Abstract：
:Seasonal influenza virus infections cause hundreds of thousands of deaths annually while viral mutation raises the threat of a novel pandemic strain. Antiviral drugs exhibit limited efficacy unless administered early and may induce viral resistance. Thus, targeting the host response directly has been proposed as a novel therapeutic strategy with the added potential benefit of not eliciting viral resistance. Severe influenza virus infections are complicated by respiratory failure due to the development of lung microvascular leak and acute lung injury. We hypothesized that enhancing lung endothelial barrier integrity could improve the outcome. Here we demonstrate that the Tie2-agonist tetrameric peptide Vasculotide improves survival in murine models of severe influenza, even if administered as late as 72 hours after infection; the benefit was observed using three strains of the virus and two strains of mice. The effect required Tie2, was independent of viral replication and did not impair lung neutrophil recruitment. Administration of the drug decreased lung edema, arterial hypoxemia and lung endothelial apoptosis; importantly, Vasculotide is inexpensive to produce, is chemically stable and is unrelated to any Tie2 ligands. Thus, Vasculotide may represent a novel and practical therapy for severe infections with influenza.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sugiyama MG,Armstrong SM,Wang C,Hwang D,Leong-Poi H,Advani A,Advani S,Zhang H,Szaszi K,Tabuchi A,Kuebler WM,Van Slyke P,Dumont DJ,Lee WLdoi
10.1038/srep11030subject
Has Abstractpub_date
2015-06-05 00:00:00pages
11030issn
2045-2322pii
srep11030journal_volume
5pub_type
杂志文章abstract：:Recent advances in the HMP (human microbiome project) research have revealed profound implications of the human microbiome to our health and diseases. We postulated that there should be distinctive features associated with healthy and/or diseased microbiome networks. Following Occam's razor principle, we further hypot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12959-3
更新日期：2017-10-16 00:00:00
abstract：:The auditory steady-state response (ASSR) has been used to detect auditory processing deficits in patients with psychiatric disorders. However, the methodology of ASSR recording from the brain surface has not been standardized in preclinical studies, limiting its use as a translational biomarker. The sites of maximal ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44936-3
更新日期：2019-06-11 00:00:00
abstract：:Leprosy remains persistently endemic in several low- or middle income countries. Transmission is still ongoing as indicated by the unabated rate of leprosy new case detection, illustrating the insufficiency of current prevention methods. Therefore, low-complexity tools suitable for large scale screening efforts to spe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36323-1
更新日期：2018-12-18 00:00:00
abstract：:The tick receptor for outer surface protein A (TROSPA) is the only identified factor involved in tick gut colonization by various Borrelia species. TROSPA is localized in the gut epithelium and can recognize and bind the outer surface bacterial protein OspA via an unknown mechanism. Based on earlier reports and our la...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25205
更新日期：2016-04-26 00:00:00
abstract：:The ability to predict others' behaviour represents a crucial mechanism which allows individuals to react faster and more appropriately. To date, several studies have investigated humans' ability to predict conspecifics' behaviour, but little is known on our ability to predict behaviour in other species. Here, we aime...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78275-5
更新日期：2020-12-04 00:00:00
abstract：:Myocardial infarction (MI) can result in sympathetic nerve loss in the infarct region. However, the contribution of hypo-innervation to electrophysiological remodeling, independent from MI-induced ischemia and fibrosis, has not been comprehensively investigated. We present a novel mouse model of regional cardiac sympa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75903-y
更新日期：2020-11-02 00:00:00
abstract：:To assess whether Helicobacter pylori (Hp) antibody (ab) reactivity against individual Hp antigens is pathogenetically relevant to multiple sclerosis (MS), we systematically investigated prevalence and clinical significance of abs against 14 immunodominant and subdominant Hp antigens by ELISA and immunoblotting in 139...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07801-9
更新日期：2017-08-11 00:00:00
abstract：:Delivery and expression of recombinant genes, a key methodology for many applications in biological research, remains a challenge especially for mature neurons. Here, we report easy, highly efficient and well tolerated transduction of adult peripheral and central neuronal populations of diverse species in culture usin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38928
更新日期：2016-12-13 00:00:00
abstract：:Transcranial focused ultrasound (US) has been demonstrated to stimulate neurons in animals and humans, but the mechanism of this effect is unknown. It has been hypothesized that US, a mechanical stimulus, may mediate cellular discharge by activating mechanosensitive ion channels embedded within cellular membranes. To ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24170
更新日期：2016-04-26 00:00:00
abstract：:The mechanisms contributing to collective attention in humans remain unclear. Research indicates that pedestrians utilise the gaze direction of others nearby to acquire environmentally relevant information, but it is not known which, if any, additional social cues influence this transmission. Extending upon previous f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05794
更新日期：2014-07-23 00:00:00
abstract：:Chloromethane (CH3Cl) is a toxic gas mainly produced naturally, in particular by plants, and its emissions contribute to ozone destruction in the stratosphere. Conversely, CH3Cl can be degraded and used as the sole carbon and energy source by specialised methylotrophic bacteria, isolated from a variety of environments...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17421-y
更新日期：2017-12-14 00:00:00
abstract：:In the present work, we introduce two new metrics i.e. hydrogen-bond strength and charge-transfer between the donor/acceptor water molecules as a measure of hydrogen-bond rearrangement dynamics. Further, we also employ a simple model based on energy flux through the donor-acceptor water pairs to quantify the extent of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35357-9
更新日期：2018-11-15 00:00:00
abstract：:Core flood and field tests have demonstrated that decreasing injection water salinity increases oil recovery from sandstone reservoirs. However, the microscopic mechanism behind the effect is still under debate. One hypothesis is that as salinity decreases, expansion of the electrical double layer decreases attraction...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09933
