Abstract：
:Licorice-induced pseudoaldosteronism is a common adverse effect in traditional Japanese Kampo medicine, and 3-monoglucuronyl glycyrrhetinic acid (3MGA) was considered as a causative agent of it. Previously, we found 22α-hydroxy-18β-glycyrrhetyl-3-O-sulfate-30-glucuronide (1), one of the metabolites of glycyrrhizin (GL) in the urine of Eisai hyperbilirubinuria rats (EHBRs) treated with glycyrrhetinic acid (GA), and suggested that it is also a possible causative agent of pseudoaldosteronism. The discovery of 1 also suggested that there might be other metabolites of GA as causal candidates. In this study, we found 22α-hydroxy-18β-glycyrrhetyl-3-O-sulfate (2) and 18β-glycyrrhetyl-3-O-sulfate (3) in EHBRs' urine. 2 and 3 more strongly inhibited rat type 2 11β-hydroxysteroid dehydrogenase than 1 did in vitro. When EHBRs were orally treated with GA, GA and 1-3 in plasma and 1-3 in urine were detected; the levels of 3MGA were quite low. 2 and 3 were shown to be the substrates of organic anion transporter (OAT) 1 and OAT3. In the plasma of a patient suffering from pseudoaldosteronism with rhabdomyolysis due to licorice, we found 8.6 µM of 3, 1.3 µM of GA, and 87 nM of 2, but 1, GL, and 3MGA were not detected. These findings suggest that 18β-glycyrrhetyl-3-O-sulfate (3) is an alternative causative agent of pseudoaldosteronism, rather than 3MGA and 1.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ishiuchi K,Morinaga O,Ohkita T,Tian C,Hirasawa A,Mitamura M,Maki Y,Kondo T,Yasujima T,Yuasa H,Minamizawa K,Namiki T,Makino Tdoi
10.1038/s41598-018-38182-2subject
Has Abstractpub_date
2019-02-07 00:00:00pages
1587issue
1issn
2045-2322pii
10.1038/s41598-018-38182-2journal_volume
9pub_type
杂志文章abstract：:Interleukin-27 (IL-27) is an important cytokine in inflammatory diseases, including coronary artery disease (CAD). To explore the precise role of IL-27 in CAD, we investigated the genetic association between IL27 and CAD in the GeneID Chinese Han population. A two-stage case control association analysis was performed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25782
更新日期：2016-05-12 00:00:00
abstract：:Characterizing a high-dimensional entanglement is fundamental in quantum information applications. Here, we propose a theoretical scheme to analyze and characterize the angular momentum hyperentanglement that two photons are entangled simultaneously in spin and orbital angular momentum. Based on the electro-optic samp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21856
更新日期：2016-02-25 00:00:00
abstract：:We demonstrate that laser peening coupled with sintering of CdTe nanowire films substantially enhances film quality and charge transfer while largely maintaining basic particle morphology. During the laser peening phase, a shockwave is used to compress the film. Laser sintering comprises the second step, where a nanos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16052
更新日期：2015-11-03 00:00:00
abstract：:Allergic contact hypersensitivity (CHS) is an inflammatory skin disease mediated by allergen specific T cells. In this study, we investigated the role of transcription factor NFAT1 in the pathogenesis of contact hypersensitivity. NFAT1 knock out (KO) mice spontaneously developed CHS-like skin inflammation in old age. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19453
更新日期：2016-01-18 00:00:00
abstract：:Chronic alcohol feeding causes lipid accumulation and apoptosis in the liver. This study investigated the role of bioactive lipid metabolites in alcohol-induced liver damage and tested the potential of targeting arachidonate 15-lipoxygenase (ALOX15) in treating alcoholic liver disease (ALD). Results showed that chroni...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02759-0
更新日期：2017-08-21 00:00:00
abstract：:Analyzing drug-drug interactions may unravel previously unknown drug action patterns, leading to the development of new drug discovery tools. We present a new approach to analyzing drug-drug interaction networks, based on clustering and topological community detection techniques that are specific to complex network sc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32745
更新日期：2016-09-07 00:00:00
abstract：:The conformation of the German shepherd dog (GSD) varies considerably within the breed. These differences may result in large variation in the movement and limb loading and undesirable consequences to their musculoskeletal health. This study aimed to investigate the relationship between conformation and biomechanical ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73550-x
更新日期：2020-10-15 00:00:00
