当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > 5,7-Di-N-acetyl-8-epiacinetaminic acid: A new non-2-ulosonic acid found in the K73 capsule produced by an Acinetobacter baumannii isolate from Singapore.

5,7-Di-N-acetyl-8-epiacinetaminic acid: A new non-2-ulosonic acid found in the K73 capsule produced by an Acinetobacter baumannii isolate from Singapore.

Abstract：

:Nonulosonic acids are found in the surface polysaccharides of many bacterial species and are often implicated in pathogenesis. Here, the structure of a novel 5,7-diacetamido-3,5,7,9-tetradeoxynon-2-ulosonic acid recovered from the capsular polysaccharide of a multiply antibiotic resistant Acinetobacter baumannii isolate was determined. The isolate carries a sugar synthesis module that differs by only a single gene from the module for the synthesis of 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-L-altro-non-2-ulosonic acid or 5,7-di-N-acetylacinetaminic acid, recently discovered in the capsule of another A. baumannii isolate. The new monosaccharide is the C8-epimer of acinetaminic acid (8eAci; 5,7-diacetamido-3,5,7,9-tetradeoxy-D-glycero-L-altro-non-2-ulosonic acid) and the C7-epimer of legionaminic acid. This monosaccharide had not previously been detected in a biological sample but had been synthesized chemically.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kenyon JJ,Notaro A,Hsu LY,De Castro C,Hall RM

doi

10.1038/s41598-017-11166-4

subject

Has Abstract

pub_date

2017-09-12 00:00:00

pages

11357

issue

1

issn

2045-2322

pii

10.1038/s41598-017-11166-4

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Inkjet-Printed Graphene/PEDOT:PSS Temperature Sensors on a Skin-Conformable Polyurethane Substrate.

    abstract：:Epidermal electronic systems (EESs) are skin-like electronic systems, which can be used to measure several physiological parameters from the skin. This paper presents materials and a simple, straightforward fabrication process for skin-conformable inkjet-printed temperature sensors. Epidermal temperature sensors are a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35289

    authors： Vuorinen T,Niittynen J,Kankkunen T,Kraft TM,Mäntysalo M

    更新日期：2016-10-18 00:00:00

  • Trace analysis of multi-class pesticide residues in Chinese medicinal health wines using gas chromatography with electron capture detection.

    abstract：:A method is described for multi-residue, high-throughput determination of trace levels of 22 organochlorine pesticides (OCPs) and 5 pyrethroid pesticides (PYPs) in Chinese medicinal (CM) health wines using a QuEChERS (quick, easy, cheap, effective, rugged, and safe) based extraction method and gas chromatography-elect...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep21558

    authors： Kong WJ,Liu QT,Kong DD,Liu QZ,Ma XP,Yang MH

    更新日期：2016-02-17 00:00:00

  • CaCDPK15 positively regulates pepper responses to Ralstonia solanacearum inoculation and forms a positive-feedback loop with CaWRKY40 to amplify defense signaling.

    abstract：:CaWRKY40 is a positive regulator of pepper (Capsicum annum) response to Ralstonia solanacearum inoculation (RSI), but the underlying mechanism remains largely unknown. Here, we functionally characterize CaCDPK15 in the defense signaling mediated by CaWRKY40. Pathogen-responsive TGA, W, and ERE boxes were identified in...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep22439

    authors： Shen L,Yang S,Yang T,Liang J,Cheng W,Wen J,Liu Y,Li J,Shi L,Tang Q,Shi W,Hu J,Liu C,Zhang Y,Mou S,Liu Z,Cai H,He L,Guan D,Wu Y,He S

    更新日期：2016-03-01 00:00:00

  • Spatially- and vector-resolved momentum flux lost to a wall in a magnetic nozzle rf plasma thruster.

    abstract：:Most of the artificial low-pressure plasmas contact with physical walls in laboratories; the plasma loss at the wall significantly affects the plasma device performance, e.g., an electric propulsion device. Near the surface of the wall, ions are spontaneously accelerated by a sheath and deliver their momentum and ener...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-58022-6

    authors： Takahashi K,Sugawara T,Ando A

    更新日期：2020-01-23 00:00:00

  • OsMYC2, an essential factor for JA-inductive sakuranetin production in rice, interacts with MYC2-like proteins that enhance its transactivation ability.

    abstract：:Biosynthesis of sakuranetin, a flavonoid anti-fungal phytoalexin that occurs in rice, is highly dependent on jasmonic acid (JA) signalling and induced by a variety of environmental stimuli. We previously identified OsNOMT, which encodes naringenin 7-O-methyltransferase (NOMT); NOMT is a key enzyme for sakuranetin prod...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40175

    authors： Ogawa S,Miyamoto K,Nemoto K,Sawasaki T,Yamane H,Nojiri H,Okada K

    更新日期：2017-01-09 00:00:00

  • Satellitome landscape analysis of Megaleporinus macrocephalus (Teleostei, Anostomidae) reveals intense accumulation of satellite sequences on the heteromorphic sex chromosome.

