Enhanced STAT3 phosphorylation and PD-L1 expression in myeloid dendritic cells indicate impaired IL-27Ralpha signaling in type 1 diabetes.

abstract：:In the highly interconnected architectures of the cerebral cortex, recurrent intracortical loops disproportionately outnumber thalamo-cortical inputs. These networks are also capable of generating neuronal activity without feedforward sensory drive. It is unknown, however, what spatiotemporal patterns may be solely at...

journal_title：Scientific reports

authors： Kodama NX,Feng T,Ullett JJ,Chiel HJ,Sivakumar SS,Galán RF

更新日期：2018-01-12 00:00:00

abstract：:We investigated the molecular mechanism(s) by which insulin prevents Bcl2-modifying factor (Bmf)-induced renal proximal tubular cell (RPTC) apoptosis and loss in diabetic mice. Transgenic mice (Tg) mice specifically overexpressing human BMF in RPTCs and non-Tg littermates were studied at 10 to 20 weeks of age. Non-dia...

journal_title：Scientific reports

authors： Ghosh A,Zhao S,Lo CS,Maachi H,Chenier I,Lateef MA,Abdo S,Filep JG,Ingelfinger JR,Zhang SL,Chan JSD

更新日期：2019-04-30 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Saldaña L,Vallés G,Bensiamar F,Mancebo FJ,García-Rey E,Vilaboa N

更新日期：2018-03-06 00:00:00

abstract：:We provide a unified and exact framework for the variance-based uncertainty relations. This unified framework not only recovers some well-known previous uncertainty relations, but also fixes the deficiencies of them. Utilizing the unified framework, we can construct the new uncertainty relations in both product and su...

journal_title：Scientific reports

authors： Zheng X,Ma SQ,Zhang GF,Fan H,Liu WM

更新日期：2020-01-10 00:00:00

abstract：:We demonstrate a simple and effective strategy for implementing a polarizing beamsplitter for the terahertz spectral region, based on an artificial dielectric medium that is scalable to a range of desired frequencies. The artificial dielectric medium consists of a uniformly spaced stack of metal plates, which is elect...

journal_title：Scientific reports

authors： Mendis R,Nagai M,Zhang W,Mittleman DM

更新日期：2017-07-19 00:00:00

abstract：:The arrival of Neolithic culture in North Africa, especially domestic animals has been essentially documented from archaeological records. As the data relative to sheep are scarce, we studied the genetic relationship between Moroccan sheep breeds and Mediterranean ones using the sequencing of 628 bp of the mitochondri...

journal_title：Scientific reports

authors： Kandoussi A,Boujenane I,Auger C,Serranito B,Germot A,Piro M,Maftah A,Badaoui B,Petit D

更新日期：2020-06-23 00:00:00

abstract：:Active deep-sea hydrothermal vents harbor abundant thermophilic and hyperthermophilic microorganisms. However, microbial communities in inactive hydrothermal vents have not been well documented. Here, we investigated bacterial and archaeal communities in the two deep-sea sediments (named as TVG4 and TVG11) collected f...

journal_title：Scientific reports

authors： Zhang L,Kang M,Xu J,Xu J,Shuai Y,Zhou X,Yang Z,Ma K

更新日期：2016-05-12 00:00:00

abstract：:Sealed-bid auction is an important tool in modern economic especially concerned with networks. However, the bidders still lack the privacy protection in previously proposed sealed-bid auction schemes. In this paper, we focus on how to further protect the privacy of the bidders, especially the non-winning bidders. We f...

journal_title：Scientific reports

authors： Shi RH,Zhang M

更新日期：2019-05-20 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the highest incidences in cancers; however, traditional chemotherapy often suffers from low efficiency caused by drug resistance. Herein, we report an arsenite-loaded dual-drug (doxorubicin and arsenic trioxide, i.e., DOX and ATO) nanomedicine system (FeAsOx@SiO2-DOX, Combo NP)...

journal_title：Scientific reports

authors： Liu H,Zhang Z,Chi X,Zhao Z,Huang D,Jin J,Gao J

更新日期：2016-08-03 00:00:00

abstract：:We established in vivo and in vitro models to investigate the role of αB-Crystallin (CryAB) and assess the ability of aspirin (ASA) to protect the myocardium during prolonged heat stress. Thirty-day-old chickens were divided into three groups (n = 90): heat stress (HS, 40±1 °C); ASA(-)HS(+), 1 mg/kg ASA orally 2 h bef...

journal_title：Scientific reports

authors： Tang S,Yin B,Song E,Chen H,Cheng Y,Zhang X,Bao E,Hartung J

更新日期：2016-11-18 00:00:00

abstract：:A three dimensional (3D) numerical solution of unsteady, Ag-MgO hybrid nanoliquid flow with heat and mass transmission caused by upward/downward moving of wavy spinning disk has been scrutinized. The magnetic field has been also considered. The hybrid nanoliquid has been synthesized in the presence of Ag-MgO nanoparti...