abstract：:Contamination by endocrine disrupting compounds (EDCs) concerns the security and sustainability of a drinking water supply system and human exposure via water consumption. This study analyzed the selected EDCs in source (river water, n = 10) and supply (tap water, n = 155) points and the associated risks. A total of 1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74061-5
更新日期：2020-10-20 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-42219-5
更新日期：2019-04-16 00:00:00
abstract：:LncRNAs have emerged as a novel class of critical regulators of cancer. We aimed to construct a landscape of lncRNAs and their potential target genes in lung adenocarcinoma. Genome-wide expression of lncRNAs and mRNAs was determined using microarray. qRT-PCR was performed to validate the expression of the selected lnc...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/s41598-017-15712-y
更新日期：2017-11-10 00:00:00
abstract：:Pot experiments were carried out to study the effects of rice straw (RS) and rice straw ash (RSA) on the growth of early rice and α-diversity of bacterial community in soils around rare earth mining areas of Xunwu and Xinfeng counties in South Jiangxi of China. The results showed that the exploitation of rare earth re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67160-w
更新日期：2020-06-25 00:00:00
abstract：:Cooperation in one-shot anonymous interactions is a widely documented aspect of human behaviour. Here we shed light on the motivations behind this behaviour by experimentally exploring cooperation in a one-shot continuous-strategy Prisoner's Dilemma (i.e. one-shot two-player Public Goods Game). We examine the distribu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06790
更新日期：2014-10-28 00:00:00
abstract：:Interferometry-based online partial discharge (PD) monitor presented in this paper can detect the occurrence of PD sensitively, evaluate the peak value of the discharge inception voltage with random waveform and the damage extent relatively cost effectively. The interferograms affected by the PD are collected online. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76134-x
更新日期：2020-11-04 00:00:00
abstract：:High efficiency polymer:fullerene photovoltaic device layers self-assemble with hierarchical features from ångströms to 100's of nanometers. The feature size, shape, composition, orientation, and order all contribute to device efficiency and are simultaneously difficult to study due to poor contrast between carbon bas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30915
更新日期：2016-08-08 00:00:00
abstract：:We previously identified Drosophila REPTOR and REPTOR-BP as transcription factors downstream of mTORC1 that play an important role in regulating organismal metabolism. We study here the mammalian ortholog of REPTOR-BP, Crebl2. We find that Crebl2 mediates part of the transcriptional induction caused by mTORC1 inhibiti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56407-w
更新日期：2019-12-27 00:00:00
abstract：:There remain parts of our planet that are seldom visited by humans, let alone scientists. In such locations, crowd-sourced or citizen scientist data can be critical in describing biodiversity and detecting change. Rangitāhua, the Kermadec Islands, are 750 km from the nearest human-habitation. Although our knowledge of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60136-w
更新日期：2020-02-21 00:00:00
abstract：:Plant essential oils are considered as important bio-sources for the development of natural and environmentally safe pest control tools due to their multiple modes of action on insects. In this paper we have evaluated the activity of commercially available thyme oil and its constituents thymol, carvacrol, and p-cymene...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79550-1
更新日期：2021-01-13 00:00:00
abstract：:Opioids are effective analgesics for the management of moderate to severe cancer pain. Here we show that κ opioid receptor (KOR) agonists act as anti-angiogenic factors in tumors. Treatment with KOR agonists, U50,488H and TRK820, significantly inhibited human umbilical vein endothelial cell (HUVEC) migration and tube ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03213
更新日期：2013-11-14 00:00:00
abstract：:The clotting factor prothrombin exists in equilibrium between closed and open conformations, but the physiological role of these forms remains unclear. As for other allosteric proteins, elucidation of the linkage between molecular transitions and function is facilitated by reagents stabilized in each of the alternativ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21304-1
