Abstract：
:A peptide vaccine designed to induce T-cell immunity to telomerase, GV1001, has been shown to modulate cellular signaling pathways and confer a direct anti-cancer effect through the interaction with heat shock protein (HSP) 90 and 70. Here, we have found that GV1001 can modulate transactivation protein-mediated human immunodeficiency virus (HIV)-1 transactivation in an HSP90-dependent manner. GV1001 treatment resulted in significant suppression of HIV-1 replication and rescue of infected cells from death by HIV-1. Transactivation of HIV-long terminal repeat (LTR) was inhibited by GV1001, indicating that GV1001 suppressed the transcription from proviral HIV DNA. The anti-HIV-1 activity of GV1001 was completely abrogated by an HSP90-neutralizing antibody, indicating that the antiviral activity depends on HSP90. Further mechanistic studies revealed that GV1001 suppresses basal NF-κB activation, which is required for HIV-1 LTR transactivation in an HSP90-dependent manner. Inhibition of LTR transactivation by GV1001 suggests its potential to suppress HIV-1 reactivation from latency. Indeed, PMA-mediated reactivation of HIV-1 from latent infected cells was suppressed by GV1001. The results suggest the potential therapeutic use of GV1001, a peptide proven to be safe for human use, as an anti-HIV-1 agent to suppress the reactivation from latently infected cells.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kim H,Choi MS,Inn KS,Kim BJdoi
10.1038/srep28896subject
Has Abstractpub_date
2016-07-01 00:00:00pages
28896issn
2045-2322pii
srep28896journal_volume
6pub_type
杂志文章abstract：:L-selectin on T-cells is best known as an adhesion molecule that supports recruitment of blood-borne naïve and central memory cells into lymph nodes. Proteolytic shedding of the ectodomain is thought to redirect activated T-cells from lymph nodes to sites of infection. However, we have shown that activated T-cells re-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41811-z
更新日期：2019-04-02 00:00:00
abstract：:Anthracnose caused by Colletotrichum is one of the most severe diseases of Hevea brasiliensis. However, research on the diversity and geographical distribution of Colletotrichum remains limited in China. In this study, we investigated the phylogenetic diversity of Colletotrichum isolates associated with symptomatic ti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28166-7
更新日期：2018-07-11 00:00:00
abstract：:With millions of new dental and orthopedic implants inserted annually, periprosthetic osteolysis becomes a major concern. In dentistry, peri-implantitis management includes cleaning using ultrasonic scaling. We examined whether ultrasonic scaling releases titanium particles and induces inflammation and osteolysis. Tit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39612
更新日期：2017-01-06 00:00:00
abstract：:The aim of this study was to find an accurate method for the detection of extracapsular extension (ECE) in papillary thyroid carcinoma (PTC). A total of 102 patients with 109 PTC nodules were retrospectively enrolled. Contrast-enhanced ultrasound (CEUS) characteristics were evaluated. The diagnostic efficacy of quanti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01650-2
更新日期：2017-05-03 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is one of the highest incidences in cancers; however, traditional chemotherapy often suffers from low efficiency caused by drug resistance. Herein, we report an arsenite-loaded dual-drug (doxorubicin and arsenic trioxide, i.e., DOX and ATO) nanomedicine system (FeAsOx@SiO2-DOX, Combo NP)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31009
更新日期：2016-08-03 00:00:00
abstract：:Inconsistent findings have reported on the inflammatory potential of diet and cardiovascular disease (CVD) and mortality risk. The aim of this meta-analysis was to investigate the association between the inflammatory potential of diet as estimated by the dietary inflammatory index (DII) score and CVD or mortality risk...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-017-06455-x
更新日期：2017-07-25 00:00:00
abstract：:The objective of this study was to evaluate the clinical ability of Near-Infrared Light-Transillumination (NILT) for approximal dentinal caries detection and to compare with direct digital-radiography (DDR), as well as to determine whether the combination of both techniques improves the diagnostic capacity of the lesi...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-50850-5
更新日期：2019-10-02 00:00:00
abstract：:The identification of clinically-relevant early diagnostic and prognostic protein biomarkers is essential to maximize therapeutic efficacy and prevent cancer progression. The aim of the current study is to determine whether aberrant plasma protein profile can be applied as a surrogate tool for early diagnosis of bladd...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67929-z
更新日期：2020-07-03 00:00:00
abstract：:Treatment of azo dye effluents has received increasing concerns over the years due to their potential harms to natural environment and human health. The present study described the degrading ability of the as-synthesized crystalline Al-Cu alloys for removal of high-concentration Acid Scarlet 3R in alkaline aqueous sol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31797
更新日期：2016-08-18 00:00:00
abstract：:Quinolinic acid, a macrophage/microglia-derived excitotoxin fulfills a plethora of functions such as neurotoxin, gliotoxin, and proinflammatory mediator, and it alters the integrity and cohesion of the blood-brain barrier in several pathophysiological states. Beta-trace protein (BTP), a monomeric glycoprotein, is know...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43642
更新日期：2017-03-09 00:00:00
abstract：:With an increasing clinical demand for functional therapeutic proteins every year, there is an increasing requirement for the massive production of bioactive recombinant human acidic fibroblast growth factor (r-haFGF). In this present study, we delicately explore a strategy for the mass production of r-haFGF protein w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16323
更新日期：2015-11-16 00:00:00
abstract：:In this work, cerium-diethyldithiocarbamate (Ce-DEDTC) complex was synthesized as a novel anti-corrosion pigment. The structure of the synthesized pigment was characterized by employing Fourier transfer infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, inductively coupled plasma optical emission sp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61946-8
更新日期：2020-03-19 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-68128-6
更新日期：2020-07-06 00:00:00
