The impact of p53 in predicting clinical outcome of breast cancer patients with visceral metastasis.

abstract：:We consider the electromagnetic response of a topological Weyl semimetal (TWS) with a pair of Weyl nodes in the bulk and corresponding Fermi arcs in the surface Brillouin zone. We compute the frequency-dependent complex conductivities σαβ(ω) and also take into account the modification of Maxwell equations by the topol...

journal_title：Scientific reports

authors： Kargarian M,Randeria M,Trivedi N

更新日期：2015-08-03 00:00:00

abstract：:Cancer stem cells play an important role on tumor progression. Biomarkers of stem cell property and their relationship to extranodal involvement of malignant lymphocytes are undefined in diffuse large B-cell lymphoma (DLBCL). Here we showed that junctional adhesion molecule-A (JAM-A) was highly expressed in DLBCL pati...

journal_title：Scientific reports

authors： Xu PP,Sun YF,Fang Y,Song Q,Yan ZX,Chen Y,Jiang XF,Fei XC,Zhao Y,Leboeuf C,Li B,Wang CF,Janin A,Wang L,Zhao WL

更新日期：2017-08-07 00:00:00

abstract：:Orb2 is a functional amyloid that plays a key role in Drosophila long-term memory formation. Orb2 has two isoforms that differ in their N-termini. The N-terminus of the A isoform (Orb2A) that precedes its Q-rich prion-like domain has been shown to be important for Orb2 aggregation and long-term memory. However, beside...

journal_title：Scientific reports

authors： Cervantes SA,Bajakian TH,Soria MA,Falk AS,Service RJ,Langen R,Siemer AB

更新日期：2016-12-06 00:00:00

abstract：:Spin Hall effect (SHE) has been discussed in the context of Kubo formulation, geometric physics, spin orbit force, and numerous semi-classical treatments. It can be confusing if the different pictures have partial or overlapping claims of contribution to the SHE. In this article, we present a gauge-theoretic, time-mom...

journal_title：Scientific reports

authors： Tan SG,Jalil MB,Ho CS,Siu Z,Murakami S

更新日期：2015-12-22 00:00:00

abstract：:Recent advances in our ability to design DNA binding factors with specificity for desired sequences have resulted in a revolution in genetic engineering, enabling directed changes to the genome to be made relatively easily. Technologies that facilitate specific and precise genome editing, such as knock-in, are critica...

journal_title：Scientific reports

authors： Wu M,Wei C,Lian Z,Liu R,Zhu C,Wang H,Cao J,Shen Y,Zhao F,Zhang L,Mu Z,Wang Y,Wang X,Du L,Wang C

更新日期：2016-04-11 00:00:00

abstract：:This work demonstrates the dynamic through-silicon-via (TSV) filling process through staged electrodeposition experiments at different current densities. Different morphologies corresponding to TSV filling results can be obtained by controlling the applied current density. Specifically, a low current density (4 mA/cm2...

journal_title：Scientific reports

authors： Wang F,Zhao Z,Nie N,Wang F,Zhu W

更新日期：2017-04-19 00:00:00

abstract：:Although there is evidence that non-steroidal anti-inflammatory drugs (NSAIDs) might be able to prevent pancreatic cancer, the findings from epidemiological studies have been inconsistent. In this paper, we conducted a meta-analysis of observational studies to examine this possibility. We searched PubMed and Embase fo...

journal_title：Scientific reports

authors： Zhang YP,Wan YD,Sun YL,Li J,Zhu RT

更新日期：2015-10-21 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptors are glutamate- and glycine-gated channels composed of two GluN1 and two GluN2 or/and GluN3 subunits. GluN3A expression is developmentally regulated, and changes in this normal pattern of expression, which occur in several brain disorders, alter synaptic maturation and function by ...

journal_title：Scientific reports

authors： Cummings KA,Popescu GK

更新日期：2016-03-22 00:00:00

abstract：:Exploration of genetic variant-to-gene relationships by quantitative trait loci such as expression QTLs is a frequently used tool in genome-wide association studies. However, the wide range of public QTL databases and the lack of batch annotation features complicate a comprehensive annotation of GWAS results. In this ...

journal_title：Scientific reports

authors： Munz M,Wohlers I,Simon E,Reinberger T,Busch H,Schaefer AS,Erdmann J

更新日期：2020-11-24 00:00:00

abstract：:Ionotropic glutamate receptors (iGluRs) are responsible for most of the fast excitatory communication between neurons in our brain. The GluD2 receptor is a puzzling member of the iGluR family: It is involved in synaptic plasticity, plays a role in human diseases, e.g. ataxia, binds glycine and D-serine with low affini...

journal_title：Scientific reports

authors： Tapken D,Steffensen TB,Leth R,Kristensen LB,Gerbola A,Gajhede M,Jørgensen FS,Olsen L,Kastrup JS

