Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: A novel in vitro cholestatic model.

abstract：:Investigation of climatic conditions prior to the Sturtian glaciations is critical to understanding the trigger mechanism for the series of Neoproterozoic global glaciations. In this study, we report high-resolution chemical index of alteration (CIA) records in the sediments of South China prior to the Sturtian glacia...

journal_title：Scientific reports

authors： Huang J,Feng L,Lu D,Zhang Q,Sun T,Chu X

更新日期：2014-10-31 00:00:00

abstract：:Tyrosine hydroxylase (TH) catalyzes the hydroxylation of L-tyrosine to L-DOPA. This is the rate-limiting step in the biosynthesis of the catecholamines - dopamine (DA), norepinephrine (NE), and epinephrine (EP). Catecholamines (CA) play a key role as neurotransmitters and hormones. Aberrant levels of CA are associated...

journal_title：Scientific reports

authors： Weinberg RP,Koledova VV,Subramaniam A,Schneider K,Artamonova A,Sambanthamurthi R,Hayes KC,Sinskey AJ,Rha C

更新日期：2019-12-09 00:00:00

abstract：:In this paper, a new strategy is reported for preparing a label-free β-trophin electrochemiluminescent (ECL) immunosensor with good specificity, reproducibility and stability. An aquagel polymer from the hydrolysis of (3-aminopropyl) trimethoxysilane acted as the linker to catch the Au nanoparticles (AuNPs) on the ind...

journal_title：Scientific reports

authors： Zheng L,Fang C,Yan J,Li H,Tu Y

更新日期：2017-09-11 00:00:00

abstract：:Electrohydrodynamic (EHD) jet printing has a variety of benefits compared to conventional inkjet techniques, such as high resolution and the ability to work with high-viscosity pastes. In this work, Ag nanoparticles with 4000 cPs were chosen because they are printable on various substrates for electronic devices. The ...

journal_title：Scientific reports

authors： Can TTT,Nguyen TC,Choi WS

更新日期：2019-06-24 00:00:00

abstract：:Differential scanning fluorimetry is a popular method to estimate the stability of a protein in distinct buffer conditions by determining its 'melting point'. The method requires a temperature controlled fluorescence spectrometer or a RT-PCR machine. Here, we introduce a low-budget version of a microcontroller based h...

journal_title：Scientific reports

authors： Hoeser J,Gnandt E,Friedrich T

更新日期：2018-01-23 00:00:00

abstract：:Due to the limitations of current imaging techniques, visualization of lymphatic capillaries within tissue in vivo has been challenging. Here, we present a label-free high resolution optical coherence tomography (OCT) based lymphangiography (OLAG) within human skin in vivo. OLAG enables rapid (~seconds) mapping of lym...

journal_title：Scientific reports

authors： Baran U,Qin W,Qi X,Kalkan G,Wang RK

更新日期：2016-02-19 00:00:00

abstract：:Giardia is a worldwide spread protozoan parasite colonizing in small intestines of vertebrates, causing Giardiasis. The controversy about whether it is an extremely primitive eukaryote or just a highly evolved parasite has become a fetter to its uses as a model for both evolutionary and parasitological studies for yea...

journal_title：Scientific reports

authors： Ye Q,Tian H,Chen B,Shao J,Qin Y,Wen J

更新日期：2017-08-25 00:00:00

abstract：:Fc domain fusion can improve the therapeutic effects of relatively small biological molecules such as peptides, cytokines, and antibody fragments. Fc fusion proteins can also be used to enhance the cytotoxic effects of small bispecific antibodies (bsAbs). However, fragmentation of Fc fusion proteins, which mainly occu...

journal_title：Scientific reports

authors： Suzuki S,Annaka H,Konno S,Kumagai I,Asano R

更新日期：2018-11-22 00:00:00

abstract：:To evaluate and improve datasets of anthropogenic land cover change used in local and global climate models, great efforts were made to reconstruct historical land use, including the LandCover 6k project which dedicated to reconstructing human land use over the past 10,000 years. In this study, we utilized historical ...

journal_title：Scientific reports

authors： Li M,He F,Li S,Yang F

更新日期：2018-09-10 00:00:00

abstract：:Recent evidence suggests that some seizures are preceded by preictal changes that start from minutes to hours before an ictal event. Nevertheless an adequate statistical evaluation in a large database of continuous multiday recordings is still missing. Here, we investigated the existence of preictal changes in long-te...

journal_title：Scientific reports

authors： Alvarado-Rojas C,Valderrama M,Fouad-Ahmed A,Feldwisch-Drentrup H,Ihle M,Teixeira CA,Sales F,Schulze-Bonhage A,Adam C,Dourado A,Charpier S,Navarro V,Le Van Quyen M

更新日期：2014-04-01 00:00:00

abstract：:A major limitation hindering the widespread use of synthetic phages in medical and industrial settings is the lack of an efficient phage-engineering platform. Classical T4 phage engineering and several newly proposed methods are often inefficient and time consuming and consequently, only able to produce an inconsisten...

