Comparative metabonomics of Wenxin Keli and Verapamil reveals differential roles of gluconeogenesis and fatty acid β-oxidation in myocardial injury protection.

abstract：:Outbreaks involving the Asian genotype Chikungunya virus (CHIKV) caused over one million infections in the Americas recently. The outbreak was preceded by a major nationwide outbreak in the Philippines. We examined the phylogenetic and phylogeographic relationships of representative CHIKV isolates obtained from the 20...

journal_title：Scientific reports

authors： Tan KK,Sy AK,Tandoc AO,Khoo JJ,Sulaiman S,Chang LY,AbuBakar S

更新日期：2015-07-23 00:00:00

abstract：:For many applications heterogeneity is a direct indicator of material quality. Reliable determination of chemical heterogeneity is however not a trivial task. Spectral imaging can be used for determining the spatial distribution of an analyte in a sample, thus transforming each pixel of an image into a sampling cell. ...

journal_title：Scientific reports

authors： Mäkelä M,Geladi P

更新日期：2018-07-11 00:00:00

abstract：:Accumulating evidence has indicated that immune regulatory cells are involved in the establishment of tumoral immune evasion. However, the role of regulatory B cells (Bregs) in this remains unclear. Here, we identified a role for Bregs in immune evasion in gastric cancer (GC) patients. The frequency of peripheral Breg...

journal_title：Scientific reports

authors： Murakami Y,Saito H,Shimizu S,Kono Y,Shishido Y,Miyatani K,Matsunaga T,Fukumoto Y,Ashida K,Sakabe T,Nakayama Y,Fujiwara Y

更新日期：2019-09-11 00:00:00

abstract：:Early detection of cancer is essential for effective intervention. Urine has been used to reflect early changes in various tumor-bearing models. However, urine has not been used to predict whether tumors will form in animal models. In this study, a cancer model was established by tail vein injection of 2 million NuTu-...

journal_title：Scientific reports

authors： Wei J,Ni N,Meng W,Huan Y,Gao Y

更新日期：2020-07-16 00:00:00

abstract：:Two-dimensional nanostructures with controllable magnetic and electronic properties are desirable for their versatile applications in quantum devices. Here, we present a first-principles design on their magnetic and electronic switching controlled by tension. We find that hydrogenated VTe2 monolayer experiences a tran...

journal_title：Scientific reports

authors： Pan H

更新日期：2014-12-17 00:00:00

abstract：:In the present study rice straw (R, control) was mixed with Cowdung (C), Azolla (A) and cellulolytic fungus Aspergillus terreus (F) in different combinations viz. RC, RA, RF, RCF, RCA, RFA and RCFA and subjected to aerobic composting (Acom) and vermicomposting (Vcom - with Eisenia fetida). It was found that addition o...

journal_title：Scientific reports

authors： Arora M,Kaur A

更新日期：2019-02-04 00:00:00

abstract：:Intestinal alkaline phosphatase (IAP) regulates bicarbonate secretion, detoxifies lipopolysaccharide (LPS), regulates gut microbes, and dephosphorylates proinflammatory nucleotides. IAP also exhibits anti-inflammatory effects in a Toll-like Receptor-4 (TLR-4) dependent manner. However, it is not known whether IAP indu...

journal_title：Scientific reports

authors： Singh SB,Carroll-Portillo A,Coffman C,Ritz NL,Lin HC

更新日期：2020-02-20 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been used for cell-based therapies in regenerative medicine, with increasing importance in central and peripheral nervous system repair. However, MSCs grafting present disadvantages, such as, a high number of cells required for transplantation and low survival rate when transplanted ...

journal_title：Scientific reports

authors： Martins LF,Costa RO,Pedro JR,Aguiar P,Serra SC,Teixeira FG,Sousa N,Salgado AJ,Almeida RD

更新日期：2017-06-23 00:00:00

abstract：:Membrane fouling remains an obstacle to wide-spread applications of membrane bioreactors (MBRs) for wastewater treatment and reclamation. Herein, we report a simple method to prepare a composite conductive microfiltration (MF) membrane by introducing a stainless steel mesh into a polymeric MF membrane and to effective...

journal_title：Scientific reports

authors： Huang J,Wang Z,Zhang J,Zhang X,Ma J,Wu Z

更新日期：2015-03-18 00:00:00

abstract：:Sex differentiation is a puzzling problem in fish due to the variety of reproductive systems and the flexibility of their sex determination mechanisms. The Sparidae, a teleost family, reflects this remarkable diversity of sexual mechanisms found in fish. Our aim was to capture the transcriptomic signature of different...

