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Auditory Steady State Response; nature and utility as a translational science tool.

Abstract：

:The auditory steady-state response (ASSR) has been used to detect auditory processing deficits in patients with psychiatric disorders. However, the methodology of ASSR recording from the brain surface has not been standardized in preclinical studies, limiting its use as a translational biomarker. The sites of maximal ASSR in humans are the vertex and/or middle frontal area, although it has been suggested that the auditory cortex is the source of the ASSR. We constructed and validated novel methods for ASSR recording using a switchable pedestal which allows ASSR recording alternatively from temporal or parietal cortex with a wide range of frequencies in freely moving rats. We further evaluated ASSR as a translational tool by assessing the effect of ketamine. The ASSR measured at parietal cortex did not show clear event-related spectral perturbation (ERSP) or inter-trial coherence (ITC) in any frequency bands or a change with ketamine. In contrast, the ASSR at temporal cortex showed clear ERSP and ITC where 40 Hz was maximal in both gamma-band frequencies. Ketamine exerted a biphasic effect in ERSP at gamma bands. These findings suggest that temporal cortex recording with a wide frequency range is a robust methodology to detect ASSR, potentially enabling application as a translational biomarker in psychiatric and developmental disorders.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kozono N,Honda S,Tada M,Kirihara K,Zhao Z,Jinde S,Uka T,Yamada H,Matsumoto M,Kasai K,Mihara T

doi

10.1038/s41598-019-44936-3

subject

Has Abstract

pub_date

2019-06-11 00:00:00

pages

8454

issue

1

issn

2045-2322

pii

10.1038/s41598-019-44936-3

journal_volume

9

pub_type

杂志文章

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