journal_title：Scientific reports

authors： Duong MM,Carmody CM,Ma Q,Peters JE,Nugen SR

更新日期：2020-10-26 00:00:00

abstract：:Sodium taurocholate cotransporting polypeptide (NTCP) is a recently discovered hepatitis B virus (HBV) receptor. In the present study, we used TK-NOG mice with a humanized liver to examine the impact of endogenous NTCP expression on HBV infection. Upon inoculation with HBV, these mice exhibited clear viremia in 2 week...

journal_title：Scientific reports

authors： Nakabori T,Hikita H,Murai K,Nozaki Y,Kai Y,Makino Y,Saito Y,Tanaka S,Wada H,Eguchi H,Takahashi T,Suemizu H,Sakamori R,Hiramatsu N,Tatsumi T,Takehara T

更新日期：2016-06-09 00:00:00

abstract：:All solid-state lithium-ion transistors are considered as promising synaptic devices for building artificial neural networks for neuromorphic computing. However, the slow ionic conduction in existing electrolytes hinders the performance of lithium-ion-based synaptic transistors. In this study, we systematically explor...

journal_title：Scientific reports

authors： Nikam RD,Kwak M,Lee J,Rajput KG,Banerjee W,Hwang H

更新日期：2019-12-11 00:00:00

abstract：:Despite the importance of urban trees, their growth reaction to climate change and to the urban heat island effect has not yet been investigated with an international scope. While we are well informed about forest growth under recent conditions, it is unclear if this knowledge can be simply transferred to urban enviro...

journal_title：Scientific reports

authors： Pretzsch H,Biber P,Uhl E,Dahlhausen J,Schütze G,Perkins D,Rötzer T,Caldentey J,Koike T,Con TV,Chavanne A,Toit BD,Foster K,Lefer B

更新日期：2017-11-13 00:00:00

abstract：:Human children show unique cognitive skills for dealing with the social world but their cognitive performance is paralleled by great apes in many tasks dealing with the physical world. Recent studies suggested that members of a songbird family-corvids-also evolved complex cognitive skills but a detailed understanding ...

journal_title：Scientific reports

authors： Pika S,Sima MJ,Blum CR,Herrmann E,Mundry R

更新日期：2020-12-10 00:00:00

abstract：:Genetic mutations of the Methyl-CpG-binding protein-2 (MECP2) gene underlie Rett syndrome (RTT). Developmental processes are often considered to be irrelevant in RTT pathogenesis but neuronal activity at birth has not been recorded. We report that the GABA developmental shift at birth is abolished in CA3 pyramidal neu...

journal_title：Scientific reports

authors： Lozovaya N,Nardou R,Tyzio R,Chiesa M,Pons-Bennaceur A,Eftekhari S,Bui TT,Billon-Grand M,Rasero J,Bonifazi P,Guimond D,Gaiarsa JL,Ferrari DC,Ben-Ari Y

更新日期：2019-06-25 00:00:00

abstract：:Gold nanoparticles (GNPs) have been demonstrated as effective radiosensitizing agents in a range of preclinical models using broad field sources of various energies. This study aimed to distinguish between these mechanisms by applying subcellular targeting using a soft X-ray microbeam in combination with GNPs. DNA dam...

journal_title：Scientific reports

authors： Ghita M,McMahon SJ,Taggart LE,Butterworth KT,Schettino G,Prise KM

更新日期：2017-03-16 00:00:00

abstract：:Spirotetramat is employed worldwide to fight insect pests due to its high efficiency. This chemical is quickly metabolized by plants into spirotetramat-enol, so current regulations establish that both compounds must be determined in foodstuffs for monitoring purposes. Nowadays, immunochemical methods constitute rapid ...

journal_title：Scientific reports

authors： Cevallos-Cedeño RE,Agulló C,Abad-Fuentes A,Abad-Somovilla A,Mercader JV

更新日期：2021-01-19 00:00:00

abstract：:Site conditions and forest management affect dendrometric parameters of chestnut (Castanea sativa Mill.) coppices, but there is modest knowledge on the effect of stand dendrometric characters on physical and mechanical wood characteristics. The aim of this study was to verify these relationships in chestnut coppices t...

journal_title：Scientific reports

authors： Marini F,Manetti MC,Corona P,Portoghesi L,Vinciguerra V,Tamantini S,Kuzminsky E,Zikeli F,Romagnoli M

更新日期：2021-01-15 00:00:00

abstract：:Friction is a major inhibitor in almost every mechanical system. Enlightened by the Leidenfrost effect - a droplet can be levitated by its own vapor layer on a sufficiently hot surface - we demonstrate for the first time that a small cart can also be levitated by Leidenfrost vapor. The levitated cart can carry certain...

