Abstract:
:Recent clinical trials have investigated the benefit of combining tyrosine kinase inhibitors (TKIs) and cytoreductive nephrectomy (CN) in patients with metastatic renal cell carcinoma. Our goal is to determine whether the perioperative use of TKIs increases the postoperative morbidity following CN in renal cell carcinoma patients. We identified 627 patients with Stage IV renal cell carcinoma who underwent CN from 2007-2010 utilizing the SEER-Medicare database. Eighty-two patients treated with TKIs were matched (3:1) to 246 controls. We calculated 30- and 90-day incidence rates of postoperative complications and mortality. On unadjusted analysis, TKI use prior to CN was associated with higher overall complication rate within 30 days (HR = 2.73, 95% CI: 1.09-6.8) after surgery. On multivariate analysis, perioperative TKI use was independently associated with higher risk for postoperative complications within 30 days (HR = 2.93, 95% CI: 1.17-7.36), as well as 90 days (HR = 1.84, 95% CI: 1.02-3.32) after nephrectomy. A higher Charlson comorbidity index also emerged to represent an independent risk factor for postoperative complications within 30 days (HR = 2.41, 95% CI: 1.44-4.02) and 90 days (HR = 2.23, 95% CI: 1.51-3.29) after nephrectomy. TKI treatment was not associated with an increased postoperative mortality at 30 and 90 days after surgery. Thus, TKI treatment was associated with an increased complication rate but not overall mortality following CN. Our results suggest that renal surgeons should be aware of possibly increased complications following CN in renal cell carcinoma patients, when TKI treatment is administered.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Carvalho FLF,Zheng C,Witmer K,O'neill J,Lynch JH,Kowalczyk KJdoi
10.1038/s41598-019-51548-4subject
Has Abstractpub_date
2019-10-24 00:00:00pages
15272issue
1issn
2045-2322pii
10.1038/s41598-019-51548-4journal_volume
9pub_type
杂志文章abstract::Atlantic bluefin tuna (Thunnus thynnus) from the two main spawning populations in the Mediterranean and Gulf of Mexico occur together in the western, central and eastern Atlantic. Stock composition of catches from mixing areas is uncertain, presenting a major challenge to the sustainable management of the fisheries. T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71355-6
更新日期:2020-09-07 00:00:00
abstract::Both targeted therapy and immunotherapy have been used successfully to treat melanoma, but the development of resistance and poor response rates to the individual therapies has limited their success. Designing rational combinations of targeted therapy and immunotherapy may overcome these obstacles, but requires assess...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37883-y
更新日期:2019-02-04 00:00:00
abstract::Microbeam radiation therapy is a novel preclinical technique, which uses synchrotron-generated X-rays for the treatment of brain tumours and drug-resistant epilepsies. In order to safely translate this approach to humans, a more in-depth knowledge of the long-term radiobiology of microbeams in healthy tissues is requi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14757-3
更新日期:2017-10-30 00:00:00
abstract::Unexpected reactor accidents and radioisotope production and consumption have led to a continuous increase in the global-scale contamination of radionuclides. In particular, anthropogenic radioiodine has become critical due to its highly volatile mobilization and recycling in global environments, resulting in widespre...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28113
更新日期:2016-06-17 00:00:00
abstract::Many experimental techniques rely on specific recognition and stringent binding of proteins by antibodies. This can readily be achieved by introducing an epitope tag. We employed an approach that uses a relative lack of evolutionary conservation to inform epitope tag site selection, followed by integration of the tag-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36986
更新日期:2016-11-28 00:00:00
abstract::Alcoholic liver disease (ALD) causes significant morbidity and mortality, and pharmacological treatment options are limited. In this study, we evaluated the PCSK9 inhibitor alirocumab, a monoclonal antibody that robustly reduces low-density lipoprotein cholesterol (LDL-C), for the treatment of ALD using a rat model of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53603-6
更新日期:2019-11-20 00:00:00
abstract::Identifying patients at risk of poor outcome after mild traumatic brain injury (MTBI) is essential to aid prognostics and treatment. Diffuse axonal injury (DAI) may be the primary pathologic feature of MTBI but is normally not detectable by conventional imaging technology. This lack of sensitivity of clinical imaging ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13628-1
更新日期:2017-10-23 00:00:00
abstract::Metamaterial full-sized absorber structures are numerically and experimentally investigated in GHz region and then examined in THz frequency. By manipulating monitoring the number and the position of the defect elements in conventional unit cells, the optimal integrative absorber structures are generated. The proposed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27920-1
更新日期:2018-06-22 00:00:00
abstract::Corals build their skeletons using extracellular calcifying fluid located in the tissue-skeleton interface. However, the mechanism by which corals control the transport of calcium and other ions from seawater and the mechanism of constant alkalization of calcifying fluid are largely unknown. To address these questions...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40324
更新日期:2017-01-18 00:00:00
abstract::Brain natriuretic peptide (BNP) is the most effective predictor of outcomes in chronic heart failure (CHF). This study sought to determine the qualitative relationship between the BNP levels at discharge and on the day of cardiovascular events in CHF patients. We devised a mathematical probabilistic model between the ...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/srep37073
更新日期:2016-11-15 00:00:00
abstract::Some 1,3-diarylureas and 1-((1,4-trans)-4-aryloxycyclohexyl)-3-arylureas (cHAUs) activate heme-regulated kinase causing protein synthesis inhibition via phosphorylation of the eukaryotic translation initiation factor 2 (eIF2) in mammalian cancer cells. To evaluate if these agents have potential to inhibit trypanosome ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23259-9
更新日期:2018-03-20 00:00:00
