Cellular dynamics of the SecA ATPase at the single molecule level.

abstract：:Activation of TLR4 by lipopolysaccharide (LPS) induces both pro-inflammatory and anti-inflammatory cytokine production in macrophages. Type 4 phosphodiesterases (PDE4) are key cAMP-hydrolyzing enzymes, and PDE4 inhibitors are considered as immunosuppressors to various inflammatory responses. We demonstrate here that P...

journal_title：Scientific reports

authors： Yang JX,Hsieh KC,Chen YL,Lee CK,Conti M,Chuang TH,Wu CP,Jin SC

更新日期：2017-04-06 00:00:00

abstract：:A cell-type saturable absorber has been demonstrated by filling the single mode photonic crystal fiber (SMPCF) with tungsten disulfide (WS2) nanosheets. The modulation depth, saturable intensity, and non-saturable loss of this SA are measured to be 3.53%, 159 MW/cm(2) and 23.2%, respectively. Based on this SA, a passi...

journal_title：Scientific reports

authors： Yan P,Liu A,Chen Y,Wang J,Ruan S,Chen H,Ding J

更新日期：2015-07-27 00:00:00

abstract：:Cognitive impairment is one of the most common problem saffecting older adults. In this study, we investigated whether Tai Chi Chuan and Baduanjin practice can modulate mental control functionand the resting state functional connectivity (rsFC) of the cognitive control network in older adults. Participants in the two ...

journal_title：Scientific reports

authors： Tao J,Chen X,Egorova N,Liu J,Xue X,Wang Q,Zheng G,Li M,Hong W,Sun S,Chen L,Kong J

更新日期：2017-02-07 00:00:00

abstract：:The same prebiotics have produced inconsistent effects on microbiota when evaluated in different batch fermentation studies. To understand the reasons behind these discrepancies, we compared impact of one prebiotic formula on the same inoculated fecal microbiota in two frequently used batch systems: phosphate-buffered...

journal_title：Scientific reports

authors： Long W,Xue Z,Zhang Q,Feng Z,Bridgewater L,Wang L,Zhao L,Pang X

更新日期：2015-08-25 00:00:00

abstract：:There is no treatment for the myelin loss in multiple sclerosis, ultimately resulting in the axonal degeneration that leads to the progressive phase of the disease. We established a multi-tiered platform for the sequential screening of drugs that could be repurposed as remyelinating agents. We screened a library of 2,...

journal_title：Scientific reports

authors： Eleuteri C,Olla S,Veroni C,Umeton R,Mechelli R,Romano S,Buscarinu MC,Ferrari F,Calò G,Ristori G,Salvetti M,Agresti C

更新日期：2017-04-07 00:00:00

abstract：:Understanding factors associated with tie strength in social networks is essential in a wide variety of settings. With the internet and cellular phones providing additional avenues of communication, measuring and inferring tie strength has become much more complex. We introduce the social bow tie framework, which cons...

journal_title：Scientific reports

authors： Mattie H,Engø-Monsen K,Ling R,Onnela JP

更新日期：2018-06-19 00:00:00

abstract：:Facial mimicry has been suggested to be a behavioral index for emotional empathy. The present study is the first to investigate the link between facial muscle activity and empathy for pain by facial electromyographic (EMG) recording while observers watched videos depicting real-life painful events. Three types of visu...

journal_title：Scientific reports

authors： Sun YB,Wang YZ,Wang JY,Luo F

更新日期：2015-12-09 00:00:00

abstract：:Recently, long non-coding RNAs (lncRNAs) have emerged as an important class of molecules involved in many cellular processes. One of their primary functions is to shape epigenetic landscape through interactions with chromatin modifying proteins. However, mechanisms contributing to the specificity of such interactions ...

journal_title：Scientific reports

authors： Tu S,Yuan GC,Shao Z

更新日期：2017-01-31 00:00:00

abstract：:Supercontinuum generation in Kerr media has become a staple of nonlinear optics. It has been celebrated for advancing the understanding of soliton propagation as well as its many applications in a broad range of fields. Coherent spectral broadening of laser light is now commonly performed in laboratories and used in c...

journal_title：Scientific reports

authors： Ciret C,Gorza SP,Husko C,Roelkens G,Kuyken B,Leo F

更新日期：2018-11-21 00:00:00

abstract：:We examined whether it is possible to identify individual subjects on the basis of brain anatomical features. For this, we analyzed a dataset comprising 191 subjects who were scanned three times over a period of two years. Based on FreeSurfer routines, we generated three datasets covering 148 anatomical regions (corti...

journal_title：Scientific reports

authors： Valizadeh SA,Liem F,Mérillat S,Hänggi J,Jäncke L

更新日期：2018-04-04 00:00:00

abstract：:The world is in the midst of an antimicrobial resistance crisis, driving a need to discover novel antibiotic substances. Using chemical cues as inducers to unveil a microorganism's full metabolic potential is considered a successful strategy. To this end, we investigated an inducible antagonistic behavior in multiple ...

