Abstract:
:Growth cones of extending axons navigate to correct targets by sensing a guidance cue gradient via membrane protein receptors. Although most signaling mechanisms have been clarified using an in vitro approach, it is still difficult to investigate the growth cone behavior in complicated extracellular environment of living animals due to the lack of tools. We develop a system for the light-dependent activation of a guidance receptor, Deleted in Colorectal Cancer (DCC), using Arabidopsis thaliana Cryptochrome 2, which oligomerizes upon blue-light absorption. Blue-light illumination transiently activates DCC via its oligomerization, which initiates downstream signaling in the illuminated subcellular region. The extending axons are attracted by illumination in cultured chick dorsal root ganglion neurons. Moreover, light-mediated navigation of the growth cones is achieved in living Caenorhabditis elegans. The photo-manipulation system is applicable to investigate the relationship between the growth cone behavior and its surrounding environment in living tissue.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Endo M,Hattori M,Toriyabe H,Ohno H,Kamiguchi H,Iino Y,Ozawa Tdoi
10.1038/srep23976subject
Has Abstractpub_date
2016-04-07 00:00:00pages
23976issn
2045-2322pii
srep23976journal_volume
6pub_type
杂志文章abstract::The rapid increase in use of electronic-cigarettes (e-cigarettes), especially among youth, raises the urgency for regulating bodies to make informed decisions, guidance, and policy on these products. This study evaluated cardiac function in an experimental model following exposure to e-cigarettes. We subjected C57BL/6...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40847-5
更新日期:2019-03-11 00:00:00
abstract::Free-surface vortices have long been studied to develop an understanding of similar rotating flow phenomena observed in nature and technology. However, a complete description of its turbulent three-dimensional flow field still remains elusive. In contrast, the related Taylor-Couette flow system has been well explicate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16950-w
更新日期:2018-01-16 00:00:00
abstract::We discover and characterise strong quantum scars, or quantum eigenstates resembling classical periodic orbits, in two-dimensional quantum wells perturbed by local impurities. These scars are not explained by ordinary scar theory, which would require the existence of short, moderately unstable periodic orbits in the p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37656
更新日期:2016-11-28 00:00:00
abstract::Recently, we reported that chemokine (C-X-C motif) receptor (CXCR)4 and atypical chemokine receptor 3 regulate α1-adrenergic receptors (α1-AR) through the formation of hetero-oligomeric complexes. Whether α1-ARs also regulate chemokine receptor function within such heteromeric receptor complexes is unknown. We observe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21096-4
更新日期:2018-02-09 00:00:00
abstract::Among its other biological roles, acetylcholinesterase (AChE, EC 3.1.1.7), encoded by two ace in most insects, catalyses the breakdown of acetylcholine, thereby terminating synaptic transmission. ace1 encodes the synaptic enzyme and ace2 has other essential actions in many insect species, such as Chilo suppressalis an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05360-7
更新日期:2017-07-10 00:00:00
abstract::LMNA gene encodes lamins A and C, two major components of the nuclear lamina, a network of intermediate filaments underlying the inner nuclear membrane. Most of LMNA mutations are associated with cardiac and/or skeletal muscles defects. Muscle laminopathies include Emery-Dreifuss Muscular Dystrophy, Limb-Girdle Muscul...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23918-x
更新日期:2018-04-04 00:00:00
abstract::Little-Parks effect names the oscillations in the superconducting critical temperature as a function of the magnetic field. This effect is related to the geometry of the sample. In this work, we show that this effect can be enhanced and manipulated by the inclusion of magnetic nanostructures with perpendicular magneti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67317-7
更新日期:2020-06-25 00:00:00
abstract::Bovine TB (bTB) is endemic in Irish cattle and has eluded eradication despite considerable expenditure, amid debate over the relative roles of badgers and cattle in disease transmission. Using a comprehensive dataset from Northern Ireland (>10,000 km(2); 29,513 cattle herds), we investigated interactions between host ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13062
更新日期:2015-08-17 00:00:00
abstract::The lack of bone morphological markers associated with the human control of wild animals has prevented the documentation of incipient animal domestication in archaeology. Here, we assess whether direct environmental changes (i.e. mobility reduction) could immediately affect ontogenetic changes in long bone structure, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75496-6
更新日期:2020-11-04 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-65027-8
更新日期:2020-05-20 00:00:00
abstract::Drought episodes decrease plant growth and productivity, which in turn cause high economic losses. Plants naturally sense and respond to water stress by activating specific signalling pathways leading to physiological and developmental adaptations. Genetically engineering genes that belong to these pathways might impr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44571-y
更新日期:2019-05-30 00:00:00
abstract::Laser Capture Microdissection (LCM) is a powerful tool to isolate and study gene expression pattern of desired and less accessible cells or tissues from a heterogeneous population. Existing LCM-based methods fail to obtain high quality RNA including small RNAs from small microdissected plant tissue and therefore, are ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21577
更新日期:2016-02-10 00:00:00
abstract::High-pressure Raman spectroscopy and x-ray diffraction of Sb2S3 up to 53 GPa reveals two phase transitions at 5 GPa and 15 GPa. The first transition is evidenced by noticeable compressibility changes in distinct Raman-active modes, in the lattice parameter axial ratios, the unit cell volume, as well as in specific int...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24246
更新日期:2016-04-06 00:00:00
abstract::Large consortia efforts and genome-wide association studies (GWASs) have linked a number of genetic variants within the 6p21 chromosomal region to non-Hodgkin lymphoma (NHL). Complementing these efforts, we genotyped previously reported SNPs in the human leukocyte antigen (HLA) class I (rs6457327) and class II (rs9271...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41400
