Combined application of NMR- and GC-MS-based metabonomics yields a superior urinary biomarker panel for bipolar disorder.

abstract：:Liver cancer stem cells (LCSCs) have attracted attention because they cause therapeutic resistance in hepatocellular carcinoma (HCC). Understanding the metabolism of LCSCs can be a key to developing therapeutic strategy, but metabolic characteristics have not yet been studied. Here, we systematically analyzed and comp...

journal_title：Scientific reports

authors： Hur W,Ryu JY,Kim HU,Hong SW,Lee EB,Lee SY,Yoon SK

更新日期：2017-04-03 00:00:00

abstract：:Developing an effective universal influenza vaccine against influenza virus with highly conserved antigenic epitopes could induce a broad-spectrum immune response to prevent infection. The soluble protein M1 that can induce the M1 specific immune response was first confirmed in our previous study. In this study, we ch...

journal_title：Scientific reports

authors： Liu F,Wang X,Zheng M,Xiong F,Liu X,Zhou L,Tan W,Chen Z

更新日期：2020-03-05 00:00:00

abstract：:Chronic inflammation can be a major driver of the failure of a variety of organs, including chronic kidney disease (CKD). The NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been shown to play a pivotal role in inflammation in a mouse kidney disease model. Nuclear factor erythroid 2-related factor 2 (Nrf...

journal_title：Scientific reports

authors： Sogawa Y,Nagasu H,Iwase S,Ihoriya C,Itano S,Uchida A,Kidokoro K,Taniguchi S,Takahashi M,Satoh M,Sasaki T,Suzuki T,Yamamoto M,Horng T,Kashihara N

更新日期：2017-08-18 00:00:00

abstract：:We compared markers of glucose homeostasis and their association with diabetes and impaired fasting glucose (IFG) in Fukuoka, Japanese subjects (n = 1108) and age-, gender- and menopausal status-matched participants in the Framingham Offspring Study (n = 1096). The markers examined included fasting glucose, insulin, a...

journal_title：Scientific reports

authors： Ikezaki H,Ai M,Schaefer EJ,Otokozawa S,Asztalos BF,Nakajima K,Zhou Y,Liu CT,Jacques PF,Cupples LA,Furusyo N

更新日期：2016-11-10 00:00:00

abstract：:The tibial tuberosity-trochlear groove (TT-TG) distance is a radiographic measurement that is used to quantify malalignment of the patellofemoral joint (PFJ) in cross-sectional imaging. There is an ongoing debate about the impact of the TT-TG-distance on lateral patellar instability and the initiating of cartilage deg...

journal_title：Scientific reports

authors： Maas KJ,Warncke M,Behzadi C,Welsch GH,Schoen G,Kaul MG,Adam G,Bannas P,Henes FO

更新日期：2020-09-18 00:00:00

abstract：:The increase in antibiotic resistant bacteria has raised global concern regarding the future effectiveness of antibiotics. Human activities that influence microbial communities and environmental resistomes can generate additional risks to human health. In this work, we characterized aquatic microbial communities and t...

journal_title：Scientific reports

authors： Posada-Perlaza CE,Ramírez-Rojas A,Porras P,Adu-Oppong B,Botero-Coy AM,Hernández F,Anzola JM,Díaz L,Dantas G,Reyes A,Zambrano MM

更新日期：2019-08-13 00:00:00

abstract：:Age-specific genetic and antigenic variations of influenza viruses have not been documented in tropical and subtropical regions. We implemented a systematic surveillance program in two tertiary hospitals in Hong Kong Island, to collect 112 A(H1N1)pdm09 and 254 A(H3N2) positive specimens from 2013 to 2014. Of these, 56...

journal_title：Scientific reports

authors： Cao P,Wong CM,Chan KH,Wang X,Chan KP,Peiris JS,Poon LL,Yang L

更新日期：2016-07-25 00:00:00

abstract：:The usage of gelatin hydrogel is limited due to its instability and poor mechanical properties, especially under physiological conditions. Divalent metal ions present in gelatin such as Ca(2+) and Fe(2+) play important roles in the gelatin molecule interactions. The objective of this study was to determine the impact ...

journal_title：Scientific reports

authors： Xing Q,Yates K,Vogt C,Qian Z,Frost MC,Zhao F

更新日期：2014-04-16 00:00:00

abstract：:Drug repositioning strategies have improved substantially in recent years. At present, two advances are poised to facilitate new strategies. First, the LINCS project can provide rich transcriptome data that reflect the responses of cells upon exposure to various drugs. Second, machine learning algorithms have been app...

journal_title：Scientific reports

authors： Xie L,He S,Wen Y,Bo X,Zhang Z

更新日期：2017-08-02 00:00:00

abstract：:Anaerobic ammonium oxidation (anammox) bacteria significantly improve the efficiency and reduce cost of nitrogen removal in wastewater treatment plants. However, their slow growth and vulnerable activity limit the application of anammox technology. In this paper, the enhancement of biotin on the nitrogen removal activ...