journal_title：Scientific reports

authors： Hashmi A,Xu Y,Coder B,Osborne PA,Spafford J,Michael GE,Yu G,Xu J

更新日期：2012-01-01 00:00:00

abstract：:Most large herbivores in arid landscapes need to drink which constrains their movements and makes them vulnerable to disturbance. Asiatic wild ass or khulan (Equus hemionus) were widespread and abundant throughout the arid landscapes of Central Asia and Mongolia, but have undergone dramatic population declines and ran...

journal_title：Scientific reports

authors： Payne JC,Buuveibaatar B,Bowler DE,Olson KA,Walzer C,Kaczensky P

更新日期：2020-02-19 00:00:00

abstract：:Inference of the biological roles of lncRNAs in breast cancer development remains a challenge. Here, we analyzed RNA-seq data in tumor and normal breast tissue samples from 18 breast cancer patients and 18 healthy controls and constructed a functional lncRNA-mRNA co-expression network. We revealed two distinctive co-e...

journal_title：Scientific reports

authors： Wu W,Wagner EK,Hao Y,Rao X,Dai H,Han J,Chen J,Storniolo AMV,Liu Y,He C

更新日期：2016-09-06 00:00:00

abstract：:Plant resistance can provide effective, economical, and sustainable pest control. Tolerance to the soybean aphid has been identified and confirmed in the soybean KS4202. Although its resistance mechanisms are not fully understood, evidence suggests that enhanced detoxification of reactive oxygen species (ROS) is an ac...

journal_title：Scientific reports

authors： Chapman KM,Marchi-Werle L,Hunt TE,Heng-Moss TM,Louis J

更新日期：2018-10-11 00:00:00

abstract：:Intervertebral disc degeneration is accompanied by a loss of Extra-cellular matrix (ECM) due to an imbalance in anabolic and catabolic pathways. Identifying ECM proteins with anabolic and/or regenerative potential could be the key to developing regenerative therapies. Since human fetal discs grow and develop rapidly, ...

journal_title：Scientific reports

authors： Rajasekaran S,Tangavel C,Djuric N,Raveendran M,Soundararajan DCR,Nayagam SM,Matchado MS,Anand KSSV

更新日期：2020-09-24 00:00:00

abstract：:Driven diffusive systems have been a paradigm for modelling many physical, chemical, and biological transport processes. In the systems, spatial correlation plays an important role in the emergence of a variety of nonequilibrium phenomena and exhibits rich features such as pronounced oscillations. However, the lack of...

journal_title：Scientific reports

authors： Hao QY,Jiang R,Hu MB,Jia B,Wang WX

更新日期：2016-01-25 00:00:00

abstract：:The revolutionary RNA-guided endonuclease CRISPR/Cas9 system has proven to be a powerful tool for gene editing in a plethora of organisms. Here, utilizing this system we developed an efficient protocol for the generation of heritable germline mutations in the parasitoid jewel wasp, Nasonia vitripennis, a rising insect...

journal_title：Scientific reports

authors： Li M,Au LYC,Douglah D,Chong A,White BJ,Ferree PM,Akbari OS

更新日期：2017-04-19 00:00:00

abstract：:Homogeneous target dose distribution in intensity-modulated radiotherapy (IMRT) for sinonasal cancer (SNC) is challenging to achieve. To solve this problem, we established and evaluated a basal-dose-compensation (BDC) optimization approach, in which the treatment plan is further optimized based on the initial plans. G...

journal_title：Scientific reports

authors： Lu JY,Zhang JY,Li M,Cheung ML,Li YK,Zheng J,Huang BT,Zhang WZ

更新日期：2015-10-26 00:00:00

abstract：:Bipolar disorder (BD) is a debilitating mental disorder that cannot be diagnosed by objective laboratory-based modalities. Our previous studies have independently used nuclear magnetic resonance (NMR)-based and gas chromatography-mass spectrometry (GC-MS)-based metabonomic methods to characterize the urinary metabolic...

journal_title：Scientific reports

authors： Chen JJ,Liu Z,Fan SH,Yang DY,Zheng P,Shao WH,Qi ZG,Xu XJ,Li Q,Mu J,Yang YT,Xie P

更新日期：2014-07-28 00:00:00

abstract：:Staphylococcus aureus strains carrying enterotoxin A gene (sea) causes food poisoning and cannot be distinguished from non-pathogenic strains by the culture method. Here, we developed a rapid, specific and sensitive visual detection of sea using loop-mediated isothermal amplification (LAMP) combined with nanogold prob...

journal_title：Scientific reports

authors： Srimongkol G,Ditmangklo B,Choopara I,Thaniyavarn J,Dean D,Kokpol S,Vilaivan T,Somboonna N

更新日期：2020-05-08 00:00:00

abstract：:The ability to accurately forecast seizures could significantly improve the quality of life of patients with drug-refractory epilepsy. Prediction capabilities rely on the adequate identification of seizure activity precursors from electroencephalography recordings. Although a long list of features has been proposed, n...

journal_title：Scientific reports

authors： Bou Assi E,Gagliano L,Rihana S,Nguyen DK,Sawan M

更新日期：2018-10-19 00:00:00