journal_title：Scientific reports

authors： Sierra-Zapata L,Álvarez JC,Romero-Tabarez M,Silby MW,Traxler MF,Behie SW,Pessotti RC,Villegas-Escobar V

更新日期：2020-03-27 00:00:00

abstract：:In this study, the effects of acetyl-xylogalactan extracted from Sarcodia suieae on RAW 264.7 macrophage polarisation were evaluated. This extracted acetyl-xylogalactan had a monosaccharide composition of 91% galactose and 9% xylose, with polysaccharide and acetyl contents of 80.6% and 19.3%, respectively. MALDI-TOF m...

journal_title：Scientific reports

authors： Wu TM,Nan FH,Chen KC,Wu YS

更新日期：2019-12-23 00:00:00

abstract：:Structural characteristics of the active layers in organic photovoltaic (OPV) devices play a critical role in charge generation, separation and transport. Here we report on morphology and structural control of p-DTS(FBTTh2)2:PC71BM films by means of thermal annealing and 1,8-diiodooctane (DIO) solvent additive process...

journal_title：Scientific reports

authors： Herath N,Das S,Keum JK,Zhu J,Kumar R,Ivanov IN,Sumpter BG,Browning JF,Xiao K,Gu G,Joshi P,Smith S,Lauter V

更新日期：2015-08-28 00:00:00

abstract：:Interleukin 27 (IL-27), a member of the IL-12 family, is important for T cell differentiation; however, little is known about its effect on dendritic cells (DCs). IL-27 can activate multiple signaling cascades, including the JAK/STAT pathway, and depending on the setting it can both promote and antagonize inflammatory...

journal_title：Scientific reports

authors： Parackova Z,Vrabcova P,Zentsova I,Kayserova J,Richtrova I,Sojka L,Stechova K,Sumnik Z,Sediva A

更新日期：2020-01-16 00:00:00

abstract：:Changes in river channel erosion or deposition affect the geomorphic evolution, aquatic ecosystems, and river regulation strategies. Fluvial processes are determined by the flow, sediment and boundary conditions, and it has long been expected that increasing sediment supply will induce aggradation. Here, based on thor...

journal_title：Scientific reports

authors： Fan N,Nie R,Wang Q,Liu X

更新日期：2016-11-18 00:00:00

abstract：:This article reports preparation of a crosslinked polydimethylsiloxane (PDMS) network via dynamic transesterification reaction between PDMS-diglycidyl ether and pripol 1017 with Zn(OAc)2 as the catalyst. The thermal dynamic nature of the network was investigated by the creep-recovery and stress-relaxation tests. The s...

journal_title：Scientific reports

authors： Zhang H,Cai C,Liu W,Li D,Zhang J,Zhao N,Xu J

更新日期：2017-09-19 00:00:00

abstract：:Sweet potato is an important food and bio-energy crop, and investigating the mechanisms underlying salt tolerance will provide information for salt-tolerant breeding of this crop. Here, the root transcriptomes of the salt-sensitive variety Lizixiang and the salt-tolerant line ND98 were compared to identify the genes a...

journal_title：Scientific reports

authors： Zhang H,Zhang Q,Zhai H,Li Y,Wang X,Liu Q,He S

更新日期：2017-01-13 00:00:00

abstract：:Microfluidic paper-based analytical devices (µPADs) have provided a breakthrough in portable and low-cost point-of-care diagnostics. Despite their significant scope, the complexity of fabrication and reliance on expensive and sophisticated tools, have limited their outreach and possibility of commercialization. Herein...

journal_title：Scientific reports

authors： Ghosh R,Gopalakrishnan S,Savitha R,Renganathan T,Pushpavanam S

更新日期：2019-05-27 00:00:00

abstract：:Aphids are important agricultural pests causing major yield losses worldwide. Since aphids can rapidly develop resistance to chemical insecticides there is an urgent need to find alternative aphid pest management strategies. Despite the economic importance of bluegreen aphid (Acyrthosiphon kondoi), very few genetic re...

journal_title：Scientific reports

authors： Jacques S,Reidy-Crofts J,Sperschneider J,Kamphuis LG,Gao LL,Edwards OR,Singh KB

更新日期：2020-01-31 00:00:00

abstract：:Because of their exceptional local-field enhancement and ultrasmall mode volume, plasmonic components can integrate photonics and electronics at nanoscale, and active control of plasmons is the key. However, all-optical modulation of plasmonic response with nanometer mode volume and unity modulation depth is still lac...

journal_title：Scientific reports

authors： Wu HY,Huang YT,Shen PT,Lee H,Oketani R,Yonemaru Y,Yamanaka M,Shoji S,Lin KH,Chang CW,Kawata S,Fujita K,Chu SW

