Abstract：
:The development of metal-based agents has had a tremendous role in the present progress in cancer chemotherapy. One well-known example of metal-based agents is Schiff based metal complexes, which hold great promise for cancer therapy. Based on the potential of Schiff based complexes for the induction of apoptosis, this study aimed to examine the cytotoxic and apoptotic activity of a CdCl2(C14H21N3O2) complex on HT-29 cells. The complex exerted a potent suppressive effect on HT-29 cells with an IC50 value of 2.57 ± 0.39 after 72 h of treatment. The collapse of the mitochondrial membrane potential and the elevated release of cytochrome c from the mitochondria to the cytosol indicate the involvement of the intrinsic pathway in the induction of apoptosis. The role of the mitochondria-dependent apoptotic pathway was further proved by the significant activation of the initiator caspase-9 and the executioner caspases-3 and -7. In addition, the activation of caspase-8, which is associated with the suppression of NF-κB translocation to the nucleus, also revealed the involvement of the extrinsic pathway in the induced apoptosis. The results suggest that the CdCl2(C14H21N3O2) complex is able to induce the apoptosis of colon cancer cells and is a potential candidate for future cancer studies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hajrezaie M,Paydar M,Looi CY,Moghadamtousi SZ,Hassandarvish P,Salga MS,Karimian H,Shams K,Zahedifard M,Majid NA,Ali HM,Abdulla MAdoi
10.1038/srep09097subject
Has Abstractpub_date
2015-03-13 00:00:00pages
9097issn
2045-2322pii
srep09097journal_volume
5pub_type
杂志文章abstract：:Pesticides, including neonicotinoids, typically target pest insects by being neurotoxic. Inadvertent exposure to foraging insect pollinators is usually sub-lethal, but may affect cognition. One cognitive trait, spatial working memory, may be important in avoiding previously-visited flowers and other spatial tasks such...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38957
更新日期：2016-12-13 00:00:00
abstract：:In this work, lamellar MnFe2O4 was successfully planted on a wood surface through the association of hydrogen bonds via the one-pot hydrothermal method. Simultaneously, the fluoroalkylsilane (FAS-17) on the surface of the MnFe2O4 layer formed long-chain or network macromolecules through a poly-condensation process and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35549
更新日期：2016-10-17 00:00:00
abstract：:Recently, slow earthquakes (slow EQ) have received much attention relative to understanding the mechanisms underlying large earthquakes and to detecting their precursors. Low-frequency earthquakes (LFE) are a specific type of slow EQ. In the present paper, we reveal the relevance of LFEs to the 11 March 2011 Great Toh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45765-0
更新日期：2019-06-27 00:00:00
abstract：:Chitin is a valuable peat substrate amendment by increasing lettuce growth and reducing the survival of the zoonotic pathogen Salmonella enterica on lettuce leaves. The production of chitin-catabolic enzymes (chitinases) play a crucial role and are mediated through the microbial community. A higher abundance of plant-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46106-x
更新日期：2019-07-09 00:00:00
abstract：:Defect engineering is a promising route for controlling the electronic properties of monolayer transition-metal dichalcogenide (TMD) materials. Here, we demonstrate that the electronic structure of MoS2 depends sensitively on the defect charge, both its sign and magnitude. In particular, we study shallow bound states ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31941-1
更新日期：2018-09-11 00:00:00
abstract：:We previously found that Homeobox containing 1 (HMBOX1) was required for bone mesenchymal stem cell (BMSC) and mouse embryonic stem cell (ESC) differentiation into vascular endothelial cells (VECs). However, the function of HMBOX1 in VECs is still unknown. In this study, we found that HMBOX1 was abundantly expressed i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15121
更新日期：2015-10-12 00:00:00
abstract：:The aim of this study was to use functional neuroimaging to investigate whether oxytocin modulates the neural response to visual food cues in brain regions involved in the control of food intake. Twenty-four normal weight volunteers received intranasal oxytocin (24 IU) or placebo in a double-blind, randomized crossove...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04600-0
更新日期：2017-06-27 00:00:00
abstract：:Endoluminal surgery for the treatment of colorectal neoplasia is typically carried out using electrocautery tools which imply limited precision and the risk of harm through collateral thermal damage to the adjacent healthy tissue. As a potential alternative, we present the successful colonic epithelial laser ablation ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73349-w
更新日期：2020-11-20 00:00:00
abstract：:There is not a clear consensus regarding the optimal treatment of locally advanced pancreatic disease. There is a potential role for neoadjuvant therapy to treat micrometastatic disease with chemotherapy, as well as for the treatment of local disease with radiotherapy. We evaluated the safety and efficacy of induction...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45845
更新日期：2017-04-05 00:00:00
abstract：:Spitzoid neoplasms constitute a morphologically distinct category of melanocytic tumors, encompassing Spitz nevus (benign), atypical Spitz tumor (intermediate malignant potential), and spitzoid melanoma (fully malignant). Currently, no reliable histopathological criteria or molecular marker is known to distinguish bor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11200
更新日期：2015-06-10 00:00:00
abstract：:Mechanistic disease progression studies using animal models require objective and quantifiable assessment of tissue pathology. Currently quantification relies heavily on staining methods which can be expensive, labor/time-intensive, inconsistent across laboratories and batch, and produce uneven staining that is prone ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78061-3
更新日期：2020-12-01 00:00:00
abstract：:The herb Centella asiatica has long been considered a memory tonic. A recent review found no strong evidence for improvement of cognitive function, suggesting negative results were due to limitations in dose, standardization and product variation. We used a standardized extract of C. asiatica (ECa 233) to study behavi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44867-z
更新日期：2019-06-10 00:00:00
abstract：:The mammalian Target of Rapamycin complex 1 (mTORC1) nutrient-sensing pathway is a central regulator of cell growth and metabolism and is dysregulated in diabetes. The eukaryotic translation initiation factor 4E (EIF-4E) protein, a key regulator of gene translation and protein function, is controlled by mTORC1 and EIF...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71987-8