abstract：:Pristine and functionalized multi-walled carbon nanotubes (MWCNTs) were investigated as adsorbent materials inside solid-phase extraction (SPE) cartridges for extraction and preconcentration of 8 EU-relevant organic micropollutants (with different pKa and polarity) before chromatographic analysis of surface water. The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79244-8
更新日期：2020-12-18 00:00:00
abstract：:The raccoon dog (Nyctereutes procyonoides) is an important canid fur-bearing animal species worldwide. Chinese raccoon dogs that present a white mutation, especially those with a white coat. Exploring melanin biosynthesis in the hair and skin of raccoon dogs is important for understanding the survival and evolutionary...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40903
更新日期：2017-01-18 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-24117-4
更新日期：2018-04-17 00:00:00
abstract：:Network structure has often proven to be important in understanding the decision behavior of individuals or agents in different interdependent situations. Computational studies predict that network structure has a crucial influence on behavior in iterated 2 by 2 asymmetric 'battle of the sexes' games. We test such beh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43260-0
更新日期：2019-05-02 00:00:00
abstract：:Relapse and metastasis of nasopharyngeal carcinoma (NPC) are presumably attributed to cancer stem cells (CSCs). In recent years, chimeric antigen receptor (CAR)-modified immune effector cells have been shown to have impressive antitumour efficacy. In this study, we aimed to identify appropriate tumour-associated antig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04756-9
更新日期：2017-07-07 00:00:00
abstract：:Coastal zones constitute one of the most heavily populated and developed land zones in the world. Despite the utility and economic benefits that coasts provide, there is no reliable global-scale assessment of historical shoreline change trends. Here, via the use of freely available optical satellite images captured si...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24630-6
更新日期：2018-04-27 00:00:00
abstract：:An inexpensive and compact frequency multi-mode diode laser enables a compact two-photon polarization entanglement source via the continuous wave broadband pumped spontaneous parametric down-conversion (SPDC) process. Entanglement degradation caused by polarization mode dispersion (PMD) is one of the critical issues i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25846
更新日期：2016-05-13 00:00:00
abstract：:Nanostructure arrays such as nanowire, nanopillar, and nanocone arrays have been proposed to be promising antireflection structures for photovoltaic applications due to their great light trapping ability. In this paper, the optical properties of Si nanopillar and nanocone arrays in visible and infrared region were stu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07810
更新日期：2015-01-15 00:00:00
abstract：:Lytic transglycosylases (LTs) catalyze the non-hydrolytic cleavage of the bacterial cell wall by an intramolecular transacetalization reaction. This reaction is critically and broadly important in modifications of the bacterial cell wall in the course of its biosynthesis, recycling, manifestation of virulence, inserti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22527-y
更新日期：2018-03-07 00:00:00
abstract：:A combination of techniques from 3D printing, tissue engineering and biomaterials has yielded a new class of engineered biological robots that could be reliably controlled via applied signals. These machines are powered by a muscle strip composed of differentiated skeletal myofibers in a matrix of natural proteins, in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03723-8
更新日期：2017-06-19 00:00:00
abstract：:Burkholderia terrae BS001 has previously been found to be able to disperse along with growing fungal hyphae in soil, with the type-3 secretion system having a supportive role in this movement. In this study, we focus on the role of two motility- and adherence-associated appendages, i.e. type-4 pili (T4P) and flagella....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02959-8
更新日期：2017-06-07 00:00:00
abstract：:MicroRNAs (miRNAs) are proposed as potential biomarkers for the diagnosis of numerous diseases. Here, we performed a meta-analysis to evaluate the utility of faecal miRNAs as a non-invasive tool in colorectal cancer (CRC) screening. A systematic literature search, according to predetermined criteria, in five databases...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-019-45570-9
更新日期：2019-07-01 00:00:00
abstract：:The study aimed to explore the epidemiology and clinical characteristics of chronic osteomyelitis observed in a northern China hospital. Clinical data of 255 patients with chronic osteomyelitis from January 2007 to January 2014 were collected and analyzed, including general information, disease data, treatment and fol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33106-6
更新日期：2018-10-05 00:00:00
abstract：:Remodeling of the collagen architecture in the extracellular matrix (ECM) has been implicated in ovarian cancer. To quantify these alterations we implemented a form of 3D texture analysis to delineate the fibrillar morphology observed in 3D Second Harmonic Generation (SHG) microscopy image data of normal (1) and high ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35734
更新日期：2016-10-21 00:00:00
abstract：:Psoriatic skin differs distinctly from normal skin by its thickened epidermis. Most gene expression comparisons utilize full-thickness biopsies, with substantial amount of dermis. We assayed the transcriptomes of normal, lesional, and non-lesional psoriatic epidermis, sampled as split-thickness skin grafts, with 5'-en...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22745
更新日期：2016-03-15 00:00:00
abstract：:Carcinoembryonic antigen (CEA) is the only blood based protein biomarker at present, used for preoperative screening of advanced colorectal cancer (CRC) patients to determine the appropriate curative treatments and post-surveillance screening for tumour recurrence. Current diagnostics for CRC detection have several li...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80354-6
更新日期：2021-01-12 00:00:00
abstract：:Melanoma is one of the most aggressive skin cancers and is well known for its high metastatic rate. Studies have shown that epithelial mesenchymal transition (EMT) is essential for melanoma cell metastasis. However, the molecular mechanisms underlying EMT are still not fully understood. We have shown that IRGM1, a mem...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12357
更新日期：2015-07-23 00:00:00
