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Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice.

Abstract：

:Insulin resistance is associated with aging in mice and humans. We have previously shown that administration of recombinant GDF11 (rGDF11) to aged mice alters aging phenotypes in the brain, skeletal muscle, and heart. While the closely related protein GDF8 has a role in metabolism, limited data are available on the potential metabolic effects of GDF11 or GDF8 in aging. To determine the metabolic effects of these two ligands, we administered rGDF11 or rGDF8 protein to young or aged mice fed a standard chow diet, short-term high-fat diet (HFD), or long-term HFD. Under nearly all of these diet conditions, administration of exogenous rGDF11 reduced body weight by 3-17% and significantly improved glucose tolerance in aged mice fed a chow (~30% vs. saline) or HF (~50% vs. saline) diet and young mice fed a HFD (~30%). On the other hand, exogenous rGDF8 showed signifcantly lesser effect or no effect at all on glucose tolerance compared to rGDF11, consistent with data demonstrating that GFD11 is a more potent signaling ligand than GDF8. Collectively, our results show that administration of exogenous rGDF11, but not rGDF8, can reduce diet-induced weight gain and improve metabolic homeostasis.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Walker RG,Barrandon O,Poggioli T,Dagdeviren S,Carroll SH,Mills MJ,Mendello KR,Gomez Y,Loffredo FS,Pancoast JR,Macias-Trevino C,Marts C,LeClair KB,Noh HL,Kim T,Banks AS,Kim JK,Cohen DE,Wagers AJ,Melton DA,Lee RT

doi

10.1038/s41598-020-61443-y

subject

Has Abstract

pub_date

2020-03-12 00:00:00

pages

4561

issue

1

issn

2045-2322

pii

10.1038/s41598-020-61443-y

journal_volume

10

pub_type

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