更新日期：2015-04-22 00:00:00
abstract：:The physical properties of polycrystalline materials depend on their microstructure, which is the nano- to centimeter scale arrangement of phases and defects in their interior. Such microstructure depends on the shape, crystallographic phase and orientation, and interfacing of the grains constituting the material. Thi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09717-w
更新日期：2017-08-25 00:00:00
abstract：:This anatomical study sought to investigate the morphological characteristics and biomechanical properties of the oblique popliteal ligament (OPL). Embalmed cadaveric knees were used for the study. The OPL and its surrounding structures were dissected; its morphology was carefully observed, analyzed and measured; its ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42698
更新日期：2017-02-16 00:00:00
abstract：:Theileria annulata is a haemoprotozoan parasite that causes a cancer-like illness known as tropical theileriosis in cattle. In the course of analyzing the genetic diversity of T. annulata in Sri Lanka, we observed that merozoite-piroplasm surface antigen (tams1) and surface protein (tasp)-like gene sequences obtained ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52512-y
更新日期：2019-11-06 00:00:00
abstract：:The metal-to-insulator transition (MIT) closest to room temperature of 68-70 °C as shown by vanadium oxide (VO2), compared with other transition metal oxides, makes it a potential candidate for smart window coating. We have successfully fabricated a potential smart window device after the optimum design of a multilaye...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58698-w
更新日期：2020-02-04 00:00:00
abstract：:The topical application of lactic acid bacteria (LAB) is recognized as a useful approach to improve skin health. This work aims to characterize by a multidisciplinary approach, the wound healing, anti-inflammatory, anti-pathogens and proteomic effects of six LAB lysates, belonging to the genus Lactobacillus. Our resul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68483-4
更新日期：2020-07-14 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-39693-2
更新日期：2019-04-17 00:00:00
abstract：:Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, yet current therapeutic treatments are inadequate due to a complex disease pathogenesis. The plant polyphenol apigenin has been shown to have anti-inflammatory and neuroprotective properties in a number of cell and animal models; however...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31450
更新日期：2016-08-12 00:00:00
abstract：:Although oxide-based resistive switching memory (OxRAM) is one of the strong next-generation high capacity memory candidates, it has the critical disadvantage that deviations of resistance levels is too severe to be adopted as a high capacity memory device. More specifically, it is known that the larger on/off current...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35838-x
更新日期：2019-01-22 00:00:00
abstract：:This study aims to evaluate the diagnostic accuracy of digital breast tomosynthesis-guided vacuum assisted breast biopsy (DBT-VABB) of screening detected suspicious mammographic abnormalities comprising of calcifications, asymmetric densities, architectural distortions and spiculated masses. In this institutionally ap...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80124-4
更新日期：2021-01-08 00:00:00
abstract：:Metabonomics/metabolomics is a rapid technology for comprehensive profiling of small molecule metabolites in cells, tissues, or whole organisms, the application of which has led to understanding pathophysiologic mechanisms of cardiometabolic diseases, defining predictive biomarkers for those diseases, and also assessi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09547-w
更新日期：2017-08-18 00:00:00
abstract：:An enormous amount of tumor sequencing data has been generated through large scale sequencing efforts. The functional consequences of the majority of mutations identified by such projects remain an open, unexplored question. This problem is particularly complicated in the case of rare mutations where frequency of occu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38968
更新日期：2016-12-16 00:00:00
abstract：:In this study we analysed the acoustic properties and presence of haddock calls in the Arctic fjord Kongsfjorden (79° N-12° E, Svalbard Islands, Norway) in one year. Data were collected with three autonomous acoustic recorders located in the inner, middle, and outer parts of the fjord. The fjord is characterized by a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75415-9
更新日期：2020-10-26 00:00:00
abstract：:Conventional myeloablative conditioning (MAC) regimens often cause severe regimen-related toxicity (RRT). Furthermore, many patients suffer from poor quality of life in accordance with the increase in long-term survivors. We therefore devised a reduced-toxicity myeloablative conditioning (RTMAC) regimen consisting of ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep06942
更新日期：2014-11-06 00:00:00
abstract：:The present work focuses on the dynamical aspects of cross-reactivity between myelin based protein (MBP) self-peptide and two microbial peptides (UL15, PMM) for Hy.1B11 T-cell receptor (TCR). This same TCR was isolated from a patient suffering from multiple sclerosis (MS). The study aims at highlighting the chemical i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42496
更新日期：2017-02-14 00:00:00
abstract：:We aimed to establish a highly sensitive method for measuring visual function using spatial-sweep steady-state pattern electroretinography (swpPERG). Overall, 35 eyes of 35 healthy adults (18 men; mean age, 32.3 years) were examined using swpPERG, and the data were recorded using spatial-patterned and contrast-reverse...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54606-z
更新日期：2019-12-02 00:00:00
abstract：:Hepcidin, a cysteine-rich peptide hormone, secreted mainly by the liver, plays a central role in iron metabolism regulation. Emerging evidence suggests that disordered iron metabolism is a risk factor for various types of diseases including cancers. However, it remains challenging to apply current mass spectrometry (M...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43756-9
更新日期：2019-05-13 00:00:00
abstract：:The fabrication of Ru nanostructures by focused electron beam induced deposition (FEBID) requires suitable precursor molecules and processes to obtain the pure metal. So far this is problematic because established organometallic Ru precursors contain large organic ligands, such as cyclopentadienyl anions, that tend to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67803-y
更新日期：2020-07-02 00:00:00
