Abstract:
:Positron emission tomography (PET) imaging is used to localize recurrent disease in prostate cancer (PCa). The tracer 68Ga-PSMA-11 visualizes lesions overexpressing prostate-specific membrane antigen (PSMA), while 11C-acetate visualizes lesions with increased anabolic metabolism. The aim of this study was to compare the performance of PSMA-PET and acetate-PET in re-staging patients with biochemical relapse. Thirty PCa patients with prostate-specific antigen (PSA) relapse after primary curative therapy were prospectively evaluated. PET/CT examinations using 11C-acetate and 68Ga-PSMA-11 were performed. Identified lesions were categorized according to anatomical location and PET measurements were correlated with PSA at time of scan. Tumour lesions showed higher semi-quantitative uptake values on PSMA-PET than acetate-PET. PSMA-PET identified more lesions in 11 patients, fewer lesions in eight patients, and identical number of lesions in 11 patients. This study indicates better diagnostic performance of PSMA-PET, particularly in detecting lymph node (81% vs 60%, p = 0.02) and bone metastasis (95% vs 61%, p = 0.0001) compared to acetate-PET. However, 38% of PSMA-expressing metastases appear to be metabolically inactive and 15% of metabolically active metastases lack PSMA expression. Addition of PET with a metabolic tracer, such as 11C-acetate, might be beneficial before making treatment decisions.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Regula N,Kostaras V,Johansson S,Trampal C,Lindström E,Lubberink M,Velikyan I,Sörensen Jdoi
10.1038/s41598-020-61910-6subject
Has Abstractpub_date
2020-03-19 00:00:00pages
4993issue
1issn
2045-2322pii
10.1038/s41598-020-61910-6journal_volume
10pub_type
杂志文章abstract::Miscarriage affects ~20% of pregnancies and maternal infections account for ~15% of early miscarriages. Chlamydia trachomatis (Ct) has been associated with miscarriage but the underlying mechanisms are unknown. Successful implantation requires endometrial stromal cell (ESC) decidualisation. Maintenance of pregnancy re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02223-z
更新日期:2017-05-17 00:00:00
abstract::Living organisms in drying environments build anisotropic structures and exhibit directionality through self-organization of biopolymers. However, the process of macro-scale assembly is still unknown. Here, we introduce a dissipative structure through a non-equilibrium process between hydration and deposition in the d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05883-z
更新日期:2017-07-21 00:00:00
abstract::Supercapacitors with aqueous electrolytes and nanostructured composite electrodes are attractive because of their high charging-discharging speed, long cycle life, low environmental impact and wide commercial affordability. However, the energy capacity of aqueous supercapacitors is limited by the electrochemical windo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09854
更新日期:2015-04-21 00:00:00
abstract::Sodefrin, a decapeptide isolated from the male dorsal gland of the Japanese fire belly newt Cynops pyrrhogaster, was the first peptide pheromone identified from a vertebrate. The fire belly salamander and sodefrin have become a model for sex pheromone investigation in aquatically courting salamanders ever since. Subse...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21880
更新日期:2016-03-03 00:00:00
abstract::Altered death receptor signaling and resistance to subsequent apoptosis is an important clinical resistance mechanism. Here, we investigated the role of death receptor resistance in breast cancer progression. Resistance of the estrogen receptor alpha (ER)-positive, chemosensitive MCF7 breast cancer cell line to tumor ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00539
更新日期:2012-01-01 00:00:00
abstract::The predictions for a warmer and drier climate and for increased likelihood of climate extremes raise high concerns about the possible collapse of dryland ecosystems, and about the formation of new drylands where native species are less tolerant to water stress. Using a dryland-vegetation model for plant species that ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56080-z
更新日期:2019-12-20 00:00:00
abstract::Arbuscular mycorrhizal fungi (AMF) are obligate symbionts, living in associations with the roots of most land plants. AMF produce wide networks of extraradical mycelium (ERM) of indeterminate length, spreading from host roots into the surrounding soil and establishing belowground interconnections among plants belongin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28354-5
更新日期:2018-07-06 00:00:00