journal_title：Scientific reports

authors： Tsakogiannis A,Manousaki T,Lagnel J,Sterioti A,Pavlidis M,Papandroulakis N,Mylonas CC,Tsigenopoulos CS

更新日期：2018-02-23 00:00:00

abstract：:Understanding of avian nocturnal flight comes mainly from northern hemisphere species in seasonal temperate ecosystems where nocturnal flight is often precisely timed and entrained by annual photoperiod. Here we investigate patterns of nocturnal flight in waterbirds of Australian desert ecosystems that fly considerabl...

journal_title：Scientific reports

authors： McEvoy JF,Ribot RFH,Wingfield JC,Bennett ATD

更新日期：2017-12-14 00:00:00

abstract：:Glioblastoma multiforme (GBM) is a highly invasive and chemoradioresistant brain malignancy. Temozolomide (TMZ), a DNA-alkylating agent, is effective against GBM and has become the standard first-line drug. However, the mechanism by which TMZ regulates the progression of GBM remains elusive. Here, we demonstrate that ...

journal_title：Scientific reports

authors： Yamaki T,Suenaga Y,Iuchi T,Alagu J,Takatori A,Itami M,Araki A,Ohira M,Inoue M,Kageyama H,Yokoi S,Saeki N,Nakagawara A

更新日期：2013-01-01 00:00:00

abstract：:To realize power efficient solution-processed phosphorescent organic light-emitting diodes (s-PhOLEDs), the corresponding high driving voltage issue should be well solved. To solve it, efforts have been devoted to the exploitation of novel host or interfacial materials. However, the issues of charge trapping of phosph...

journal_title：Scientific reports

authors： Wang S,Wang X,Yao B,Zhang B,Ding J,Xie Z,Wang L

更新日期：2015-07-24 00:00:00

abstract：:In this article we advance a cutting-edge methodology for the study of the dynamics of plant movements of nutation. Our approach, unlike customary kinematic analyses of shape, period, or amplitude, is based on three typical signatures of adaptively controlled processes and motions, as reported in the biological and be...

journal_title：Scientific reports

authors： Raja V,Silva PL,Holghoomi R,Calvo P

更新日期：2020-11-10 00:00:00

abstract：:Esophageal and gastric cancers share some risk factors. This study aimed to compare the long-term trends in mortality rates of esophageal and gastric cancers in China to provide evidence for cancer prevention and control. Mortality data were derived from 103 continuous points of the Disease Surveillance Points system ...

journal_title：Scientific reports

authors： Li M,Wan X,Wang Y,Sun Y,Yang G,Wang L

更新日期：2017-07-28 00:00:00

abstract：:Super-Planckian near-field radiative heat transfer allows effective heat transfer between a hot and a cold body to increase beyond the limits long known for black bodies. Until present, experimental techniques to measure the radiative heat flow relied on steady-state systems. Here, we present a dynamic measurement app...

journal_title：Scientific reports

authors： Lang S,Sharma G,Molesky S,Kränzien PU,Jalas T,Jacob Z,Petrov AY,Eich M

更新日期：2017-10-24 00:00:00

abstract：:Brassinosteroids are phytohormones involved in plant development and physiological processes. Brassinosteroids Insensitive 1 (BRI1) is required for BR perception and initiation of subsequent signal transduction in Arabidopsis. In this study, the orthologue of BRI1 in the model legume species Medicago truncatula, MtBRI...

journal_title：Scientific reports

authors： Cheng X,Gou X,Yin H,Mysore KS,Li J,Wen J

更新日期：2017-08-24 00:00:00

abstract：:We investigated the relationship between aqueous cytokine levels, changes in ocular blood flow, and morphological and functional improvements after intravitreal ranibizumab injection (IRI) in treatment-naïve eyes with center-involving diabetic macular edema (DME). Thirty-three eligible patients with DME (33 eyes) were...

journal_title：Scientific reports

authors： Mizui T,Noma H,Yasuda K,Kanemaki T,Goto H,Shimura M

更新日期：2020-12-10 00:00:00

abstract：:The Tcf/Lef family of transcription factors mediates the Wnt/β-catenin pathway that is involved in a wide range of biological processes, including vertebrate embryogenesis and diverse pathogenesis. Post-translational modifications, including phosphorylation, sumoylation and acetylation, are known to be important for t...

journal_title：Scientific reports

authors： Han W,Lee H,Han JK

更新日期：2017-02-15 00:00:00

abstract：:The objective of this study was to investigate the effects of slightly elevated atmospheric temperature in the spring on photosynthetic products in wheat seedlings and on organic compounds and biological activity in rhizosphere soil under cadmium (Cd) stress. Elevated temperature was associated with increased soluble ...