journal_title：Scientific reports

authors： Ahmadian A,Bilal M,Khan MA,Asjad MI

更新日期：2020-11-02 00:00:00

abstract：:We demonstrate theoretically that photon-photon attraction can be engineered in the continuum of scattering states for pairs of photons propagating in a hollow-core photonic crystal fiber filled with cold atoms. The atoms are regularly spaced in an optical lattice configuration and the photons are resonantly tuned to ...

journal_title：Scientific reports

authors： Litinskaya M,Tignone E,Pupillo G

更新日期：2016-05-12 00:00:00

abstract：:Eucalyptus globulus is an aromatic medicinal plant which known for its 1,8-cineole main pharmacological constituent exhibits as natural analgesic agent. Eucalyptus globulus-loaded micellar nanoparticle was developed via spontaneous emulsification technique and further evaluation for its analgesic efficacy study, in vi...

journal_title：Scientific reports

authors： Aziz ZAA,Nasir HM,Ahmad A,Setapar SHM,Ahmad H,Noor MHM,Rafatullah M,Khatoon A,Kausar MA,Ahmad I,Khan S,Al-Shaeri M,Ashraf GM

更新日期：2019-09-23 00:00:00

abstract：:Appropriate analytical methods are needed for the detection of food authentication. We investigated the applicability of a duplex real-time PCR assay targeting chromosome 1 and two singleplex real-time PCR assays targeting chromosome 9, both published recently, for the qualitative and quantitative determination of wil...

journal_title：Scientific reports

authors： Kaltenbrunner M,Mayer W,Kerkhoff K,Epp R,Rüggeberg H,Hochegger R,Cichna-Markl M

更新日期：2020-10-14 00:00:00

abstract：:Seasonal influenza virus infections cause hundreds of thousands of deaths annually while viral mutation raises the threat of a novel pandemic strain. Antiviral drugs exhibit limited efficacy unless administered early and may induce viral resistance. Thus, targeting the host response directly has been proposed as a nov...

journal_title：Scientific reports

authors： Sugiyama MG,Armstrong SM,Wang C,Hwang D,Leong-Poi H,Advani A,Advani S,Zhang H,Szaszi K,Tabuchi A,Kuebler WM,Van Slyke P,Dumont DJ,Lee WL

更新日期：2015-06-05 00:00:00

abstract：:Adaptive evolution by serial subcultivation of co-cultured Bacillus thuringiensis and Ketogulonicigenium vulgare significantly enhanced the productivity of 2-keto-L-gulonic acid in two-step vitamin C production. The adaptation mechanism in K. vulgare-B. thuringiensis consortium was investigated in this study based on ...

journal_title：Scientific reports

authors： Jia N,Ding MZ,Zou Y,Gao F,Yuan YJ

更新日期：2017-04-25 00:00:00

abstract：:During the late Eocene, the Earth's climate experienced several transient temperature fluctuations including the Vonhof cooling event (C16n.1n; ~35.8 Ma) hitherto known mainly from the southern oceans. Here we reconstruct sea-surface temperatures (SST) and provide δ18O and δ13C foraminiferal records for the late Eocen...

journal_title：Scientific reports

authors： Śliwińska KK,Thomsen E,Schouten S,Schoon PL,Heilmann-Clausen C

更新日期：2019-03-14 00:00:00

abstract：:Long-term potentiation (LTP) is the persistent increase in the strength of the synapses. However, the neural networks would become saturated if there is only synaptic strenghthening. Synaptic weakening could be facilitated by active processes like long-term depression (LTD). Molecular mechanisms that facilitate the we...

journal_title：Scientific reports

authors： Navakkode S,Chew KCM,Tay SJN,Lin Q,Behnisch T,Soong TW

更新日期：2017-11-14 00:00:00

abstract：:Much uncertainty exists about the history of the Greenland Ice Sheet (GIS), particularly as to the frequency of extreme shelf edge glaciations. Because the last glaciation removed most of the record of earlier GIS extent on land and shelf exploration of the older GIS glacial record requires the use of deeper marine ar...

journal_title：Scientific reports

authors： Nielsen T,Kuijpers A

更新日期：2013-01-01 00:00:00

abstract：:Microtus fortis exhibits natural resistance against Schistosoma japonicum, and the parasite cannot grow and develop in M. fortis. Extensive research has been carried out, however, the associated mechanism remains unclear. In the present study, we analysed the combined data obtained from a cytokine chip assay, transcri...

journal_title：Scientific reports

authors： Hu Y,Sun L,Yuan Z,Xu Y,Cao J

更新日期：2017-09-12 00:00:00

abstract：:Oligomers populated during the early amyloid aggregation process are more toxic than mature fibrils, but pinpointing the exact toxic species among highly dynamic and heterogeneous aggregation intermediates remains a major challenge. β-barrel oligomers, structurally-determined recently for a slow-aggregating peptide de...