abstract::Behavioural studies revealed that the dog-human relationship resembles the human mother-child bond, but the underlying mechanisms remain unclear. Here, we report the results of a multi-method approach combining fMRI (N = 17), eye-tracking (N = 15), and behavioural preference tests (N = 24) to explore the engagement of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79247-5
更新日期:2020-12-17 00:00:00
abstract::Nonulosonic acids are found in the surface polysaccharides of many bacterial species and are often implicated in pathogenesis. Here, the structure of a novel 5,7-diacetamido-3,5,7,9-tetradeoxynon-2-ulosonic acid recovered from the capsular polysaccharide of a multiply antibiotic resistant Acinetobacter baumannii isola...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11166-4
更新日期:2017-09-12 00:00:00
abstract::The aim was to analyze the effect of fractional flow reserve (FFR), intravascular ultrasound (IVUS) and optical coherence tomography (OCT) on fluoroscopy time (FT), radiation dose (RD) and contrast volume (CV) in patients undergoing coronary angiography. This case-control study included consecutive patients above the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63791-1
更新日期:2020-04-24 00:00:00
abstract::We investigate collective modes in three dimensional (3D) gapless multi-Weyl semimetals with anisotropic energy band dispersions (i.e., with a positive integer J). For comparison, we also consider the gapless semimetals with the isotropic band dispersions (i.e. E ~ kJ). We calculate analytically long-wavelength plasma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34023
更新日期:2016-09-30 00:00:00
abstract::Glycans are biologically important structures synthesised by glycosyltransferase (GT) enzymes. Disruptive genetic null variants in GT genes can lead to serious illness but benign phenotypes are also seen, including antigenic differences on the red blood cell (RBC) surface, giving rise to blood groups. To characterise ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24445-5
更新日期:2018-04-16 00:00:00
abstract::Maize is China's largest grain crop. Mechanical grain harvesting is the key technology in maize production, and the kernel moisture concentration (KMC) is the main controlling factor in mechanical maize harvesting in China. The kernel dehydration rate (KDR) is closely related to the KMC. Thus, it is important to condu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80391-1
更新日期:2021-01-19 00:00:00
abstract::During action observation, several visual features of observed actions can modulate the level of sensorimotor reactivity in the onlooker. Among possibly relevant parameters, one of the less investigated in humans is the visual perspective from which actions are observed. In the present EEG study, we assessed the react...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30912-w
更新日期:2018-08-20 00:00:00
abstract::The seed storage proteins of soybean (Glycine max) are composed mainly of glycinin (11S globulin) and β-conglycinin (7S globulin). The subunits of glycinin (A1aB1b, A1bB2, A2B1a, A3B4, and A5A4B3) are synthesized as a single polypeptide precursor. These precursors are assembled into trimers with a random combination o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18697-w
更新日期:2018-01-18 00:00:00
abstract::Hurricane Patricia in 2015 was the strongest Pacific hurricane to make landfall in Mexico. Although Patricia fortuitously spared major cities, it reminded us of the threat tropical cyclones (TCs) pose in the eastern North Pacific (ENP) and the importance of improving our understanding and prediction of ENP TCs. Patric...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01962-3
更新日期:2017-05-10 00:00:00
abstract::A peptide vaccine designed to induce T-cell immunity to telomerase, GV1001, has been shown to modulate cellular signaling pathways and confer a direct anti-cancer effect through the interaction with heat shock protein (HSP) 90 and 70. Here, we have found that GV1001 can modulate transactivation protein-mediated human ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28896
更新日期:2016-07-01 00:00:00
abstract::Obesity is associated with dysregulated lipid metabolism and adipokine secretion. Our group has previously reported obesity and adipokines are associated with % total fatty acid (FA) differences in plasma phospholipids. The objective of our current study was to identify in which complex lipid species (i.e., phosphatid...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05785-0
更新日期:2017-07-24 00:00:00
abstract::In the field of correlative microscopy, light and electron microscopy form a powerful combination for morphological analyses in zoology. Due to sample thickness limitations, these imaging techniques often require sectioning to investigate small animals and thereby suffer from various artefacts. A recently introduced n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60977-5