journal_title：Scientific reports

authors： Jia X,Zhao Y,Wang W,He Y

更新日期：2015-09-23 00:00:00

abstract：:Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare disease, characterised by the aplasia of vagina and uterus in women with a 46,XX karyotype. Most cases are sporadic, but familial recurrence has also been described. Herein, we investigated an Italian cohort of 36 unrelated MRKH patients to explore the presence ...

journal_title：Scientific reports

authors： Pontecorvi P,Bernardini L,Capalbo A,Ceccarelli S,Megiorni F,Vescarelli E,Bottillo I,Preziosi N,Fabbretti M,Perniola G,Benedetti Panici P,Pizzuti A,Grammatico P,Marchese C

更新日期：2021-01-11 00:00:00

abstract：:Abnormalities in actin cytoskeleton have been linked to Friedreich's ataxia (FRDA), an inherited peripheral neuropathy characterised by an early loss of neurons in dorsal root ganglia (DRG) among other clinical symptoms. Despite all efforts to date, we still do not fully understand the molecular events that contribute...

journal_title：Scientific reports

authors： Muñoz-Lasso DC,Mollá B,Calap-Quintana P,García-Giménez JL,Pallardo FV,Palau F,Gonzalez-Cabo P

更新日期：2020-03-23 00:00:00

abstract：:Development of novel anti-influenza A virus (IAV) drugs with high efficiency and low toxicity is critical for preparedness against influenza outbreaks. Herein, we investigated the anti-IAV activities and mechanisms of fucoidan in vitro and in vivo. The results showed that a fucoidan KW derived from brown algae Kjellma...

journal_title：Scientific reports

authors： Wang W,Wu J,Zhang X,Hao C,Zhao X,Jiao G,Shan X,Tai W,Yu G

更新日期：2017-01-17 00:00:00

abstract：:Active methane seepage occurs congruent with a high density of up to 1 km-wide and 35 m deep seafloor craters (>100 craters within 700 km2 area) within lithified sedimentary rocks in the northern Barents Sea. The crater origin has been hypothesized to be related to rapid gas hydrate dissociation and methane release ar...

journal_title：Scientific reports

authors： Waage M,Serov P,Andreassen K,Waghorn KA,Bünz S

更新日期：2020-05-21 00:00:00

abstract：:Neural connectivity requires neuronal differentiation, axon growth, and precise target innervation. Midbrain dopaminergic neurons project via the nigrostriatal pathway to the striatum to regulate voluntary movement. While the specification and differentiation of these neurons have been extensively studied, the molecul...

journal_title：Scientific reports

authors： Hegarty SV,Wyatt SL,Howard L,Stappers E,Huylebroeck D,Sullivan AM,O'Keeffe GW

更新日期：2017-08-17 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Sahani RM,Kumari C,Pandya A,Dixit A

更新日期：2020-02-19 00:00:00

abstract：:Stem cells have been discovered as key players in the genesis of different neoplasms including craniopharyngioma (CP), a rare tumour entity in the sellar region. Sox2 and Sox9 are well-known stem cell markers involved in pituitary development. In this study we analysed the expression of both transcription factors usin...

journal_title：Scientific reports

authors： Thimsen V,John N,Buchfelder M,Flitsch J,Fahlbusch R,Stefanits H,Knosp E,Losa M,Buslei R,Hölsken A

更新日期：2017-11-20 00:00:00

abstract：:Knowledge of the structure-property-function relationship of humic substances (HSs) is key for understanding their role in soil. Despite progress, studies on this topic are still under discussion. We analyzed 37 humic fractions with respect to their isotopic composition, structural characteristics, and properties resp...

journal_title：Scientific reports

authors： García AC,de Souza LG,Pereira MG,Castro RN,García-Mina JM,Zonta E,Lisboa FJ,Berbara RL

更新日期：2016-02-10 00:00:00

abstract：:Oligomers populated during the early amyloid aggregation process are more toxic than mature fibrils, but pinpointing the exact toxic species among highly dynamic and heterogeneous aggregation intermediates remains a major challenge. β-barrel oligomers, structurally-determined recently for a slow-aggregating peptide de...

journal_title：Scientific reports

authors： Sun Y,Ge X,Xing Y,Wang B,Ding F

更新日期：2018-07-09 00:00:00

abstract：:18-flurodesoxyglucose position emission tomography (FDG-PET) with computed tomography (CT) or magnetic resonance imaging (MRI) is a broadly accepted tool for pretherapeutic staging and post-therapeutic assessment of response. The prognostic value of sequential post-therapeutic FDG-PETs and the impact of change in meta...

journal_title：Scientific reports

authors： Stadler TM,Hüllner MW,Broglie MA,Morand GB

更新日期：2020-10-07 00:00:00