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Long non-coding RNA PARTICLE bridges histone and DNA methylation.

Abstract：

:PARTICLE (Gene PARTICL- 'Promoter of MAT2A-Antisense RadiaTion Induced Circulating LncRNA) expression is transiently elevated following low dose irradiation typically encountered in the workplace and from natural sources. This long non-coding RNA recruits epigenetic silencers for cis-acting repression of its neighbouring Methionine adenosyltransferase 2A gene. It now emerges that PARTICLE operates as a trans-acting mediator of DNA and histone lysine methylation. Chromatin immunoprecipitation sequencing (ChIP-seq) and immunological evidence established elevated PARTICLE expression linked to increased histone 3 lysine 27 trimethylation. Live-imaging of dbroccoli-PARTICLE revealing its dynamic association with DNA methyltransferase 1 was confirmed by flow cytometry, immunoprecipitation and direct competitive binding interaction through electrophoretic mobility shift assay. Acting as a regulatory docking platform, the long non-coding RNA PARTICLE serves to interlink epigenetic modification machineries and represents a compelling innovative component necessary for gene silencing on a global scale.

journal_name

Sci Rep

journal_title

Scientific reports

authors

O'Leary VB,Hain S,Maugg D,Smida J,Azimzadeh O,Tapio S,Ovsepian SV,Atkinson MJ

doi

10.1038/s41598-017-01875-1

subject

Has Abstract

pub_date

2017-05-11 00:00:00

pages

1790

issue

1

issn

2045-2322

pii

10.1038/s41598-017-01875-1

journal_volume

7

pub_type

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