Abstract：
:Long non-coding RNAs (LNC) regulate numerous biological processes. In contrast to human, the identification of LNC in farm species, like chicken, is still lacunar. We propose a catalogue of 52,075 chicken genes enriched in LNC ( http://www.fragencode.org/ ), built from the Ensembl reference extended using novel LNC modelled here from 364 RNA-seq and LNC from four public databases. The Ensembl reference grew from 4,643 to 30,084 LNC, of which 59% and 41% with expression ≥ 0.5 and ≥ 1 TPM respectively. Characterization of these LNC relatively to the closest protein coding genes (PCG) revealed that 79% of LNC are in intergenic regions, as in other species. Expression analysis across 25 tissues revealed an enrichment of co-expressed LNC:PCG pairs, suggesting co-regulation and/or co-function. As expected LNC were more tissue-specific than PCG (25% vs. 10%). Similarly to human, 16% of chicken LNC hosted one or more miRNA. We highlighted a new chicken LNC, hosting miR155, conserved in human, highly expressed in immune tissues like miR155, and correlated with immunity-related PCG in both species. Among LNC:PCG pairs tissue-specific in the same tissue, we revealed an enrichment of divergent pairs with the PCG coding transcription factors, as for example LHX5, HXD3 and TBX4, in both human and chicken.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jehl F,Muret K,Bernard M,Boutin M,Lagoutte L,Désert C,Dehais P,Esquerré D,Acloque H,Giuffra E,Djebali S,Foissac S,Derrien T,Pitel F,Zerjal T,Klopp C,Lagarrigue Sdoi
10.1038/s41598-020-77586-xsubject
Has Abstractpub_date
2020-11-24 00:00:00pages
20457issue
1issn
2045-2322pii
10.1038/s41598-020-77586-xjournal_volume
10pub_type
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