Relationships of Non-coding RNA with diabetes and depression.

abstract：:The discovery of novel ligand chemotypes allows to explore uncharted regions in chemical space, thereby potentially improving synthetic accessibility, potency, and the drug-likeness of molecules. Here, we demonstrate the scaffold-hopping ability of the new Weighted Holistic Atom Localization and Entity Shape (WHALES) ...

journal_title：Scientific reports

authors： Grisoni F,Merk D,Byrne R,Schneider G

更新日期：2018-11-07 00:00:00

abstract：:Pompe disease (PD) is a metabolic myopathy due to acid alpha-glucosidase deficiency and characterized by extensive glycogen storage and impaired autophagy. We previously showed that modulation of autophagy and lysosomal exocytosis by overexpression of the transcription factor EB (TFEB) gene was effective in improving ...

journal_title：Scientific reports

authors： Gatto F,Rossi B,Tarallo A,Polishchuk E,Polishchuk R,Carrella A,Nusco E,Alvino FG,Iacobellis F,De Leonibus E,Auricchio A,Diez-Roux G,Ballabio A,Parenti G

更新日期：2017-11-08 00:00:00

abstract：:We report the new insight into the dielectric barrier discharge (DBD) induced inactivation of Microcystis aeruginosa, the dominant algae which caused harmful cyanobacterial blooms in many developing countries. In contrast with the previous work, we employed flow cytometry to examine the algal cells, so that we could a...

journal_title：Scientific reports

authors： Li L,Zhang H,Huang Q

更新日期：2015-09-08 00:00:00

abstract：:Prenatal ethanol exposure (PEE) is an established risk factor for intrauterine growth retardation. The present study was designed to determine whether PEE can increase the susceptibility of high-fat diet (HFD)-induced metabolic syndrome (MS) in adult offspring in a sex-specific manner, based on a generalized linear mo...

journal_title：Scientific reports

authors： He Z,Li J,Luo H,Zhang L,Ma L,Chen L,Wang H

更新日期：2015-12-03 00:00:00

abstract：:The ability of Treponema pallidum, the syphilis spirochete to colonize various tissues requires the presence of surface-exposed adhesins that have been difficult to identify due to the inability to culture and genetically manipulate T. pallidum. Using a Borrelia burgdorferi-based heterologous system and gain-in-functi...

journal_title：Scientific reports

authors： Chan K,Nasereddin T,Alter L,Centurion-Lara A,Giacani L,Parveen N

更新日期：2016-05-10 00:00:00

abstract：:SIRT1 is one of seven mammalian homologs of Sir2 that catalyzes NAD(+)-dependent protein deacetylation. The aim of the present study is to explore the effect of SIRT1 small molecule activator on the anticancer activity and the underlying mechanism. We examined the anticancer activity of a novel oral agent, curcumin, w...

journal_title：Scientific reports

authors： Hu A,Huang JJ,Li RL,Lu ZY,Duan JL,Xu WH,Chen XP,Fan JP

更新日期：2015-08-24 00:00:00

abstract：:The first-ever study of nickel selenide materials as efficient anode materials for Na-ion rechargeable batteries is conducted using the electrospinning process. NiSe2-reduced graphene oxide (rGO)-C composite nanofibers are successfully prepared via electrospinning and a subsequent selenization process. The electrospun...

journal_title：Scientific reports

authors： Cho JS,Lee SY,Kang YC

更新日期：2016-03-21 00:00:00

abstract：:Decreasing egg quality following oocyte ageing is a major restricting factor for the breeding programs. The mechanisms behind this process has not yet been clarified. To examine the possible involvement of oxidative stress in the oocyte ageing process, the relative mRNA abundance of specific transcripts were determine...

journal_title：Scientific reports

authors： Samarin AM,Samarin AM,Østbye TK,Ruyter B,Sampels S,Burkina V,Blecha M,Policar T

更新日期：2019-07-18 00:00:00

abstract：:In our previous study, a liver-targeting peptide CSP I-plus modified recombinant human Endostatin (rEndostatin, endostar) (rES-CSP) was constructed and showed potent antiangiogenic capability and could specifically bind to human hepatocellular carcinoma cells to make a direct inhibition in vitro. In this study, the bi...

journal_title：Scientific reports

authors： Yan M,Dongmei B,Jingjing Z,Xiaobao J,Jie W,Yan W,Jiayong Z

更新日期：2017-10-26 00:00:00

abstract：:Ziziphus is a genus of spiny shrubs and small trees in the Rhamnaceae family. This group has a controversial taxonomy, with more than 200 species described, including Chinese jujube (Ziziphus jujuba Mill. var. jujuba) and Indian jujube (Z. mauritiana), as well as several other important cultivated fruit crops. Using 2...