    abstract：:The accumulation of repetitive DNA sequences on the sex-limited W or Y chromosomes is a well-known process that is likely triggered by the suppression of recombination between the sex chromosomes, which leads to major differences in their sizes and genetic content. Here, we report an analysis conducted on the satellit...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42383-8

    authors： Utsunomia R,Silva DMZA,Ruiz-Ruano FJ,Goes CAG,Melo S,Ramos LP,Oliveira C,Porto-Foresti F,Foresti F,Hashimoto DT

    更新日期：2019-04-10 00:00:00

  • Collective chemotaxis and segregation of active bacterial colonies.

    abstract：:Still recently, bacterial fluid suspensions have motivated a lot of works, both experimental and theoretical, with the objective to understand their collective dynamics from universal and simple rules. Since some species are active, most of these works concern the strong interactions that these bacteria exert on a for...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep21269

    authors： Ben Amar M

    更新日期：2016-02-18 00:00:00

  • First Miocene rodent from Lebanon provides the 'missing link' between Asian and African gundis (Rodentia: Ctenodactylidae).

    abstract：:Ctenodactylinae (gundis) is a clade of rodents that experienced, in Miocene time, their greatest diversification and widest distribution. They expanded from the Far East, their area of origin, to Africa, which they entered from what would become the Arabian Peninsula. Questions concerning the origin of African Ctenoda...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12871

    authors： López-Antoñanzas R,Knoll F,Maksoud S,Azar D

    更新日期：2015-08-07 00:00:00

  • Revised role for Hfq bacterial regulator on DNA topology.

    abstract：:Hfq is a pleiotropic regulator that mediates several aspects of bacterial RNA metabolism. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, usually via its interaction with small regulatory RNA. Besides these RNA-related functions, Hfq has also been described as one of the n...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35060-9

    authors： Malabirade A,Partouche D,El Hamoui O,Turbant F,Geinguenaud F,Recouvreux P,Bizien T,Busi F,Wien F,Arluison V

    更新日期：2018-11-14 00:00:00

  • Divergent mammalian body size in a stable Eocene greenhouse climate.

    abstract：:A negative correlation between body size and the latitudinal temperature gradient is well established for extant terrestrial endotherms but less so in the fossil record. Here we analyze the middle Eocene site of Geiseltal (Germany), whose record is considered to span ca. 5 Myrs of gradual global cooling, and generate ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-60379-7

    authors： Ring SJ,Bocherens H,Wings O,Rabi M

    更新日期：2020-03-04 00:00:00

  • Random mutagenesis of the hyperthermophilic archaeon Pyrococcus furiosus using in vitro mariner transposition and natural transformation.

    abstract：:Transposition mutagenesis is a powerful tool to identify the function of genes, reveal essential genes and generally to unravel the genetic basis of living organisms. However, transposon-mediated mutagenesis has only been successfully applied to a limited number of archaeal species and has never been reported in Therm...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep36711

    authors： Guschinskaya N,Brunel R,Tourte M,Lipscomb GL,Adams MWW,Oger P,Charpentier X

    更新日期：2016-11-08 00:00:00

  • Development of a novel risk score to predict mortality in patients admitted to hospital with COVID-19.

    abstract：:Patients hospitalised with COVID-19 have a high mortality. Identification of patients at increased risk of adverse outcome would be important, to allow closer observation and earlier medical intervention for those at risk, and to objectively guide prognosis for friends and family of affected individuals. We conducted ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-78505-w

    authors： Gue YX,Tennyson M,Gao J,Ren S,Kanji R,Gorog DA

    更新日期：2020-12-07 00:00:00

  • Expresser phenotype determines ABO(H) blood group antigen loading on platelets and von Willebrand factor.

    abstract：:ABO blood group is associated with cardiovascular disease, with significantly lower risk in blood group O individuals. ABO(H) blood group determinants are expressed on different glycoproteins on platelet surfaces. In addition, ABO(H) structures are also present on VWF glycans. These ABO(H) carbohydrates influence both...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75462-2

    authors： O'Donghaile D,Jenkins PV,McGrath RT,Preston L,Field SP,Ward SE,O'Sullivan JM,O'Donnell JS

    更新日期：2020-10-27 00:00:00

  • Tidally disrupted stars as a possible origin of both cosmic rays and neutrinos at the highest energies.

