Abstract：
:Due to the limitations of current imaging techniques, visualization of lymphatic capillaries within tissue in vivo has been challenging. Here, we present a label-free high resolution optical coherence tomography (OCT) based lymphangiography (OLAG) within human skin in vivo. OLAG enables rapid (~seconds) mapping of lymphatic networks, along with blood vessel networks, over 8 mm x 8 mm of human skin and 5 mm x 5 mm of human areola. Moreover, lymphatic system's response to inflammation within human skin is monitored throughout an acne lesion development over 7 days. The demonstrated results promise OLAG as a revolutionary tool in the clinical research and treatment of patients with pathologic conditions such as cancer, diabetes, and autoimmune diseases.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Baran U,Qin W,Qi X,Kalkan G,Wang RKdoi
10.1038/srep21122subject
Has Abstractpub_date
2016-02-19 00:00:00pages
21122issn
2045-2322pii
srep21122journal_volume
6pub_type
杂志文章abstract：:Enterobacter aerogenes LU2 was isolated from cow rumen and recognized as a potential succinic acid producer in our previous study. Here, we present the first complete genome sequence of this new, wild strain and report its basic genetic features from a biotechnological perspective. The MinION single-molecule nanopore ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58929-0
更新日期：2020-02-06 00:00:00
abstract：:The Rho-family small GTPase Cdc42 localizes at plasma membrane and Golgi complex and aside from protrusion and migration operates in vesicle trafficking, endo- and exocytosis as well as establishment and/or maintenance of cell polarity. The formin family members FMNL2 and -3 are actin assembly factors established to r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09952-1
更新日期：2017-08-29 00:00:00
abstract：:Intelligent development is an inevitable choice for the green development of manufacturing enterprises, environmental regulations and green innovation play an important role in the intelligent development of manufacturing enterprises. By analyzing the interrelationships between environmental regulations, green innovat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71423-x
更新日期：2020-09-02 00:00:00
abstract：:Acinetobacter baumannii is a common cause of health care associated infections worldwide. A. pittii is an opportunistic pathogen also frequently isolated from Acinetobacter infections other than those from A. baumannii. Knowledge of Acinetobacter virulence factors and their role in pathogenesis is scarce. Also, there ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04870-8
更新日期：2017-07-04 00:00:00
abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) is a difficult-to-treat infection. Increasing efforts have been taken to mitigate the epidemics and to avoid potential outbreaks in low endemic settings. Understanding the population dynamics of MRSA is essential to identify the causal mechanisms driving the epidemics...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66270-9
更新日期：2020-06-09 00:00:00
abstract：:Here, we report results on systematic analysis of DNA substrate preferences of three N6-adenine β-class DNA methyltransferases that are part of the type II restriction-modification systems. The studied enzymes were: M.EcoVIII, M.HindIII and M.LlaCI, which although found in phylogenetically distant bacteria (γ-proteoba...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26434-0
更新日期：2018-05-29 00:00:00
abstract：:Cellular membrane distortion invokes variations in cellular physiology. However, lack of an appropriate system to control the stress and facilitate molecular analyses has hampered progress of relevant studies. In this study, a microfluidic system that finely manipulates membrane distortion of Chlamydomonas reinhardtii...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04675
更新日期：2014-04-14 00:00:00
abstract：:In order to improve the accuracy and reliability of micropipetting, a method of micro-pipette detection and calibration combining the dynamic pressure monitoring in pipetting process and quantitative identification of pipette volume in image processing was proposed. Firstly, the normalized pressure model for the pipet...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24145-0
更新日期：2018-04-10 00:00:00
abstract：:We present a detailed experimental and theoretical study of the acoustic phonon modes in rolled-up multilayers with thickness of the layers in the nanometre and diameters in the micrometre range. We compare our results to planar, unrolled multilayers grown by molecular beam epitaxy. For the planar multilayers the expe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05739-6
更新日期：2017-07-14 00:00:00
abstract：:The Toarcian Oceanic Anoxic Event (TOAE, Early Jurassic, ~182 Ma ago) was characterised by severe environmental perturbations which led to habitat degradation and extinction of marine species. Warming-induced anoxia is usually identified as main driver, but because marine life was also affected in oxygenated environme...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61393-5
更新日期：2020-03-13 00:00:00
abstract：:Mechanical forces are critical to modulate cell spreading, contractility, gene expression, and even stem cell differentiation. Yet, existing tools that can apply controllable subcellular forces to a large number of single cells simultaneously are still limited. Here we report a novel ultrasound tweezing cytometry util...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02176
更新日期：2013-01-01 00:00:00
abstract：:Improving the prevention efficacy of health screening campaigns by increasing their attendance rate represents a challenge that calls for new strategies. This paper analyzes the response to a Pap test screening campaign of 155,000 women over the last decade. Using a mathematical model of statistical physics origins we...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09904
更新日期：2015-04-23 00:00:00
abstract：:Muscle specific receptor tyrosine kinase (MuSK) is an essential postsynaptic transmembrane molecule that mediates clustering of acetylcholine receptors (AChR). MUSK exon 10 is alternatively skipped in human, but not in mouse. Skipping of this exon disrupts a cysteine-rich region (Fz-CRD), which is essential for Wnt-me...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06841
更新日期：2014-10-30 00:00:00