更新日期：2016-04-11 00:00:00

abstract：:Highly coordinated and coincidental patterns of activity-dependent mechanisms ("fire together wire together") are thought to serve as inductive signals during synaptogenesis, enabling neuronal pairing between specific sub-sets of excitatory partners. However, neither the nature of activity triggers, nor the "activity ...

journal_title：Scientific reports

authors： Luk CC,Lee AJ,Wijdenes P,Zaidi W,Leung A,Wong NY,Andrews J,Syed NI

更新日期：2015-04-01 00:00:00

abstract：:Here we investigated whether endothelial colony forming cells (ECFC) and mesenchymal progenitor cells (MPC) form vascular networks and restore blood flow in ischemic skeletal muscle, and whether host myeloid cells play a role. ECFC + MPC, ECFC alone, MPC alone, or vehicle alone were injected into the hind limb ischemi...

journal_title：Scientific reports

authors： Kang KT,Lin RZ,Kuppermann D,Melero-Martin JM,Bischoff J

更新日期：2017-04-10 00:00:00

abstract：:Time dependent plastic deformation in a single crystal nickel-base superalloy during cooling from casting relevant temperatures has been studied using a combination of in-situ neutron diffraction, transmission electron microscopy and modelling. Visco-plastic deformation during cooling was found to be dependent on the ...

journal_title：Scientific reports

authors： Panwisawas C,D'Souza N,Collins DM,Bhowmik A

更新日期：2017-09-11 00:00:00

abstract：:Stable isotope mixing models are regularly used to provide probabilistic estimates of source contributions to dietary mixtures. Whilst Bayesian implementations of isotope mixing models have become prominent, the use of appropriate diet-tissue discrimination factors (DTDFs) remains as the least resolved aspect. The DTD...

journal_title：Scientific reports

authors： Kadye WT,Redelinghuys S,Parnell AC,Booth AJ

更新日期：2020-09-25 00:00:00

abstract：:Caspase-1, also known as interleukin-1β (IL-1β)-converting enzyme (ICE), regulates antimicrobial host defense, tissue repair, tumorigenesis, metabolism and membrane biogenesis. On activation within an inflammasome complex, caspase-1 induces pyroptosis and converts pro-IL-1β and pro-IL-18 into their biologically active...

journal_title：Scientific reports

authors： Man SM,Karki R,Briard B,Burton A,Gingras S,Pelletier S,Kanneganti TD

更新日期：2017-03-27 00:00:00

abstract：:We developed a reporter system that can be used in a dual manner in visualizing mature osteoblast formation. The system is based on a helper-dependent adenoviral vector (HDAdV), in which a fluorescent protein, Venus, is expressed under the control of the 19-kb human osteocalcin (OC) genomic locus. By infecting human a...

journal_title：Scientific reports

authors： Sone T,Shin M,Ouchi T,Sasanuma H,Miyamoto A,Ohte S,Tsukamoto S,Nakanishi M,Okano H,Katagiri T,Mitani K

更新日期：2019-07-04 00:00:00

abstract：:Root damage due to aluminum (Al) toxicity restricts crop production on acidic soils, which are extensive in the tropics. The sorghum root Al-activated citrate transporter, SbMATE, underlies the Al tolerance locus, AltSB, and increases grain yield under Al toxicity. Here, AltSB loci associated with Al tolerance were co...

journal_title：Scientific reports

authors： Hufnagel B,Guimaraes CT,Craft EJ,Shaff JE,Schaffert RE,Kochian LV,Magalhaes JV

更新日期：2018-07-04 00:00:00

abstract：:A superhydrophilic and underwater superoleophobic surface is fabricated by simply coating silica nanospheres onto a glass fiber membrane through a sol-gel process. Such membrane has a complex framework with micro and nano structures covering and presents a high efficiency (more than 98%) of oil-in-water emulsion separ...

journal_title：Scientific reports

authors： Chen Y,Liu N,Cao Y,Lin X,Xu L,Zhang W,Wei Y,Feng L

更新日期：2016-09-06 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) are major food-borne pathogens whose survival and virulence in the human digestive tract remain unclear owing to paucity of relevant models. EHEC interact with the follicle-associated epithelium of Peyer's patches of the distal ileum and translocate across the intestinal epith...

journal_title：Scientific reports

authors： Cordonnier C,Etienne-Mesmin L,Thévenot J,Rougeron A,Rénier S,Chassaing B,Darfeuille-Michaud A,Barnich N,Blanquet-Diot S,Livrelli V

更新日期：2017-03-20 00:00:00

abstract：:This study aims to identify promising biomarkers for the early detection of lung cancer and evaluate the prognosis of lung cancer patients. Genome-wide mRNA expression data obtained from the Gene Expression Omnibus (GSE19188, GSE18842 and GSE40791), including 231 primary tumor samples and 210 normal samples, were used...

journal_title：Scientific reports

authors： Shi YX,Yin JY,Shen Y,Zhang W,Zhou HH,Liu ZQ

更新日期：2017-08-14 00:00:00