journal_title：Scientific reports

authors： Sun Y,Ge X,Xing Y,Wang B,Ding F

更新日期：2018-07-09 00:00:00

abstract：:A primary cilium is a hair-like structure with a width of approximately 200 nm. Over the past few decades, the main challenge in the study of the ultrastructure of cilia has been the high sensitivity of cilia to chemical fixation, which is required for many imaging techniques. In this report, we demonstrate a combined...

journal_title：Scientific reports

authors： Mohieldin AM,AbouAlaiwi WA,Gao M,Nauli SM

更新日期：2015-11-02 00:00:00

abstract：:Complex associations exist between inflammation and thrombosis, with the inflammatory state tending to promote coagulation. Fibrinogen, an acute phase protein, has been shown to interact with the amyloidogenic ß-amyloid protein of Alzheimer's disease. However, little is known about the association between fibrinogen a...

journal_title：Scientific reports

authors： Page MJ,Thomson GJA,Nunes JM,Engelbrecht AM,Nell TA,de Villiers WJS,de Beer MC,Engelbrecht L,Kell DB,Pretorius E

更新日期：2019-02-28 00:00:00

abstract：:Symptoms of chronic widespread muscle pain (CWP) meet most of the diagnostic criteria for fibromyalgia syndrome, which is prevalent in females. We used an acid injection-induced muscle pain (AIMP) model to mimic CWP. After female rats received an ovariectomy (OVX), acid saline solution was injected into the left gastr...

journal_title：Scientific reports

authors： Chang JH,Tsai SY,Zeng YJ,Liu YC,Li CY,Chen KB,Wen YR

更新日期：2019-02-28 00:00:00

abstract：:Women who have previously had an induced abortion (IA) before their first birth have been associated with preterm birth (PTB). However, previous studies on the PTB are inconsistent. Therefore, the aim of this study was to clarify the association between IA and PTB and low birth weight (LBW) for first-time mothers. A t...

journal_title：Scientific reports

authors： Ke L,Lin W,Liu Y,Ou W,Lin Z

更新日期：2018-03-29 00:00:00

abstract：:Inner Mongolia cashmere goats, as an important part of animal husbandry production, play an important role in animal fiber industry. In recent years, scientific research has made a lot of explorations on the molecular regulation mechanism of hair follicle cycle growth, but few studies have been reported on the develop...

journal_title：Scientific reports

authors： Han W,Yang F,Wu Z,Guo F,Zhang J,Hai E,Shang F,Su R,Wang R,Wang Z,Liu Z,Zhao Y,Wang Z,Zhang Y,Li J

更新日期：2020-03-11 00:00:00

abstract：:Precisely controlling the protein-nanomaterial interactions at selective sites is crucial in engineering biomolecule composite architectures with tailored nanostructures and functions for a variety of biomedical applications. This strategy, however, is only beginning to be explored. Here, we demonstrate the facet-spec...

journal_title：Scientific reports

authors： Dong L,Luo Q,Cheng K,Shi H,Wang Q,Weng W,Han WQ

更新日期：2014-05-28 00:00:00

abstract：:To better understand the brain function based on neural activity, a minimally invasive analysis technology in a freely moving animal is necessary. Such technology would provide new knowledge in neuroscience and contribute to regenerative medical techniques and prosthetics care. An application that combines optogenetic...

journal_title：Scientific reports

authors： Kobayashi T,Haruta M,Sasagawa K,Matsumata M,Eizumi K,Kitsumoto C,Motoyama M,Maezawa Y,Ohta Y,Noda T,Tokuda T,Ishikawa Y,Ohta J

更新日期：2016-02-16 00:00:00

abstract：:Study of knockout (KO) mice has helped understand the link between many genes/proteins and human diseases. Identification of infertile KO mice provides valuable tools to characterize the molecular mechanisms underlying gamete formation. The KIAA0319L gene has been described to have a putative association with dyslexia...

journal_title：Scientific reports

authors： Guidi LG,Holloway ZG,Arnoult C,Ray PF,Monaco AP,Molnár Z,Velayos-Baeza A

更新日期：2018-07-10 00:00:00

abstract：:There have been no large nationwide birth cohort studies examining for the effects of maternal alcohol use during pregnancy on placental abnormality. This study searched for associations between alcohol consumption and the placental abnormalities of placenta previa, placental abruption, and placenta accreta using the ...

journal_title：Scientific reports

authors： Ohira S,Motoki N,Shibazaki T,Misawa Y,Inaba Y,Kanai M,Kurita H,Shiozawa T,Nakazawa Y,Tsukahara T,Nomiyama T,Japan Environment & Children’s Study (JECS) Group.

更新日期：2019-07-16 00:00:00