journal_title：Scientific reports

authors： Xu C,Gao J,Du Z,Li D,Wang Z,Li Y,Pang X

更新日期：2016-08-17 00:00:00

abstract：:Adult stem cells are considered promising candidates for cellular therapies due to their capacity to differentiate and self-renew. Differentiation leads to changes in the metabolism, structure, and gene expression patterns of cells. Hedgehog is one of the pathways that is involved in the enhancement of osteogenesis an...

journal_title：Scientific reports

authors： Shigunov P,Balvedi LT,Santos MDM,Herai RH,de Aguiar AM,Dallagiovanna B

更新日期：2018-05-30 00:00:00

abstract：:We isolated a novel bacterial strain from a prokaryotic consortium associated to the psychrophilic marine ciliate Euplotes focardii, endemic of the Antarctic coastal seawater. The 16S rDNA sequencing and the phylogenetic analysis revealed the close evolutionary relationship to the Antarctic marine bacterium Marinomona...

journal_title：Scientific reports

authors： John MS,Nagoth JA,Ramasamy KP,Ballarini P,Mozzicafreddo M,Mancini A,Telatin A,Liò P,Giuli G,Natalello A,Miceli C,Pucciarelli S

更新日期：2020-06-23 00:00:00

abstract：:In this study, we report a microfluidic device for the whole-life culture of the nematode Caenorhabditis elegans that allows the scoring of animal survival and health measures. This device referred to as the NemaLife chip features: (1) an optimized micropillar arena in which animals can crawl, (2) sieve channels that ...

journal_title：Scientific reports

authors： Rahman M,Edwards H,Birze N,Gabrilska R,Rumbaugh KP,Blawzdziewicz J,Szewczyk NJ,Driscoll M,Vanapalli SA

更新日期：2020-10-01 00:00:00

abstract：:In endometriosis, M2 MΦs are dominant in endometriotic lesions, but the actual role of M2 MΦ is unclear. CD206 positive (+) MΦ is classified in one of M2 type MΦs and are known to produce cytokines and chemokines. In the present study, we used CD206 diphtheria toxin receptor mice, which enable to deplete CD206+ cells ...

journal_title：Scientific reports

authors： Ono Y,Yoshino O,Hiraoka T,Sato E,Furue A,Nawaz A,Hatta H,Fukushi Y,Wada S,Tobe K,Hirota Y,Osuga Y,Unno N,Saito S

更新日期：2021-01-13 00:00:00

abstract：:We have assembled the complete sequence of the Durio zibethinus chloroplast genome using long PacBio reads. Durian is a valuable commercial tree that produces durian fruit, which is popular in Southeast Asia. The chloroplast genome assembled into a single 143 kb cyclic contig that contained 111 genes. There were 46 sh...

journal_title：Scientific reports

authors： Shearman JR,Sonthirod C,Naktang C,Sangsrakru D,Yoocha T,Chatbanyong R,Vorakuldumrongchai S,Chusri O,Tangphatsornruang S,Pootakham W

更新日期：2020-10-07 00:00:00

abstract：:Probing the cellular structure of in vivo biological tissue is a fundamental problem in biomedical imaging and medical science. This work introduces an approach for analyzing diffusion magnetic resonance imaging data acquired by the novel tensor-valued encoding technique for characterizing tissue microstructure. Our a...

journal_title：Scientific reports

authors： Ning L,Szczepankiewicz F,Nilsson M,Rathi Y,Westin CF

更新日期：2021-01-08 00:00:00

abstract：:The synthesis of highly biocompatible polymers is important for modern biotechnologies and medicine. Here, we report a unique process based on a two-step high-pressure ramp (HPR) for the ultrafast and efficient bulk polymerization of 2-(hydroxyethyl)methacrylate (HEMA) at room temperature without photo- and thermal ac...

journal_title：Scientific reports

authors： Evlyukhin E,Museur L,Traore M,Perruchot C,Zerr A,Kanaev A

更新日期：2015-12-16 00:00:00

abstract：:DNA-based data storage has emerged as a promising method to satisfy the exponentially increasing demand for information storage. However, practical implementation of DNA-based data storage remains a challenge because of the high cost of data writing through DNA synthesis. Here, we propose the use of degenerate bases a...

journal_title：Scientific reports

authors： Choi Y,Ryu T,Lee AC,Choi H,Lee H,Park J,Song SH,Kim S,Kim H,Park W,Kwon S

更新日期：2019-04-29 00:00:00

abstract：:Ice-albedo feedback due to the albedo contrast between water and ice is a major factor in seasonal sea ice retreat, and has received increasing attention with the Arctic Ocean shifting to a seasonal ice cover. However, quantitative evaluation of such feedbacks is still insufficient. Here we provide quantitative eviden...

journal_title：Scientific reports

authors： Kashiwase H,Ohshima KI,Nihashi S,Eicken H

更新日期：2017-08-15 00:00:00

abstract：:We present a new collusion attack to a kind of quantum secret sharing schemes with entangled states. Using this attack, an unauthorized set of agents can gain access to the shared secret without the others' cooperation. Furthermore, we establish a general model for this kind of quantum secret sharing schemes and then ...