journal_title：Scientific reports

authors： Li Q,Chen J,Liu GH,Xu X,Zhang Q,Wang Y,Yuan J,Li Y,Qi L,Wang H

更新日期：2021-01-21 00:00:00

abstract：:The colon can have an absorptive function similar to that of the small intestine after the massive resection of the small bowel. To improve colonic absorptive function, we created a valve in the colon (artificial colonic valve, ACV). ACVs were created in 20 rats that had 80 percent of their small intestine resected, w...

journal_title：Scientific reports

authors： Deng G,Deng Z

更新日期：2020-01-21 00:00:00

abstract：:In this study we uncovered, through targeted ablation, a potential role for corticospinal, cerebello-rubro-spinal, and hypothalamic A11 dopaminergic systems in the development of restless legs syndrome (RLS)-like movements during sleep. Targeted lesions in select basal ganglia (BG) structures also revealed a major rol...

journal_title：Scientific reports

authors： Guo CN,Yang WJ,Zhan SQ,Yang XF,Chen MC,Fuller PM,Lu J

更新日期：2017-08-29 00:00:00

abstract：:Wildfires burn large parts of the tropics every year, shaping ecosystem structure and functioning. Yet the complex interplay between climate, vegetation and human factors that drives fire dynamics is still poorly understood. Here we show that on all continents, except Australia, tropical fire regimes change drasticall...

journal_title：Scientific reports

authors： Hantson S,Scheffer M,Pueyo S,Xu C,Lasslop G,van Nes EH,Holmgren M,Mendelsohn J

更新日期：2017-10-30 00:00:00

abstract：:Vaccines have become fundamental in the control and elimination of Glässer Disease, a systemic disease of pigs caused by Haemophilus parasuis. The classic vaccines available for prevention of this infection were developed without a robust knowledge about host immunological mechanisms. In this study, we demonstrated th...

journal_title：Scientific reports

authors： Barasuol BM,Guizzo JA,Fegan JE,Martínez-Martínez S,Rodríguez-Ferri EF,Gutiérrez-Martín CB,Kreutz LC,Schryvers AB,Frandoloso R

更新日期：2017-09-04 00:00:00

abstract：:Pavlovské vrchy Hills represent a distinctive elevation near the Czech-Austrian border where the active, dormant and relict landslides cover 12% of the area. Here we focused on the chronology of landsliding in this area using geological, archaeological and historical evidence. The earliest records of landsliding were ...

journal_title：Scientific reports

authors： Bíl M,Krejčí O,Dolák L,Krejčí V,Martínek J,Svoboda J

更新日期：2020-01-22 00:00:00

abstract：:Major depression (MDD) has been associated with an altered EEG frontal asymmetry measured in resting state; nevertheless, this association has showed a weak consistency across studies. In the present study, which starts from an evolutionistic view of psychiatric disorders, we investigated frontal asymmetry in MDD, usi...

journal_title：Scientific reports

authors： Spironelli C,Maffei A,Romeo Z,Piazzon G,Padovan G,Magnolfi G,Pasini I,Gomez Homen F,Concari G,Angrilli A

更新日期：2020-05-18 00:00:00

abstract：:The plant selective autophagy cargo receptor neighbour of breast cancer 1 gene (NBR1) has been scarcely studied in the context of abiotic stress. We wanted to expand this knowledge by using Arabidopsis thaliana lines with constitutive ectopic overexpression of the AtNBR1 gene (OX lines) and the AtNBR1 Knock-Out (KO li...

journal_title：Scientific reports

authors： Tarnowski L,Rodriguez MC,Brzywczy J,Piecho-Kabacik M,Krčkova Z,Martinec J,Wawrzynska A,Sirko A

更新日期：2020-05-08 00:00:00

abstract：:Glucose homeostasis is regulated by insulin, which is produced in the β-cells of the pancreas. The synthesis of insulin is controlled by several transcription factors including PDX-1, USF1 and USF2. Both, PDX-1 and USF1 were identified as substrates for protein kinase CK2. Here, we have analysed the interplay of PDX-1...

journal_title：Scientific reports

authors： Spohrer S,Groß R,Nalbach L,Schwind L,Stumpf H,Menger MD,Ampofo E,Montenarh M,Götz C

更新日期：2017-11-27 00:00:00

abstract：:Sex steroids, such as estrogens and androgens, are important regulators of the humoral immune response. Studies in female mice have demonstrated that alteration of circulating estrogen concentration regulates antibody-mediated immunity. As males have normally little endogenous estrogen, we hypothesized that in males h...

journal_title：Scientific reports

authors： Aguilar-Pimentel JA,Cho YL,Gerlini R,Calzada-Wack J,Wimmer M,Mayer-Kuckuk P,Adler T,Schmidt-Weber CB,Busch DH,Fuchs H,Gailus-Durner V,Ollert M,Hrabě de Angelis M,Ohlsson C,Poutanen M,Teperino R,Strauss L