abstract::Plant-based proteins are increasingly being used in aquafeeds, but one of the limitations is taurine deficiency that can be especially detrimental for carnivorous fish. In this study, taurine supplementation in high plant protein diets (low fish meal, 15%) was investigated on the growth performance and fillet organole...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69014-x
更新日期:2020-07-23 00:00:00
abstract::While there is a rich literature on transcription dynamics during the development of many organisms, protein data is limited. We used iTRAQ isotopic labeling and mass spectrometry to generate the largest developmental proteomic dataset for any animal. Expression dynamics of nearly 4,000 proteins of Xenopus laevis was ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04365
更新日期:2014-03-14 00:00:00
abstract::Optical coherence tomography (OCT) is a valuable ancillary test in the diagnosis and management of chorioretinal disease. The evaluation of choroid thickness using OCT has become the focus of clinical applications. We report a linear artifact that acts as a confounding factor in choroidal thickness measurements by enh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08811-3
更新日期:2017-08-16 00:00:00
abstract::The prominent comprehensive properties of solid-solution- and intermetallic-based Ti alloys are derived from their diverse microstructures induced by multi-component alloying, which results in a chemical composition complexity. A cluster-plus-glue-atom model, characterizing the chemical short-range orders, was introdu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40302-5
更新日期:2019-03-04 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-68818-1
更新日期:2020-08-10 00:00:00
abstract::This study focused on the mechanisms that fatty acid conjugating strains - Bifidobacterium breve NCIMB 702258 and Bifidobacterium breve DPC 6330 - influence lipid metabolism when ingested with α-linolenic acid (ALA) enriched diet. Four groups of BALB/c mice received ALA enriched diet (3% (w/w)) either alone or in comb...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43300
更新日期:2017-03-07 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) plays an important role in aggravating invasiveness and metastatic behavior of colorectal cancer (CRC). Identification of EMT is important for structuring treatment strategy, but has not yet been studied by using noninvasive imaging modality. Diffusion kurtosis imaging (DKI) is ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11808-7
更新日期:2017-09-12 00:00:00
abstract::Although re-sequencing of gene panels and mRNA expression profiling are now firmly established in clinical laboratories, in-depth proteome analysis has remained a niche technology, better suited for studying model systems rather than challenging materials such as clinical trial samples. To address this limitation, we ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34949
更新日期:2016-10-07 00:00:00
abstract::Fear is an adaptive emotion that elicits defensive behavioural responses against aversive threats in animals. In mammals, serotonin receptors (5-HTRs) have been shown to modulate fear-related neural circuits in the basolateral amygdala complex (BLA). To understand the phylogenetic continuity of the neural basis for fe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78247-9
更新日期:2020-12-03 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-48627-x
更新日期:2019-08-28 00:00:00
abstract::Anticarsia gemmatalis (velvetbean caterpillar) and Chrysodeixis includens (soybean looper) are two important defoliation pests of soybeans. In the present study, we have investigated the susceptibility and brush border membrane-binding properties of both species to Bacillus thuringiensis Cry1Ea toxin. Bioassays perfor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54850-3
更新日期:2019-12-03 00:00:00
abstract::A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41598-018-20356-7
更新日期:2018-02-02 00:00:00
abstract::Melanoma is one of the most aggressive skin cancers and is well known for its high metastatic rate. Studies have shown that epithelial mesenchymal transition (EMT) is essential for melanoma cell metastasis. However, the molecular mechanisms underlying EMT are still not fully understood. We have shown that IRGM1, a mem...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12357
更新日期:2015-07-23 00:00:00
abstract::Besides clinical characteristics, easy-accessible laboratory markers could be of value to refine risk stratification in peripheral artery disease. In the current study, we investigated whether α-hydroxybutyrate dehydrogenase (HBDH) is associated with atherothrombotic events in 83 stable patients undergoing infrainguin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54899-0
更新日期:2019-12-03 00:00:00
abstract::The regulation of inflammatory responses by innate immune receptors is recognized as a crucial step in the development of atherosclerosis, although the precise molecular mechanisms remain to be elucidated. This study focused on illustrating the roles of dendritic cell-specific intercellular adhesion molecule-3-grabbin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03740-7
更新日期:2017-06-12 00:00:00
abstract::Sealed-bid auction is an important tool in modern economic especially concerned with networks. However, the bidders still lack the privacy protection in previously proposed sealed-bid auction schemes. In this paper, we focus on how to further protect the privacy of the bidders, especially the non-winning bidders. We f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44030-8
更新日期:2019-05-20 00:00:00
abstract::The PIM1 serine/threonine protein kinase mediates growth factor and survival signalling, and cooperates potently with c-MYC during tumorigenesis. PIM1 is overexpressed in many human cancers and is a promising target for drug development. PIM1 levels are regulated mainly through cytokine-induced transcription and prote...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03775-w
更新日期:2017-06-15 00:00:00
abstract::We propose a virtual sound barrier system that blocks sound transmission through openings without affecting access, light and air circulation. The proposed system applies active control technique to cancel sound transmission with a double layered loudspeaker array at the edge of the opening. Unlike traditional transpa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13546-2
更新日期:2017-10-17 00:00:00
abstract::Annually averaged solar radiation in the McMurdo Dry Valleys, Antarctica has varied by over 20 W m-2 during the past three decades; however, the drivers of this variability are unknown. Because small differences in radiation are important to water availability and ecosystem functioning in polar deserts, determining th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23390-7
更新日期:2018-03-22 00:00:00