journal_title：Scientific reports

authors： Wang TY,Liu YZ,Wei CY,Cai XQ,Ma JF

更新日期：2017-05-30 00:00:00

abstract：:Fungal pathogens represent a significant threat to immunocompromised patients or individuals with traumatic injury. Strategies to efficiently remove fungal spores from hospital surfaces and, ideally, patient skin thus offer the prospect of dramatically reducing infections in at-risk patients. Photodynamic inactivation...

journal_title：Scientific reports

authors： Trzaska WJ,Wrigley HE,Thwaite JE,May RC

更新日期：2017-07-04 00:00:00

abstract：:Recent research in filamentous fungi has revealed that the motility of an endocytic organelle early endosome (EE) has a versatile role in many physiological functions. Here, to further examine the motility of EEs in the industrially important fungus Aspergillus oryzae, we visualized these organelles via the Rab5 homol...

journal_title：Scientific reports

authors： Togo Y,Higuchi Y,Katakura Y,Takegawa K

更新日期：2017-11-17 00:00:00

abstract：:Au nanoparticles (AuNPs), which easily aggregate in organic thin film, are observed to well-disperse in chicken albumen thin films. The incorporated AuNPs is distributed uniformly inside the thin film and is as dense as 650 (particles/μm(3)). In addition, enhanced ultraviolet (UV) fluorescence centered at 350 nm is ob...

journal_title：Scientific reports

authors： Tsung Chen I,Chang PH,Chang YC,Guo TF

更新日期：2013-01-01 00:00:00

abstract：:Zebrafish (Danio rerio), largely used as a model for studying developmental processes, has also emerged as a valuable system for modelling human inflammatory diseases. However, in a context where even mice have been questioned as a valid model for these analysis, a systematic study evaluating the reproducibility of hu...

journal_title：Scientific reports

authors： Forn-Cuní G,Varela M,Pereiro P,Novoa B,Figueras A

更新日期：2017-02-03 00:00:00

abstract：:PARTICLE (Gene PARTICL- 'Promoter of MAT2A-Antisense RadiaTion Induced Circulating LncRNA) expression is transiently elevated following low dose irradiation typically encountered in the workplace and from natural sources. This long non-coding RNA recruits epigenetic silencers for cis-acting repression of its neighbour...

journal_title：Scientific reports

authors： O'Leary VB,Hain S,Maugg D,Smida J,Azimzadeh O,Tapio S,Ovsepian SV,Atkinson MJ

更新日期：2017-05-11 00:00:00

abstract：:If the components of a battery, including electrodes, separator, electrolyte and the current collectors can be designed as paints and applied sequentially to build a complete battery, on any arbitrary surface, it would have significant impact on the design, implementation and integration of energy storage devices. Her...

journal_title：Scientific reports

authors： Singh N,Galande C,Miranda A,Mathkar A,Gao W,Reddy AL,Vlad A,Ajayan PM

更新日期：2012-01-01 00:00:00

abstract：:Rhodopseudomonas palustris CGA009 is a purple non-sulfur bacterium that can fix carbon dioxide (CO2) and nitrogen or break down organic compounds for its carbon and nitrogen requirements. Light, inorganic, and organic compounds can all be used for its source of energy. Excess electrons produced during its metabolic pr...

journal_title：Scientific reports

authors： Alsiyabi A,Immethun CM,Saha R

更新日期：2019-09-02 00:00:00

abstract：:Determining mechanisms that naturally protect species from developing cancer is critical in order to prevent and treat cancer. Here, we describe a novel cancer-suppressing mechanism, via the secretion of bioactive factors by mammary cells, that is present in domesticated mammals with a low mammary cancer incidence. Sp...

journal_title：Scientific reports

authors： Ledet MM,Harman RM,Fan JC,Schmitt-Matzen E,Diaz-Rubio ME,Zhang S,Van de Walle GR

更新日期：2020-11-25 00:00:00

abstract：:The current research on cellular heat stress management focuses on the roles of heat shock proteins (HSPs) and the proteostasis network under severe stress conditions. The mild, fever-type stress and the maintenance of membrane homeostasis are less well understood. Herein, we characterized the acute effect of mild, fe...

journal_title：Scientific reports

authors： Peksel B,Gombos I,Péter M,Vigh L Jr,Tiszlavicz Á,Brameshuber M,Balogh G,Schütz GJ,Horváth I,Vigh L,Török Z

更新日期：2017-11-15 00:00:00

abstract：:Ultrathin transmission metasurface devices are designed on the basis of the Yang-Gu amplitude-phase retrieval algorithm for focusing the terahertz (THz) radiation into four or nine spots with focal spacing of 2 or 3 mm at a frequency of 0.8 THz. The focal properties are experimentally investigated in detail, and the r...

journal_title：Scientific reports

authors： He J,Ye J,Wang X,Kan Q,Zhang Y

更新日期：2016-06-27 00:00:00