Abstract:
:Glioblastoma multiforme (GBM) is a highly invasive and chemoradioresistant brain malignancy. Temozolomide (TMZ), a DNA-alkylating agent, is effective against GBM and has become the standard first-line drug. However, the mechanism by which TMZ regulates the progression of GBM remains elusive. Here, we demonstrate that TMZ targets TAp63, a p53 family member, inducing its expression to suppress the progression of human GBM. High levels of TAp63 expression in GBM tissues after TMZ treatment was an indicator of favourable prognosis. In human GBM cells, TMZ-induced TAp63 directly repressed MYC transcription. Activation of this TAp63-MYC pathway by TMZ inhibited human GBM progression both in vitro and in vivo. Furthermore, downregulation of MYC mRNA levels in recurrent GBMs after TMZ treatment correlated with better patient survival. Therefore, our results suggest that the TAp63-mediated transcriptional repression of MYC is a novel pathway regulating TMZ efficacy in GBM.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yamaki T,Suenaga Y,Iuchi T,Alagu J,Takatori A,Itami M,Araki A,Ohira M,Inoue M,Kageyama H,Yokoi S,Saeki N,Nakagawara Adoi
10.1038/srep01160subject
Has Abstractpub_date
2013-01-01 00:00:00pages
1160issn
2045-2322journal_volume
3pub_type
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