更新日期：2020-09-25 00:00:00
abstract：:Radiotherapy with protons and heavier ions landmarks a novel era in the field of high-precision cancer therapy. To identify patients most benefiting from this technologically demanding therapy, fast assessment of comparative treatment plans utilizing different ion species is urgently needed. Moreover, to overcome unce...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33194-4
更新日期：2018-10-04 00:00:00
abstract：:The microwave emitting Radio Electric Asymmetric Conveyor (REAC) is a technology able to interact with biological tissues at low emission intensity (2 mW at the emitter and 2.4 or 5.8 GHz) by inducing radiofrequency generated microcurrents. It shows remarkable biological effects at many scales from gene modulations up...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18200
更新日期：2015-12-11 00:00:00
abstract：:Recently, we reported that chemokine (C-X-C motif) receptor (CXCR)4 and atypical chemokine receptor 3 regulate α1-adrenergic receptors (α1-AR) through the formation of hetero-oligomeric complexes. Whether α1-ARs also regulate chemokine receptor function within such heteromeric receptor complexes is unknown. We observe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21096-4
更新日期：2018-02-09 00:00:00
abstract：:Biological armors such as mollusk shells have long been recognized and studied for their values in inspiring novel designs of engineering materials with higher toughness and strength. However, no material is invincible and biological armors also have their rivals. In this paper, our attention is focused on the teeth o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23509
更新日期：2016-03-22 00:00:00
abstract：:Previous studies have discussed the relationship between simple renal cysts (SRC) and serum uric acid level in healthy individuals. We performed a cross-sectional study to evaluate the association between serum uric acid level and fractional excretion of uric acid (FEUA) and simple renal cysts in males and postmenopau...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-04036-6
更新日期：2017-06-19 00:00:00
abstract：:Boulders are ubiquitously found on the surfaces of small rocky bodies in the inner solar system and their spatial and size distributions give insight into the geological evolution and collisional history of the parent bodies. Using images acquired by the Chang'e-2 spacecraft, more than 200 boulders have been identifie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16029
更新日期：2015-11-02 00:00:00
abstract：:Tumour growth and metastatic colonization is strongly influenced by the tumour stroma, including cancer-associated fibroblasts (CAF). Multipotent mesenchymal stromal cells (MSC) are a possible source of CAF following myofibroblastic differentiation, and we have previously shown that MSC support tumour growth. Triggere...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48142-z
更新日期：2019-08-13 00:00:00
abstract：:There is a huge request for the development of low dielectric constant polymeric materials for microelectronic applications. In thisstudy, polymer blends based on PVA:POZ with low dielectric constant has been fabricated. The results of XRD indicate that crystalline domain is enhanced at higher POZ concentration. Brill...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49715-8
更新日期：2019-09-11 00:00:00
abstract：:In the northeastern United States, chronic wasting disease has recently been detected in white-tailed deer (Odocoileus virginianus) populations, and understanding the relationship between landscape configuration and home range may improve disease surveillance and containment efforts. The objectives of our study were t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32937-7
更新日期：2018-10-02 00:00:00
abstract：:Kalata B1 has been demonstrated to have bioactivity relating to membrane disruption. In this study, we conducted coarse-grained molecular dynamics simulations to gain further insight into kB1 bioactivity. The simulations were performed at various concentrations of kB1 to capture the overall progression of its activity...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03933
更新日期：2014-02-03 00:00:00
abstract：:Increasing levels of human activity threaten wildlife populations through direct mortality, habitat degradation, and habitat fragmentation. Area closures can improve habitat quality for wildlife, but may be difficult to achieve where tourism or other economic drivers are a priority. Temporal closures that limit human ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40581-y
更新日期：2019-03-07 00:00:00
abstract：:The performance and emission affected by piston catalytic coating have been analyzed in this study. The main contributing factors for improving performance such as load, fuel and speed have been preferred to reduce the emission and improve the performance of an IC engine. These specific standard parameters have been m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57129-9
更新日期：2020-02-07 00:00:00
abstract：:The transcriptional responses of yeast cells to diverse stresses typically include gene activation and repression. Specific stress defense, citric acid cycle and oxidative phosphorylation genes are activated, whereas protein synthesis genes are coordinately repressed. This view was achieved from comparative transcript...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26170-5
更新日期：2018-05-21 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-24031-9
更新日期：2018-04-11 00:00:00
abstract：:Frequency shifts in signals of bats flying near conspecifics have been interpreted as a spectral jamming avoidance response (JAR). However, several prerequisites supporting a JAR hypothesis have not been controlled for in previous studies. We recorded flight and echolocation behavior of foraging Pipistrellus pipistrel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30978
更新日期：2016-08-09 00:00:00
abstract：:The magnetic skyrmion is a nanoscale topological object characterized by the winding of magnetic moments, appearing in magnetic materials with broken inversion symmetry. Because of its low current threshold for driving the skyrmion motion, they have been intensely studied toward novel storage applications by using ele...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54833-4
更新日期：2019-12-05 00:00:00
abstract：:Multiple Sclerosis (MS) require medications controlling severity of the pathology and depression, affecting more than half of the patients. In this study, the effect of antidepressant drug fluvoxamine, a selective serotonin reuptake inhibitor, was investigated in vitro and in vivo. Nanomolar concentrations of fluvoxam...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04968-z
更新日期：2017-07-07 00:00:00