更新日期：2017-04-07 00:00:00

abstract：:The human β-defensin-1 (HBD1) is an antimicrobial peptide constitutively expressed by epithelial cells at mucosal surfaces. In addition to its microbicidal properties, the loss of HBD1 expression in several cancers suggests that it may also have an anti-tumor activity. Here, we investigated the link between HBD1 expre...

journal_title：Scientific reports

authors： Bonamy C,Sechet E,Amiot A,Alam A,Mourez M,Fraisse L,Sansonetti PJ,Sperandio B

更新日期：2018-12-21 00:00:00

abstract：:Selective inhibition of function-specific β-GlcNAcase has great potential in terms of drug design and biological research. The symmetrical bis-naphthalimide M-31850 was previously obtained by screening for specificity against human glycoconjugate-lytic β-GlcNAcase. Using protein-ligand co-crystallization and molecular...

journal_title：Scientific reports

authors： Liu T,Guo P,Zhou Y,Wang J,Chen L,Yang H,Qian X,Yang Q

更新日期：2014-08-26 00:00:00

abstract：:Landscape's spatial structure has vast implications for the dynamics and distribution of species populations and ecological communities. However, the characterization of the structure of spatial networks has not received nearly as much attention as networks of species interactions counterparts. Recent experiments show...

journal_title：Scientific reports

authors： Gilarranz LJ

更新日期：2020-05-26 00:00:00

abstract：:Genome-wide association studies (GWAS) have uncovered numerous variants associated with body mass index (BMI), waist circumference, and waist-to-hip ratio. Our study aims to investigate how these variants are linked to fat distribution. We genotyped 56 validated variants of BMI, waist circumference, and waist-to-hip r...

journal_title：Scientific reports

authors： Wang T,Ma X,Peng D,Zhang R,Sun X,Chen M,Yan J,Wang S,Yan D,He Z,Jiang F,Bao Y,Hu C,Jia W

更新日期：2016-02-05 00:00:00

abstract：:Despite technical advances in brain machine interfaces (BMI), for as-yet unknown reasons the ability to control a BMI remains limited to a subset of users. We investigate whether individual differences in BMI control based on motor imagery (MI) are related to differences in MI ability. We assessed whether differences ...

journal_title：Scientific reports

authors： Marchesotti S,Bassolino M,Serino A,Bleuler H,Blanke O

更新日期：2016-04-07 00:00:00

abstract：:Printable, wide band-gap chalcopyrite compound films (CuInGaS2, CIGS) were synthesized on transparent conducting oxide substrates. The wide band-gap and defective nature of the films reveal semi-transparent and bifacial properties that are beneficial for power generating window applications. Importantly, solar cell de...

journal_title：Scientific reports

authors： Moon SH,Park SJ,Hwang YJ,Lee DK,Cho Y,Kim DW,Min BK

更新日期：2014-03-18 00:00:00

abstract：:Oxidative stress plays a role in the progression of chronic heart failure (CHF). We investigated whether systemic oxidative stress is linked to exercise intolerance and skeletal muscle abnormalities in patients with CHF. We recruited 30 males: 17 CHF patients, 13 healthy controls. All participants underwent blood test...

journal_title：Scientific reports

authors： Yokota T,Kinugawa S,Hirabayashi K,Yamato M,Takada S,Suga T,Nakano I,Fukushima A,Matsushima S,Okita K,Tsutsui H

更新日期：2021-01-26 00:00:00

abstract：:Dairy cows are often fed a high-concentrate (HC) diet to meet lactation demands; however, long-term concentrate feeding is unhealthy and decreases milk fat. Therefore, we investigated the effects of liver lipid metabolism on milk fat synthesis. Ten lactating Holstein cows were assigned randomly into HC and LC (low-con...

journal_title：Scientific reports

authors： Li L,Cao Y,Xie Z,Zhang Y

更新日期：2017-03-13 00:00:00

abstract：:Identifying how spatially distributed information becomes integrated in the brain is essential to understanding higher cognitive functions. Previous computational and empirical studies suggest a significant influence of brain network structure on brain network function. However, there have been few analytical approach...

journal_title：Scientific reports

authors： Moon JY,Kim J,Ko TW,Kim M,Iturria-Medina Y,Choi JH,Lee J,Mashour GA,Lee U

更新日期：2017-04-20 00:00:00

abstract：:As a follow-up on the data presented for seals, we herein report and discuss outcomes resulting from a retrospective evaluation of harbour porpoise stranding and necropsy data from Schleswig-Holstein, Germany (n = 4463) to enable an objective evaluation of potential ecological effects of grey seal predation on porpois...

journal_title：Scientific reports

authors： van Neer A,Gross S,Kesselring T,Grilo ML,Ludes-Wehrmeister E,Roncon G,Siebert U