更新日期:2020-03-03 00:00:00
abstract::Accurate estimation of carrier probabilities of cancer susceptibility gene mutations is an important part of pre-test genetic counselling. Many predictive models are available but their applicability in the Asian population is uncertain. We evaluated the performance of five BRCA mutation risk predictive models in a Ch...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46707-6
更新日期:2019-07-15 00:00:00
abstract::Simulation models in respiratory research are increasingly used for medical product development and testing, especially because in-vivo models are coupled with a high degree of complexity and ethical concerns. This work introduces a respiratory simulation system, which is bridging the gap between the complex, real ana...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56176-6
更新日期:2019-12-24 00:00:00
abstract::The development of metal-based agents has had a tremendous role in the present progress in cancer chemotherapy. One well-known example of metal-based agents is Schiff based metal complexes, which hold great promise for cancer therapy. Based on the potential of Schiff based complexes for the induction of apoptosis, thi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09097
更新日期:2015-03-13 00:00:00
abstract::Ocean acidification is predicted to have detrimental effects on many marine organisms and ecological processes. Despite growing evidence for direct impacts on specific species, few studies have simultaneously considered the effects of ocean acidification on individuals (e.g. consequences for energy budgets and resourc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20194
更新日期:2016-01-29 00:00:00
abstract::Oxidized low-density lipoprotein (oxLDL) inhibits mammalian target of rapamycin (mTOR) and induces autophagy and apoptosis in vascular endothelial cells (VECs) that play very critical roles for the cardiovascular homostasis. We recently defined 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one (3BDO) as a ne...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05519
更新日期:2014-07-01 00:00:00
abstract::Three carbapenem-resistant Escherichia coli were recovered from rectal swabs of different patients in a tertiary hospital and were found carrying bla NDM-4, an uncommon bla NDM variant. Genome sequences of the isolates were obtained using Illumina technology and the long-read MinION sequencer. The isolates belonged to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18910-w
更新日期:2018-01-10 00:00:00
abstract::Although acute psychosocial stress can impact autobiographical memory retrieval, the nature of this effect is not entirely clear. One reason for this ambiguity is because stress can have opposing effects on the different stages of autobiographical memory retrieval. We addressed this issue by testing how acute stress a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26890-8
更新日期:2018-06-06 00:00:00
abstract::Donor-specific CD4+CD127-CD25+FOXP3+ regulatory T cells (AgTregs) have the potential to induce clinical transplant tolerance; however, their expansion ex vivo remains challenging. We optimized a novel expansion protocol to stimulate donor-specific Tregs using soluble 4-trimer CD40 ligand (CD40L)-activated donor B cell...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19621-6
更新日期:2018-01-18 00:00:00
abstract::High temperature stable selective emitters can significantly increase efficiency and radiative power in thermophotovoltaic (TPV) systems. However, optical properties of structured emitters reported so far degrade at temperatures approaching 1200 °C due to various degradation mechanisms. We have realized a 1D structure...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43640-6
更新日期:2019-05-10 00:00:00
abstract::Measurements of skeletal muscle cross-sectional area, index, and radiation attenuation utilizing clinical computed tomography (CT) scans are used in assessments of sarcopenia, the loss of skeletal muscle mass and function associated with aging. To classify individuals as sarcopenic, sex-specific cutoffs for 'low' valu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29825-5
更新日期:2018-07-27 00:00:00
abstract::Helicobacter pylori (H. pylori ) infection is a major cause of chronic gastritis and is highly related to duodenal ulcer (DU) and gastric cancer (GC). To identify H. pylori-related GC biomarkers with high seropositivity in GC patients, differences in levels of protein expression between H. pylori from GC and DU patien...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36442
更新日期:2016-11-07 00:00:00