更新日期：2018-02-13 00:00:00
abstract：:MicroRNA-130b (miR-130b) downregulation has been identified in diabetes, but the role and mechanisms for miR-130b in mediating renal tubulointerstitial fibrosis in diabetic nephropathy (DN) remain unknown. We demonstrated that plasma miR-130b downregulation exhibited clinical and biological relevance as it was linked ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20475
更新日期：2016-02-03 00:00:00
abstract：:Adenosine receptors (ARs) are potential therapeutic targets for Parkinson's disease, diabetes, pain, stroke and cancers. Prediction of subtype selectivity is therefore important from both therapeutic and mechanistic perspectives. In this paper, we introduced a shape similarity profile as molecular descriptor, namely t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36595
更新日期：2016-11-04 00:00:00
abstract：:The reproductive performance of Octopus vulgaris broodstocks fed two different diets (mixed fish [F group, BW 1,048.14 g] or mixed crustaceans [C group, BW 998.44 g]) was analyzed using an experimental recirculating aquaculture system consisting of a tank equipped with spawning and incubation chambers. A total of 8 fe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72151-y
更新日期：2020-09-17 00:00:00
abstract：:Circulating microRNAs (c-miRNAs) in human plasma have been described as a potential marker of exercise. The present study investigated the effects of three acute resistance training (RT) protocols on the time-course changes of the c-miRNAs profiles in young males. The subjects (n = 45) were randomly divided into three...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02294-y
更新日期：2017-05-19 00:00:00
abstract：:The Great Amazon Reef (GARS) is an extensive mesophotic reef ecosystem between Brazil and the Caribbean. Despite being considered as one of the most important mesophotic reef ecosystems of the South Atlantic, recent criticism on the existence of a living reef in the Amazon River mouth was raised by some scientists and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50245-6
更新日期：2019-09-23 00:00:00
abstract：:This study for the first time examined the prophylactic role of Tungrymbai, a well-known fermented soybean food of North-East India, against hepatic steatosis. Treatment with hexane-isopropanolic (2:1, HIET) but not hydro-alcoholic (70% ethanol, HAET) extract dose-dependently (0.1, 0.2, or 0.3 µg/mL) reduced the intra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27607-7
更新日期：2018-07-03 00:00:00
abstract：:Regional differences in ion channel activity in the heart control the sequence of repolarization and may contribute to differences in contraction. Corticosteroids such as aldosterone or corticosterone increase the L-type Ca2+ current (ICaL) in the heart via the mineralocorticoid receptor (MR). Here, we investigate the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68308-4
更新日期：2020-07-14 00:00:00
abstract：:Metalloproteinases (MMPs) contribute to tissue remodeling and acute inflammation not only by degrading extracellular matrix proteins but also by controlling the influx of chemokines through the regulation and shedding of syndecans. B-lymphocytes, in addition to their well-known function as antibody producing cells, pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04199-2
更新日期：2017-06-20 00:00:00
abstract：:The cycling between GDP- and GTP- bound forms of the Ras protein is partly regulated by the binding of Sos. The structural/dynamic behavior of the complex formed between activated Sos and Ras at the point of the functional cycle where the nucleotide exchange is completed has not been described to date. Here we show th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29706
更新日期：2016-07-14 00:00:00
abstract：:Visceral adiposity is a risk factor for cardiovascular disorders, type 2 diabetes mellitus (T2D) and associated metabolic diseases. Sub-cutaneous fat is believed to be intrinsically different from visceral fat. To understand molecular mechanisms involved in metabolic advantages of fat transplantation, we studied a rat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00081
更新日期：2011-01-01 00:00:00
abstract：:In this paper, we present the first realization of an elastic metamaterial allowing independent tuning of negative density and stiffness for elastic waves propagating along a designated direction. In electromagnetic (or acoustic) metamaterials, it is now possible to tune permittivity (bulk modulus) and permeability (d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23630
更新日期：2016-03-23 00:00:00