更新日期：2020-10-01 00:00:00

abstract：:Here, we report direct band gap transition for Gallium Phosphide (GaP) when alloyed with just 1-2 at% antimony (Sb) utilizing both density functional theory based computations and experiments. First principles density functional theory calculations of GaSbxP(1-x) alloys in a 216 atom supercell configuration indicate t...

journal_title：Scientific reports

authors： Russell HB,Andriotis AN,Menon M,Jasinski JB,Martinez-Garcia A,Sunkara MK

更新日期：2016-02-10 00:00:00

abstract：:Cohesins are vital for chromosome organisation during meiosis and mitosis. In addition to the important function in sister chromatid cohesion, these complexes play key roles in meiotic recombination, DSB repair, homologous chromosome pairing and segregation. Egg-laying mammals (monotremes) feature an unusually complex...

journal_title：Scientific reports

authors： Casey AE,Daish TJ,Barbero JL,Grützner F

更新日期：2017-06-26 00:00:00

abstract：:Phosphorus (P) is a non-renewable resource which may be depleted within next few decades; hence high P use efficiency is need of time. Plants have evolved an array of adaptive mechanisms to enhance external P acquisition and reprioritize internal utilization under P deficiency. Tissue specific biomass and P allocation...

journal_title：Scientific reports

authors： Irfan M,Aziz T,Maqsood MA,Bilal HM,Siddique KHM,Xu M

更新日期：2020-03-09 00:00:00

abstract：:Neurite growth is controlled by a complex molecular signaling network that regulates filamentous actin (F-actin) dynamics at the growth cone. The evolutionarily conserved ezrin, radixin, and moesin family of proteins tether F-actin to the cell membrane when phosphorylated at a conserved threonine residue and modulate ...

journal_title：Scientific reports

authors： Jin EJ,Ko HR,Hwang I,Kim BS,Choi JY,Park KW,Cho SW,Ahn JY

更新日期：2018-02-07 00:00:00

abstract：:In this work, we demonstrate theoretically and experimentally the possibility of tuning the electromagnetic properties of metamaterials with magnetic fields by incorporating amorphous magnetic microwires. The large permeability of these wires at microwave frequencies allows tuning the resonance of the metamaterial by ...

journal_title：Scientific reports

authors： Lopez-Dominguez V,Garcia MA,Marin P,Hernando A

更新日期：2017-08-24 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) plays an important role in aggravating invasiveness and metastatic behavior of colorectal cancer (CRC). Identification of EMT is important for structuring treatment strategy, but has not yet been studied by using noninvasive imaging modality. Diffusion kurtosis imaging (DKI) is ...

journal_title：Scientific reports

authors： Liu H,Shen W,Zhang C,Cui Y,Li J,Zhang T,Chen W,Wang D

更新日期：2017-09-12 00:00:00

abstract：:Patients with end stage renal disease (ESRD) suffer high mortality from arrhythmias linked to fibrosis, but are contraindicated to late gadolinium enhancement magnetic resonance imaging (MRI). We present a quantitative method for gadolinium-free cardiac fibrosis imaging using magnetization transfer (MT) weighted MRI, ...

journal_title：Scientific reports

authors： Stromp TA,Spear TJ,Holtkamp RM,Andres KN,Kaine JC,Alghuraibawi WH,Leung SW,Fornwalt BK,Vandsburger MH

更新日期：2018-11-19 00:00:00

abstract：:Selective removal of lignin and other recalcitrant compounds, collectively registered as acid-unhyrolyzable residue (AUR), results in bleaching of leaf litter, but the importance of bleaching in decomposition processes on forest soil has not been fully evaluated. The aims of this study were to elucidate the occurrence...

journal_title：Scientific reports

authors： Osono T,Hiradate S,Hobara S

更新日期：2021-01-19 00:00:00

abstract：:Nucleic acid polymers (NAPs) block the release of subviral particles from hepatocytes, a mechanism consistent with their antiviral activity against hepatitis B virus (HBV) in patients. Analysis of immunostimulatory properties of NAPs were conducted with several NAP species: REP 2006, the prototypic degenerate NAP [dN]...

journal_title：Scientific reports

authors： Real CI,Werner M,Paul A,Gerken G,Schlaak JF,Vaillant A,Broering R

更新日期：2017-03-08 00:00:00

abstract：:Drug-induced cholestasis is a leading cause of drug withdrawal. However, the use of primary human hepatocytes (PHHs), the gold standard for predicting cholestasis in vitro, is limited by their high cost and batch-to-batch variability. Mature hepatocyte characteristics have been observed in human induced hepatocytes (h...

journal_title：Scientific reports

authors： Ni X,Gao Y,Wu Z,Ma L,Chen C,Wang L,Lin Y,Hui L,Pan G

更新日期：2016-12-09 00:00:00