更新日期：2020-10-27 00:00:00

abstract：:Insecticide-treated nets (ITNs) remain major components for vector control despite the spread of resistance mechanisms among mosquito populations. Multiple exposures to pyrethroids may induce physiological and behavioral changes in mosquitoes, possibly reducing efficacy of control tools. Despite epidemiological releva...

journal_title：Scientific reports

authors： Mulatier M,Pennetier C,Porciani A,Chandre F,Dormont L,Cohuet A

更新日期：2019-06-03 00:00:00

abstract：:SIRT1 is one of seven mammalian homologs of Sir2 that catalyzes NAD(+)-dependent protein deacetylation. The aim of the present study is to explore the effect of SIRT1 small molecule activator on the anticancer activity and the underlying mechanism. We examined the anticancer activity of a novel oral agent, curcumin, w...

journal_title：Scientific reports

authors： Hu A,Huang JJ,Li RL,Lu ZY,Duan JL,Xu WH,Chen XP,Fan JP

更新日期：2015-08-24 00:00:00

abstract：:Recent studies demonstrate that the invasion and metastasis of gastric cancer (GC) is closely associated with a multi-subunit vacuolar H+-ATPase (V-ATPase). Here we investigated the expression and role of the human ATP6V1A gene that encodes the catalytic subunit A of V-ATPase in GC. We found that ATP6V1A expression le...

journal_title：Scientific reports

authors： Wang P,Wang L,Sha J,Lou G,Lu N,Hang B,Mao JH,Zou X

更新日期：2017-06-07 00:00:00

abstract：:Bimetallic Pd1-x Pt x solid-solution nanoparticles (NPs) display charging/discharging of hydrogen gas, which has relevance for fuel cell technologies; however, the constituent elements are immiscible in the bulk phase. We examined these material systems using high-energy synchrotron X-ray diffraction, X-ray absorption...

journal_title：Scientific reports

authors： Kumara LSR,Sakata O,Kobayashi H,Song C,Kohara S,Ina T,Yoshimoto T,Yoshioka S,Matsumura S,Kitagawa H

更新日期：2017-11-06 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Zhou G,Zhu Y,Yin Y,Su M,Li M

更新日期：2018-03-22 00:00:00

abstract：:Hyperspectral imaging (HSI) is being explored in endoscopy as a tool to extract biochemical information that may improve contrast for early cancer detection in the gastrointestinal tract. Motion artefacts during medical endoscopy have traditionally limited HSI application, however, recent developments in the field hav...

journal_title：Scientific reports

authors： Grigoroiu A,Yoon J,Bohndiek SE

更新日期：2020-03-03 00:00:00

abstract：:Application of PCR to multiplexing assays is not trivial; it requires multiple fluorescent labels for amplicon detection and sophisticated software for data interpretation. Alternative PCR-free methods exploiting new concepts in nanotechnology exhibit high sensitivities but require multiple labeling and/or amplificati...

journal_title：Scientific reports

authors： Papadakis G,Tsortos A,Kordas A,Tiniakou I,Morou E,Vontas J,Kardassis D,Gizeli E

更新日期：2013-01-01 00:00:00

abstract：:Mounting evidence indicated that human mesenchymal stem cells (hMSCs) are responsive not only to biochemical but also to physical cues, such as substrate topography and stiffness. To simulate the dynamic structures of extracellular environments of the marrow in vivo, we designed a novel surrogate substrate for marrow ...

journal_title：Scientific reports

authors： Frank V,Kaufmann S,Wright R,Horn P,Yoshikawa HY,Wuchter P,Madsen J,Lewis AL,Armes SP,Ho AD,Tanaka M

更新日期：2016-04-15 00:00:00

abstract：:In music, the perception of pitch is governed largely by its tonal function given the preceding harmonic structure of the music. While behavioral research has advanced our understanding of the perceptual representation of musical pitch, relatively little is known about its representational structure in the brain. Usin...

journal_title：Scientific reports

authors： Sankaran N,Thompson WF,Carlile S,Carlson TA

更新日期：2018-01-16 00:00:00

abstract：:Animals thriving in hot deserts rely on extraordinary adaptations and thermoregulatory capacities to cope with heat. Uncovering such adaptations, and how they may be favoured by selection, is essential for predicting climate change impacts. Recently, the arid-adapted zebra finch was discovered to program their offspri...

journal_title：Scientific reports

authors： Pessato A,McKechnie AE,Buchanan KL,Mariette MM

更新日期：2020-11-03 00:00:00

abstract：:Optical thermometry has been widely studied to achieve an inaccessible temperature measurement in submicron scale and it has been reported that the temperature sensitivity depends mainly on host types. In this work, we propose a new method to improve the optical temperature sensitivity of Yb3+-Er3+ co-doped CaWO4 phos...

journal_title：Scientific reports

authors： Wang X,Wang Y,Bu Y,Yan X,Wang J,Cai P,Vu T,Seo HJ

更新日期：2017-02-27 00:00:00