihh pathway were analyzed at 1...

journal_title：Scientific reports

authors： Li S,Xiang C,Wei X,Li H,Li K,Sun X,Wang S,Zhang M,Deng J,Wang X,Li P,Li R,Zhang Y,Wei L

更新日期：2018-07-09 00:00:00

abstract：:Magma transport through the Earth's crust occurs dominantly via sheet intrusions, such as dykes and cone-sheets, and is fundamental to crustal evolution, volcanic eruptions and geochemical element cycling. However, reliable methods to reconstruct flow direction in solidified sheet intrusions have proved elusive. Aniso...

journal_title：Scientific reports

authors： Andersson M,Almqvist BS,Burchardt S,Troll VR,Malehmir A,Snowball I,Kübler L

更新日期：2016-06-10 00:00:00

abstract：:Radiotherapy can result in lung diseases pneumonitis or fibrosis dependent on patient susceptibility. Herein we used inbred and genetically altered mice to investigate whether the tissue adaptive immune response to radiation injury influences the development of radiation-induced lung disease. Six inbred mouse strains ...

journal_title：Scientific reports

authors： Paun A,Bergeron ME,Haston CK

更新日期：2017-09-14 00:00:00

abstract：:This study aimed to identify single nucleotide polymorphisms (SNPs) associated with milk cholesterol (CHL) content via a genome wide association study (GWAS). Milk CHL content was determined by gas chromatography and expressed as mg of CHL in 100 g of fat (CHL_fat) or in 100 mg of milk (CHL_milk). GWAS was performed w...

journal_title：Scientific reports

authors： Do DN,Schenkel FS,Miglior F,Zhao X,Ibeagha-Awemu EM

更新日期：2018-09-05 00:00:00

abstract：:Which factors are related to false negative results of the interferon-γ release assay (IGRA) is unclear. This systematic review described the risk factors associated with false negative IGRA results. Two authors independently identified studies designed to evaluate risk factors for false negative IGRA results from Pub...

journal_title：Scientific reports

authors： Yamasue M,Komiya K,Usagawa Y,Umeki K,Nureki SI,Ando M,Hiramatsu K,Nagai H,Kadota JI

更新日期：2020-01-31 00:00:00

abstract：:Identifying the vital nodes in networks is of great significance for understanding the function of nodes and the nature of networks. Many centrality indices, such as betweenness centrality (BC), eccentricity centrality (EC), closeness centricity (CC), structural holes (SH), degree centrality (DC), PageRank (PR) and ei...

journal_title：Scientific reports

authors： Xu X,Zhu C,Wang Q,Zhu X,Zhou Y

更新日期：2020-02-14 00:00:00