    abstract：:Tidal Disruption Events (TDEs) are processes where stars are torn apart by the strong gravitational force near to a massive or supermassive black hole. If a jet is launched in such a process, particle acceleration may take place in internal shocks. We demonstrate that jetted TDEs can simultaneously describe the observ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29022-4

    authors： Biehl D,Boncioli D,Lunardini C,Winter W

    更新日期：2018-07-17 00:00:00

  • Detecting sedimentary cycles using autocorrelation of grain size.

    abstract：:Detection of sedimentary cycles is difficult in fine-grained or homogenous sediments but is a prerequisite for the interpretation of depositional environments. Here we use a new autocorrelation analysis to detect cycles in a homogenous sediment core, E602, from the northern shelf of the South China Sea. Autocorrelatio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01653

    authors： Xiao S,Li R,Chen M

    更新日期：2013-01-01 00:00:00

  • Associations of Plasma FGF2 Levels and Polymorphisms in the FGF2 Gene with Obesity Phenotypes in Han Chinese Population.

    abstract：:Obesity is highly heritable, but the specific genes influencing obesity related traits are largely unknown. Fibroblast growth factor 2 (FGF2) could influence adipocyte differentiation. However, the association of FGF2 polymorphisms and obesity remains unclear. This study aimed to investigate the associations of both t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19868

    authors： Hao RH,Guo Y,Dong SS,Weng GZ,Yan H,Zhu DL,Chen XF,Chen JB,Yang TL

    更新日期：2016-02-16 00:00:00

  • Investigation and Restoration of BEST1 Activity in Patient-derived RPEs with Dominant Mutations.

    abstract：:BEST1 is a Ca2+-activated Cl- channel predominantly expressed in retinal pigment epithelium (RPE), and over 250 genetic mutations in the BEST1 gene have been identified to cause retinal degenerative disorders generally known as bestrophinopathies. As most BEST1 mutations are autosomal dominant, it is of great biomedic...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54892-7

    authors： Ji C,Li Y,Kittredge A,Hopiavuori A,Ward N,Yao P,Fukuda Y,Zhang Y,Tsang SH,Yang T

    更新日期：2019-12-13 00:00:00

  • Optogenetic activation of axon guidance receptors controls direction of neurite outgrowth.

    abstract：:Growth cones of extending axons navigate to correct targets by sensing a guidance cue gradient via membrane protein receptors. Although most signaling mechanisms have been clarified using an in vitro approach, it is still difficult to investigate the growth cone behavior in complicated extracellular environment of liv...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23976

    authors： Endo M,Hattori M,Toriyabe H,Ohno H,Kamiguchi H,Iino Y,Ozawa T

    更新日期：2016-04-07 00:00:00

  • High affinity anchoring of the decoration protein pb10 onto the bacteriophage T5 capsid.

    abstract：:Bacteriophage capsids constitute icosahedral shells of exceptional stability that protect the viral genome. Many capsids display on their surface decoration proteins whose structure and function remain largely unknown. The decoration protein pb10 of phage T5 binds at the centre of the 120 hexamers formed by the major ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep41662

    authors： Vernhes E,Renouard M,Gilquin B,Cuniasse P,Durand D,England P,Hoos S,Huet A,Conway JF,Glukhov A,Ksenzenko V,Jacquet E,Nhiri N,Zinn-Justin S,Boulanger P

    更新日期：2017-02-06 00:00:00

  • Microsomal Prostaglandin E Synthase-1 Plays a Critical Role in Long-term Motility Dysfunction after Bowel Obstruction.

    abstract：:Motility dysfunction is present not only during bowel obstruction (BO), but after obstruction is resolved. Previous studies found that lumen distension associated mechano-transcription of COX-2 and production of PGE2 in gut smooth muscle cells (SMC) account for motility dysfunction during obstruction. We hypothesized ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-27230-6

    authors： Lin YM,Fu Y,Hegde S,Tang Y,Radhakrishnan R,Shi XZ

    更新日期：2018-06-11 00:00:00

  • Aspirin might reduce the incidence of pancreatic cancer: A meta-analysis of observational studies.

    abstract：:Although there is evidence that non-steroidal anti-inflammatory drugs (NSAIDs) might be able to prevent pancreatic cancer, the findings from epidemiological studies have been inconsistent. In this paper, we conducted a meta-analysis of observational studies to examine this possibility. We searched PubMed and Embase fo...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/srep15460

    authors： Zhang YP,Wan YD,Sun YL,Li J,Zhu RT

    更新日期：2015-10-21 00:00:00

  • Functional stability analyses of maxillofacial skeleton bearing cleft deformities.

    abstract：:The symmetrically stable craniofacial bony structure supports the complex functions and delicate contour of the face. Congenital craniofacial deformities are often accompanied by bony defects and have been repetitively correlated with compromised dento-maxillary stability, but neither the extent nor the pattern of cle...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40478-w

    authors： Luo X,Huang H,Yin X,Shi B,Li J

    更新日期：2019-03-12 00:00:00

  • Amide-controlled, one-pot synthesis of tri-substituted purines generates structural diversity and analogues with trypanocidal activity.