abstract：:Members of the diffusible signal factor (DSF) family are a novel class of quorum sensing (QS) signals in diverse Gram-negative bacteria. Although previous studies have identified RpfF as a key enzyme for the biosynthesis of DSF family signals, many questions in their biosynthesis remain to be addressed. In this study ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13294
更新日期：2015-08-20 00:00:00
abstract：:Most Group I Clostridium botulinum strains harbor botulinum neurotoxin (bont) genes on their chromosome, while some carry these genes (including bont/a, bont/b, and bont/f) on large plasmids. Prior work in our laboratory demonstrated that Group I BoNT plasmids were mobilized to C. botulinum recipient strains containin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21342-9
更新日期：2018-02-15 00:00:00
abstract：:Hearing loss resulting from hair cell degeneration is a common disease that affects millions of people worldwide. Strategies to overcome the apparent irreversible hair cell loss in mammals become paramount for hearing protection. Here we reported that, by using a well-established gentamicin-induced hair cell loss mode...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08181
更新日期：2015-02-02 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-62742-0
更新日期：2020-04-10 00:00:00
abstract：:Long daylength artificial light exposure associates with disorders, and a potential physiological mechanism has been proposed. However, previous studies have examined no more than three artificial light treatments and limited metabolic parameters, which have been insufficient to demonstrate mechanical responses. Here,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24808
更新日期：2016-04-21 00:00:00
abstract：:Analytical equations are derived depicting four possible scenarios resulting from pulsed signaling of a system subject to Hill-type dynamics. Pulsed Hill-type dynamics involves the binding of multiple signal molecules to a receptor and occurs e.g., when transcription factor p53 orchestrates cancer prevention, during c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20466-2
更新日期：2018-02-01 00:00:00
abstract：:Pregnancy-associated malaria (PAM) is associated with poor pregnancy outcomes. Hemoglobin S (HbS) and hemoglobin C (HbC) mutations are frequently encountered in malaria-endemic areas of Africa, where they protect children from severe and uncomplicated Plasmodium falciparum malaria. However, scant epidemiological data ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01495-9
更新日期：2017-05-03 00:00:00
abstract：:Cells grown in three-dimensional (3D) cultures are more likely to have native cell-cell and cell-matrix interactions than in 2D cultures that impose mechanical constraints to cells. However, most 3D cultures utilise gel matrix which, while serving as a scaffold, limits application due to its solid and opaque nature an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21950-5
更新日期：2018-02-26 00:00:00
abstract：:Different marine habitats are characterised by different soundscapes. How or which differences may be representative of the habitat characteristics and/or community structure remains however to be explored. A growing project in passive acoustics is to find a way to use soundscapes to have information on the habitat an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33326
更新日期：2016-09-15 00:00:00
abstract：:Thymol, as a dietary monoterpene, is a phenol derivative of cymene, which is the major component of the essential oil of Trachyspermum ammi (L.). It shows multiple biological activities: antifungal, antibacterial, antivirus and anti-inflammatory. T. ammi, commonly known as ajowan, belongs to Apiaceae and is an importa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31618-9
更新日期：2018-09-07 00:00:00
abstract：:The effects of surface treatment combining corona discharge and hydrogen peroxide (H2O2) on the electrochemical performance of carbon felt electrodes for vanadium redox flow batteries (VRFBs) have been thoroughly investigated. A high concentration of oxygen functional groups has been successfully introduced onto the s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06906
更新日期：2014-11-04 00:00:00
abstract：:We recently reported that R-spondin 2 (Rspo2), a secreted activator of Wnt/β-catenin signaling, promotes acetylcholine receptor (AChR) clustering and neuromuscular junction (NMJ) formation via its receptor, Lgr5. Rspo2 is expressed highly in spinal motor neurons (SMNs) and marginally in the skeletal muscle, but the or...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31949-7
更新日期：2018-09-11 00:00:00
abstract：:Viral hepatitis leads to immune-mediated liver injury. The rate of disease progression varies between individuals. We aimed to phenotype immune cells associated with preservation of normal liver function during hepatitis C virus (HCV) infection. Clinical data and specimens were obtained from 19 HCV-infected patients u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80819-8
更新日期：2021-01-15 00:00:00
abstract：:The transparency of animals is an important biological feature. Ascidian eggs have various degrees of transparency, but this characteristic has not yet been measured quantitatively and comprehensively. In this study, we established a method for evaluating the transparency of eggs to first characterize the transparency...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77585-y
更新日期：2020-11-30 00:00:00
abstract：:Insulin resistance is associated with aging in mice and humans. We have previously shown that administration of recombinant GDF11 (rGDF11) to aged mice alters aging phenotypes in the brain, skeletal muscle, and heart. While the closely related protein GDF8 has a role in metabolism, limited data are available on the po...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61443-y
更新日期：2020-03-12 00:00:00
abstract：:Non-alcoholic fatty liver disease (NAFLD) is a chronic disease with several degrees of histological features which may progress to cirrhosis. Obesity is an important risk factor and although NAFLD has no specific pharmacological treatment, bariatric surgery has been associated with NAFLD regression in severely obese p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65556-2
更新日期：2020-05-22 00:00:00
abstract：:A fundamental challenge for behavioral neuroscientists is to accurately quantify (dis)similarities in animal behavior without excluding inherent variability present between individuals. We explored two new applications of curve and shape alignment techniques to address this issue. As a proof-of-concept we applied thes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52300-8
更新日期：2019-11-12 00:00:00