更新日期:2017-01-31 00:00:00
abstract::Diamond attracts considerable attention as a versatile and technologically useful material. For many demanding applications, such as recently emerged quantum optics and sensing, it is important to develop new routes for fabrication of diamond containing defects with specific optical, electronic and magnetic properties...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14789
更新日期:2015-10-05 00:00:00
abstract::Betaine alleviates high-fat diet-induced fatty liver and prenatal betaine programs offspring hepatic lipid metabolism. Excessive corticosterone (CORT) exposure causes fatty liver in chickens, yet it remains unknown whether and how prenatal betaine modulates the susceptibility of CORT-induced fatty liver later in life....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40251
更新日期:2017-01-06 00:00:00
abstract::Cellular locomotion is a central hallmark of eukaryotic life. It is governed by cell-extrinsic molecular factors, which can either emerge in the soluble phase or as immobilized, often adhesive ligands. To encode for direction, every cue must be present as a spatial or temporal gradient. Here, we developed a microfluid...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36440
更新日期:2016-11-07 00:00:00
abstract::In order to study the molecular differences between type 2 diabetes mellitus (T2DM) and T2DM with depression (DD), we aimed to screen the differential expression of lncRNA, mRNA, and circRNA in the blood of patients with T2DM and DD. Based on the self-rating depression scale (SDS), patient health questionnaire 9 (PHQ9...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47077-9
更新日期:2019-07-24 00:00:00
abstract::Glypican-3 (GPC3) is a cell-surface heparan sulfate proteoglycan highly expressed in hepatocellular carcinoma (HCC). We have generated a group of high-affinity mouse monoclonal antibodies targeting GPC3. Here, we report the humanization and testing of these antibodies for clinical development. We compared the affinity...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33878
更新日期:2016-09-26 00:00:00
abstract::The ST2/IL33 signalling pathway has been associated with ulcerative colitis (UC). ST2, encoded by the IL1RL1 gene, is expressed as both a membrane-anchored receptor (ST2L) activated by IL33 and as a soluble receptor (sST2) with anti-inflammatory properties. In UC patients, sST2 is further increased by corticosteroid t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10465-0
更新日期:2017-08-31 00:00:00
abstract::Globally, a small percentage of oil is recovered from reservoirs using primary and secondary recovery mechanisms, and thus a major focus of the oil industry is toward developing new technologies to increase recovery. Many new technologies utilize surfactants, macromolecules, and even nanoparticles, which are difficult...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11816-7
更新日期:2017-09-14 00:00:00
abstract::The rapid rise of bacterial resistance to traditional antibiotics combined with the decline in discovery of novel antibacterial agents has created a global public health crisis. Repurposing existing drugs presents an alternative strategy to potentially expedite the discovery of new antimicrobial drugs. The present stu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16407
更新日期:2015-11-10 00:00:00
abstract::MicroRNAs (miRNAs) are proposed as potential biomarkers for the diagnosis of numerous diseases. Here, we performed a meta-analysis to evaluate the utility of faecal miRNAs as a non-invasive tool in colorectal cancer (CRC) screening. A systematic literature search, according to predetermined criteria, in five databases...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-019-45570-9
更新日期:2019-07-01 00:00:00
abstract::Although cholecystectomy has been reported to be associated with increased risk of developing hepatocellular carcinoma (HCC), the association between cholecystectomy and prognosis of HCC patients underwent curative resection has never been examined. Through retrospective analysis of the data of 3933 patients underwent...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28229
更新日期:2016-06-20 00:00:00
abstract::This study aimed to investigate the prevalence, antibiogram of Pseudomonas aeruginosa (P. aeruginosa), and the distribution of virulence genes (oprL, exoS, phzM, and toxA) and the antibiotic-resistance genes (blaTEM, tetA, and blaCTX-M). A total of 285 fish (165 Oreochromis niloticus and 120 Clarias gariepinus) were c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72264-4
更新日期:2020-09-29 00:00:00
abstract::The purpose of this study was to evaluate changes in the prevalence and risk factors of cognitive impairment (CI) by analyzing and comparing two cross-sectional epidemiological surveys of CI and its subtypes were performed in a rural area of northern China between 2010 and 2015. Residents aged ≥60 years were drawn in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37286-z
更新日期:2019-01-29 00:00:00
abstract::Finding overlapping communities of complex networks remains a challenge in network science. To address this challenge, one of the widely used approaches is finding the communities of links by optimizing the objective function, partition density. In this study, we show that partition density suffers from inverse resolu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12432-1
更新日期:2017-09-29 00:00:00
abstract::The strong electronegativity of O dictates that the ground state of singlet CO has positively charged C and negatively charged O, in agreement with ab initio charge analysis, but in disagreement with the dipole direction. Though this unusual phenomenon has been fairly studied, the study of electrostatic potential (EP)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16307
更新日期:2015-11-06 00:00:00
abstract::While nanowires and nanospheres have been utilized in the design of a diverse array of nanoscale devices, recent schemes frequently require nanoscale architectures of higher complexity. However, conventional techniques are largely unsatisfactory for the production of more intricate nanoscale shapes and patterns, and e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04864
更新日期:2014-05-06 00:00:00
abstract::A junction between two boundaries of a topological superconductor (TSC), mediated by localized edge modes of Majorana fermions, is investigated. The tunneling of fermions across the junction depends on the magnetic flux. It breaks the time-reversal symmetry at the boundary of the sample. The persistent current is dete...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07492-2
更新日期:2017-08-02 00:00:00