    abstract：:A novel one-pot synthesis of tri-substituted purines and the discovery of purine analogues with trypanocidal activity are reported. The reaction is initiated by a metal-free oxidative coupling of primary alkoxides and diaminopyrimidines with Schiff base formation and subsequent annulation in the presence of large N,N-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09139

    authors： Pineda de las Infantas y Villatoro MJ,Unciti-Broceta JD,Contreras-Montoya R,Garcia-Salcedo JA,Gallo Mezo MA,Unciti-Broceta A,Diaz-Mochon JJ

    更新日期：2015-03-16 00:00:00

  • Thermal conductivity enhancement in gold decorated graphene nanosheets in ethylene glycol based nanofluid.

    abstract：:We report on the synthesis and thermal conductivity of gold nanoparticles (AuNPs) decorated graphene nanosheets (GNs) based nanofluids. The GNs-AuNPs nanocomposites were synthesised using a nanosecond pulsed Nd:YAG laser (wavelength = 1,064 nm) to ablate graphite target followed by Au in ethylene glycol (EG) base flui...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71740-1

    authors： Mbambo MC,Madito MJ,Khamliche T,Mtshali CB,Khumalo ZM,Madiba IG,Mothudi BM,Maaza M

    更新日期：2020-09-07 00:00:00

  • 18β-glycyrrhetyl-3-O-sulfate would be a causative agent of licorice-induced pseudoaldosteronism.

    abstract：:Licorice-induced pseudoaldosteronism is a common adverse effect in traditional Japanese Kampo medicine, and 3-monoglucuronyl glycyrrhetinic acid (3MGA) was considered as a causative agent of it. Previously, we found 22α-hydroxy-18β-glycyrrhetyl-3-O-sulfate-30-glucuronide (1), one of the metabolites of glycyrrhizin (GL...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-38182-2

    authors： Ishiuchi K,Morinaga O,Ohkita T,Tian C,Hirasawa A,Mitamura M,Maki Y,Kondo T,Yasujima T,Yuasa H,Minamizawa K,Namiki T,Makino T

    更新日期：2019-02-07 00:00:00

  • Stable and discriminating features are predictive of cancer presence and Gleason grade in radical prostatectomy specimens: a multi-site study.

    abstract：:Site variation in fixation, staining, and scanning can confound automated tissue based image classifiers for disease characterization. In this study we incorporated stability into four feature selection methods for identifying the most robust and discriminating features for two prostate histopathology classification t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-33026-5

    authors： Leo P,Elliott R,Shih NNC,Gupta S,Feldman M,Madabhushi A

    更新日期：2018-10-08 00:00:00

  • Detection and segmentation of cell nuclei in virtual microscopy images: a minimum-model approach.

    abstract：:Automated image analysis of cells and tissues has been an active research field in medical informatics for decades but has recently attracted increased attention due to developments in computer and microscopy hardware and the awareness that scientific and diagnostic pathology require novel approaches to perform object...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00503

    authors： Wienert S,Heim D,Saeger K,Stenzinger A,Beil M,Hufnagl P,Dietel M,Denkert C,Klauschen F

    更新日期：2012-01-01 00:00:00

  • A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity.

    abstract：:The PIM1 serine/threonine protein kinase mediates growth factor and survival signalling, and cooperates potently with c-MYC during tumorigenesis. PIM1 is overexpressed in many human cancers and is a promising target for drug development. PIM1 levels are regulated mainly through cytokine-induced transcription and prote...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03775-w

    authors： Iyer RS,Chatham L,Sleigh R,Meek DW

    更新日期：2017-06-15 00:00:00

  • Genome targeting by hybrid Flp-TAL recombinases.

    abstract：:Genome engineering is a rapidly evolving field that benefits from the availability of different tools that can be used to perform genome manipulation tasks. We describe here the development of the Flp-TAL recombinases that can target genomic FRT-like sequences in their native chromosomal locations. Flp-TAL recombinase...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-74474-2

    authors： Voziyanova E,Li F,Shah R,Voziyanov Y

    更新日期：2020-10-15 00:00:00

  • New Insight into AuNP Applications in Tumour Treatment and Cosmetics through Wavy Annuli at the Nanoscale.

    abstract：:The purpose of this study is to probe the peristaltic propulsion of a non-Newtonian fluid model with suspended gold nanoparticles. The base fluid is considered to simulate blood using the Carreau fluid model. We model a small annulus as a tube with a peristaltic wave containing a clot propagating towards the tube wall...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-36459-0

    authors： Abdelsalam SI,Bhatti MM

    更新日期：2019-01-22 00:00:00